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Nailfold capillaroscopy

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https://www.readbyqxmd.com/read/27888176/nailfold-capillary-morphological-characteristics-of-hand-arm-vibration-syndrome-a-cross-sectional-study
#1
QingSong Chen, GuiPing Chen, Bin Xiao, HanSheng Lin, HongYing Qu, DanYing Zhang, MaoGong Shi, Li Lang, Bei Yang, MaoSheng Yan
OBJECTIVE: The purpose of this study was to investigate the characteristics of nailfold capillaroscopy associated with hand-arm vibration syndrome (HAVS). METHODS: In total, 113 male gold miners were recruited: 35 workers who were chronically exposed to vibration and developed vibration-induced white finger were defined as the HAVS group, 39 workers who were exposed to vibration but did not have HAVS were classified as the vibration-exposed controls (VEC) group, and 39 workers without vibration exposure were categorised as the non-VEC (NVEC) group...
November 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27828654/nailfold-capillaroscopy-in-leprosy
#2
Adma Silva de Lima, Vanessa Irusta Dal Pizzol, Scheila Fritsch, Gabriela Poglia Fonseca, Fabiane Andrade Mulinari-Brenner, Carolina de Souza Muller, Vanessa Cristhine Dalombo Ottoboni
Due to mounting evidences of interaction between Hansen's bacilli with endothelial cells and the paucity of studies addressing the presence of nailfold capillaroscopic alterations in patients with Hansen's disease, a study was carried out in order to verify the presence of capillaroscopic alterations in patients with leprosy in its various forms and its correlation with clinical parameters. Ten patients were evaluated at a specialized university service. Sixty percent of those had some capillaroscopic change, such as micro-hemorrhages, ectatic, bushy and corkscrew capillaries...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27614146/capillary-density-an-important-parameter-in-nailfold-capillaroscopy
#3
Zahra Emrani, Abdolamir Karbalaie, Alimohammad Fatemi, Mahnaz Etehadtavakol, Björn-Erik Erlandsson
Nailfold capillaroscopy is one of the various noninvasive bioengineering methods used to investigate skin microcirculation. It is an effective examination for assessing microvascular changes in the peripheral circulation; hence it has a significant role for the diagnosis of Systemic sclerosis with the classic changes of giant capillaries as well as the decline in capillary density with capillary dropout. The decline in capillary density is one of microangiopathic features existing in connective tissue disease...
September 7, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27594391/nailfold-capillaroscopy-microscopy-an-interdisciplinary-appraisal
#4
Peter Franz Klein-Weigel, Cord Sunderkötter, Oliver Sander
Nailfold capillaroscopy is a method of great diagnostic value in the differential diagnosis of primary versus secondary Raynaud´s phenomenon, of systemic sclerosis versus other so called connective tissue diseases and of additional diagnostic value in other entities. Rheumatologists, dermatologists, and angiologists in Germany have convened in an interdisciplinary working group in which they synergistically combined their expertise to develop a common nomenclature and standards for the technical performance of nailfold capillary microscopy...
September 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27552783/the-place-of-nailfold-capillaroscopy-among-instrumental-methods-for-assessment-of-some-peripheral-ischaemic-syndromes-in-rheumatology
#5
Sevdalina N Lambova
Micro- and macrovascular pathology is a frequent finding in a number of common rheumatic diseases. Secondary Raynaud's phenomenon (RP) is among the most common symptoms in systemic sclerosis and several other systemic autoimmune diseases including a broad differential diagnosis. It should be also differential from other peripheral vascular syndromes such as embolism, thrombosis, etc., some of which lead to clinical manifestation of the blue toe syndrome. The current review discusses the instrumental methods for vascular assessments...
April 2016: Folia Medica
https://www.readbyqxmd.com/read/27494080/raynaud-s-syndrome-in-children-systematic-review-and-development-of-recommendations-for-assessment-and-monitoring
#6
Clare E Pain, Tamás Constantin, Natasa Toplak, Monica Moll, Christof Iking-Konert, Daniella P Piotto, Nuray Aktay Ayaz, Dana Nemcova, Peter H Hoeger, Maurizio Cutolo, Vanessa Smith, Ivan Foeldvari
OBJECTIVES: To develop recommendations for investigation and monitoring of children with Raynaud's syndrome, based on paediatric evidence collated by a systematic review. METHODS: A systematic review was undertaken to establish the paediatric evidence for assessment and monitoring of Raynaud's syndrome. An expert panel including members of the Paediatric Rheumatology European Society (PRES) Scleroderma Working Group, were invited to a consensus meeting where recommendations were developed based on evidence graded by the systematic review and where evidence was lacking, consensus opinion...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27476627/low-vitamin-d-serum-levels-in-diffuse-systemic-sclerosis-a-correlation-with-worst-quality-of-life-and-severe-capillaroscopic-findings
#7
Marília M Sampaio-Barros, Liliam Takayama, Percival D Sampaio-Barros, Eloísa Bonfá, Rosa Maria R Pereira
OBJECTIVE: The aim of this study was to analyze the correlation of vitamin D levels with clinical parameters, bone mineral density (BMD), quality of life (QoL) and nailfold capillaroscopy (NC) in patients with diffuse systemic sclerosis (SSc). METHODS: Thirty-eight female patients with diffuse SSc were analyzed regarding 25-hydroxyvitamin D (25OHD) serum levels. At inclusion, organ involvement, autoantibodies, modified Rodnan skin score (mRSS), Medsger Disease Severity Index (MDSI), body mass index (BMI), BMD, NC, Short-Form-36 Questionnaire (SF-36), and Health Assessment Questionnaire (HAQ), were performed through a standardized interview, physical examination and electronic chart review...
July 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27421220/raynaud-s-phenomenon
#8
REVIEW
Michael Hughes, Ariane L Herrick
Raynaud's phenomenon (RP) is a major cause of pain and disability in patients with autoimmune connective tissue diseases (CTDs), particularly systemic sclerosis (SSc). The clinician must perform a comprehensive clinical assessment in patients with RP to differentiate between primary (idiopathic) and secondary RP, in particular (for rheumatologists), secondary to an autoimmune CTD, as both the prognosis and treatment may differ significantly. Key investigations are nailfold capillaroscopy and testing for autoantibodies (in particular, those associated with SSc)...
February 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27407282/capillaroscopy-a-role-in-modern-rheumatology
#9
REVIEW
Marek M Chojnowski, Anna Felis-Giemza, Marzena Olesińska
Capillaroscopy is a non-invasive, easy and safe diagnostic technique designed to evaluate small vessels of the microcirculation in the nailfold. It can reveal both the general architecture of capillary rows and fine details of particular vessels. The most important indications for performing capillaroscopy include differential diagnosis of primary and secondary Raynaud's phenomenon, as well as assessment of scleroderma spectrum disorders. In systemic sclerosis capillary abnormalities appear and evolve in a clearly defined sequence called the scleroderma pattern, which correlates with internal organ involvement...
2016: Reumatologia
https://www.readbyqxmd.com/read/27392528/capillaroscopic-findings-and-vascular-biomarkers-in-systemic-sclerosis-association-of-low-cd40l-levels-with-late-scleroderma-pattern
#10
Yasemin Yalçınkaya, Suzan Adın-Çınar, Bahar Artim-Esen, Sevil Kamalı, Özlem Pehlivan, Lale Öcal, Günnür Deniz, Murat Inanç
OBJECTIVE: To determine the relationship between vascular biomarkers reflecting the vascular injury and neoangiogenesis with capillaroscopic changes in systemic sclerosis (SSc). METHODS: Nailfold video-capillaroscopy (NVC) was performed qualitatively (early, active and late scleroderma patterns) in 72 SSc patients (66 female) fulfilling ACR/EULAR (2013) criteria. Serum samples of patients were collected and analysed by flow cytometer with multiplex kits of sCD40L, tPA, MCP-1, sE-selectin, IL-8, IL-6, VEGF, sP-selectin, TGF-β1 and VCAM at the same time with NVC...
November 2016: Microvascular Research
https://www.readbyqxmd.com/read/27373498/validation-of-the-2013-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-systemic-sclerosis-in-patients-from-a-capillaroscopy-clinic
#11
Sheila Melchor, Beatriz E Joven, Jose Luis Andreu, Estibaliz Loza, M Jesus Garcia de Yebenes, Loreto Carmona, Patricia E Carreira
OBJECTIVE: To validate the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc) in patients from a capillaroscopy clinic. METHODS: All patients attended in a capillaroscopy clinic were included. Sociodemographic and SSc-related variables were collected. Using as gold standard for SSc the clinical judgement, the performance (sensitivity, specificity, predictive values, and likelihood ratios) of the 2013 ACR/EULAR criteria were analyzed. Receiver operating characteristic (ROC) curve and the area under the curve (AUC) were calculated for the global score and individual items, and the best cutoffs were obtained...
June 3, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27366896/dynamic-optical-coherence-tomography-capillaroscopy-a-new-imaging-tool-in-autoimmune-connective-tissue-disease
#12
Hans Christian Ring, Lotte Themstrup, Christina Alette Banzhaf, Gregor B E Jemec, Mette Mogensen
Importance: Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis and dermatomyositis. Although there are several advantages in using capillaroscopy, the method does not offer insight on the skin architecture, flow status, or morphology of the deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection of high-speed changes in back-scattered light caused by moving cells in vessels...
June 29, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27357717/nailfold-capillaroscopy-assessment-of-microcirculation-abnormalities-and-endothelial-dysfunction-in-children-with-primary-or-secondary-raynaud-syndrome
#13
Joanna Latuskiewicz-Potemska, Antonina Chmura-Skirlinska, Ryszard J Gurbiel, Elzbieta Smolewska
Raynaud syndrome (RS) manifests as episodes of transient spasms of peripheral blood vessels, most often in response to cold. The reason of that symptom (primary RS (pRS)) usually cannot be found but may be accompanied by some autoimmune diseases (secondary RS (sRS)). In this study, we assessed microcapillary status and serum concentrations of chosen cytokines, adhesive molecules, and nitric oxide (NO) in patients with pRS and sRS in comparison with healthy children. Eighty-six patients with RS were enrolled into the study, including 52 with pRS and 34 with sRS...
August 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27312381/digital-ulcers-and-cutaneous-subsets-of-systemic-sclerosis-clinical-immunological-nailfold-capillaroscopy-and-survival-differences-in-the-spanish-rescle-registry
#14
Carles Tolosa-Vilella, Maria Lluisa Morera-Morales, Carmen Pilar Simeón-Aznar, Begoña Marí-Alfonso, Dolores Colunga-Arguelles, José Luis Callejas Rubio, Manuel Rubio-Rivas, Maika Freire-Dapena, Alfredo Guillén-Del Castillo, Nerea Iniesta-Arandia, Maria Jesús Castillo-Palma, Marivi Egurbide-Arberas, Luis Trapiellla-Martínez, José A Vargas-Hitos, José Antonio Todolí-Parra, Mónica Rodriguez-Carballeira, Adela Marin-Ballvé, Xavier Pla-Salas, Juan José Rios-Blanco, Vicent Fonollosa-Pla
OBJECTIVE: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc. METHODS: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE)...
October 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27267184/proximal-nailfold-microhemorrhage-events-are-manifested-as-distal-cuticular-eponychial-hemosiderin-containing-deposits-cehd-syn-maricq-sign-and-can-aid-in-the-diagnosis-of-dermatomyositis-and-systemic-sclerosis
#15
Jeffrey D McBride, Richard D Sontheimer
IMPORTANCE: Many patients present with cutaneous signs and symptoms that suggest a diagnosis on the autoimmune disease spectrum. During the "acute phase" of disease activity, patients with systemic sclerosis (SSc) and dermatomyositis (DM) have characteristic nailfold findings, including dilated capillaries, microhemorrhages, and hemosiderin deposits. OBJECTIVE: To review the literature on the presentation of microhemorrhages and to highlight the differences (in terms of terminology, characterization, and clinical relevance) between proximal microhemorrhage events and the distal products, often thought of as "hemosiderin deposits" located in the cuticle (eponychium)...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27265366/impaired-metabolic-profile-is-a-predictor-of-capillary-rarefaction-in-a-population-of-hypertensive-and-normotensive%C3%A2-individuals
#16
Areti Triantafyllou, Panagiota Anyfanti, Georgios Triantafyllou, Xenophon Zabulis, Spyros Aslanidis, Stella Douma
Capillary rarefaction is typically encountered in essential hypertension, yet identification of factors interfering with this phenomenon remains substantially underinvestigated. We examined whether components of metabolic profile (dyslipidemia, insulin resistance), inflammatory (high-sensitivity C-reactive protein, high-sensitivity C-reactive protein), and angiogenic (vascular endothelial growth factor) factors are implicated in this phenomenon in a population of newly diagnosed, never-treated hypertensive patients and normotensive controls...
August 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27165522/low-vitamin-d-serum-levels-in-diffuse-systemic-sclerosis-a-correlation-with-worst-quality-of-life-and-severe-capillaroscopic-findings
#17
Marília M Sampaio-Barros, Liliam Takayama, Percival D Sampaio-Barros, Eloísa Bonfá, Rosa Maria R Pereira
OBJECTIVE: The aim of this study was to analyze the correlation of vitamin D levels with clinical parameters, bone mineral density (BMD), quality of life (QoL) and nailfold capillaroscopy (NC) in patients with diffuse systemic sclerosis (SSc). METHODS: Thirty-eight female patients with diffuse SSc were analyzed regarding 25-hydroxyvitamin D (25OHD) serum levels. At inclusion, organ involvement, autoantibodies, modified Rodnan skin score (mRSS), Medsger Disease Severity Index (MDSI), body mass index (BMI), BMD, NC, Short-Form-36 Questionnaire (SF-36), and Health Assessment Questionnaire (HAQ), were performed through a standardized interview, physical examination and electronic chart review...
April 19, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27157691/improvement-of-nailfold-capillary-microangiopathy-after-immunosuppressant-therapy-in-a-child-with-clinically-amyopathic-juvenile-dermatomyositis
#18
Lúcia Maria Arruda Campos, Adriana M E Sallum, Cintia Z Camargo, Luís Eduardo C Andrade, Cristiane Kayser
Clinically amyopathic dermatomyositis (CADM) is an extremely rare entity in childhood and only 75 cases have been described in the literature. These patients present mild or no muscle involvement, while skin involvement is similar to that seen in classic dermatomyositis (DM). Systemic inflammatory vasculopathy is a hallmark of juvenile dermatomyositis (JDM), especially affecting the microcirculation. Nailfold capillaroscopy (NFC) is a non-invasive method that allows direct visualization of nailfold capillary loops around the proximal edge of the finger nails...
April 18, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27136918/symptoms-of-raynaud-s-phenomenon-rp-in-fibromyalgia-syndrome-are-similar-to-those-reported-in-primary-rp-despite-differences-in-objective-assessment-of-digital-microvascular-function-and-morphology
#19
M Scolnik, B Vasta, D J Hart, J A Shipley, N J McHugh, J D Pauling
Symptoms of Raynaud's phenomenon (RP) are common in fibromyalgia syndrome (FMS). We compared symptom characteristics and objective assessment of digital microvascular function using infrared thermography (and nailfold capillaroscopy where available) in patients with FMS (reporting RP symptoms) and primary RP. We retrospectively reviewed the outcome of microvascular imaging studies and RP symptom characteristics (captured using patient-completed questionnaire at the time of assessment) for patients with FMS (reporting RP symptoms) and patients with primary RP referred for thermographic assessment of RP symptoms over a 2-year period...
October 2016: Rheumatology International
https://www.readbyqxmd.com/read/27115103/capillaroscopy-2016-new-perspectives-in-systemic-sclerosis
#20
C Pizzorni, A Sulli, V Smith, A Lladó, S Paolino, M Cutolo, B Ruaro
Systemic sclerosis (SSc) is an autoimmune disorder of unknown aetiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc. The best method to evaluate vascular injury is nailfold videocapillaroscopy, which detects peripheral capillary morphology, and classifies and scores the abnormalities into different patterns of microangiopathy. Microangiopathy appears to be the best evaluable predictor of the disease development and has been observed to precede the other symptoms by many years...
January 2016: Acta Reumatológica Portuguesa
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