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https://www.readbyqxmd.com/read/29395686/comparison-of-3-anesthetic-protocols-for-the-elective-cesarean-section-in-the-dog-effects-on-the-bitch-and-the-newborn-puppies
#1
José M Vilar, M Batista, R Pérez, A Zagorskaia, E Jouanisson, L Díaz-Bertrana, S Rosales
This study assessed the influence of 3 different anesthetic protocols based on the quality of anesthesia induction and maintenance in four dog breeds (French Bulldog, n = 13; Yorkshire terrier, n = 12; Chihuahua, n = 10; Bull Terrier, n = 10) subjected to cesarean section. Neonatal mortality, birth defects and newborn viability were assessed. All females were pre-medicated with morphine (IM), and then were assigned to three different anesthetic protocols: group P (n = 17), anesthesia was induced with propofol (IV) and then also maintained with propofol until the complete delivery of puppies and then anesthesia was maintained afterwards with sevoflurane; group PS (n = 14), anesthesia was induced with IV propofol, and maintenance of the anesthesic plan was performed with sevoflurane; group PES (n = 14) the females were induced by propofol and an epidural anesthesia was then performed, anesthesia was then maintained with propofol until the complete extraction of all puppies and then anesthesia was maintained afterwards with sevoflurane...
March 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29327490/fetal-subcutaneous-cells-have-potential-for-autologous-tissue-engineering
#2
Åsa Ekblad, Magnus Westgren, Magdalena Fossum, Cecilia Götherström
BACKGROUND: Major congenital malformations affect up to 3% of newborns. Infants with prenatally diagnosed soft tissue defects should benefit from having autologous tissue readily available for surgical implantation in the perinatal period. In this study, we investigate fetal subcutaneous cells (fSC) as cellular source for tissue engineering. METHODS: Fetal subcutaneous biopsies were collected from elective terminations at gestational week 20-21. Cells were isolated, expanded and characterized in vitro...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29299743/basic-fibroblast-growth-factor-protects-astrocytes-against-ischemia-reperfusion-injury-by-upregulating-the-caveolin-1-vegf-signaling-pathway
#3
Meixia Liu, Yudan Wu, Yidian Liu, Zhenzhen Chen, Shujuan He, Huimei Zhang, Liang Wu, Fengxia Tu, Yun Zhao, Chan Liu, Xiang Chen
A previous in vivo study demonstrated that intracerebroventricular injection of basic fibroblast growth factor (bFGF) in middle cerebral artery occlusion rats increased the expression of caveolin-1 (cav-1) and vascular endothelial growth factor (VEGF) in cerebral ischemia penumbra. Because astrocytes are the largest population in the brain, the aim of this in vitro study was to investigate the influence of bFGF on cav-1 and VEGF expression in rat astrocytes following oxygen glucose deprivation/reoxygenation (OGD/R)...
January 3, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29295636/caffeine-prevents-bilirubin-induced-cytotoxicity-in-cultured-newborn-rat-astrocytes
#4
Mehmet Deliktaş, Hacer Ergin, Aydın Demiray, Hakan Akça, Özmert M A Özdemir, Mehmet Bülent Özdemir
OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain. Caffeine used in the treatment of apnea of prematurity was reported to decrease mechanical ventilation requirement, the frequencies of bronchopulmonary dysplasia, patent ductus arteriosus, cerebral palsy and neurodevelopmental disorders in very low birth weight infants. However, the effect of caffeine on hyperbilirubinemia was not yet clarified...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29278964/mild-hypothermia-protects-neurons-against-oxygen-glucose-deprivation-via-poly-adp-ribose-signaling
#5
Yubo Gao, Zhihua Wang, Weikun He, Wenjing Ma, Xinli Ni
OBJECTIVE: Hypothermia is a neuroprotective mechanism that has been validated for use in alleviating neonatal hypoxic-ischemic (HI) brain injury. Nevertheless, it is unclear whether poly (ADP-ribose) (PAR) signaling is involved in hypothermia-induced neuroprotection. In this study, we investigated whether mild hypothermia rescues oxygen glucose deprivation (OGD)-induced cell death by modifying PAR-relative protein expression, such as AIF, PARP-1, and PAR polymer, in primary-cultured hippocampal neurons...
December 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29228121/low-dose-bisphenol-a-activates-the-erk-signaling-pathway-and-attenuates-steroidogenic-gene-expression-in-human-placental-cells
#6
Po-Wei Chu, Zhi-Jie Yang, Huei-Shing Huang, Ai-An Chang, Yu-Chen Cheng, Gwo-Jang Wu, Hsin-Chieh Lan
Bisphenol A (BPA) is an industrial material used for many plastic products and is considered an endocrine disruptor. BPA can be released into the environment and can spread through the food chain. It is well known that BPA exposure leads to lesions, especially in the reproductive system. According to previous studies, BPA reduces newborn numbers in pregnant mice and affects placentation. The placenta is a special endocrine organ during pregnancy. It secretes important hormones, such as progesterone and estrogen, to maintain gestation...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29097635/the-impact-of-zika-virus-infection-on-human-neuroblastoma-sh-sy5y-cell-line
#7
Natthanej Luplertlop, San Suwanmanee, Watcharamat Muangkaew, Sumate Ampawong, Thitinan Kitisin, Yong Poovorawan
BACKGROUND & OBJECTIVES: An increase in Zika virus (ZIKV) epidemic during the last decade has become a major global concern as the virus affects both newborns and adult humans. Earlier studies have shown the impact of ZIKV infection in developing human foetus. However, effective in vitro model of target cells for studying the ZIKV infection in adult human neurons is not available. This study aimed to establish the use of human neuroblastoma cell line (SH-SY5Y) for studying an infection of ZIKV in vitro...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29073813/silencing-thioredoxin1-exacerbates-damage-of-astrocytes-exposed-to-ogd-r-by-aggravating-apoptosis-through-the-actin-ras2-camp-pka-pathway
#8
Kunting Zhu, Qi He, Lingyu Li, Yong Zhao, Jing Zhao
Induction of endogenous antioxidants is one of the key molecular mechanisms of cell resistance to hypoxia/ischemia. Thioredoxin1 (Trx1) is a small multifunctional ubiquitous antioxidant with redox-active dithiol and plays an important role in cell apoptosis through mitochondrial apoptosis pathways. The specific role of Trx1 in ischemia-reperfusion induced astrocyte apoptosis, however, remains unclear. In this study, we investigated the effect of Trx1 on apoptosis of astrocyte using an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model which mimics ischemic/reperfusion conditions in vivo...
October 27, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29073777/neuroprotective-effects-of-orientin-on-oxygen-glucose-deprivation-reperfusion-induced-cell-injury-in-primary-culture-of-rat-cortical-neurons
#9
Tian Tian, Junan Zeng, Guangyu Zhao, Wenjing Zhao, Songyi Gao, Li Liu
Orientin (luteolin-8-C-glucoside) is a phenolic compound found abundantly in millet, juice, and peel of passion fruit and has been shown to have antioxidant properties. In the present study, we explored the effects of orientin on oxygen-glucose deprivation/reperfusion (OGD/RP)-induced cell injury in primary culture of rat cortical neurons using an in vitro model of neonatal ischemic brain injury. The reduced cell viability and elevated lactate dehydrogenase leakage were observed after OGD/RP exposure, which were then reversed by orientin (10, 20, and 30 µM) pretreatment in a dose-dependent manner...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29058455/newborn-neurons-are-damaged-in-vitro-by-a-low-concentration-of-silver-nanoparticles-through-the-inflammatory-oxidative-stress-pathway
#10
Xiaoyuan Guo, Guilong Zhang, Lukui Chen, Ahsan Ali Khan, Bin Gu, Bingqian Li
With increasing applications of nanomaterials, including silver nanoparticles (AgNPs), unknown potential risks are present against humans and the environment, especially to the fetus and neonates, which are more sensitive to the cytotoxicity of such agents. This study focused on the effects of AgNP exposure on newborn neurons differentiated from neural stem cells (NSCs) in vitro. We isolated NSCs from fetal rat hippocampus and incubated them in neural differentiation medium for 3-7 days to form newborn neurons and networks...
December 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29053705/vagus-nerve-stimulation-in-pregnant-rats-and-effects-on-inflammatory-markers-in-the-brainstem-of-neonates
#11
Allison Judkins, Rhaya L Johnson, Samuel T Murray, Steven M Yellon, Christopher G Wilson
BackgroundVagus nerve stimulation (VNS) is an Food and Drug Administration-approved method delivering electrical impulses for treatment of depression and epilepsy in adults. The vagus nerve innervates the majority of visceral organs and cervix, but potential impacts of VNS on the progress of pregnancy and the fetus are not well studied.MethodsWe tested the hypothesis that VNS in pregnant dams does not induce inflammatory changes in the cardio-respiratory control regions of the pups' brainstem, potentially impacting the morbidity and mortality of offspring...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29044351/surgical-management-of-necrotizing-enterocolitis-in-an-incredibly-low-birth-weight-infant-and-review-of-the-literature
#12
A Zangari, C Noviello, S Nobile, G Cobellis, C Gulia, R Piergentili, S Gigli, V Carnielli
Survival of preterm infants have dramatically improved over the last decades. Nonetheless, infants born preterm remain vulnerable to many complications, including necrotizing enterocolitis (NEC). The severity of the disease and the mortality rate are directly correlated with decreasing gestational age and birth weight. Despite surgical treatment mortality rate remains very high in extremely premature infants, especially in newborns at the lowest limit of viability. Survival of infants of birth weight (BW) below 750 g has been increasingly reported in recent years, however the overall mortality in extremely low "BW" infants (ELBW) requiring surgery for NEC has not decreased over the past years...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29027248/ursodeoxycholic-acid-protects-cardiomyocytes-against-cobalt-chloride-induced-hypoxia-by-regulating-transcriptional-mediator-of-cells-stress-hypoxia-inducible-factor-1%C3%AE-and-p53-protein
#13
Anis Syamimi Mohamed, Noorul Izzati Hanafi, Siti Hamimah Sheikh Abdul Kadir, Julina Md Noor, Narimah Abdul Hamid Hasani, Sharaniza Ab Rahim, Rosfaiizah Siran
In hepatocytes, ursodeoxycholic acid (UDCA) activates cell signalling pathways such as p53, intracellular calcium ([Ca(2+) ]i ), and sphingosine-1-phosphate (S1P)-receptor via Gαi -coupled-receptor. Recently, UDCA has been shown to protect the heart against hypoxia-reoxygenation injury. However, it is not clear whether UDCA cardioprotection against hypoxia acts through a transcriptional mediator of cells stress, HIF-1α and p53. Therefore, in here, we aimed to investigate whether UDCA could protect cardiomyocytes (CMs) against hypoxia by regulating expression of HIF-1α, p53, [Ca(2+) ]i , and S1P-Gαi -coupled-receptor...
October 12, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29022648/probiotics-for-experimental-obesity-prevention-focus-on-strain-dependence-and-viability-of-composition
#14
Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Beregova, Mykola Spivak
INTRODUCTION: a comparative animal study of the efficacy of intermittent short-course administration of lyophilised single-, three-, and live multistrain probiotic on obesity. METHODS: We included 70 rats divided into seven groups (n = 10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were untreated. The group III-V received lyophilised monoprobiotics B...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28937572/obstetric-care-consensus-no-6-periviable-birth
#15
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937567/obstetric-care-consensus-no-6-summary-periviable-birth
#16
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28926834/heme-oxygenase-activity-and-heme-binding-in-a-neonatal-mouse-model
#17
Stephanie Kourula, Joyce Ang, Hui Zhao, Flora Kalish, Peter Vandenabeele, Karl G Sylvester, Ronald J Wong, David K Stevenson
BACKGROUND: Severe hemolytic disease of the newborn leads to the release of pro-oxidative free heme (FH). Heme oxygenase (HO) is primarily responsible for detoxifying FH. OBJECTIVE: To investigate the protective effects of HO in a model of heme overload. METHODS: For in vitro studies, NIH3T3 HO-1-luc cells were incubated with 10, 30, or 60 µM FH or methemalbumin (MHA). HO-1 promoter activity was assessed 3, 6, and 24 h after treatment. Cell survival was indexed by viability assays...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28774314/surfactant-effects-on-the-viability-and-function-of-human-mesenchymal-stem-cells-in-vitro-and-in-vivo-assessment
#18
Chung-Ming Chen, Hsiu-Chu Chou, Willie Lin, Chris Tseng
BACKGROUND: Surfactant therapy has become the standard of care for preterm infants with respiratory distress syndrome. Preclinical studies have reported the therapeutic benefits of mesenchymal stem cells (MSCs) in experimental bronchopulmonary dysplasia. This study investigated the effects of a surfactant on the in vitro viability and in vivo function of human MSCs. METHODS: The viability, phenotype, and mitochondrial membrane potential (MMP) of MSCs were assessed through flow cytometry...
August 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28753596/inhibition-of-i%C3%AE%C2%BAb%C3%AE-nf%C3%AE%C2%BAb-signaling-prevents-lps-induced-il1%C3%AE-expression-without-increasing-apoptosis-in-the-developing-mouse-lung
#19
Sarah McKenna, Brittany Butler, Laurie Jatana, Sankar Ghosh, Clyde J Wright
BackgroundThe pro-inflammatory consequences of IL1β expression contribute to the pathogenesis of bronchopulmonary dysplasia. Selectively targeting Lipopolysaccharide (LPS)-induced IκBβ/NFκB signaling attenuates IL1β mRNA expression in macrophages. Whether targeting IκBβ/NFκB signaling affects the anti-apoptotic gene expression, a known consequence of global LPS-induced NFκB inhibition, is unknown.MethodsMacrophages (RAW 264.7, bone marrow-derived macrophage) were assessed for LPS-induced IL1β mRNA/protein expression, anti-apoptotic gene expression, cell viability (trypan blue exclusion), and activation of apoptosis (caspase-3 and PARP cleavage) following pharmacologic and genetic attenuation of IκBβ/NFκB signaling...
December 2017: Pediatric Research
https://www.readbyqxmd.com/read/28747684/generation-and-validation-of-novel-adeno-associated-viral-vectors-for-the-analysis-of-ca-2-homeostasis-in-motor-neurons
#20
Rosa Pia Norante, Maria Lina Massimino, Paolo Lorenzon, Agnese De Mario, Caterina Peggion, Mattia Vicario, Mattia Albiero, Maria Catia Sorgato, Raffaele Lopreiato, Alessandro Bertoli
A finely tuned Ca(2+) homeostasis in restricted cell domains is of fundamental importance for neurons, where transient Ca(2+) oscillations direct the proper coordination of electro-chemical signals and overall neuronal metabolism. Once such a precise regulation is unbalanced, however, neuronal functions and viability are severely compromised. Accordingly, disturbed Ca(2+) metabolism has often been claimed as a major contributor to different neurodegenerative disorders, such as amyotrophic lateral sclerosis that is characterised by selective motor neuron (MN) damage...
July 26, 2017: Scientific Reports
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