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https://www.readbyqxmd.com/read/29031191/the-effectiveness-of-a-head-heart-hands-model-for-natural-and-environmental-science-learning-in-urban-schools
#1
Radha Jagannathan, Michael J Camasso, Maia Delacalle
We describe an environmental and natural science program called Nurture thru Nature (NtN) that seeks to improve mathematics and science performance of students in disadvantaged communities, and to increase student interest in Science, Technology, Engineering and Mathematics (STEM) careers. The program draws conceptual guidance from the Head-Heart-Hands model that informs the current educational movement to foster environmental understanding and sustainability. Employing an experimental design and data from seven cohorts of students, we find some promising, albeit preliminary, indications that the program can increase students' science knowledge and grades in mathematics, science and language arts...
September 18, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29029322/a-dynamic-mathematical-model-of-bile-acid-clearance-in-heparg-cells
#2
Daniel Kaschek, Ahmad Sharanek, André Guillouzo, Jens Timmer, Richard J Weaver
A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid in human HepaRG cells is presented. The highly reproducible inter-assay experimental data were used to reliably estimate model parameters. Primary human hepatocytes were similarly evaluated to establish a mathematical model, but with notably higher inter-assay differences in taurocholic acid clearance and bile canaliculi dynamics. By use of the HepaRG cell line, the simultaneous taurocholic acid clearance associated to basolateral uptake, canalicular and sinusoidal efflux, was predicted...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29028841/efficacies-of-prevention-and-control-measures-applied-during-an-outbreak-in-southwest-madrid-spain
#3
Anaiá da Paixão Sevá, Maia Martcheva, Necibe Tuncer, Isabella Fontana, Eugenia Carrillo, Javier Moreno, James Keesling
Leishmaniasis is a vector-borne disease of worldwide distribution, currently present in 98 countries. Since late 2010, an unusual increase of human visceral and cutaneous leishmaniasis cases has been observed in the south-western Madrid region, totaling more than 600 cases until 2015. Some hosts, such as human, domestic dog and cat, rabbit (Oryctolagus cuniculus), and hare (Lepus granatensis), were found infected by the parasite of this disease in the area. Hares were described as the most important reservoir due to their higher prevalence, capacity to infect the vector, and presence of the same strains as in humans...
2017: PloS One
https://www.readbyqxmd.com/read/29028492/modelling-an-industrial-anaerobic-granular-reactor-using-a-multi-scale-approach
#4
H Feldman, X Flores-Alsina, P Ramin, K Kjellberg, U Jeppsson, D J Batstone, K V Gernaey
The objective of this paper is to show the results of an industrial project dealing with modelling of anaerobic digesters. A multi-scale mathematical approach is developed to describe reactor hydrodynamics, granule growth/distribution and microbial competition/inhibition for substrate/space within the biofilm. The main biochemical and physico-chemical processes in the model are based on the Anaerobic Digestion Model No 1 (ADM1) extended with the fate of phosphorus (P), sulfur (S) and ethanol (Et-OH). Wastewater dynamic conditions are reproduced and data frequency increased using the Benchmark Simulation Model No 2 (BSM2) influent generator...
September 20, 2017: Water Research
https://www.readbyqxmd.com/read/29028334/dynamic-control-of-aptamer-ligand-activity-using-strand-displacement-reactions
#5
Jonathan Lloyd, Claire H Tran, Krishen Wadhwani, Christian Cuba Samaniego, Hari K K Subramanian, Elisa Franco
Nucleic acid aptamers are an expandable toolkit of sensors and regulators. To employ aptamer regulators within non-equilibrium molecular networks, the aptamer-ligand interactions should be tunable over time, so that functions within a given system can be activated or suppressed on demand. This is accomplished through complementary sequences to aptamers, which achieve programmable aptamer-ligand dissociation by displacing the aptamer from the ligand. We demonstrate the effectiveness of our simple approach on light-up aptamers as well as on aptamers inhibiting viral RNA polymerases, dynamically controlling the functionality of the aptamer-ligand complex...
October 13, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29028131/a-motion-analysis-protocol-for-kinematic-assessment-of-poly-articulated-prosthetic-hands-with-cosmetic-gloves
#6
Andrea Giovanni Cutti, Francesca Cordella, Giulia D'Amico, Rinaldo Sacchetti, Angelo Davalli, Eugenio Guglielmelli, Loredana Zollo
To provide upper-limb amputees with devices that best fit their needs and to test innovative solutions, it is necessary to quantitatively appraise a device performance with rigorous measurement methods. The aim of this work was to define an optimal motion analysis protocol, suitable for optoelectronic systems, to measure the kinematics of poly-articulated hands even when covered by a cosmetic glove. This is a fundamental aspect, because gloves can decrease device speed and range of motion and, ultimately, patients' acceptance of the artificial limb...
October 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29027943/low-grade-dysplastic-nodules-revealed-as-the-tipping-point-during-multistep-hepatocarcinogenesis-by-dynamic-network-biomarkers
#7
Lina Lu, Zhonglin Jiang, Yulin Dai, Luonan Chen
Hepatocellular carcinoma (HCC) is a complex disease with a multi-step carcinogenic process from preneoplastic lesions, including cirrhosis, low-grade dysplastic nodules (LGDNs), and high-grade dysplastic nodules (HGDNs) to HCC. There is only an elemental understanding of its molecular pathogenesis, for which a key problem is to identify when and how the critical transition happens during the HCC initiation period at a molecular level. In this work, for the first time, we revealed that LGDNs is the tipping point (i...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29027415/-application-of-quality-by-design-in-granulation-process-for-ginkgo-leaf-tablet-%C3%A2-%C3%AF-process-control-strategy-based-on-design-space
#8
Xiang-Long Cui, Bing Xu, Fei Sun, Sheng-Yun Dai, Xin-Yuan Shi, Yan-Jiang Qiao
In this paper, under the guidance of quality by design (QbD) concept, the control strategy of the high shear wet granulation process of the ginkgo leaf tablet based on the design space was established to improve the process controllability and product quality consistency. The median granule size (D50) and bulk density (Da) of granules were identified as critical quality attributes (CQAs) and potential critical process parameters (pCPPs) were determined by the failure modes and effect analysis (FMEA). The Plackeet-Burmann experimental design was used to screen pCPPs and the results demonstrated that the binder amount, the wet massing time and the wet mixing impeller speed were critical process parameters (CPPs)...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29026686/pain-prediction-from-ecg-in-vascular-surgery
#9
Tricia Adjei, Wilhelm Von Rosenberg, Valentin Goverdovsky, Katarzyna Powezka, Usman Jaffer, Danilo P Mandic
Varicose vein surgeries are routine outpatient procedures, which are often performed under local anaesthesia. The use of local anaesthesia both minimises the risk to patients and is cost effective, however, a number of patients still experience pain during surgery. Surgical teams must therefore decide to administer either a general or local anaesthetic based on their subjective qualitative assessment of patient anxiety and sensitivity to pain, without any means to objectively validate their decision. To this end, we develop a 3-D polynomial surface fit, of physiological metrics and numerical pain ratings from patients, in order to model the link between the modulation of cardiovascular responses and pain in varicose vein surgeries...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29026441/modeling-the-architecture-of-the-regulatory-system-controlling-methylenomycin-production-in-streptomyces-coelicolor
#10
Jack E Bowyer, Emmanuel Lc de Los Santos, Kathryn M Styles, Alex Fullwood, Christophe Corre, Declan G Bates
BACKGROUND: The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regulatory and resistance genes are located on a single cluster on the SCP1 plasmid, making the entire module easily transferable between different bacterial strains. Understanding further the regulation and biosynthesis of the methylenomycin producing gene cluster could assist in the identification of motifs that can be exploited in synthetic regulatory systems for the rational engineering of novel natural products and antibiotics...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29026267/control-of-reaction-diffusion-equations-on-time-evolving-manifolds
#11
Francesco Rossi, Nastassia Pouradier Duteil, Nir Yakoby, Benedetto Piccoli
Among the main actors of organism development there are morphogens, which are signaling molecules diffusing in the developing organism and acting on cells to produce local responses. Growth is thus determined by the distribution of such signal. Meanwhile, the diffusion of the signal is itself affected by the changes in shape and size of the organism. In other words, there is a complete coupling between the diffusion of the signal and the change of the shapes. In this paper, we introduce a mathematical model to investigate such coupling...
December 2016: Proceedings of the ... IEEE Conference on Decision & Control
https://www.readbyqxmd.com/read/29024884/adsorption-desorption-and-hysteresis-phenomenon-of-tebuconazole-in-colombian-agricultural-soils-experimental-assays-and-mathematical-approaches
#12
Carmen S Mosquera-Vivas, María J Martinez, Glenda García-Santos, Jairo A Guerrero-Dallos
The adsorption-desorption, hysteresis phenomenon, and leachability of tebuconazole were studied for Inceptisol and Histosol soils at the surface (0-10 cm) and in the subsurface (40-50 cm) of an agricultural region from Colombia by the batch-equilibrium method and mathematical approaches. The experimental Kfa and Kd (L kg(-1)) values (7.9-289.2) decreased with depth for the two Inceptisols and increased with depth for the Histosol due to the organic carbon content, aryl and carbonyl carbon types. Single-point and desorption isotherms depended on adsorption reversibility and suggested that tebuconazole showed hysteresis; which can be adequately evaluated with the single-point desorption isotherm and the linear model using the hysteresis index HI...
September 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29024464/influence-of-lipophilicity-in-o-acyl-and-o-alkyl-derivatives-of-juglone-and-lawsone-a-structure-activity-relationship-study-in-the-search-for-natural-herbicide-models
#13
Alexandra G Durán, Nuria Chinchilla, José M G Molinillo, Francisco A Macías
BACKGROUND: Naphthoquinones are known for their broad range of biological activities. Given the increasing demands of consumers in relation to food quality and growing concerns about the impact of synthetic herbicides, it is necessary to search for new agrochemicals. Natural products and allelopathy provide new alternatives for the development of pesticides with lower toxicity and greater environmental compatibility. RESULTS: A structure-activity relationship to evaluate the effect of bioavailability was performed...
October 12, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29024294/cognitive-motor-behavioural-and-academic-performances-of-children-born-preterm-a-meta-analysis-and-systematic-review-involving-64-061-children
#14
REVIEW
J Allotey, J Zamora, F Cheong-See, M Kalidindi, D Arroyo-Manzano, E Asztalos, Jam van der Post, B W Mol, D Moore, D Birtles, K S Khan, S Thangaratinam
BACKGROUND: Preterm birth may leave the brain vulnerable to dysfunction. Knowledge of future neurodevelopmental delay in children born with various degrees of prematurity is needed to inform practice and policy. OBJECTIVE: To quantify the long-term cognitive, motor, behavioural and academic performance of children born with different degrees of prematurity compared with term-born children. SEARCH STRATEGY: PubMed and Embase were searched from January 1980 to December 2016 without language restrictions...
October 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29024278/why-do-sglt2-inhibitors-reduce-heart-failure-hospitalization-a-differential-volume-regulation-hypothesis
#15
REVIEW
K Melissa Hallow, Gabriel Helmlinger, Peter J Greasley, John J V McMurray, David W Boulton
The effect of a sodium glucose cotransporter 2 inhibitor (SGLT2i) in reducing heart failure hospitalization in the EMPA-REG OUTCOMES trial has raised the possibility of using these agents to treat established heart failure. We hypothesize that osmotic diuresis induced by SGLT2 inhibition, a distinctly different diuretic mechanism than other diuretic classes, results in greater electrolyte-free water clearance, and ultimately in greater fluid clearance from the interstitial fluid (IF) space than from the circulation, potentially resulting in congestion relief with minimal impact on blood volume, arterial filling, and organ perfusion...
October 12, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29023409/a-high-stability-time-difference-readout-technique-of-rtd-fluxgate-sensors
#16
Na Pang, Defu Cheng, Yanzhang Wang
The performance of Residence Times Difference (RTD)-fluxgate sensors is closely related to the time difference readout technique. The noise of the induction signal affects the quality of the output signal of the following circuit and the time difference detection, so the stability of the sensor is limited. Based on the analysis of the uncertainty of the RTD-fluxgate using the Bidirectional Magnetic Saturation Time Difference (BMSTD) readout scheme, the relationship between the saturation state of the magnetic core and the target (DC) magnetic field is studied in this article...
October 12, 2017: Sensors
https://www.readbyqxmd.com/read/29023391/experimental-analysis-and-mathematical-modeling-on-mg-li-alloy-sheets-with-three-crystal-structures-during-cold-rolling-and-heat-treatment
#17
Yan Tang, Qichi Le, Tong Wang, Xingrui Chen
The microstructural evolution, mechanical properties, and mathematical relationship of an α, α + β, and β phase Mg-Li alloy during the cold rolling and annealing process were investigated. The results showed that the increased Li element gradually transformed the Mg matrix structure from hcp to bcc. Simultaneously, the alloy plasticity was improved remarkably during cold rolling. In the annealing process, a sort of abnormal grain growth was found in Mg-11Li-3Al-2Zn-0.2Y, but was not detected in Mg-5Li-3Al-2Zn-0...
October 12, 2017: Materials
https://www.readbyqxmd.com/read/29021609/a-cdk1-gradient-guides-surface-contraction-waves-in-oocytes
#18
Johanna Bischof, Christoph A Brand, Kálmán Somogyi, Imre Májer, Sarah Thome, Masashi Mori, Ulrich S Schwarz, Péter Lénárt
Surface contraction waves (SCWs) in oocytes and embryos lead to large-scale shape changes coupled to cell cycle transitions and are spatially coordinated with the cell axis. Here, we show that SCWs in the starfish oocyte are generated by a traveling band of myosin II-driven cortical contractility. At the front of the band, contractility is activated by removal of cdk1 inhibition of the RhoA/RhoA kinase/myosin II signaling module, while at the rear, contractility is switched off by negative feedback originating downstream of RhoA kinase...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29021534/quorum-sensing-integrates-environmental-cues-cell-density-and-cell-history-to-control-bacterial-competence
#19
Stefany Moreno-Gámez, Robin A Sorg, Arnau Domenech, Morten Kjos, Franz J Weissing, G Sander van Doorn, Jan-Willem Veening
Streptococcus pneumoniae becomes competent for genetic transformation when exposed to an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was originally described as a quorum-sensing signal, enabling individual cells to regulate competence in response to population density. However, recent studies suggest that CSP may instead serve as a probe for sensing environmental cues, such as antibiotic stress or environmental diffusion. Here, we show that competence induction can be simultaneously influenced by cell density, external pH, antibiotic-induced stress, and cell history...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29021289/quantifying-the-regulatory-effect-size-of-cis-acting-genetic-variation-using-allelic-fold-change
#20
Pejman Mohammadi, Stephane E Castel, Andrew A Brown, Tuuli Lappalainen
Mapping cis-acting expression quantitative trait loci (cis-eQTL) has become a popular approach for characterizing proximal genetic regulatory variants. In this paper, we describe and characterize log allelic fold change (aFC), the magnitude of expression change associated with a given genetic variant, as a biologically interpretable unit for quantifying the effect size of cis-eQTLs and a mathematically convenient approach for systematic modeling of cis-regulation. This measure is mathematically independent from expression level and allele frequency, additive, applicable to multiallelic variants, and generalizable to multiple independent variants...
October 11, 2017: Genome Research
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