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Keywords postoperative cognitive dysfun...

postoperative cognitive dysfunction

https://read.qxmd.com/read/38364258/liraglutide-improves-sevoflurane-induced-postoperative-cognitive-dysfunction-via-activating-autophagy-and-inhibiting-apoptosis
#21
JOURNAL ARTICLE
Ying Hu, Haijin Huang, Yao Jiang, Jingling Zhang, Yang Zhang, Ying Tian, Qin Zhang
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients. Liraglutide (LRG) has high homology (97%) with natural glucagon like peptide-1, and it has been proved to be effective in some nervous system diseases. Whether LRG could regulate POCD has not been reported. METHODS: Sevoflurane (Sev) was used to simulate postoperative cognitive dysfunction (POCD) model. Morris water maze test was performed to evaluate the memory ability and neurological function of rats...
February 15, 2024: Aging
https://read.qxmd.com/read/38357422/postoperative-cognitive-dysfunction-current-research-progress
#22
REVIEW
Qi Zhao, Hui Wan, Hui Pan, Yiquan Xu
Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery...
2024: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38357042/reviving-consciousness-a-neurophysiotherapy-triumph-in-decompressive-craniotomy-recovery
#23
Anandi R Dave, Nikita H Seth, Snehal Samal
This case report presents a 54-year-old male with a history of type-2 diabetes mellitus who experienced sudden unconsciousness and vomiting, leading to aspiration and subsequent diagnosis of a hemorrhagic stroke. The patient underwent an immediate decompressive craniotomy, revealing a sizable intraparenchymal hematoma in the right basal ganglia and corona radiata. Postoperatively, the patient exhibited left-sided weakness, hyporeflexia, and cognitive impairment. A comprehensive neurophysiotherapy intervention addressed impaired mobility, strength, balance, coordination, respiratory complications, pain management, and other associated challenges...
January 2024: Curēus
https://read.qxmd.com/read/38348365/what-do-cancer-surgery-and-orthopedic-surgery-elderly-patients-have-in-common-a-long-term-postoperative-cognitive-dysfunction-in-orthopedic-and-cancer-patients-original-research
#24
JOURNAL ARTICLE
Kalliopi Megari, Evanthia Thomaidou, Georgios A Kougioumtzis, Maria Theodoratou, Dimitra Katsarou, Eleni Karlafti, Matthaios Didaggelos, Daniel Paramythiotis, Eleni Argyriadou
OBJECTIVES-BACKGROUND: Postoperative cognitive dysfunction (POCD) involves decline in several cognitive domains after surgery and is particularly common after cardiac surgery, while also common among other types of surgery. Given the potential effects of such cognitive dysfunction on the quality of life, it is important to study it in multiple populations in order to limit its occurrence. STUDY DESIGN: We present the long-term neuropsychological outcome of 200 patients, 100 of whom had orthopedic surgery and 100 oncological surgery...
2024: Neuroscience insights
https://read.qxmd.com/read/38343339/the-impact-of-ketamine-on-delayed-neurocognitive-recovery-in-elderly-patients-undergoing-spinal-anaesthesia-for-orthopaedic-procedures-a-pilot-study
#25
JOURNAL ARTICLE
Mostafa Samy Abbas, Mohamed Gamal Abo-Zeid, Fatma Gad-Elrab Askar, Omnia Ahmed Askar
OBJECTIVE: Delayed neurocognitive recovery is an objectively measurable decline in the cognitive status at varying intervals after surgery under both general and spinal anaesthesia. In this study, we used the Short Portable Mental Status Questionnaire to evaluate the protective effect of ketamine infusion on cognitive function of elderly patients undergoing spinal anaesthesia for orthopaedic procedures. METHODS: A randomised, double-blinded placebo-controlled trial...
February 12, 2024: Journal of Perioperative Practice
https://read.qxmd.com/read/38340430/connectome-guided-initiation-of-dopamine-agonists-facilitates-cognitive-recovery-after-frontal-lobe-resection-a-case-report
#26
Rosivel Galvez, Souvik Singha, Samuel Singer, Randy S D'Amico
Abulia is a common problem that manifests following various brain conditions, including brain surgeries. Abulia is felt to be related to dysfunction with the brain's dopamine-dependent circuitry. The role of default mode network (DMN) in its pathogenesis is crucial. In this case report, we detail the presentation of abulia in an elderly woman following surgical resection of a right frontal glioblastoma involving the DMN. Connectomic imaging was used pre-operatively and post-operatively, demonstrating disruption of regions integral to the DMN and the central executive network...
January 28, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38334656/post-anesthesia-cognitive-dysfunction-in-mice-is-associated-with-an-age-related-increase-in-neuronal-intracellular-ca-2-neuroprotective-effect-of-reducing-intracellular-ca-2-in-vivo-and-in-vitro-studies
#27
JOURNAL ARTICLE
Arkady Uryash, Alfredo Mijares, Carlos E Lopez, Jose A Adams, Paul D Allen, Jose R Lopez
Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear. Methods: We investigated the effect of isoflurane with or without dantrolene pretreatment on intracellular calcium concentration ([Ca2+ ]i ), reactive oxygen species (ROS) production, cellular lactate dehydrogenase (LDH) leak, calpain activity, and cognitive function using the Morris water maze test of young (3 months), middle-aged (12-13 months), and aged (24-25 months) C57BL6/J mice...
January 31, 2024: Cells
https://read.qxmd.com/read/38331831/risk-factors-and-incidence-of-postoperative-delirium-after-cardiac-surgery-in-children-a-systematic-review-and-meta-analysis
#28
REVIEW
Maoling Fu, Quan Yuan, Qiaoyue Yang, Wenshuai Song, Yaqi Yu, Ying Luo, Xiaoju Xiong, Genzhen Yu
Delirium, a form of acute cerebral dysfunction, is a common complication of postoperative cardiac surgery in children. It is strongly associated with adverse outcomes, including prolonged hospitalization, increased mortality, and cognitive dysfunction. This study aimed to identify risk factors and incidence of delirium after cardiac surgery in children to facilitate early identification of delirium risk and provide a reference for the implementation of effective prevention and management. A systematic literature search was conducted in PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, Sinomed, and Wanfang for studies published in English or Chinese from the inception of each database to November 2023...
February 8, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38327895/effects-of-ulinastatin-combined-with-dexmedetomidine-on-cognitive-dysfunction-and-emergence-agitation-in-elderly-patients-who-underwent-total-hip-arthroplasty
#29
JOURNAL ARTICLE
Qi-Fan Huo, Li-Juan Zhu, Jian-Wei Guo, Yan-An Jiang, Jing Zhao
BACKGROUND: With the continuous growth of the modern elderly population, the risk of fracture increases. Hip fracture is a common type of fracture in older people. Total hip arthroplasty (THA) has significant advantages in relieving chronic pain and promoting the recovery of hip joint function. AIM: To investigate the effect of ulinastatin combined with dexmedetomidine (Dex) on the incidences of postoperative cognitive dysfunction (POCD) and emergence agitation in elderly patients who underwent THA...
January 19, 2024: World Journal of Psychiatry
https://read.qxmd.com/read/38325753/unveiling-the-role-of-astrocytes-in-postoperative-cognitive-dysfunction
#30
REVIEW
Liang He, Xiyuan Duan, Shikuo Li, Ruqiang Zhang, Xulei Dai, Meilin Lu
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive cognitive decline and the accumulation of amyloid-beta plaques, tau tangles, and neuroinflammation in the brain. Postoperative cognitive dysfunction (POCD) is a prevalent and debilitating condition characterized by cognitive decline following neuroinflammation and oxidative stress induced by procedures. POCD and AD are two conditions that share similarities in the underlying mechanisms and pathophysiology. Compared to normal aging individuals, individuals with POCD are at a higher risk for developing AD...
February 5, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38321534/effect-of-remote-ischemic-preconditioning-on-postoperative-cognitive-dysfunction-in-adult-patients-with-general-anesthesia-a-meta-analysis
#31
REVIEW
Mengnan Han, Yanru Du, Jianli Li, Yi Li, Shuang Han, Chong Li
BACKGROUND: Remote ischemic preconditioning (RIPC) is proven to have neuroprotective protective effects. Nevertheless, the impact of RIPC on postoperative cognitive dysfunction (POCD) in patients undergoing general anesthesia is controversial. This meta-analysis of randomized controlled trials (RCTs) aimed to assess the effect of RIPC on POCD in adults after general anesthesia. METHODS: Relevant literature was obtained by searching Embase, PubMed, Web of Science, Cochrane Library, Wanfang, and China National Knowledge Infrastructure (CNKI) databases in July 2022...
February 6, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38297396/effects-of-conventional-nursing-in-the-operating-room-combined-with-transcutaneous-electrical-acupoint-stimulation-on-postoperative-cognitive-dysfunction-after-total-knee-arthroplasty-in-elderly-patients
#32
JOURNAL ARTICLE
Xinxin Wang, Jia Zhou, Gaojiao Zhang
BACKGROUND: To observe the effects of conventional theatre nursing combined with transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive dysfunction (POCD) in elderly total knee arthroplasty (TKA) patients. METHODS: Forty elderly TKA patients were randomly divided into a conventional nursing (control) group and a TEAS group. Using conventional nursing, TEAS was used to stimulate the "Zusanli" and "Sanyinjiao" in the healthy leg of patients in the TEAS group...
February 1, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38290461/effect-of-dexmedetomidine-on-apoptosis-and-early-cognitive-dysfunction-in-rats-following-propofol-anesthesia
#33
JOURNAL ARTICLE
Jianbin Zhu, Haixiang Wei, Minying Jiang, Ting Li, Ruizhu Wu, Hualiang Chen
BACKGROUND: To address the intricate interplay between surgical anesthesia, hippocampal apoptosis, and early cognitive dysfunction in rats, this study delves into the impact of dexmedetomidine (DEX). With a focus on understanding the alterations in the PI3K/Akt pathway, our investigation aims to shed light on the comprehensive dynamics of these processes. METHODS: Sixty healthy Sprague-Dawley rats were randomly divided into three groups: controls (intraperitoneal saline injection), group A (intraperitoneal propofol injection), and group A + DEX (intraperitoneal propofol and DEX injection), with 20 rats in each group...
January 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38289296/peripheral-nerve-block-and-cognitive-impairment-after-thoracic-surgery-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Ying Zhang, Meinv Liu, Jinhua He, Huanhuan Zhang, Meng Zhang, Jianli Li
INTRODUCTION: Postoperative cognitive impairment is common in surgical patients, including postoperative delirium and postoperative cognitive dysfunction. Several studies investigating the association between peripheral nerve block and the risk of cognitive impairment after thoracic surgery showed conflicting results. Therefore, we conducted the current systematic review and meta-analysis to determine the effects of peripheral nerve block on postoperative cognitive impairment in thoracic surgical patients...
January 30, 2024: Minerva Anestesiologica
https://read.qxmd.com/read/38282693/preoperative-mild-cognitive-impairment-as-a-risk-factor-of-postoperative-cognitive-dysfunction-in-elderly-patients-undergoing-spine-surgery
#35
JOURNAL ARTICLE
Sujung Park, Jeongmin Kim, Yoon Ha, Keung N Kim, Seong Yi, Bon-Nyeo Koo
INTRODUCTION: Any persistent degree of cognitive impairment in older adults is a concern as it can progress to dementia. This study aimed to determine the incidence and risk factors for early postoperative cognitive dysfunction (POCD) in elderly patients undergoing spine surgery. METHODS: Patients were enrolled from a previous prospective observational study after screening for normal cognitive function using the Mini Mental State Examination (MMSE). Cognitive function was evaluated before surgery and at 1 week, month, and year post-surgery using MMSE and Montreal Cognitive Assessment scores (MoCA)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38278582/perioperative-evaluation-of-brain-health
#36
REVIEW
Carolina S Romero, Richard D Urman, Markus M Luedi
As the global population is aging and surgical needs rise, the occurrence of perioperative neurocognitive disorders (PND) is becoming a significant concern. PND refers to cognitive changes that occur before or after surgery, including neurocognitive disorders, postoperative delirium, and delayed neurocognitive recovery. To address this issue, a brain health assessment initiative within a multidisciplinary team is an emerging concept. Assessing cognitive function, comorbidities, severity of neurocognitive disorders, medications, nutritional status, sleep quality, and other factors can help mitigate the risk of PND and improve patient outcomes...
March 2024: Anesthesiology Clinics
https://read.qxmd.com/read/38273248/effects-of-dexmedetomidine-combined-with-etomidate-on-postoperative-cognitive-function-in-older-patients-undergoing-total-intravenous-anaesthesia-a-randomized-double-blind-controlled-trial
#37
RANDOMIZED CONTROLLED TRIAL
Wuchang Fu, Hongchun Xu, Ting Zhao, Jun Xu, Fangjun Wang
BACKGROUND: Etomidate has been advocated for anesthesia in older and critically ill patients because of its hemodynamic stability. Clinical studies have shown that dexmedetomidine has neuroprotective and anti-inflammatory properties and improves postoperative cognitive dysfunction in older patients. The present study was to evaluate the effects of the combination of etomidate and dexmedetomidine with different anaesthesia time on postoperative cognitive function in older patients. METHODS: A total of 132 older patients undergoing ureteroscopic holmium laser lithotripsy were randomly divided into EN group and ED group equally...
January 25, 2024: BMC Geriatrics
https://read.qxmd.com/read/38265605/irreversible-postoperative-cognitive-impairment-after-unruptured-intracranial-aneurysm-treatment-in-the-elderly
#38
JOURNAL ARTICLE
Kokyo Sakurada, Taichi Ikedo, Yuma Hosokawa, Shin Sugasawa, Koji Shimonaga, Yuji Kushi, Akihiro Niwa, Saya Ozaki, Etsuko Yamamoto Hattori, Eika Hamano, Kiyofumi Yamada, Hirotoshi Imamura, Hisae Mori, Koji Iihara, Hiroharu Kataoka
PURPOSE: Postoperative cognitive dysfunction and recovery remain unclear in older patients undergoing interventional therapies for unruptured intracranial aneurysms (UIAs). This study aimed to compare changes in postoperative cognitive function between younger and older patients and to detect factors associated with non-recovery from postoperative cognitive dysfunction. METHODS: This study reviewed 59 consecutive patients with UIAs who underwent interventional therapies, including microsurgical clipping or endovascular treatment, from 2021 to 2022...
January 24, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38261527/integrative-analysis-of-circrna-networks-in-postoperative-cognitive-dysfunction
#39
JOURNAL ARTICLE
Jian Tang, Yanhong Tang, Peimin Lin, Jie Zheng, Zhengfen Li, Ying Zhang
OBJECTIVE: In the quest to decipher the molecular intricacies of Postoperative Cognitive Dysfunction (POCD), this study focused on circular RNA (circRNA) and their regulatory networks. MATERIALS AND METHODS: Analyzing the Gene Expression Omnibus Series (GSE)147277 dataset, we pinpointed 10 differentially expressed circRNAs linked to POCD. RESULTS: The ensuing competing endogenous RNA (ceRNA) network, featuring pivotal players like Homo sapiens(hsa)_circ_0003424 and hsa-miR-193b-5p, provided a comprehensive understanding of the molecular players at play in POCD...
January 23, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38253999/early-postoperative-neurocognitive-complications-in-elderly-patients-comparing-those-with-and-without-preexisting-mild-cognitive-impairment-a-prospective-study
#40
JOURNAL ARTICLE
Pawit Somnuke, Pensiri Srishewachart, Chalita Jiraphorncharas, Asamaporn Khempetch, Jirapa Weeranithan, Patumporn Suraarunsumrit, Varalak Srinonprasert, Arunotai Siriussawakul
BACKGROUND: As societies age, increasing numbers of older adults undergo surgeries with anesthesia. Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) frequently occur in older surgical patients. Most of these patients already have preoperative mild cognitive impairment (MCI). However, the correlation between MCI and POD remains unclear. This study aimed to determine the incidence of POD in elderly patients with and without preexisting MCI. METHODS: A prospective study enrolled patients aged 60 years and above scheduled for major surgeries between December 2017 and April 2022...
January 22, 2024: BMC Geriatrics
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