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https://www.readbyqxmd.com/read/29226890/relationship-between-the-extent-of-coronary-artery-disease-and-in-stent-restenosis-in-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#1
Erkan Yıldırım, Murat Çelik, Uygar Çağdaş Yüksel, Barış Buğan, Yalçın Gökoğlan, Suat Görmel, Salim Yaşar, Mustafa Koklu, Atila İyisoy, Cem Barçın
OBJECTIVE: The pathophysiological mechanism of in-stent restenosis (ISR) is different from atherosclerosis of native coronary arteries. The aim of this study was to evaluate the relationship between ISR and the extent of coronary artery disease (CAD), and to identify other risk factors associated with ISR in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: A total of 372 consecutive patients presenting with first acute STEMI who were successfully treated with primary percutaneous coronary intervention within 12 hours from the onset of symptoms and who had an angiographic follow-up at 3 months were included in the study...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29226137/identification-of-key-pathways-and-genes-in-advanced-coronary-atherosclerosis-using-bioinformatics-analysis
#2
Xiaowen Tan, Xiting Zhang, Lanlan Pan, Xiaoxuan Tian, Pengzhi Dong
Background: Coronary artery atherosclerosis is a chronic inflammatory disease. This study aimed to identify the key changes of gene expression between early and advanced carotid atherosclerotic plaque in human. Methods: Gene expression dataset GSE28829 was downloaded from Gene Expression Omnibus (GEO), including 16 advanced and 13 early stage atherosclerotic plaque samples from human carotid. Differentially expressed genes (DEGs) were analyzed. Results: 42,450 genes were obtained from the dataset...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225577/if-channel-as-an-emerging-therapeutic-target-for-cardiovascular-diseases-a-review-of-current-evidence-and-controversies
#3
REVIEW
Hayelom G Mengesha, Tadesse B Tafesse, Mohammed H Bule
In 2015, non-communicable diseases accounted for 39.5 million (70%) of the total 56.4 million deaths that occurred globally, of which 17.7 million (45%) were due to cardiovascular diseases. An elevated heart rate is considered to be one of the independent predictors and markers of future cardiovascular diseases. A variety of experimental and epidemiological studies have found that atherosclerosis, heart failure, coronary artery disease, stroke, and arrhythmia are linked to elevated heart rate. Although there are established drugs to reduce the heart rate, these drugs have undesirable side effects...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29224678/atherosclerosis-in-systemic-lupus-erythematosus
#4
REVIEW
Sara Croca, Anisur Rahman
Cardiovascular disease (CVD), comprising coronary heart disease and stroke, is one of the most important causes of death in patients with systemic lupus erythematosus (SLE). The risks of developing both clinical CVD and sub-clinical atherosclerosis are increased in patients with SLE. This increase is not fully explained by traditional cardiovascular risk factors such as smoking, hypertension and elevated cholesterol, and it is believed that immune dysfunction also contributes to CVD risk in SLE. In particular, recent studies have shown that abnormalities in both serum lipid profile and the autoantibody and T lymphocyte response to lipids may play a role in development of atherosclerosis...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#5
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29221893/cardioprotective-effect-of-influenza-and-pneumococcal-vaccination-in-patients-with-cardiovascular-diseases
#6
REVIEW
Andrzej Ciszewski
Due to the wide interaction between the respiratory and the circulatory systems, influenza and pneumococcal vaccinations are recommended in the prevention and treatment of cardiovascular diseases. The review summarizes the results of recent studies and meta-analyses demonstrating that in this group of high-risk patients both vaccinations have potentially beneficial properties. However, in the era of Evidence Base Medicine, there is still a lack of randomized prospective clinical trials, especially those evaluating the effect of pneumococcal vaccination...
December 5, 2017: Vaccine
https://www.readbyqxmd.com/read/29220061/comparison-of-carotid-intima-media-thickness-and-coronary-artery-calcium-score-for-estimating-subclinical-atherosclerosis-in-patients-with-fatty-liver-disease
#7
Hyun-Jin Kim, Hyung-Bok Park, Yongsung Suh, Yoon-Hyeong Cho, Eui-Seok Hwang, Deok-Kyu Cho, Tae-Young Choi
INTRODUCTION: Fatty liver disease (FLD) is correlated with cardiovascular disease. Carotid intima-media thickness (CIMT) and coronary artery calcium score (CACS) can noninvasively identify subclinical atherosclerosis and predict risk for cardiovascular events. This study evaluated CIMT and CACS measurements to detect subclinical atherosclerosis in patients with and without FLD. METHODS: Patients who underwent carotid and abdominal ultrasounds as well as cardiac computed tomography (CT) scans were evaluated retrospectively...
December 8, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29217920/correlation-between-serum-lipid-profile-with-anthropometric-and-clinical-variables-in-patients-with-type-2-diabetes-mellitus
#8
Belete Biadgo, Solomon Mekonnen Abebe, Habtamu Wondifraw Baynes, Mohammed Yesuf, Aynadis Alemu, Molla Abebe
Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There is ample evidence that abnormalities in lipid metabolism are important risk factors for increased incidence of diabetes associated complications. The most important risk indicators for these complications are lipid profile abnormalities. Therefore, the aim of this study was to assess the correlation between serum lipid profile with anthropometric and clinical variables among type 2 diabetes mellitus patients...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29212987/association-of-coronary-artery-calcification-with-estimated-coronary-heart-disease-risk-from-prediction-models-in-a-community-based-sample-of-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#9
Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization...
December 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29212965/effects-of-ezetimibe-statin-combination-therapy-on-coronary-atherosclerosis-in-acute-coronary-syndrome
#10
Kiyoshi Hibi, Shinjo Sonoda, Masanori Kawasaki, Yutaka Otsuji, Toyoaki Murohara, Hideki Ishii, Katsuhiko Sato, Ryoji Koshida, Yukio Ozaki, Masataka Sata, Yoshihiro Morino, Tadashi Miyamoto, Tetsuya Amano, Satoshi Morita, Ken Kozuma, Kazuo Kimura, Hisayoshi Fujiwara
BACKGROUND: The results of previous clinical trials on the effects of ezetimibe-statin combination therapy on atherosclerosis are inconsistent, and the anti-atherosclerotic effect of ezetimibe remains controversial.Methods and Results:We conducted a prospective, randomized open-label study at 10 centers. One hundred and twenty-eight statin-naïve patients with acute coronary syndrome (ACS) undergoing intravascular ultrasound (IVUS)-guided percutaneous coronary intervention were randomized to receive either 2 mg/day pitavastatin plus 10 mg/day ezetimibe, or 2 mg/day pitavastatin...
December 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29212895/functional-metabolomics-characterizes-a-key-role-for-n-acetyl-neuraminic-acid-in-coronary-artery-diseases
#11
Lei Zhang, Ting-Ting Wei, Yong Li, Jing Li, Yong Fan, Feng-Qing Huang, Yuan-Yuan Cai, Gaoxiang Ma, Jin-Feng Liu, Qian-Qian Chen, Shi-Lei Wang, Honglin Li, Raphael N Alolga, Baolin Liu, Dong-Sheng Zhao, Jian-Hua Shen, Xiang-Ming Wang, Wei Zhu, Ping Li, Lian-Wen Qi
Background -As new biomarkers of coronary artery diseases (CAD) emerge via metabolomics, the underlying functional mechanisms remain to be elucidated. Functional metabolomics aims to translate metabolomics-derived biomarkers to disease mechanisms. Methods -A cohort of 2324 patients who underwent coronary angiography from 4 independent centers was studied. A combination of ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) in the negative ion mode was employed for untargeted analysis of metabolites in plasma...
December 6, 2017: Circulation
https://www.readbyqxmd.com/read/29212544/plaque-volume-and-plaque-risk-profile-in-diabetic-vs-non-diabetic-patients-undergoing-lipid-lowering-therapy-a-study-based-on-3d-intravascular-ultrasound-and-virtual-histology
#12
Tomas Kovarnik, Zhi Chen, Gary S Mintz, Andreas Wahle, Kristyna Bayerova, Ales Kral, Martin Chval, Karel Kopriva, John Lopez, Milan Sonka, Ales Linhart
BACKGROUND: Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity and mortality in such patients compared to non-diabetics ones (non-DM). We quantify changes in plaque volume and plaque phenotype during lipid-lowering therapy in DM versus non-DM patients using advanced intracoronary imaging. METHODS: We analyzed data from 61 patients with stable angina pectoris included to the PREDICT trial searching for prediction of plaque changes during intensive lipid-lowering therapy (40 mg rosuvastatin daily)...
December 7, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29211884/impact-of-current-and-past-cancer-history-on-the-risk-of-cardiovascular-events-following-percutaneous-coronary-intervention-a-kumamoto-university-malignancy-and-atherosclerosis-kuma-study
#13
Noriaki Tabata, Daisuke Sueta, Eiichiro Yamamoto, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Kenshi Yamanaga, Masanobu Ishii, Kenji Sakamoto, Hisanori Kanazawa, Koichiro Fujisue, Shinsuke Hanatani, Hirofumi Soejima, Seiji Hokimoto, Yasuhiro Izumiya, Sunao Kojima, Hiroshige Yamabe, Koichi Kaikita, Kenichi Tsujita
Background: As progress is made in successfully treating cancer, there is increasing need to focus on the risk and complexity of treating cardiovascular events in cancer survivors - thus, the field of onco-cardiology/cardio-oncology has emerged. We examined the differential incidence of cardiovascular events after percutaneous coronary intervention (PCI) in patients with or without cancer. Methods and Results: Participants were divided into a non-cancer group and a cancer group, which consisted of patients who were receiving or had ever received cancer treatment...
December 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29209775/effect-of-aggressive-lipid-lowering-treatment-with-rosuvastatin-on-vascular-endothelium-function-evaluation-of-vascular-endothelium-function-earth-study
#14
Tadateru Takayama, Takafumi Hiro, Shunichi Yoda, Daisuke Fukamachi, Hironori Haruta, Takaaki Kogo, Takashi Mineki, Hironobu Murata, Toru Oshima, Atsushi Hirayama
Vascular endothelial dysfunction plays an important role in the process of atherosclerosis up to the final stage of plaque rupture. Vascular endothelial dysfunction is reversible, and can be recovered by medications and life-style changes. Improvement in endothelial function may reduce cardiovascular events and improve long-term prognosis. A total of 50 patients with stable angina and dyslipidemia were enrolled, including patients who had not received prior treatment with statins and had serum LDL-C levels ≥ 100 mg/dL, and patients who had previously received statin treatment...
December 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29209328/antibodies-against-myc-associated-zinc-finger-protein-an-independent-marker-in-acute-coronary-syndrome
#15
Diana Ernst, Christian Widera, Niklas T Baerlecken, Wolfgang Schlumberger, Cornelia Daehnrich, Reinhold E Schmidt, Katja Gabrysch, Lars Wallentin, Torsten Witte
Introduction: Atherosclerosis is considered the pathophysiology underlying cardiovascular (CVD), cerebrovascular, and peripheral vascular diseases. Evidence supporting an autoimmune component is emerging, with imaging studies correlating MYC-associated zinc finger protein antibody (MAZ-Ab) optical density (OD) with plaque activity. This study compares MAZ-Ab OD on ELISA testing among patients presenting with acute coronary syndromes (ACSs) to healthy controls and investigates the association of MAZ-Ab to traditional CVD risk factors...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29207167/prazosin-protects-myocardial-cells-against-anoxia-reoxygenation-injury-via-the-extracellular-signal%C3%A2-regulated-kinase-signaling-pathway
#16
Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui
Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms underlying the effects of prazosin have not been fully elucidated. The aim of the present study was to investigate the protective effects of prazosin on myocardial cells against anoxia‑reoxygenation injury in a mouse model...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207114/elderly-apolipoprotein-e%C3%A2-%C3%A2-mice-with-advanced-atherosclerotic-lesions-in-the-aorta-do-not-develop-alzheimer-s-disease-like-pathologies
#17
Reut Shnerb Ganor, Dror Harats, Ginette Schiby, Kinneret Rosenblatt, Irit Lubitz, Aviv Shaish, Ophira Salomon
Atherosclerosis and Alzheimer's disease (AD) are a major cause of morbidity and mortality in Western societies. These diseases share common risk factors, which are exhibited in old age, including hypertension, diabetes, hypercholesterolemia and apolipoprotein (Apo) ε4 allele. We previously demonstrated that factor XI (FXI) deficiency in mice reduced the atherosclerotic plaque area in coronary sinuses and the aortic arch. This led us to investigate whether FXI deficiency in elderly ApoE knockout (KO) mice would decrease pathological alterations compatible with atherosclerosis and AD...
November 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203885/monocyte-gene-expression-in-childhood-obesity-is-associated-with-obesity-and-complexity-of-atherosclerosis-in-adults
#18
G C Keustermans, D Kofink, A Eikendal, W de Jager, J Meerding, R Nuboer, J Waltenberger, A O Kraaijeveld, J W Jukema, J W Sels, J Garssen, B J Prakken, F W Asselbergs, E Kalkhoven, I E Hoefer, G Pasterkamp, H S Schipper
Childhood obesity coincides with increased numbers of circulating classical CD14++CD16- and intermediate CD14++CD16+ monocytes. Monocytes are key players in the development and exacerbation of atherosclerosis, which prompts the question as to whether the monocytosis in childhood obesity contributes to atherogenesis over the years. Here, we dissected the monocyte gene expression profile in childhood obesity using an Illumina microarray platform on sorted monocytes of 35 obese children and 16 lean controls. Obese children displayed a distinctive monocyte gene expression profile compared to lean controls...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203734/effect-of-pioglitazone-on-insulin-resistance-progression-of-atherosclerosis-and-clinical-course-of-coronary-heart-disease
#19
Olha V Skochko, Igor P Kaidashev
INTRODUCTION: Pioglitazone, a medication of thiazolidinedione group, is capable of triggering the peroxisome proliferator-activated receptors (PPAR-γ). Activation of receptor PPAR-γ regulates carbohydrate and lipid metabolism, immune and inflammatory responses in heart tissues. THE AIM: Our aim was to study the effect of pioglitazone on insulin resistance, the clinical course of atherosclerosis and coronary heart disease (CHD). MATERIALS AND METHODS: The study included 43 patients with coronary artery disease...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29203080/diastolic-wall-strain-is-associated-with-incident-heart-failure-in-african-americans-insights-from-the-atherosclerosis-risk-in-communities-study
#20
Daisuke Kamimura, Takeki Suzuki, Michael E Hall, Wanmei Wang, Michael D Winniford, Amil M Shah, Carlos J Rodriguez, Kenneth R Butler, Thomas H Mosley
BACKGROUND: Increased left ventricular (LV) myocardial stiffness may be associated with impaired LV hemodynamics and incident heart failure (HF). However, an indicator that estimates LV myocardial stiffness easily and non-invasively is lacking. The purpose of this study was to determine whether diastolic wall strain (DWS), an echocardiographic estimator of LV myocardial stiffness, is associated with incident HF in a middle-aged community-based cohort of African Americans. METHODS AND RESULTS: We investigated associations between DWS and incident HF among 1528 African Americans (mean age 58...
December 1, 2017: Journal of Cardiology
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