keyword
https://read.qxmd.com/read/38488092/nailfold-capillaroscopy-findings-of-a-multicentric-multi-ethnic-cohort-of-patients-with-idiopathic-inflammatory-myopathies
#1
JOURNAL ARTICLE
Jiram Torres-Ruiz, Iago Pinal-Fernandez, Albert Selva-O'Callaghan, Bianca Campbell, Sandra Muñoz-Braceras, Nancy R Mejía-Domínguez, Carlos Núñez-Álvarez, José Milisenda, Maria Casal-Domínguez, Katherine Pak, Alfredo Guillén-Del-Castillo, Ernesto Trallero-Araguas, Albert Gil-Vila, Andrew Lee Mammen
OBJECTIVES: To assess nailfold video capillaroscopic (NVC) abnormalities and their association with clinical features, myositis-specific autoantibodies (MSA), and myositis-associated antibodies (MAA) in a large multi-ethnic cohort of patients with idiopathic inflammatory myopathies (IIM). METHODS: We recruited 155 IIM patients from three centres in Mexico, Spain, and the USA. We evaluated the clinical and laboratory features of the patients and performed semiquantitative and quantitative analyses of the NVC...
February 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38479828/unusual-overlap-of-systemic-sclerosis-with-takayasu-arteritis
#2
JOURNAL ARTICLE
Anoop Chithrabhanu, Arul Rajamurugan Ponniah Subramanian, Ramesh Ramamoorthy, Mythili Seetharaman Varadhan
Overlap syndromes are diseases that meet the criteria of two or more rheumatic diseases. In this case report, a woman in her 20s presented with a constellation of symptoms, including skin thickening, Raynaud's phenomenon, hypertension, absent pulse in both lower limbs with bilateral renal artery bruit. The antinuclear antibody profile revealed Scl-70 positivity. CT thorax identified early interstitial lung disease, and nailfold capillaroscopy showed severe capillary loss. CT angiogram features were suggestive of Takayasu arteritis...
March 13, 2024: BMJ Case Reports
https://read.qxmd.com/read/38465507/re-evaluation-of-nailfold-capillaroscopy-in-discriminating-primary-from-secondary-raynaud-s-phenomenon-and-in-predicting-systemic-sclerosis-a-randomised-observational-prospective-cohort-study
#3
JOURNAL ARTICLE
Marta C Amaral, F Seguro Paula, Joana Caetano, Paul Rj Ames, J Delgado Alves
BACKGROUND: Primary Raynaud's phenomenon (pRP) is difficult to distinguish from secondary (sRP). Although nailfold capillaroscopy (NFC) may detect early alterations, no universal criteria yet discriminate between pRP from sRP. OBJECTIVES: To create and validate two NFC scores that could distinguish pRP from sRP and that could predict systemic sclerosis (SSc), respectively. METHODS: We performed NFC on two separate cohorts with isolated RP, and recorded number of capillaries per field, enlarged/giant capillaries, crossed/bizarre patterns, microhemorrhages, neoangiogenesis, rarefaction, edema, blood flow velocity, stasis...
March 11, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38436165/nailfold-capillaroscopy-abnormalities-and-pulmonary-hypertension-in-mixed-connective-tissue-disease-and-systemic-sclerosis-patients
#4
JOURNAL ARTICLE
A Munteanu, N R Kundnani, A Caraba
OBJECTIVE: Pulmonary arterial hypertension (PAH) represents an important vascular complication of mixed connective tissue disease (MCTD) and systemic sclerosis (SSc). Microvascular involvement in these diseases can be investigated by means of nailfold capillaroscopy (NFC). Microvascular involvement detected in the nailfold bed is the mirror of the microvascular damage occurring in the entire body, further indicating the involvement of the target organs. The aim of this study was to evaluate the microvascular involvement in MCTD patients with or without PAH, compared to that found in SSc patients with or without PAH...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38337770/nailfold-capillaroscopy-analysis-can-add-a-new-perspective-to-biomarker-research-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#5
REVIEW
Gianluca Screm, Lucrezia Mondini, Paola Confalonieri, Francesco Salton, Liliana Trotta, Mariangela Barbieri, Marco Mari, Nicolò Reccardini, Rossana Della Porta, Metka Kodric, Giulia Bandini, Michael Hughes, Mattia Bellan, Selene Lerda, Marco Confalonieri, Barbara Ruaro
BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), all of which are characterised by inflammation of small-medium-sized vessels. Progressive understanding of these diseases has allowed researchers and clinicians to start discussing nailfold video capillaroscopy (NVC) as a future tool for many applications in daily practice...
January 24, 2024: Diagnostics
https://read.qxmd.com/read/38334058/capillaroscopic-differences-between-primary-raynaud-phenomenon-and-healthy-controls-indicate-potential-microangiopathic-involvement-in-benign-vasospasms
#6
JOURNAL ARTICLE
Sophie Brunner-Ziegler, Eva Dassler, Markus Müller, Marco Pratscher, Nikolaus Franz-Ferdinand Maria Forstner, Renate Koppensteiner, Oliver Schlager, Bernd Jilma
BACKGROUND: For primary Raynaud phenomenon (PRP), an otherwise unexplained vasospastic disposition is assumed. To test the hypothesis of an additional involvement of distinct ultrastructural microvascular alterations, we compared the nailfold capillary pattern of patients with PRP and healthy controls. METHODS: A total of 120 patients with PRP (with a median duration of vasospastic symptoms of 60 [IQR: 3-120] months) were compared against 125 controls. In both groups, nailfold capillaroscopy was performed to record the presence of dilatations, capillary edema, tortuous capillaries, ramifications, hemorrhages, and reduced capillary density and to determine a semiquantitative rating score...
February 9, 2024: Vascular Medicine
https://read.qxmd.com/read/38309517/high-resolution-peripheral-quantitative-computed-tomography-for-the-assessment-of-acroosteolysis-and-calcinosis-in-patients-with-systemic-sclerosis
#7
JOURNAL ARTICLE
Frederik Cosedis Enevoldsen, Josephine Therkildsen, Rasmus Klose Jensen, Amanda Lynggaard Elkjær, Esben Uggerby Næser, Rikke Fuglsang Klicman, Katja Thorup Aaen, Klaus Henrik Søndergaard, Ellen-Margrethe Hauge
OBJECTIVE: To assist the development of future treatments in systemic sclerosis (SSc), the development of reliable outcome measures is pivotal. We aimed to evaluate the use of high-resolution peripheral quantitative CT (HR-pQCT) for visualization and gradation of acroosteolysis (AO) and calcinosis compared to conventional hand radiographs (CR) in patients with SSc. METHODS: HR-pQCT scans of the 2nd to 4th fingers, CR, nailfold capillaroscopy, and a clinical examination were conducted...
February 1, 2024: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/38282947/the-role-of-nailfold-capillaroscopy-in-evaluating-patients-with-interstitial-lung-disease-related-to-connective-tissue-disease
#8
JOURNAL ARTICLE
Aliki I Venetsanopoulou, Andreas V Goules, Panayiotis G Vlachoyiannopoulos, Alexandros A Drosos, Athanasios G Tzioufas, Paraskevi V Voulgari
Capillaroscopy is a non-invasive and safe imaging method that allows the evaluation of the microcirculation of the small vessels of the skin. The method's main advantage is the early detection of microvascular changes that may occur in certain connective tissue diseases (CTDs). Today, the presence of specific autoantibodies and capillaroscopic findings are generally accepted and emerge as a powerful diagnostic tool for detecting underlying CTDs in patients with Raynaud's phenomenon. The role of capillaroscopy has also been investigated in patients with CTD and interstitial lung disease (ILD)...
December 2023: Mediterranean journal of rheumatology
https://read.qxmd.com/read/38279673/analysis-of-microvascular-pattern-in-diabetes-mellitus-condition-using-the-nailfold-capillaroscopy-images
#9
JOURNAL ARTICLE
Sowmiya Elumalai, Nirmala Krishnamoorthi, Naveen Periyasamy, Mohamed Farazullah, Kiran Raj, Shriraam Mahadevan
Diabetes is often considered a vascular disease due to its impact on blood vessels, it is a complex condition with various metabolic and autoimmune factors involved. One of the long term comorbidities of diabetes includes microvascular complications. The microvascular complications can be analyzed using the Nailfold capillaroscopy, a non-invasive technique that allows for the visualization and analysis of capillaries in the proximal nailfold area. Using advanced video capillaroscopy with high magnification, capillary images can be captured from and processed to analyze their morphology...
January 27, 2024: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://read.qxmd.com/read/38251814/nailfold-dermoscopy-predicts-the-absence-of-a-capillaroscopy-sclerodermic-pattern-the-multicentre-prospective-vascul-r-trial
#10
JOURNAL ARTICLE
Jean-Benoît Monfort, Tiffany Klejtman, Isabelle Lazareth, Diane Kottler, Sophie Blaise, Bernard Imbert, Guillaume Chaby, Catherine Lok, Hervé Maillard, Nathalie Beneton, Julie Journet-Tollhupp, Elisa Goujon, Aurélien Jacquin, Emilie Tella, Bassirou Mboup, Eric Vicaut, Patricia Senet
BACKGROUND: Nailfold capillaroscopy is recommended to diagnose primary or secondary Raynaud's phenomenon (RP). Capillaroscopy is normal in primary RP, which is the most frequent. Screening for RP capillary anomalies with nailfold dermoscopy has been promising. OBJECTIVE: To determine whether normal nailfold dermoscopy-based on the absence of five criteria that define a sclerodermic pattern-is able to predict normal capillaroscopy with good positive-predictive value (PPV)...
January 22, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38251485/mri-digital-artery-volume-index-davix-as-a-surrogate-outcome-measure-of-digital-ulcer-disease-in-patients-with-systemic-sclerosis-a-prospective-cohort-study
#11
JOURNAL ARTICLE
Michael Hughes, Stefano Di Donato, Klodian Gjeloshi, Giuseppina Abignano, Fiammetta Danzo, Giovanni Lettieri, Enrico De Lorenzis, Dominic Bertham, Philip O'Connor, Olga Kubassova, Jamshid Dehmeshki, Francesco Del Galdo
BACKGROUND: Vascular fibrosis is a key manifestation of systemic sclerosis that leads to the narrowing of small and medium arteries, causing vascular clinical manifestations including digital ulcers and pulmonary arterial hypertension. We investigated the potential of the MRI-based Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of vascular fibrosis by using it to quantify and predict the burden of digital ulcer disease in patients with systemic sclerosis. METHODS: Two independent cohorts of patients participating in the prospective observational study STRIKE were consecutively enrolled from the Scleroderma Clinic of the Leeds Teaching Hospitals Trust, Leeds, UK...
October 2023: Lancet Rheumatology
https://read.qxmd.com/read/38170546/peripheral-microvascular-function-is-linked-to-cardiac-involvement-on-cmr-in-systemic-sclerosis-related-pulmonary-arterial-hypertension
#12
JOURNAL ARTICLE
Jacqueline L Vos, Jacqueline M J Lemmers, Saloua El Messaoudi, Miranda Snoeren, Arie P J van Dijk, Anthonie L Duijnhouwer, Laura Rodwell, Sander I van Leuven, Martijn C Post, Madelon C Vonk, Robin Nijveldt
BACKGROUND: Systemic sclerosis (SSc) is characterized by vasculopathy, inflammation and fibrosis, and carries one of the worst prognoses if patients also develop pulmonary arterial hypertension (PAH). Although PAH is a known prognosticator, SSc-PAH patients demonstrate disproportionately high mortality, presumably due to cardiac involvement. In this cross-sectional study, the relation between cardiac involvement revealed by cardiovascular magnetic resonance (CMR) and systemic microvascular disease severity measured with nailfold capillaromicroscopy in SSc-PAH patients is evaluated, and compared to idiopathic PAH (IPAH) patients...
January 3, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38167073/nailfold-videocapillaroscopy-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#13
JOURNAL ARTICLE
Megan M Sullivan, Andy Abril, Nabeel Aslam, Colleen T Ball, Florentina Berianu
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of illnesses that cause inflammation and alterations to small vessels in the body. Some of the most common and detrimental manifestations, including alveolar hemorrhage and glomerulonephritis, are caused by this capillary inflammation. We sought to clarify whether patients with AAV would have abnormal nailfold capillaries when evaluated with nailfold videocapillaroscopy. METHODS: Patients with a current diagnosis of AAV and a control group were identified for enrollment...
January 2, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38141212/boxer-s-shape-an-unusual-finding-in-nailfold-capillaroscopy
#14
JOURNAL ARTICLE
Patricia Corzo, Jose A Gómez-Puerta
No abstract text is available yet for this article.
December 23, 2023: Rheumatology
https://read.qxmd.com/read/38133798/macular-choroidal-thickness-volume-and-vascularity-index-in-patients-with-systemic-sclerosis
#15
JOURNAL ARTICLE
Barbara Pieklarz, Ewa Gińdzieńska-Sieśkiewicz, Izabela Zawadzka, Magdalena Bagrowska, Joanna Daniluk, Marcin Palewski, Agnieszka Zonenberg, Otylia Kowal-Bielecka, Joanna Konopińska, Diana Anna Dmuchowska
PURPOSE: The aim of this study was to investigate choroidal parameters in patients with systemic sclerosis (SSc) using enhanced depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT) and to determine their relationships with clinical variables and ocular features. METHODS: Thirty-three patients with SSc and 40 controls were enrolled. The groups did not differ with regard to age, sex, and axial length. The mean choroidal thickness and volume were obtained in each conventional Early Treatment of Diabetic Retinopathy Study grid subfield...
December 22, 2023: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38061409/flow-mediated-dilation-in-systemic-sclerosis-association-with-clinical-findings-capillaroscopic-patterns-and-endothelial-circulating-markers
#16
JOURNAL ARTICLE
Addolorata Corrado, Natalia Mansueto, Michele Correale, Valeria Rella, Lucia Tricarico, Alberto Altomare, Natale Daniele Brunetti, Francesco Paolo Cantatore, Cinzia Rotondo
AIM: Endothelial dysfunction represents a key feature of the pathological process underlying micro and macro-vascular damage in Systemic Sclerosis (SSc). This study aims to improve knowledge of the physiopathology of vascular damage in SSc through the assessment of the endothelial dysfunction by Flow Mediated Dilation (FMD) and serum levels of circulating endothelial dysfunction markers and the correlation of macrovascular damage with clinical findings and microvascular capillaroscopic patterns...
December 5, 2023: Vascular Pharmacology
https://read.qxmd.com/read/38046253/towards-a-consensus-on-the-clinical-applications-and-interpretations-of-the-nailfold-capillaroscopy-standards-in-clinical-practice-an-initiative-by-the-egyptian-society-of-microcirculation
#17
JOURNAL ARTICLE
Yasser El Miedany, Sherif Ismail, Mary Wadie Fawzy, Ulf Müller-Ladner, Roberto Giacomelli, Vasiliki Liakouli, W Hermann, Nihal Fathy, Maha El Gaafary, Nermin A Fouad, Sally Saber, Mohammed Hassan Abu-Zaid
OBJECTIVES: Based on the mainstream adoption of nailfold capillaroscopy as an investigative tool for rheumatologists, this work was carried out by a panel of experts in the field of capillaroscopy and microcirculation to issue a consensus view on capillaroscopic image acquisition and analysis standardization. PATIENTS AND METHODS: After the key clinical questions were identified by the core team, a systematic review of the published research was carried out focusing on variable capillaroscopic techniques, definitions, and characteristics, including capillary density (number of capillaries), capillary morphology (shape of each capillary), capillary dimensions (width of apical, arterial, and venous limb of the capillary), and the presence of hemorrhages...
September 2023: Archives of Rheumatology
https://read.qxmd.com/read/38015433/nailfold-capillaroscopy-shows-microvascular-dysfunction-in-children-and-adolescents-with-poorly-controlled-type-1-diabetes-and-normal-retinal-assessment
#18
JOURNAL ARTICLE
Francesco Martino, Francesco Barillà, Eliana Martino, Giuseppe Placanica, Vincenzo Paravati, Pier P Bassareo
No abstract text is available yet for this article.
November 28, 2023: Minerva pediatrics
https://read.qxmd.com/read/38013625/clinical-presentation-course-and-prognosis-of-patients-with-mixed-connective-tissue-disease-a-multicenter-retrospective-cohort
#19
JOURNAL ARTICLE
Kevin Chevalier, Benjamin Thoreau, Marc Michel, Bertrand Godeau, Christian Agard, Thomas Papo, Karim Sacre, Raphaèle Seror, Xavier Mariette, Patrice Cacoub, Ygal Benhamou, Hervé Levesque, Cécile Goujard, Olivier Lambotte, Bernard Bonnotte, Maxime Samson, Félix Ackermann, Jean Schmidt, Pierre Duhaut, Jean-Emmanuel Kahn, Thomas Hanslik, Nathalie Costedoat-Chalumeau, Benjamin Terrier, Alexis Regent, Bertrand Dunogue, Pascal Cohen, Véronique Le Guern, Eric Hachulla, Benjamin Chaigne, Luc Mouthon
OBJECTIVES: The objective of this study is to better characterize the features and outcomes of a large population of patients with mixed connective tissue disease (MCTD). METHODS: We performed an observational retrospective multicenter cohort study in France. Patients who fulfilled at least one diagnostic criterion set for MCTD and none of the criteria for other differentiated CTD (dCTD) were included. RESULTS: Three hundred and thirty patients (88% females, median [interquartile range] age of 35 years [26-45]) were included...
November 27, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37993641/artificial-intelligence-for-nailfold-capillaroscopy-analyses-a-proof-of-concept-application-in-juvenile-dermatomyositis
#20
JOURNAL ARTICLE
Peyman Hosseinzadeh Kassani, Louis Ehwerhemuepha, Chloe Martin-King, Ryan Kassab, Ellie Gibbs, Gabrielle Morgan, Lauren M Pachman
BACKGROUND: Biomarkers for idiopathic inflammatory myopathies are difficult to identify and may involve expensive laboratory tests. We assess the potential for artificial intelligence (AI) to differentiate children with juvenile dermatomyositis (JDM) from healthy controls using nailfold capillaroscopy (NFC) images. We also assessed the potential of NFC images to reflect the range of disease activity with JDM. METHODS: A total of 1,120 NFC images from 111 children with active JDM, diagnosed between 1990 and 2020, and 321 NFC images from 31 healthy controls were retrieved from the CureJM JDM Registry...
November 22, 2023: Pediatric Research
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