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Nailfold capillaroscopy

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https://www.readbyqxmd.com/read/29018976/capillary-loss-on-nailfold-capillary-microscopy-is-associated-with-mortality-in-systemic-sclerosis
#1
Thais Rohde Pavan, Markus Bredemeier, Vanessa Hax, Karina Gatz Capobianco, Rafael da Silva Mendonça Chakr, Ricardo Machado Xavier
The objective of this study is to test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). One hundred and seventy SSc patients underwent an extensive evaluation (including high-resolution computed tomography, pulmonary function tests, and Doppler echocardiography) at baseline following a standard protocol. Capillary loss on NFC was evaluated using the avascular score (AS, ranging from 0 to 3), and the mean number of ectasias, megacapillaries, and hemorrhages per finger was also recorded...
October 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28957564/reproducibility-of-the-scleroderma-pattern-assessed-by-wide-field-capillaroscopy-in-subjects-suffering-from-raynaud-s-phenomenon
#2
MULTICENTER STUDY
Carine Boulon, Sophie Blaise, Isabelle Lazareth, Claire Le Hello, Marc-Antoine Pistorius, Bernard Imbert, Marion Mangin, Pierre Sintes, Patricia Senet, Joëlle Decamps-Le Chevoir, Laurent Tribout, Patrick Carpentier, Joël Constans
Objectives: The aim of this work was to study inter- and intra-observer agreement for the diagnosis of scleroderma pattern by wide-field capillaroscopy. Methods: Images were taken from 50 patients known to have SSc and 50 controls consulting for RP who did not have SSc. These images were rated simultaneously by 11 experienced vascular medicine physicians as scleroderma pattern or not. Two weeks later, 7 of the 11 observers again rated the same images. Results: Inter-observer agreement was almost perfect between the 11 observers (κ 0...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28926461/nailfold-capillaroscopy-findings-mimicking-systemic-sclerosis-in-a-patient-with-port-wine-stain
#3
Serdar Can Güven, Özkan Varan, Hamit Küçük
No abstract text is available yet for this article.
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28898558/combination-of-capillaroscopic-and-ultrasonographic-evaluations-in-systemic-sclerosis-results-of-a-cross-sectional-study
#4
Alain Lescoat, Guillaume Coiffier, Marine de Carlan, Catherine Droitcourt, Alice Ballerie, Cazalets Claire, Aleth Perdriger, Jégo Patrick
OBJECTIVES: To compare microvascular damages on nailfold capillaroscopy (NC) with macrovascular manifestations evaluated by hand power doppler ultrasonography (PDUS) in Systemic Sclerosis (SSc) patients, and to assess the associations of these damages with the main digital manifestations of the disease: digital ulcers (DU), acro-osteolysis and Calcinosis. METHODS: NC, hand X-Rays and PDUS were systematically performed in 64 unselected SSc patients. PDUS evaluation with assessment of ulnar artery occlusion (UAO) and finger pulp blood flow (FPBF) was performed blinded for the results of X-Rays and NC...
September 12, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28894946/an-international-survey-on-non-invasive-techniques-to-assess-the-microcirculation-in-patients-with-raynaud-s-phenomenon-sunshine-survey
#5
Francesca Ingegnoli, Nicola Ughi, Graham Dinsdale, Annalisa Orenti, Patrizia Boracchi, Yannick Allanore, Ivan Foeldvari, Alberto Sulli, Maurizio Cutolo, Vanessa Smith, Ariane L Herrick
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud's phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapillaroscopy (NVC), dermoscopy, stereomicroscopy, digital USB microscopy], four laser Doppler methods (laser Doppler flowmetry, imaging, anemometry/velocimetry, laser speckle contrast analysis), thermographic imaging, and upper limb arterial Doppler ultrasound. Emails with a link to the survey were sent to physicians from the European Scleroderma Trials and Research group (EUSTAR), the EULAR Study Group on Microcirculation in Rheumatic Diseases (SG_MC/RD) and members of the pediatric rheumatology Email board...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28805016/microvascular-abnormalities-assessed-by-nailfold-capillaroscopy-in-juvenile-dermatomyositis-after-medium-to-long-term-follow-up
#6
Zoltan Barth, Birgit N Witczak, Berit Flatø, Akos Koller, Ivar Sjaastad, Helga Sanner
OBJECTIVE: In juvenile dermatomyositis (JDM), microvascular abnormalities measured by nailfold capillaroscopy (NFC) are common early in disease course. We aimed to compare the presence of NFC abnormalities in patients with medium- to longstanding JDM with that of controls, and to explore associations between NFC abnormalities and disease activity and other disease characteristics. METHODS: Fifty-eight JDM patients clinically examined median 16.8 (2-38) years after disease onset were compared with matched controls...
August 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28770704/undifferentiated-connective-tissue-disease-predictors-of-evolution-into-definite-disease
#7
María García-González, Beatriz Rodríguez-Lozano, Sagrario Bustabad, Ivan Ferraz-Amaro
OBJECTIVES: The natural evolution of undifferentiated connective tissue diseases (UCTD) has not yet been established. The aim of our study was to analyse the clinical outcomes of a cohort of UCTD patients followed in a routine outpatient setting and to establish which clinical, serological or capillaroscopy features are associated with an increased risk of evolution to definite connective tissue disease (CTD). METHODS: Data for this study were collected by a retrospective review of 758 patients referred to our hospital, between 1999 and 2008, with suspected CTD...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28745214/nailfold-capillaroscopy-of-fingers-and-toes-variations-of-normal
#8
Sevdalina Lambova, Ulf Müller-Ladner
INTRODUCTION: Nailfold capillaroscopy is the only method for morphological assessment of nutritive capillaries. The literature data about capillaroscopic findings of toes in healthy individuals are scarce. THE AIM OF THE STUDY: To evaluate and compare the capillaroscopic findings of fingers and toes in healthy subjects. MATERIALS AND METHODS: 22 healthy individuals were included in the study. Capillaroscopic examination was performed with videocapillaroscope Videocap 3...
July 26, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28668440/state-of-the-art-on-nailfold-capillaroscopy-in-dermatomyositis-and-polymyositis
#9
REVIEW
Chiara Bertolazzi, Maurizio Cutolo, Vanessa Smith, Marwin Gutierrez
OBJECTIVES: To provide an overview of the main nailfold capillaroscopy (NFC) changes described in dermatomyositis (DM) and polymyositis (PM) and to discuss the current evidence supporting its clinical relevance and applications in daily practice. METHODS: All relevant literature in the field of NFC and DM and PM published in the last 30 years has been systematically reviewed. A systematic research was performed in the electronic databases PubMed and EMBASE. RESULTS: A total of 540 publications were identified according to the proposed filters and 27 were included for the review...
June 28, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28641553/capillaroscopy-in-routine-diagnostics-potentials-and-limitations
#10
Francesca Ingegnoli, Vanessa Smith, Alberto Sulli, Maurizio Cutolo
Nailfold capillaroscopy is a safe and useful investigational tool that allows an early detection and a qualitative description of the microvascular abnormalities in patients with Raynaud's phenomenon secondary to scleroderma-spectrum disorders. Nowadays, the role of capillaroscopy in the diagnosis of systemic sclerosis is well known. Capillaroscopy has been included in the new 2013 classification criteria for systemic sclerosis and it is considered a key investigation in the very early phases of the disease...
June 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28641551/nailfold-capillaroscopy-within-and-beyond-the-scope-of-connective-tissue-diseases
#11
Sevdalina Lambova, Ulf Müller-Ladner
Nailfold capillaroscopy is a noninvasive instrumental method for morphological analysis of the nutritive capillaries in the nailfold area. In rheumatology, it is a method of choice among instrumental modalities for differentiation of primary and secondary Raynaud's phenomenon (RP) in rheumatic diseases. RP is a common diagnostic problem in rheumatology. Defining the proper diagnosis is a prerequisite for administration of the appropriate treatment. Thus, nailfold capillaroscopic examination is of crucial importance for the every-day practice of the rheumatologists and is currently gaining increasing attention...
June 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28641550/bier-spots-report-of-two-cases-and-review-of-the-literature
#12
Hristo Dobrev, Desislava Nocheva
Bier spots are asymptomatic white anemic macules with irregular shape located on the upper limbs and less often on the lower limbs and trunkus. They are observed predominantly in youg males and may be idiopathic or associated with other conditions. We report two cases with Bier spots in which videodermatoscopy and nailfold capillaroscopy were performed. Patient 1 was a 34-year-old otherwise healthy male who presented with white spots on his upper limbs for 10 years. Dermoscopy revealed marked narrowing of skin capillaries within the borders of white macules whereas capillaroscopy pattern was normal...
June 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28495471/quantitative-outcome-measures-for-systemic-sclerosis-related-microangiopathy-reliability-of-image-acquisition-in-nailfold-capillaroscopy
#13
Graham Dinsdale, Tonia Moore, Neil O'Leary, Michael Berks, Christopher Roberts, Joanne Manning, John Allen, Marina Anderson, Maurizio Cutolo, Roger Hesselstrand, Kevin Howell, Carmen Pizzorni, Vanessa Smith, Alberto Sulli, Marie Wildt, Christopher Taylor, Andrea Murray, Ariane L Herrick
BACKGROUND: Nailfold capillaroscopic parameters hold increasing promise as outcome measures for clinical trials in systemic sclerosis (SSc). Their inclusion as outcomes would often naturally require capillaroscopy images to be captured at several time points during any one study. Our objective was to assess repeatability of image acquisition (which has been little studied), as well as of measurement. METHOD: 41 patients (26 with SSc, 15 with primary Raynaud's phenomenon) and 10 healthy controls returned for repeat high-magnification (300×) videocapillaroscopy mosaic imaging of 10 digits one week after initial imaging (as part of a larger study of reliability)...
May 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28414021/elliptical-broken-line-method-for-calculating-capillary-density-in-nailfold-capillaroscopy-proposal-and-evaluation
#14
Abdolamir Karbalaie, Farhad Abtahi, Alimohammad Fatemi, Mahnaz Etehadtavakol, Zahra Emrani, Björn-Erik Erlandsson
Nailfold capillaroscopy is a practical method for identifying and obtaining morphological changes in capillaries which might reveal relevant information about diseases and health. Capillaroscopy is harmless, and seems simple and repeatable. However, there is lack of established guidelines and instructions for acquisition as well as the interpretation of the obtained images; which might lead to various ambiguities. In addition, assessment and interpretation of the acquired images are very subjective. In an attempt to overcome some of these problems, in this study a new modified technique for assessment of nailfold capillary density is introduced...
April 14, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28386138/nailfold-digital-capillaroscopic-findings-in-patients-with-diffuse-and-limited-cutaneous-systemic-sclerosis
#15
Saeedeh Shenavandeh, Mahyar Yousefipour Haghighi, Mohammad Ali Nazarinia
BACKGROUND: Systemic sclerosis (SSc) is a chronic disease with microvascular damage. Nailfold capillaroscopy is a non-invasive method used for evaluating capillaries in SSc. Its findings could be related to the internal organ involvement and SSc course. In this study, we aimed to determine the association of the capillaroscopic patterns of nailfold capillaries with the disease subtypes of SSc, disease duration, and clinical manifestations. MATERIAL AND METHODS: Seventy patients with SSc (15 cases with diffuse cutaneous SSc [DcSSc] and 55 patients with limited SSc [LcSSc]) were studied...
2017: Reumatologia
https://www.readbyqxmd.com/read/28340234/detection-of-severe-digital-vasculopathy-in-systemic-sclerosis-by-colour-doppler-sonography-is-associated-with-digital-ulcers
#16
Susanne Lüders, Stefanie Friedrich, Sarah Ohrndorf, Anne-Marie Glimm, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Marina Backhaus
Objective: Colour Doppler ultrasonography (CDUS) is very important in general vascular diagnostic procedures. Its role in determining the extent of vasculopathy in Systemic Sclerosis (SSc) needs further investigation. The aim of this study was to compare the presence of altered arteries with nailfold capillaroscopy and clinical signs of ischaemia, that is, digital ulcers or pitting scars (DU/PS). A feasible CDUS protocol is provided. Methods: Two thousand five hundred and twenty-eight arteries of the fingers, palms and wrists from 79 SSc patients (32 arteries per patient) were examined using CDUS...
November 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28274735/nailfold-capillaroscopy-in-diabetes-mellitus
#17
G Maldonado, R Guerrero, C Paredes, C Ríos
INTRODUCTION: Diabetes mellitus (DM) is characterized by chronic hyperglycemia states and the development of specific microvascular disorders such as retinopathy and nephropathy. Conventional methods are used to study the vascular compromise of this entity, however, the use of capillaroscopy for the evaluation of capillary microarchitecture is not frequently used. METHODS AND MATERIALS: Observational and descriptive study of 65 patients with an established diagnosis of DM and a control group that underwent an initial capillaroscopy examination...
July 2017: Microvascular Research
https://www.readbyqxmd.com/read/28229821/integration-of-capillary-microscopy-and-dermoscopy-into-the-rheumatology-fellow-curriculum
#18
Christopher Hatzis, Daniele Lerner, Stephen Paget, Maurizio Cutolo, Vanessa Smith, Robert Spiera, Jessica Gordon
OBJECTIVES: This study evaluates a novel, three-part nailfold capillaroscopy training curriculum for adult and paediatric rheumatology fellows. METHODS: All rheumatology fellows training at an academic medical centre took part in the three-part nailfold capillaroscopy curriculum. Tests of fellows' usage, interest, confidence, and ability in nailfold capillaroscopy were taken at multiple time-points throughout the curriculum. RESULTS: Fellows self-reported high levels of interest, increased confidence in delineating normal and abnormal nailfold capillaries (p=0...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28163035/intra-and-inter-observer-reliability-of-nailfold-videocapillaroscopy-a-possible-outcome-measure-for-systemic-sclerosis-related-microangiopathy
#19
Graham Dinsdale, Tonia Moore, Neil O'Leary, Philip Tresadern, Michael Berks, Christopher Roberts, Joanne Manning, John Allen, Marina Anderson, Maurizio Cutolo, Roger Hesselstrand, Kevin Howell, Carmen Pizzorni, Vanessa Smith, Alberto Sulli, Marie Wildt, Christopher Taylor, Andrea Murray, Ariane L Herrick
OBJECTIVES: Our aim was to assess the reliability of nailfold capillary assessment in terms of image evaluability, image severity grade ('normal', 'early', 'active', 'late'), capillary density, capillary (apex) width, and presence of giant capillaries, and also to gain further insight into differences in these parameters between patients with systemic sclerosis (SSc), patients with primary Raynaud's phenomenon (PRP) and healthy control subjects. METHODS: Videocapillaroscopy images (magnification 300×) were acquired from all 10 digits from 173 participants: 101 patients with SSc, 22 with PRP and 50 healthy controls...
February 2, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28137497/interstitial-pneumonia-with-autoimmune-features-clinical-radiologic-and-histological-characteristics-and-outcome-in-a-series-of-57-patients
#20
Kais Ahmad, Thomas Barba, Delphine Gamondes, Marylise Ginoux, Chahera Khouatra, Paolo Spagnolo, Mary Strek, Françoise Thivolet-Béjui, Julie Traclet, Vincent Cottin
BACKGROUND: Interstitial pneumonia with autoimmune features (IPAF) has recently been defined by an international Taskforce to characterize interstitial lung disease associated with systemic manifestations limited to subtle serological and clinical autoimmune abnormalities and not fulfilling the international criteria for the diagnosis of a given connective tissue disease. OBJECTIVE: to report on a series of patients with IPAF, and to compare their outcome to that of a cohort of patients with idiopathic pulmonary fibrosis (IPF)...
February 2017: Respiratory Medicine
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