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Keywords postoperative cognitive dysfun...

postoperative cognitive dysfunction

https://read.qxmd.com/read/38486379/effect-of-oxygen-delivery-during-cardiopulmonary-bypass-on-postoperative-neurological-outcomes-in-patients-undergoing-cardiac-surgery-a-scoping-review-of-the-literature
#1
REVIEW
Abdelrahman Elsebaie, Ayesha Shakeel, Shetuan Zhang, Marianne Alarie, Mohamed El Tahan, Mohammad El-Diasty
BACKGROUND: Reduced oxygen delivery (DO2 ) during cardiopulmonary bypass (CPB) was proposed as a risk factor for the development of postoperative neurological complications (PONCs), including cerebrovascular accidents (CVA), delirium, and postoperative cognitive dysfunction (POCD). We aimed to review the current evidence on the association between intraoperative DO2 and the incidence of PONCs. METHODS: MEDLINE, Embase, the Cochrane Library, and Web of Science were electronically searched to identify comparative studies from inception until July 2023 that reported the association between intraoperative DO2 levels and the incidence of PONCs (as defined by the scales and diagnostic tools utilized by the studies' authors) in adults patients undergoing cardiac surgery using CPB...
March 14, 2024: Perfusion
https://read.qxmd.com/read/38481801/mtdna-cgas-sting-axis-dependent-nlrp3-inflammasome-activation-contributes-to-postoperative-cognitive-dysfunction-induced-by-sevoflurane-in-mice
#2
JOURNAL ARTICLE
Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Guan
The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the molecular mechanism by which sevoflurane activates the NLRP3 inflammasome in microglia remains unclear. The cGAS-STING pathway is an evolutionarily conserved inflammatory defense mechanism. The role of the cGAS-STING pathway in sevoflurane-induced NLRP3 inflammasome-dependent neuroinflammation and the underlying mechanisms require further investigation...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38478029/circakt3-alleviates-postoperative-cognitive-dysfunction-by-stabilizing-the-feedback-cycle-of-mir-106a-5p-hdac4-mef2c-axis-in-hippocampi-of-aged-mice
#3
JOURNAL ARTICLE
Xuan Wang, Xiaole Tang, Pengfei Zhu, Dongyu Hua, Zheng Xie, Mingke Guo, Mengxin Que, Jing Yan, Xing Li, Qian Xia, Xiaoxiao Luo, Jiangjiang Bi, Yilin Zhao, Zhiqiang Zhou, Shiyong Li, Ailin Luo
Circular RNAs (circRNAs) have garnered significant attention in the field of neurodegenerative diseases including Alzheimer's diseases due to their covalently closed loop structure. However, the involvement of circRNAs in postoperative cognitive dysfunction (POCD) is still largely unexplored. To identify the genes differentially expressed between non-POCD (NPOCD) and POCD mice, we conducted the whole transcriptome sequencing initially in this study. According to the expression profiles, we observed that circAKT3 was associated with hippocampal neuronal apoptosis in POCD mice...
March 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38473954/the-preventive-effect-of-urinary-trypsin-inhibitor-on-postoperative-cognitive-dysfunction-on-the-aspect-of-behavior-evaluated-by-y-maze-test-via-modulation-of-microglial-activity
#4
JOURNAL ARTICLE
Eun-Hwa Cho, Chi-Bum In, Gyu-Won Lee, Seung-Wan Hong, Eun-Hye Seo, Won Hyung Lee, Seong-Hyop Kim
This experimental study was designed to evaluate the effect of ulinastatin, a urinary trypsin inhibitor, on postoperative cognitive dysfunction (POCD) in rats under general anesthesia with isoflurane, on the aspect of behavior, as evaluated using a Y-maze test and focusing on microglial activity. Ulinastatin (50,000 U/mL) and normal saline (1 mL) were randomly (1:1) administered intraperitoneally to the ulinastatin and control groups, respectively, before general anesthesia. Anesthesia with isoflurane 1.5 volume% was maintained for 2 h...
February 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38454310/astrocytic-phagocytosis-in-the-medial-prefrontal-cortex-jeopardises-postoperative-memory-consolidation-in-mice
#5
JOURNAL ARTICLE
Xin Ma, Yuan Le, Lin Hu, Wen Ouyang, Cheng Li, Daqing Ma, Jianbin Tong
Memory impairment is one of the main characteristics of postoperative cognitive dysfunction. It remains elusive how postoperative pathological changes of the brain link to the memory impairment. The clinical setting of perioperation was mimicked via partial hepatectomy under sevoflurane anaesthesia together with preoperative restraint stress (Hep-Sev-stress) in mice. Memory changes were assessed with fear conditioning. The medial prefrontal cortex (mPFC)-dorsal hippocampus connectivity was evaluated with injecting neurotracer 28 days before surgery...
March 7, 2024: Brain Pathology
https://read.qxmd.com/read/38451341/electroencephalographic-guided-propofol-remifentanil-tci-anesthesia-with-and-without-dexmedetomidine-in-a-geriatric-population-electroencephalographic-signatures-and-clinical-evaluation
#6
JOURNAL ARTICLE
Dominik M Mehler, Matthias Kreuzer, David P Obert, Luis F Cardenas, Ignacio Barra, Fernando Zurita, Francisco A Lobo, Stephan Kratzer, Gerhard Schneider, Pablo O Sepúlveda
Elderly and multimorbid patients are at high risk for developing unfavorable postoperative neurocognitive outcomes; however, well-adjusted and EEG-guided anesthesia may help titrate anesthesia and improve postoperative outcomes. Over the last decade, dexmedetomidine has been increasingly used as an adjunct in the perioperative setting. Its synergistic effect with propofol decreases the dose of propofol needed to induce and maintain general anesthesia. In this pilot study, we evaluate two highly standardized anesthetic regimens for their potential to prevent burst suppression and postoperative neurocognitive dysfunction in a high-risk population...
March 7, 2024: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/38449062/comparison-of-metabolic-rates-of-ropivacaine-in-cerebrospinal-fluid-as-inferred-from-plasma-concentrations-between-elderly-patients-and-young-patients
#7
JOURNAL ARTICLE
Dongshi Lu, Fei Cai, Yu Ming, Danqing Zhang, Demu Ba, Zhouyang Wu, Zhao Zhang
BACKGROUND: With the aging of human society, more and more elderly patients have to undergo surgery and anesthesia. Clinical observations have indicated from time to time that spinal anesthesia in the elderly appears to last longer than in young people, although there is limited research in this area and the mechanism is unclear at present time. This research work is expected to help understand the decline of local anesthetic metabolism in cerebrospinal fluid of elderly patients so as to help them with precise anesthesia and rapid rehabilitation...
March 6, 2024: Perioperative Medicine
https://read.qxmd.com/read/38447508/vestibular-testing-and-impairments-in-postoperative-pediatric-cerebellar-mutism-syndrome-a-case-series
#8
JOURNAL ARTICLE
Stephanie Smalling, Jeremy Roberts, Karen Hendrick, Margot Gray, Jordan M Wyrwa
BACKGROUND: Postoperative pediatric cerebellar mutism syndrome (CMS) may occur following a process affecting the posterior cranial fossa. Recent evidence demonstrates disabling and potentially lasting motor components of this syndrome, including ataxia, hemiparesis, and oculomotor dysfunction. These impairments may contribute to vestibular deficits. METHODS: This case series contributes data to quantify vestibular dysfunction in postoperative CMS. The pair consisted of one female and one male...
February 7, 2024: Pediatric Neurology
https://read.qxmd.com/read/38432509/spinal-anesthesia-reduces-perioperative-polypharmacy-and-opioid-burden-in-patients-over-65-who-undergo-transforaminal-lumbar-interbody-fusion
#9
JOURNAL ARTICLE
Helen Karimi, Jainith Patel, Michelle Olmos, Matthew Kanter, Nicholas S Hernandez, Rachel E Silver, Penny Liu, Ron I Riesenburger, James Kryzanski
BACKGROUND: Polypharmacy and opioid administration are thought to increase the risk of postoperative cognitive dysfunction (POCD) and delirium in elderly patients. Spinal anesthesia (SA) holds potential to reduce perioperative polypharmacy in spine surgery. As more geriatric patients undergo spine surgery, understanding how SA can reduce polypharmacy and opioid administration is warranted. AIMS: Compare the perioperative polypharmacy and dose of administered opioids in patients ≥65 years who undergo transforaminal lumbar interbody fusion (TLIF) under SA versus general anesthesia (GA)...
March 1, 2024: World Neurosurgery
https://read.qxmd.com/read/38430040/sirtuin-3-sirt3-improves-sevoflurane-induced-postoperative-cognitive-impairment-by-regulating-mitochondrial-oxidative-stress
#10
JOURNAL ARTICLE
Changzong Dai, Changquan Fu, Zhiguo Yi, Xiaohong Guan, Jiandong Deng
One of the most prevalent co-operative disorders is postoperative cognitive dysfunction (POCD), however, its pathogenesis remains unclear. Thus, the aim of this work was to evaluate SIRT3's impact on cognitive decline in aged mice under anesthesia. Adeno-associated virus SIRT3 vector (AAV-SIRT3) or empty vector (AAV-VEH) was injected into the hippocampal region of aged mice after sevoflurane induction in order to upregulate the expression of SIRT3. The expression levels of SIRT3, pro-inflammatory cytokines, and apoptotic factors in hippocampus tissues were identified by PCR, Western blotting, TUNEL staining, and enzyme-linked immunosorbent assay (ELISA), and the cognitive function of mice was assessed...
February 29, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38428506/exercise-attenuates-the-perioperative-neurocognitive-disorder-induced-by-hyperhomocysteinemia-in-mice
#11
JOURNAL ARTICLE
Qian Zhang, Peilin Cong, Li Tian, Tingmei Wu, Xinwei Huang, Yuxin Zhang, Huanghui Wu, Huazheng Liang, Lize Xiong
The perioperative neurocognitive disorder (PND) is a severe complication that affects millions of surgical patients each year. Homocysteine (Hcy) is known to increase the risk of developing PND in both young and elderly mice. However, whether Hcy alone can induce cognitive deficits in middle-aged mice (12-month-old), whether exercise can attenuate Hcy-induced hippocampus-related cognitive deficits after surgery through suppressing neuroinflammation, synaptic elimination, and the level of Hcy remains unknown...
February 28, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38419265/a-novel-risk-assessment-tool-for-postoperative-delirium-in-vascular-surgery-the-stress-model-siena-postoperative-delirium-in-vascular-surgery
#12
JOURNAL ARTICLE
Edoardo Pasqui, Gianmarco de Donato, Brenda Brancaccio, Giulia Casilli, Giulia Ferrante, Giancarlo Palasciano
OBJECTIVE: Postoperative delirium (POD) is a common complication with a high health-related impact. The creation of a model (Siena posTopeRative dElirium in vaScular Surgery) to identify high-risk patients with consecutive prompt diagnosis and correct management. METHODS: This is an observational retrospective study to evaluate POD incidence in patients who underwent elective vascular surgery procedures between 2018 and 2020. POD was detected using CAM and defined as the onset of an acute confusional state, clinically manifesting as a disturbed state of consciousness, cognitive dysfunction, or alteration in perception and behavior...
February 28, 2024: Vascular
https://read.qxmd.com/read/38418961/the-activation-impact-of-lactobacillus-derived-extracellular-vesicles-on-lipopolysaccharide-induced-microglial-cell
#13
JOURNAL ARTICLE
Yanfang Yang, Na Li, Yubo Gao, Fanning Xu, Hui Chen, Chun Zhang, Xinli Ni
Perioperative neurocognitive dysfunction (PND) emerges as a common postoperative complication among elderly patients. Currently, the mechanism of PND remains unclear, but there exists a tendency to believe that inflammation plays a significant role in PND. Alterations in the abundance of intestinal microbiota can increase the permeability of the intestinal mucosal barrier and incite extraintestinal inflammatory responses. Metabolites from these microbiota can be absorbed by the intestinal mucosa into the bloodstream, exerting influence upon the central nervous system (CNS)...
February 28, 2024: BMC Microbiology
https://read.qxmd.com/read/38415263/sevoflurane-alters-serum-metabolites-in-elders-and-aging-mice-and-increases-inflammation-in-hippocampus
#14
JOURNAL ARTICLE
Tingting Wang, Xia Wu, Xiaoli Zhao, Jiaqi Li, Jian Yu, Maozheng Sheng, Mingyuan Gao, Yutang Cao, Jiawen Wang, Xiaozhen Guo, Kai Zeng
PURPOSE: Postoperative cognitive dysfunction (POCD) is a central nervous system complication that occurs after anesthesia, particularly among the elderly. However, the neurological pathogenesis of postoperative cognitive dysfunction remains unclear. The aim of this study was to evaluate the effects of sevoflurane exposure on serum metabolites and hippocampal gene expression in elderly patients and aging mice by metabolomics and transcriptomic analysis and to explore the pathogenesis of sevoflurane induced POCD...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38413319/cognitive-function-10-years-after-adolescent-bariatric-surgery
#15
JOURNAL ARTICLE
Erin Burke, Todd Jenkins, Richard E Boles, James E Mitchell, Thomas Inge, John Gunstad
BACKGROUND: Adolescent bariatric surgery produces substantial weight loss and reduction of medical co-morbidities. Research in adult samples shows improved cognitive function postoperatively, although much less is known about the potential cognitive benefits of bariatric surgery in adolescents-especially at extended follow-up. OBJECTIVE: Examine cognitive function 10 years after adolescent bariatric surgery. SETTING: University hospital. METHODS: A total of 99 young adults who underwent bariatric surgery as adolescents completed a computerized cognitive test battery as part of a larger 10-year postoperative assessment...
January 24, 2024: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/38411634/ss-31-inhibits-mtdna-cgas-sting-signaling-to-improve-pocd-by-activating-mitophagy-in-aged-mice
#16
JOURNAL ARTICLE
Yelong Ji, Yuanyuan Ma, Yimei Ma, Ying Wang, Xining Zhao, Danfeng Jin, Li Xu, Shengjin Ge
BACKGROUND: Neuroinflammation is crucial in the development of postoperative cognitive dysfunction (POCD), and microglial activation is an active participant in this process. SS-31, a mitochondrion-targeted antioxidant, is widely regarded as a potential drug for neurodegenerative diseases and inflammatory diseases. In this study, we sought to explore whether SS-31 plays a neuroprotective role and the underlying mechanism. METHODS: Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction...
February 27, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38401770/latest-advances-and-clinical-application-prospects-of-resveratrol-therapy-for-neurocognitive-disorders
#17
REVIEW
Meng-Qin Pei, Li-Ming Xu, Yu-Shen Yang, Wei-Can Chen, Xin-Li Chen, Yu-Ming Fang, Shu Lin, He-Fan He
Neurocognitive disorders, such as Alzheimer's disease, vascular dementia, and postoperative cognitive dysfunction, are non-psychiatric brain syndromes in which a significant decline in cognitive function causes great trauma to the mental status of the patient. The lack of effective treatments for neurocognitive disorders imposes a considerable burden on society, including a substantial economic impact. Over the past few decades, the identification of resveratrol, a natural plant compound, has provided researchers with an opportunity to formulate novel strategies for the treatment of neurocognitive disorders...
February 22, 2024: Brain Research
https://read.qxmd.com/read/38395794/the-role-of-dexmedetomidine-administered-via-intravenous-infusion-as-adjunctive-therapy-to-mitigate-postoperative-delirium-and-postoperative-cognitive-dysfunction-in-elderly-patients-undergoing-regional-anesthesia-a-meta-analysis-of-randomized-controlled-trials
#18
JOURNAL ARTICLE
Di Wang, Xiao He, Zicen Li, He Tao, Congjie Bi
STUDY OBJECTIVE: This meta-analysis aimed to assess whether continuous intravenous administration of DEX during surgery can be part of the measures to prevent the onset of postoperative delirium and postoperative cognitive dysfunction in elderly individuals following regional anesthesia. METHODS: We searched the databases of PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure (by June 1, 2023) for all available randomized controlled trials assessing whether intravenous application of dexmedetomidine can help with postoperative delirium and postoperative cognitive dysfunction in the elderly with regional anesthesia...
February 23, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38379517/an-exploratory-research-report-on-brain-mineralization-in-postoperative-delirium-and-cognitive-decline
#19
JOURNAL ARTICLE
Florian Lammers-Lietz, Friedrich Borchers, Insa Feinkohl, Stefan Hetzer, Cicek Kanar, Frank Konietschke, Gunnar Lachmann, Claudia Chien, Claudia Spies, Georg Winterer, Laszlo Zaborszky, Norman Zacharias, Friedemann Paul
Delirium is a severe postoperative complication associated with poor overall and especially neurocognitive prognosis. Altered brain mineralization is found in neurodegenerative disorders but has not been studied in postoperative delirium and postoperative cognitive decline. We hypothesized that mineralization-related hypointensity in susceptibility-weighted magnetic resonance imaging (SWI) is associated with postoperative delirium and cognitive decline. In an exploratory, hypothesis-generating study, we analysed a subsample of cognitively healthy patients ≥65 years who underwent SWI before (N = 65) and 3 months after surgery (N = 33)...
February 21, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38371163/intraventricular-subependymoma-with-obstructive-hydrocephalus-a-case-report-and-literature-review
#20
Corneliu Toader, Razvan-Adrian Covache-Busuioc, Bogdan-Gabriel Bratu, Luca-Andrei Glavan, Andrei Adrian Popa, Matei Serban, Alexandru Vladimir Ciurea
Subependymomas are benign tumors of the ventricles that grow from the ventricular wall into the cerebrospinal fluid spaces within the brain, obstructing the flow of the cerebrospinal fluid and causing obstructive hydrocephalus. It is estimated that ependymomas represent between 0.2% and 0.7% of all intracranial tumors. They arise most frequently in the fourth ventricle (50-60%) and the lateral ventricles (30-40%). We present the case of a 50-year-old patient, previously diagnosed with an intraventricular process, admitted in our clinic...
January 2024: Curēus
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