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Cutaneous lupus erythematosis

B S Suganya Priyadharshini, I Syed Ummar
Objectives: Objective in our study is i) To assess the prevalence and sociodemographic profile of cutaneous side effects in bipolar affective disorder patients (BPAD) on lithium. ii) To assess the course of pre-existing skin reactions, when patient is initiated on lithium therapy. Methods: Lithium induced cutaneous side effects were assessed at baseline and monthly for 6 months followed by every 2 months over a year. Dermatologist opinion obtained to diagnose and treat for each patient who developed cutaneous side effects...
September 2017: Indian Journal of Psychological Medicine
A Najm, B Le Goff, A Achille, O Espitia, C Durant, F Perrin, C Agard
INTRODUCTION: Jaccoud's arthropathy (JA) is a chronic and non-erosive deforming arthropathy, usually affecting the hands. JA pathophysiology is poorly known but involves periarticular structures such as tendons and the joint capsule. JA is associated with various conditions including the connective tissue disease, especially systemic lupus erythematosis. JA has been rarely described and studied in systemic sclerosis. CASE REPORTS: We report the clinical histories of 3 patients with systemic sclerosis (ScS) who developed JA...
October 2016: La Revue de Médecine Interne
Hui Jin, Guiying Zhang, Ying Zhou, Christopher Chang, Qianjin Lu
Patients with lupus erythematosus (LE) specific cutaneous manifestations distributed along the lines of Blaschko are seldom encountered in clinic. In this paper, we reported 5 new cases and perform a systematic review of all the published cases in the English and Chinese literature. We provide a comprehensive summary of the clinical manifestations and explore potential etiology and pathogenesis. Sixty-eight published papers (53 English and 15 Chinese) and 93 cases (including 5 cases reported by us) were included in the analysis...
April 2016: Autoimmunity Reviews
Rocío Porcel Chacón, Leopoldo Tapia Ceballos, Rocío Díaz Cabrera, María Teresa Gutiérrez Perandones
Neonatal lupus erythematosus is an infrequent disease seen in newborns. It is caused by transplacental maternal autoantibody passage. Cutaneous involvement and congenital heart block (CHB) are the most common affections, although it may involve multiple organs like the liver, lungs, blood, nervous or digestive systems. This article present a review of the four cases diagnosed in the past five years in a Neonatal Unit, which shows the different clinical spectrum which can develop around this disease (CHB, multisystemic affection and two cutaneous cases), different autoantibodies (specially anti-SSA) with an early negativization during the first year of life and the possibility of future collagen vascular disease as occurred in one case...
May 2014: Reumatología Clinica
Yi-jin Luo, Guo-zhen Tan, Min Yu, Kai-wen Li, Yue-yang Liu, Qing Guo, Fan-qin Zeng, Liangchun Wang
Detection of immunoreactants including IgG, IgM, IgA, and C3 by direct immunofluorescence (DIF) from skin is useful for distinguishing lupus lesions from other skin disorders. Despite their diagnostic value, the type and number of cutaneous immunoreactants as they relate to serological disorders and disease severity has been poorly studied. We examined 36 patients with systemic lupus erythematosis (SLE) with positive DIF (DIF+) and 28 patients with negative DIF (DIF-) tests performed on lesional skin. Among DIF+ patients, the most frequent patterns of immunoreactants were IgM alone (36%) and the coexistence of IgM with C3 (28%)...
2013: PloS One
Arfan Ul Bari
OBJECTIVE: To determine the frequency of nasal leishmaniasis and the presentation of disease involving nose as well as nasal mucosa in patients reporting from the Muzaffarabad district of Azad Jammu and Kashmir (AJK). STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Combined Military Hospital, Muzaffarabad, from January 2006 to May 2008. METHODOLOGY: All patients belonging to Muzaffarabad district of AJK, clinically suggestive of Cutaneous Leishmaniasis (CL) and supported by laboratory diagnosis were registered...
March 2009: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Fayyaz Ahmed Qureshi, Muhammad Imran Suliman, Javed Sarwar
A remarkable spectrum of clinical expressions of cutaneous leishmaniases is observed in humans ranging from nodular, hyperkeratotic, sporotrichoid, erysipeloid, zosteriform, eczematoid, warty, impetiginized and lupoid forms. Uncommon forms may also be observed. This case describes a 55-year-old lady who apparently looked liked offering from systemic lupus erythematosis due to butterfly distribution of a rash on face. She was misdiagnosed till laboratory tests including histopathology revealed that her lesion was due to cutaneous leishmaniases...
October 2007: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
J Sibilia, C Sordet
SUBJECT: After several decades of hegemony of the T lymphocyte, recent work has suggested the importance of the B lymphocyte in auto-immune diseases. As a consequence, there has emerged over the last few years the idea of using anti-B lymphocyte therapy, in particular rituximab (a chimeric anti-CD20 monoclonal antibody). CURRENT TOPICS AND IMPORTANT RESULTS: This review addresses various current topics: a) the role of B lymphocytes in auto-immune diseases, notably their capacity to be antigen presenting cells and to be activated by original systems like Blys/Baff; b) the mechanism of action of rituximab (apoptosis, complement-dependent cytotoxicity and antibody-dependent cell cytotoxicity) and the phenomena explaining failures and cases escaping treatment, in particular among lymphoproliferations; c) The results include efficacy and tolerance data for the principal auto-immune affections...
June 2005: La Revue de Médecine Interne
M T Dieng, B Ndiaye
We report 3 cases of squamous cell carcinoma arising respectively after 30, 6 and 19 years of spontaneous evolution of cutaneous discoid lupus erythematosus. In each case the histopathologic examination confirmed the diagnosis of cutaneous lupus discoid and squamous cell carcinoma. As phagedenic ulcer which is the main preneoplastic dermatosis, discoid lupus erythematosis must be considered. The long duration before the cancerisation allows a correct treatment of the disease to prevent the transformation.
2001: Dakar Médical
Kenneth T Calamia, Maria Balabanova
Vasculitis in connective tissue diseases is not an uncommon complication. Vasculitis complicates both rheumatoid arthritis and systemic lupus erythematosis (SLE) in about 4% of cases. Cutaneous lesions, representing small-vessel involvement, are most common; however, widespread, necrotizing visceral medium-and large-vessel involvement, mimicking primary vasculitic syndromes, may also occur. Connective tissue disease-associated vasculitis is separated from primary vasculitis syndromes in classification schemes...
March 2004: Clinics in Dermatology
Hélène Brocvielle, Patrice Muret, Emmanuel Plenat, Jean-Pierre Kantelip, Philippe Humbert
THE USE OF A DRUG WITH A TEMPORARY MARKETING AUTHORISATION: Thalidomide is currently available in France for nominative or cohort use with a temporary marketing authorisation (TMA). It is only prescribed and delivered in hospital settings. SIX OFFICIAL INDICATIONS: Its current indications are principally lepromatous nodular erythema, severe aphtosis, Jessner-Kanoff's cutaneous lymphocyte infiltration, discoid lupus erythematosis, chronic graft-versus-host reactions, and relapsed and or refractory multiple myeloma (after the failure of standard therapies)...
December 20, 2003: La Presse Médicale
D A Price, E L C Ong
No abstract text is available yet for this article.
May 2003: Lancet Infectious Diseases
Jörg Wenzel
No abstract text is available yet for this article.
February 28, 2003: Deutsche Medizinische Wochenschrift
JoEllen Van Zander, James C Shaw
Papular and nodular mucinosis is a distinct form of cutaneous mucinosis associated with systemic lupus erythematosis. We report a case in which papular and nodular mucinosis predated early findings of progressive systemic sclerosis.
February 2002: Journal of the American Academy of Dermatology
E Ghayad, F Haddad, A Tohme, E Salame
Neonatal lupus erythematosus is a rare syndrome. It is characterized by a transient lupus dermatitis and congenital heart block. The immunopathogenesis of the disease has been linked to the presence of the SSA antibody. In this report, we describe a symptomatic congenital heart block in a 13-year-old male whose mother had documented systemic lupus erythematosus. We also discuss how to manage a woman with lupus erythematosus and positive antiSSA/Ro antibodies. We conclude that patients with neonatal lupus and their mothers should be observed closely before delivery and for prolonged periods for signs of active disease...
January 1998: Le Journal Médical Libanais. the Lebanese Medical Journal
D L Sylvestre, J V Ravetch
Antibody-antigen complexes are central to the inflammatory response and are implicated in the development of such diverse diseases as systemic lupus erythematosis, rheumatoid arthritis, immune glomerulonephritis, and vasculitis. We recently demonstrated that experimental immune complex-mediated injury in mice, as modeled by the cutaneous Arthus reaction, requires receptors for the Fc portion of the antibody and is unaffected by deficiencies in complement components. However, the responsible cell type(s) and Fc receptor(s) were not known...
October 1996: Immunity
F Furukawa, H Kanauchi, H Wakita, Y Tokura, T Tachibana, Y Horiguchi, S Imamura, S Ozaki, M Takigawa
The autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mouse is characterized by the lpr mutation, which is a defect in the Fas antigen. Since Fas mediates apoptosis, this defect results in CD4-CD8- double negative T-cell proliferation, lupus nephritis, and macroscopic lupus erythematosus-like skin lesions. The control counterpart of MRL/lpr mouse is the MRL/Mp-+/+ (MRL/n) mouse, which lacks the lpr mutation and is almost normal during the first 6 mo of life. The lpr mutation, however, accelerates autoimmune phenomena in MRL/lpr mice...
July 1996: Journal of Investigative Dermatology
M Yamada, S Watanabe, T Takeda, T Aoshima, T Ikeda
No abstract text is available yet for this article.
May 1968: Acta Dermatologica-Kyoto. English Edition
M Ramanathan, M N Abidin, M Muthukumarappan
The presenting features of 236 thyrotoxic patients seen in the thyroid clinic were reviewed. 18.65% of these patterns had one or more dermatological complaints at presentation. There was no specific difference in this group of patients when compared with the general hyperthyroid population with regard to age, race, sex, duration of hyperthyroidism or biochemical indices of thyrotoxicosis. The two major complaints were itching and alopecia. The prevalence of pruritus at 6.4% in our series was identical to that of other workers, but we had a much lower occurrence of alopecia at 2...
December 1989: Medical Journal of Malaysia
F Furukawa, M B Lyons, L A Lee, S N Coulter, D A Norris
A strong association between anti-SS-A/Ro and anti-SS-B/La antibodies and skin lesions has been well documented in subacute cutaneous lupus erythematosus and neonatal lupus erythematosis in which 70 to 80% of patients are female. In order to better understand the mechanisms of the influence of sex hormones on cutaneous lupus, we designed immunopathological in vitro experiments to evaluate the effects of estradiol and other sex steroids on the binding of SS-A/Ro- and SS-B/La-specific antibodies to cultured human keratinocytes from neonates...
September 1, 1988: Journal of Immunology: Official Journal of the American Association of Immunologists
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