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https://www.readbyqxmd.com/read/28102362/evaluation-of-region-selective-bilirubin-induced-brain-damage-as-a-basis-for-a-pharmacological-treatment
#1
Matteo Dal Ben, Cristina Bottin, Fabrizio Zanconati, Claudio Tiribelli, Silvia Gazzin
The neurologic manifestations of neonatal hyperbilirubinemia in the central nervous system (CNS) exhibit high variations in the severity and appearance of motor, auditory and cognitive symptoms, which is suggestive of a still unexplained selective topography of bilirubin-induced damage. By applying the organotypic brain culture (OBC: preserving in vitro the cellular complexity, connection and architecture of the in vivo brain) technique to study hyperbilirubinemia, we mapped the regional target of bilirubin-induced damage, demonstrated a multifactorial toxic action of bilirubin, and used this information to evaluate the efficacy of drugs applicable to newborns to protect the brain...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28007510/-palliative-care-for-newborn-infants-with-congenital-malformations-or-genetic-abnormalities
#2
M-L Viallard, G Moriette
The choice of palliative care can be made today in the perinatal period, as it can be made in children and adults. Palliative care, rather than curative treatment, may be considered in three clinical situations: babies born at the limits of viability, withholding/withdrawing treatments in the NICU, and babies with severe malformations of genetic abnormalities identified during pregnancy. Only the last situation is addressed hereafter. In newborn infants as in older patients, palliative care aims at taking care of the baby and at providing comfort and well-being...
December 19, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28003751/effect-of-dexmedetomidine-on-hippocampal-neuron-development-and-bdnf-trkb-signal-expression-in-neonatal-rats
#3
Jie Lv, Wei Ou, Xiao-Hua Zou, Yin Yao, Jin-Li Wu
The study aimed to explore the effect of dexmedetomidine (DEX) on hippocampal neuron development process and on molecular expression of brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling pathway in neonatal rats. The hippocampal neuron cells were isolated from newborn neonatal rats and cultured in vitro. One control group and three treated groups with 1, 10, and 100 μmol/L DEX were used for the study. Cell activity and apoptosis were detected by the MTT and terminal deoxynucleotidyl transferase-mediated biotinylated uridine triphosphate (UTP) nick end labeling assays...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27894120/end-of-life-care-and-survival-without-major-brain-damage-in-newborns-at-the-limit-of-viability
#4
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, José Ángel García Hernández, Josep Figueras Aloy, Alfredo García-Alix Pérez
BACKGROUND: The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES: To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) relative to the total number of survivors, whether these probabilities vary with GA, and how end-of-life (EoL) decisions influence these results...
November 29, 2016: Neonatology
https://www.readbyqxmd.com/read/27829004/outcome-at-two-years-of-very-preterm-infants-born-after-rupture-of-membranes-before-viability
#5
Amelie Kieffer, Gaelle Pinto Cardoso, Caroline Thill, Eric Verspyck, Stéphane Marret
PURPOSE: To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM. DESIGN AND PATIENTS: This single-center case-control retrospective study was conducted at Rouen University Hospital between 1st January 2000 and 31st December 2010. All the cases with EPPROM born from 26WG to 32WG were included...
2016: PloS One
https://www.readbyqxmd.com/read/27800030/fertility-preservation-in-males-with-cancer-16-year-monocentric-experience-of-sperm-banking-and-post-thaw-reproductive-outcomes
#6
Raffaella Depalo, Doriana Falagario, Paola Masciandaro, Claudia Nardelli, Margherita Patrizia Vacca, Pasquale Capuano, Giorgina Specchia, Michele Battaglia
BACKGROUND: Anticancer treatments can impair male fertility. Cryopreservation of semen is an efficient procedure for fertility preservation. The aim of this study was to evaluate pre-freeze semen parameters among the various types of cancer, post-thaw sperm viability and reproductive outcome of samples used for assisted reproductive treatment (ART). METHODS: This study included 721 men with cancer that had their semen cryopreserved in our bank in 1999-2015. Semen analysis and cryopreservation were performed before the start of antineoplastic treatment, according to the World Health Organization recommendations, European Commission and Italian law...
November 2016: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/27744430/impact-of-fetal-weight-estimation-on-the-prediction-of-neonatal-morbidity-and-mortality-at-the-limit-of-viability
#7
Jarmila A Zdanowicz, Chantal Huber, Roland Gerull, Martin Mueller, Luigi Raio, Daniel Surbek
INTRODUCTION: To determine the accuracy of estimated fetal weight (EFW) at the limit of viability in a delivery room setting and its impact on the prediction of neonatal outcome. MATERIAL AND METHODS: In this retrospective, single-center cohort study we included patients with preterm birth between 230/7 and 260/7 weeks of gestation. Neonates were divided into 3 groups according to birth weight at delivery (accuracy index 90-110%, <90%, >110%). Neonatal outcome for each group was categorized into survival with and without impairment and death, with a follow-up period of 6 weeks...
October 15, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27716335/feasibility-of-community-level-interventions-for-pre-eclampsia-perspectives-knowledge-and-task-sharing-from-nigeria-mozambique-pakistan-and-india
#8
Mary V Kinney, Jeffrey Michael Smith, Tanya Doherty, Jorge Hermida, Karen Daniels, José M Belizán
Hypertensive disorders of pregnancy (HDP), particularly pre-eclampsia and eclampsia, remain one of the leading causes of maternal mortality and are contributory in many foetal/newborn deaths. This editorial discusses a supplement of seven papers which provide the results of the first round of the CLIP (Community Level Interventions for Pre-eclampsia) Feasibility Studies. These studies report a number of enablers and barriers in each setting, which have informed the implementation of a cluster-randomized trial (cRCT) aimed at reducing pre-eclampsia-related, and all-cause, maternal and perinatal mortality and major morbidity using community-based identification and treatment of pre-eclampsia in selected geographies of Nigeria, Mozambique, Pakistan and India...
September 30, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27690708/characterization-of-mothers-at-risk-of-delivery-at-the-limit-of-viability-and-factors-related-to-infant-survival
#9
Fermín García-Muñoz Rodrigo, José Ángel García Hernández, Alfredo García-Alix
OBJECTIVES: To determine the socio-demographic and clinical characteristics of mothers of infants at the limit of viability, and to know the perinatal factors associated to infants' survival. METHOD: Single center cohort study of mothers and newborns assisted in our tertiary care center (2004-2010). Demographic and perinatal variables were compared between mothers who gave birth ≤26 weeks GA and the general population. The association between perinatal factors and neonatal survival was studied by Cox regression analysis...
October 3, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27686886/neuroprotective-effects-of-cannabidiol-in-hypoxic-ischemic-insult-the-therapeutic-window-in-newborn-mice
#10
Nagat Mohammed, Maria Ceprián, Laura Jimenez, M Ruth Pazos, Jose Martínez-Orgado
BACKGROUND: A relevant therapeutic time window (TTW) is an important criterion for considering the clinical relevance of a substance preventing newborn hypoxic-ischemic (HI) brain damage. OBJECTIVE: to test the TTW of the neuroprotective effects of cannabidol (CBD), a non-psychoactive cannabinoid in a model of newborn HI brain damage. METHOD: 9-10 day-old C57BL6 mice underwent a HI insult (10% oxygen for 90 min after left carotid artery electrocoagulation)...
September 27, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27670940/assessment-of-canine-neonatal-viability-the-apgar-score
#11
M C Veronesi
Perinatal mortality is relatively high in dogs, with deaths peaking around the time of birth and during the first week of age. Among the several causes of canine perinatal mortality, whelping is the greatest cause. Therefore, early neonatal assistance at birth should be mandatory with dogs. In comparison with human neonatology, knowledge and technological ability in canine neonatology is tremendously scarce. The Apgar score for the newborn viability assessment at birth represents a feasible method for the prompt recognition of newborns that will need special assistance immediately after birth...
September 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27644875/protection-of-carboxymethylated-chitosan-on-chondrocytes-from-nitric-oxide-induced-apoptosis-by-regulating-phosphatidylinositol-3-kinase-akt-signaling-pathway
#12
Bin He, Haiying Tao, Ailin Wei, Shiqing Liu, Xiaohai Li, Ren Chen
Chondrocyte apoptosis is the most important element of development and progression of osteoarthritis (OA). Nitric oxide (NO) was used as the agent to induce chondrocyte apoptosis. Carboxymethylated chitosan (CMCS) has anti-apoptosis effect on many cell types in vitro. This study was designed to investigate the protective effect of CMCS on NO-induced chondrocyte apoptosis and the probable molecular mechanisms. The newborn Sprague-Dawley (SD) rats were used in this study for isolation of chondrocytes. The cell viability was determined by cell counting kit (CCK-8), cell apoptosis was detected by Annexin-V/PI double staining assay kit...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27632778/an-in-vivo-study-of-hypoxia-inducible-factor-1%C3%AE-signaling-in-ginsenoside-rg1-mediated-brain-repair-after-hypoxia-ischemia-brain-injury
#13
Binzhi Tang, Dejian Wang, Maojun Li, Qing Wu, Qian Yang, Wei Shi, Changhui Chen
BACKGROUND: Hypoxia/ischemia (HI) brain injury is a common central nervous system insult in newborns. Studies have demonstrated bioactivity of ginsenoside Rg1 in increasing neural viability and promoting angiogenesis. However, there are few reports on roles of Rg1 in brain repair of neonatal HI, and the mechanisms involved are unclear. METHODS: a neonatal HI model was established by a modified Rice-Vannucci model (RVM) and pups received ginsenoside Rg1 or monosialotetrahexosyl ganglioside (GM1) treatment...
January 2017: Pediatric Research
https://www.readbyqxmd.com/read/27579525/effect-of-low-dose-x-ray-irradiation-on-micronucleus-formation-in-human-embryo-newborn-and-child-cells
#14
Shin Koyama, Eijiro Narita, Naoki Shinohara, Junji Miyakoshi
PURPOSE: It is well known that a high-dose of ionizing radiation is sufficient to break DNA strands, which leads to elevated genotoxic risks; however, the risks associated with low doses of ionizing radiation remain unclear. In addition, there is little data about the effect of low-dose ionizing radiation on human-derived embryo, newborn and child cells. We investigated the frequency of micronucleus (MN) formation in these cells to understand the genotoxic effects of ionizing radiation...
August 31, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27578021/bilirubin-induced-er-stress-contributes-to-the-inflammatory-response-and-apoptosis-in-neuronal-cells
#15
Mohammed Qaisiya, Cristina Brischetto, Jana Jašprová, Libor Vitek, Claudio Tiribelli, Cristina Bellarosa
Unconjugated bilirubin (UCB) in newborns may lead to bilirubin neurotoxicity. Few studies investigated the activation of endoplasmic reticulum stress (ER stress) by UCB. We performed an in vitro comparative study using undifferentiated SH-SY5Y, differentiated GI-ME-N neuronal cells and human U87 astrocytoma cells. ER stress and its contribution to inflammation and apoptosis induced by UCB were analyzed. Cytotoxicity, ER stress and inflammation were observed only in neuronal cells, despite intracellular UCB accumulation in all three cell types...
August 30, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27565713/exercise-during-pregnancy-decreases-doxorubicin-induced-cardiotoxic-effects-on-neonatal-hearts
#16
Verônica B Brito, Leopoldo V M Nascimento, Ramiro B Nunes, Dinara J Moura, Pedro Dal Lago, Jenifer Saffi
Cancer treatment with Doxorubicin (DOX) is limited due its dose-dependent cardiotoxicity, mainly related to the oxidative stress production. In experimental models of DOX treatment exercise can be used as a beneficial adjuvant therapy. This work aimed to investigate the effects of exercise during pregnancy on DOX-induced cardiotoxicity in cardiomyocytes of progeny, examining the possible intergenerational cardioprotective effects of maternal exercise. For this purpose pregnant rats were divided in control and exercise groups and pre-treated during gestational days...
August 10, 2016: Toxicology
https://www.readbyqxmd.com/read/27557631/effects-of-tgf-%C3%AE-1-on-mineralization-mediated-by-rat-calvaria-derived-osteogenic-cells
#17
Tatiani A G Donato, Elizabeth F Martinez, Victor E Arana-Chavez
In this study, we have analyzed the viability and cell growth, as well as, the mineralization of extracellular matrix (ECM) by alizarin red and von Kossa staining of calvaria-derived osteogenic cultures, treated with TGF-β1 alone or associated with Dex comparing with acid ascorbic (AA) + β-glicerophosphate (βGP) (positive mineralization control). The expression of the noncollagenous proteins bone sialoprotein (BSP), osteopontin (OPN) and fibronectin (FN) were evaluated by indirect immunofluorescence...
December 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27551168/once-the-light-touch-to-the-brain-cytotoxic-effects-of-low-dose-gamma-ray-laser-light-and-visible-light-on-rat-neuronal-cell-culture
#18
Murteza Cakir, Abdullah Colak, Cagatay Calikoglu, Numan Taspinar, Mustafa Erdem Sagsoz, Hakan Hadi Kadioglu, Ahmet Hacimuftuoglu, Sabriye Seven
OBJECTIVE: We aimed to evaluate the effects of gamma-ray, laser light, and visible light, which neurons are commonly exposed to during treatment of various cranial diseases, on the viability of neurons. MATERIALS AND METHODS: Neuronal cell culture was prepared from the frontal cortex of 9 newborn rats. Cultured cells were irradiated with gamma-ray for 1-10 min by (152)Eu, (241)Am, and (132)Ba isotopes, visible light for 1-160 min, and laser light for 0.2-2 seconds...
June 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/27429295/ethosomes-for-enhanced-skin-delivery-of-griseofulvin
#19
Joana Marto, Catarina Vitor, Ana Guerreiro, Cristiana Severino, Carla Eleutério, Andreia Ascenso, Sandra Simões
Griseofulvin (GRF) is an important antifungal drug with low bioavailability and, for this reason, a topical formulation with a targeted action and minimal systemic effects, appears to be a preferable solution. GRF poor solubility has limited the development of topical formulations and their release to the market. The aim of this work was to prepare a new GRF formulation for topical application using lipid-based nanosystems; to study its permeation and penetration, cell viability and to evaluate its therapeutic action...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27285711/the-ability-of-different-thermal-aids-to-reduce-hypothermia-in-neonatal-piglets
#20
L J Pedersen, M L V Larsen, J Malmkvist
We investigated whether hypothermia in newborn piglets could be reduced by applying different thermal aids. The experiment was performed on 150 newborn piglets from 24 sows. Right after birth, the piglets were moved to a wire mesh cage for the first 2 h of life where they experienced 1 of 7 different combinations of flooring (solid vs. slatted) and treatments: control, with no additional thermal aids on a solid floor ( = 26) or a slatted floor ( = 26); built-in floor heating ( = 31) or floor heating as a radiant floor plate on solid floor (FloorPlate; = 19); radiant heater above a solid floor (RadiantC; = 22) or a slatted floor (RadiantSlat; = 18); and provision of straw on a solid floor (Straw; = 8)...
May 2016: Journal of Animal Science
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