Xuan Wang, Xiaole Tang, Pengfei Zhu, Dongyu Hua, Zheng Xie, Mingke Guo, Mengxin Que, Jing Yan, Xing Li, Qian Xia, Xiaoxiao Luo, Jiangjiang Bi, Yilin Zhao, Zhiqiang Zhou, Shiyong Li, Ailin Luo
Circular RNAs (circRNAs) have garnered significant attention in the field of neurodegenerative diseases including Alzheimer's diseases due to their covalently closed loop structure. However, the involvement of circRNAs in postoperative cognitive dysfunction (POCD) is still largely unexplored. To identify the genes differentially expressed between non-POCD (NPOCD) and POCD mice, we conducted the whole transcriptome sequencing initially in this study. According to the expression profiles, we observed that circAKT3 was associated with hippocampal neuronal apoptosis in POCD mice...
March 13, 2024: Cellular and Molecular Life Sciences: CMLS