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coronary atherosclerosis

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https://www.readbyqxmd.com/read/29928990/asymmetric-dimethylarginine-adma-as-an-important-risk-factor-for-the-increased-cardiovascular-diseases-and-heart-failure-in-chronic-kidney-disease
#1
REVIEW
Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen
Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. Increased plasma ADMA and/or L-NMMA are strong and independent risk factor for chronic kidney disease, and various cardiovascular diseases such as hypertension, coronary artery disease, atherosclerosis, diabetes, and heart failure...
June 18, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29927869/association-of-aortic-arch-width-assessed-by-noncontrast-cardiac-computed-tomography-with-cardiac-remodeling-cardiac-function-and-atherosclerosis-in-a-japanese-cohort
#2
Huong Nguyen-Thu, Yoshiaki Ohyama, Ayako Taketomi-Takahashi, Tien Nguyen-Cong, Akio Sugimoto, Makito Sato, Hisako Sumiyoshi, Tetsuya Nakamura, Masahiko Kurabayashi, Yoshito Tsushima
PURPOSE: Age-related aortic changes are related to adverse cardiac remodeling and reduced cardiac function. Here, we aim to assess the correlations between aortic arch width (AAW) and left ventricular (LV) remodeling and LV function as well as coronary artery calcification (CAC). MATERIALS AND METHODS: This retrospective study included 194 patients (ages, 67±12 y) who underwent both coronary computed tomography angiography and echocardiography. The AAW is defined as the longest width between the ascending and descending aorta on a transaxial noncontrast coronary computed tomography angiography image at the level of the pulmonary artery bifurcation...
July 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29927412/-the-influence-of-confounders-on-the-outcome-of-ischemic-stroke
#3
I G Hovhannisyan, R A Hovhanessyan
AIM: To determine the degree of influence of the confounders on the outcome of ischemic stroke (IS). MATERIAL AND METHODS: One hundred and eight patients were included in the prospective clinical cohort study. Based on disease outcomes, two groups of patients were singled out: 1st group - survivors (n=93), 2nd group - patients with fatal outcomes (n=15). RESULTS: Concomitant diseases were found in 80 (74.1%) patients. Twenty-eight (25.9%) patients had no concomitant pathology (without taking into account atherosclerosis, arterial hypertension, diabetes mellitus and coronary heart disease)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29926559/-from-atherosclerosis-to-atherothrombosis-from-a-silent-chronic-pathology-to-an-acute-critical-event
#4
A J Scheen
Cardiovascular disease still represents, together with cancer, a major cause of morbidity and mortality. Atherosclerosis is a silent progressive process, which can start in early life and usually progresses with advancing age. Besides genetic predisposition, atherosclerosis is accelerated by the presence of several modifiable risk factors such as smoking, dyslipidaemia, arterial hypertension and diabetes mellitus. Asymptomatic atherosclerosis may lead to an acute event, mostly due to plaque rupture and secondary thrombosis...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29926215/hdl-mimetics-infusion-and-regression-of-atherosclerosis-is-it-still-considered-a-valid-therapeutic-option
#5
REVIEW
I Karalis, J W Jukema
PURPOSE OF REVIEW: This review aims to summarize and discuss the recent findings in the field of using HDL mimetics for the treatment of patients with coronary artery disease. RECENT FINDINGS: Following the largely disappointing results with the cholesteryl ester transfer protein inhibitors, focus moved to HDL functionality rather than absolute HDL cholesterol values. A number of HDL/apoA-I mimicking molecules were developed, aiming to enhance reverse cholesterol transport that has been associated with an atheroprotective effect...
June 21, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29925433/target-achievement-and-cardiovascular-event-rates-with-lomitapide-in-homozygous-familial-hypercholesterolaemia
#6
Dirk J Blom, Marina Cuchel, Miranda Ager, Helen Phillips
BACKGROUND: Homozygous familial hypercholesterolaemia (HoFH) is characterized by a markedly increased risk of premature cardiovascular (CV) events and cardiac death. Lomitapide reduces low-density lipoprotein cholesterol (LDL-C) levels; however, the probable impact on LDL-C goals and CV events is unknown. METHODS: We used data collected in the first 26 weeks of the lomitapide pivotal phase 3 study (NCT00730236) to evaluate achievement of European Atherosclerosis Society (EAS) LDL-C targets...
June 20, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29924784/-in-hospital-outcomes-of-reconstructive-interventions-on-the-aortofemoral-segment-in-patients-with-multifocal-atherosclerosis
#7
N N Burkov, A N Kazantsev, R S Tarasov
The purpose of the study was to analyse the in-hospital results of surgical treatment in a total of 275 patients presenting with atherosclerotic occlusive and stenotic lesions of the aortofemoral segment within the framework of a single-centre prospective register. The authors performed a detailed analysis of prognostic significance of a wide spectrum of clinico-instrumental, anatomo-angiographic and perioperative factors, followed by revealing the causes of an unfavourable prognosis during the in-hospital period...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924782/-transradial-approach-in-carotid-stenting
#8
I N Shchanitsyn, M R Sharafutdinov, R A Iakubov, I V Larin
A femoral approach is the main access in stenting of carotid arteries, mainly due to rapid training in how to perform the procedure and a possibility of using large-diameter catheters. However, this approach is not always feasible in atherosclerosis, tortuosity of lower-limb arteries and in certain anatomical peculiarities of the aortic arch. Using a transradial approach is based on the desire to diminish the incidence rate of haemorrhagic complications in the zone of the puncture and to avoid the necessity of a long-term bed rest...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29923127/pregnancy-associated-myocardial-infarction
#9
REVIEW
Michael C Honigberg, Nandita S Scott
PURPOSE OF REVIEW: To educate clinicians about the epidemiology, etiologies, diagnosis, and management of pregnancy-associated myocardial infarction (PAMI). RECENT FINDINGS: The risk of myocardial infarction is increased more than threefold around the time of pregnancy. In the recent series, PAMI is most commonly caused by spontaneous coronary artery dissection, followed by atherosclerosis. Percutaneous coronary intervention or coronary artery bypass grafting may be required, but conservative management with medical therapy is generally advised when possible, particularly in cases of coronary dissection...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29920523/telomere-length-and-mortality-in-the-ludwigshafen-risk-and-cardiovascular-health-study
#10
Irene Pusceddu, Marcus Kleber, Graciela Delgado, Wolfgang Herrmann, Winfried März, Markus Herrmann
INTRODUCTION: Short telomeres have been associated with adverse lifestyle factors, cardiovascular risk factors and age-related diseases, including cardiovascular disease (CVD), myocardial infarction, atherosclerosis, hypertension, diabetes, and also with mortality. However, previous studies report conflicting results. OBJECTIVES: The aim of the present study has been to investigate the involvement of telomere length in all-cause and CVD mortality in subjects hospitalized for diagnostic coronary angiography of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study...
2018: PloS One
https://www.readbyqxmd.com/read/29915649/cytomegalovirus-infection-in-a-patient-with-systemic-lupus-erythematosus-and-acute-myocardial-infarction-cause-or-causal-relationship
#11
Anum Asif, Maria Del Pilar Morales
The possible role of infectious and inflammatory states in the pathogenesis of atherosclerotic disease has been a matter of debate in the literature. There are case reports of active cytomegalovirus (CMV) infection unmasking underlying dormant systemic lupus erythematosus (SLE). CMV infection has also been postulated to be associated with atherosclerosis development in the coronaries. We present a unique case where a patient with newly diagnosed SLE and acute myocardial infarction was found to have high anti-CMV titers suggesting concomitant active CMV infection...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915211/prognostic-value-of-culprit-artery-double-stranded-dna-in-st-segment-elevated-myocardial-infarction
#12
Xiqiang Wang, Dandan Yang, Jing Liu, Xiude Fan, Aiqun Ma, Ping Liu
The double-stranded DNA (dsDNA) which is scaffold of neutrophil extracellular traps (NETs) has been reported to be associated with the occurrence of major adverse cardiovascular events (MACEs) in patients with coronary atherosclerosis. However, the relationship between the dsDNA and the occurrence of MACEs in patients with ST-segment elevated myocardial infarction (STEMI) remains unclear. In this study, 142 consecutive STEMI patients were admitted to medical institutions. Blood from the infarct-related coronary artery (ICA) and peripheral artery (PA) were obtained during percutaneous coronary intervention...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915101/proteomic-architecture-of-human-coronary-and-aortic-atherosclerosis
#13
David M Herrington, Chunhong Mao, Sarah J Parker, Zongming Fu, Guoqiang Yu, Lulu Chen, Vidya Venkatraman, Yi Fu, Yizhi Wang, Timothy D Howard, Goo Jun, Caroline F Zhao, Yongmei Liu, Georgia Saylor, Weston R Spivia, Grace B Athas, Dana Troxclair, James E Hixson, Richard S Vander Heide, Yue Wang, Jennifer E Van Eyk
BACKGOUND: The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets. METHODS: Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens)...
June 19, 2018: Circulation
https://www.readbyqxmd.com/read/29912879/polyclonal-human-antibodies-against-glycans-bearing-red-meat-derived-non-human-sialic-acid-n-glycolylneuraminic-acid-are-stable-reproducible-complex-and-vary-between-individuals-total-antibody-levels-are-associated-with-colorectal-cancer-risk
#14
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of a "xeno-autoantigen", against which circulating human "xeno-autoantibodies" can react. The resulting inflammation ("xenosialitis") has been demonstrated in human-like Neu5Gc-deficient mice and contributed to carcinoma progression via antibody-mediated inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29912318/bayesian-inference-for-network-meta-regression-using-multivariate-random-effects-with-applications-to-cholesterol-lowering-drugs
#15
Hao Li, Ming-Hui Chen, Joseph G Ibrahim, Sungduk Kim, Arvind K Shah, Jianxin Lin, Andrew M Tershakovec
Low-density lipoprotein cholesterol (LDL-C) has been identified as a causative factor for atherosclerosis and related coronary heart disease, and as the main target for cholesterol- and lipid-lowering therapy. Statin drugs inhibit cholesterol synthesis in the liver and are typically the first line of therapy to lower elevated levels of LDL-C. On the other hand, a different drug, Ezetimibe, inhibits the absorption of cholesterol by the small intestine and provides a different mechanism of action. Many clinical trials have been carried out on safety and efficacy evaluation of cholesterol lowering drugs...
April 18, 2018: Biostatistics
https://www.readbyqxmd.com/read/29912234/-heart-gut-interactions
#16
Claudio Borghi, Enrico Strocchi
The known interactions between the heart and the digestive system, concerning the semeiotic and the pathophysiology of coronary and non-coronary pain and the possible causal relationship between reflux pathology and the onset of atrial fibrillation, have been implemented by the most recent acquisitions on the role of intestinal microbiota in the development of atherosclerosis, hypertension and heart failure; this brief review also addresses these more innovative aspects.
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29910226/a-compound-heterozygous-mutation-of-lipase-maturation-factor-1-is-responsible-for-hypertriglyceridemia-of-a-patient
#17
Yihui Liu, Jiang Xu, Wanyun Tao, Rong Yu, Xinjiang Zhang
AIM: Dyslipidemia is the most common lipid metabolism disorder in humans, and its etiology remains elusive. Hypertriglyceridemia (HTG) is a type of dyslipidemia that contributes to atherosclerosis and coronary heart disease. Previous studies have demonstrated that mutations in lipoprotein lipase (LPL), apolipoprotein CII (APOC2), apolipoprotein AV (APOA5), glycosylphosphatidylinositol anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1), and glycerol-3 phosphate dehydrogenase 1 (GPD1) are responsible for HTG by using genomic microarrays and next-generation sequencing...
June 15, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29909109/effects-of-statins-on-coronary-atherosclerotic-plaques-the-paradigm-progression-of-atherosclerotic-plaque-determined-by-computed-tomographic-angiography-imaging-study
#18
Sang-Eun Lee, Hyuk-Jae Chang, Ji Min Sung, Hyung-Bok Park, Ran Heo, Asim Rizvi, Fay Y Lin, Amit Kumar, Martin Hadamitzky, Yong Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Jonathon A Leipsic, Sanghoon Shin, Jung Hyun Choi, Kavitha Chinnaiyan, Gilbert Raff, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min
OBJECTIVES: This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. BACKGROUND: Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis remain unclear. METHODS: We performed a prospective, multinational study consisting of a registry of consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography at an interscan interval of ≥2 years...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29908999/the-roles-of-pai-1-gene-polymorphisms-in-atherosclerotic-diseases-a-systematic-review-and-meta-analysis-involving-149-908-subjects
#19
Yu Liu, Jianxin Cheng, Xiangyi Guo, Jingjing Mo, Beibei Gao, Huiyuan Zhou, Yixin Wu, Zhijuan Li
BACKGROUND: The roles of plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in atherosclerotic diseases were intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between PAI-1 genetic variations and atherosclerosis. METHODS: Eligible studies were searched in PubMed, Medline, Embase and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess relationship between PAI-1 polymorphisms and atherosclerotic diseases...
June 14, 2018: Gene
https://www.readbyqxmd.com/read/29903734/ige-to-the-mammalian-oligosaccharide-galactose-%C3%AE-1-3-galactose-is-associated-with-increased-atheroma-volume-and-plaques-with-unstable-characteristics
#20
Jeffrey M Wilson, Anh T Nguyen, Alexander J Schuyler, Scott P Commins, Angela M Taylor, Thomas A E Platts-Mills, Coleen A McNamara
OBJECTIVE: Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease. APPROACH AND RESULTS: Total IgE and specific IgE to α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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