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postoperative cognitive dysfunction

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https://www.readbyqxmd.com/read/28193536/blood-brain-barrier-disruption-after-cardiopulmonary-bypass-diagnosis-and-correlation-to-cognition
#1
Dan Abrahamov, Oren Levran, Sharon Naparstek, Yael Refaeli, Shani Kaptson, Mahmud Abu Salah, Yaron Ishai, Gideon Sahar
BACKGROUND: Cardiopulmonary bypass (CPB) elicits a systemic inflammatory response that may impair blood-brain barrier (BBB) integrity. BBB disruption can currently be detected by dynamic contrast enhancement magnetic resonance imaging (MRI), reflected by an increase in the permeability constant (K(trans)). We aimed to determine (1) whether CPB induces BBB disruption, (2) duration until BBB disruption resolution, and (3) the obtainable correlation between BBB injury (location and intensity) and neurocognitive dysfunction...
February 10, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28165545/nf-%C3%AE%C2%BAb-p65-signaling-pathway-a-potential-therapeutic-target-in-postoperative-cognitive-dysfunction-after-sevoflurane-anesthesia
#2
J-W Zheng, B Meng, X-Y Li, B Lu, G-R Wu, J-P Chen
OBJECTIVE: This study aimed to explore the role of NF-κB/P65 signaling pathway in postoperative cognitive dysfunction (POCD) after sevoflurane anesthesia. MATERIALS AND METHODS: A total of 120 male Sprague-Dawley (SD) rats were selected and assigned into five groups (24 rats in each group): the control, sevoflurane, sevoflurane + splenectomy, pyrrolidine dithiocarbamate (PDTC, a specific inhibitor of NF-κB), and sevoflurane + splenectomy + PDTC groups. Electrocardiogram (ECoG) and behavior changes of rats were monitored before and after anesthesia/operation...
2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28151820/associations-between-impaired-cerebral-blood-flow-autoregulation-cerebral-oxygenation-and-biomarkers-of-brain-injury-and-postoperative-cognitive-dysfunction-in-elderly-patients-after-major-noncardiac-surgery
#3
Nicolai Goettel, Christoph S Burkhart, Ariane Rossi, Brenno C T Cabella, Manfred Berres, Andreas U Monsch, Marek Czosnyka, Luzius A Steiner
BACKGROUND: Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed to investigate whether POCD is associated with impaired intraoperative cerebral autoregulation and oxygenation, and increased levels of biomarkers of brain injury. METHODS: Study subjects were patients ≥65 years of age scheduled for major noncardiac surgery...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28126343/management-of-impulse-control-disorders-with-deep-brain-stimulation-a-double-edged-sword
#4
REVIEW
Chayut Kasemsuk, Genko Oyama, Nobutaka Hattori
Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease. Although DBS is used to treat motor fluctuation, DBS may affect non-motor symptoms including mood disorders, cognitive dysfunction, and behavior problems. Impulse control disorders (ICDs) are abnormal behaviors with various manifestations such as pathological gambling, hypersexuality, compulsive shopping, and binge eating, which can affect the quality of life in patients with Parkinson's disease. The effect of DBS on ICD is controversial...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28109286/acetaminophen-attenuates-lipopolysaccharide-induced-cognitive-impairment-through-antioxidant-activity
#5
Wei-Xing Zhao, Jun-Han Zhang, Jiang-Bei Cao, Wei Wang, Dong-Xin Wang, Xiao-Ying Zhang, Jun Yu, Yong-Yi Zhang, You-Zhi Zhang, Wei-Dong Mi
BACKGROUND: Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) and other progressive neurodegenerative disorders. Increasing evidence suggests that acetaminophen (APAP) has unappreciated antioxidant and anti-inflammatory properties. However, the impact of APAP on the cognitive sequelae of inflammatory and oxidative stress is unknown. The objective of this study is to explore whether APAP could have neuroprotective effects on lipopolysaccharide (LPS)-induced cognitive impairment in mice...
January 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28101151/effect-of-general-anesthesia-on-serum-%C3%AE-amyloid-protein-and-regional-cerebral-oxygen-saturation-of-elderly-patients-after-subtotal-gastrectomy
#6
Peng Yu, Hua Wang, Lei Mu, Xuemei Ding, Wei Ding
The aim of the present study was to investigate the influence of general anesthesia on serum β-amyloid protein (Aβ) and regional cerebral oxygen saturation (rSO2) of elderly patients after subtotal gastrectomy. From June, 2014 to December, 2015, among 168 patients undergoing subtotal gastrectomy, the Mini-Mental State Examination and Montreal Cognitive Assessment was administered the day prior to surgery and the second and ninth days after the operation. In addition, we administered the tests to 168 healthy adult volunteers (healthy controls) who were treated in our hospital medical center in the same period...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28098692/postoperative-cognitive-dysfunction-and-low-regional-cerebral-oxygen-saturation-is-this-relationship-fragile-or-fractured-altogether
#7
Hilary P Grocott
No abstract text is available yet for this article.
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28093200/postoperative-serum-thioredoxin-concentrations-correlate-with-delirium-and-cognitive-dysfunction-after-hip-fracture-surgery-in-elderly-patients
#8
Xiao-Min Wu, Wei-Cai Xu, Yong-Jian Yu, Liang Han, Jun Zhang, Li-Jiao Yang
BACKGROUND: Oxidative stress correlates with occurrence and development of postoperative delirium (POD) and cognitive dysfunction (POCD). Thioredoxin (TRX) is a potent anti-oxidant and its circulating concentrations reflect extent of brain injury. We determined the relation of serum TRX concentrations to POD and POCD in elderly patients undergoing hip fracture surgery. METHODS: In this prospective, observatory study, TRX concentrations in preoperative and postoperative serum from 192 patients and serum from 192 controls were measured using an enzyme-linked immunosorbent assay...
January 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28089560/critical-role-of-p2x7-receptors-in-the-neuroinflammation-and-cognitive-dysfunction-after-surgery
#9
Bin Zheng, Renchun Lai, Jun Li, Zhiyi Zuo
Postoperative cognitive dysfunction worsens patient outcome after surgery. Neuroinflammation is a critical neuropathological process for it. We determined the role of P2X7 receptors, proteins that participate in inflammatory response, in the neuroinflammation induction after surgery, and whether the choice of volatile anesthetics affects its occurrence. Eight-week old C57BL/6J or P2X7 receptor knockout male mice were subjected to right carotid arterial exposure under anesthesia with 1.8% isoflurane, 2.5% sevoflurane or 10% desflurane...
January 10, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28086911/enhanced-neuroinflammation-mediated-by-dna-methylation-of-the-glucocorticoid-receptor-triggers-cognitive-dysfunction-after-sevoflurane-anesthesia-in-adult-rats-subjected-to-maternal-separation-during-the-neonatal-period
#10
Yangzi Zhu, Yu Wang, Rui Yao, Ting Hao, Junli Cao, He Huang, Liwei Wang, Yuqing Wu
BACKGROUND: Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life adversity alters the expression or functioning of the glucocorticoid receptor (GR) throughout the course of life and thereby increases sensitivity to inflammatory stimulation. An exaggerated pro-inflammatory response is generally considered to be a key cause of postoperative cognitive dysfunction (POCD)...
January 7, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28048971/insulin-resistance-plays-a-potential-role-in-postoperative-cognitive-dysfunction-in-patients-following-cardiac-valve-surgery
#11
Ni Tang, Rongrong Jiang, Xiaobin Wang, Jian Wen, Li Liu, Jiali Wu, Chunxiang Zhang
Severe insulin resistance(IR) promotes the development of Alzheimer disease. IR and postoperative cognitive dysfunction (POCD) are a common complication during the cardiac perioperative period. The authors hypothesized that IR of individuals with cardiac valve surgery would have increased the risk of POCD. The purpose of the study was to analyze the association of IR and POCD after cardiac valve surgery. Total 131 patients who underwent valve replacement via cardiopulmonary bypass(CPB) were included. Cognitive function was assessed by a series of neuropsychological measurements at 1 day before and 7 days after the surgery...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/28018896/factors-influencing-neurodevelopment-after-cardiac-surgery-during-infancy
#12
REVIEW
Hedwig Hubertine Hövels-Gürich
Short- and long-term neurodevelopmental (ND) disabilities with negative impact on psychosocial and academic performance, quality of life, and independence in adulthood are known to be the most common sequelae for surviving children after surgery for congenital heart disease (CHD). This article reviews influences and risk factors for ND impairment. For a long time, the search for independent risk factors was focused on the perioperative period and modalities of cardiopulmonary bypass (CPB). CPB operations to ensure intraoperative vital organ perfusion and oxygen supply with or without circulatory arrest or regional cerebral perfusion bear specific risks...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28017853/pre-treatment-with-nimodipine-and-7-5-hypertonic-saline-protects-aged-rats-against-postoperative-cognitive-dysfunction-via-inhibiting-hippocampal-neuronal-apoptosis
#13
Zhang Qi, Yuan Tianbao, Li Yanan, Xin Xi, He Jinhua, Wang Qiujun
OBJECTIVE: This study aimed to investigate the effects of pre-treatment with nimodipine and 7.5% hypertonic saline (HS) on postoperative cognitive dysfunction (POCD) in aged rats. METHODS: Healthy Sprague-Dawley aged rats were randomly assigned into 4 groups: POCD group, nimodipine group, HS group, and nimodipine+HS group. Rats in POCD group received normal saline injection and then splenectomy 30min later under 1.8% isoflurane inhalation for 2h. In remaining groups, rats received injection of 1mg/kg nimodipine (i...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28003670/isoflurane-induces-transient-impairment-of-retention-of-spatial-working-memory-in-rats
#14
Masaaki Tanino, Motomu Kobayashi, Toshihiro Sasaki, Ken Takata, Yoshimasa Takeda, Satoshi Mizobuchi, Kiyoshi Morita, Taku Nagai, Hiroshi Morimatsu
Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane- induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10...
December 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27989970/neurocognitive-function-surrounding-the-resection-of-frontal-who-grade-i-meningiomas-a-prospective-matched-control-study
#15
Philipp Hendrix, Elisa Hans, Christoph J Griessenauer, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Patients suffering from intracranial meningiomas may suffer from neurocognitive dysfunctions in specific cognitive domains depending on tumor location and size. The literature on the cognitive function surrounding the resection of frontal meningiomas is sparse. METHODS: We performed a prospective matched-control study to investigate the cognitive performance of frontal meningioma patients undergoing resection. The neurocognitive status one week and two months post resection was compared to the preoperative status and to matched-controls...
October 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27987229/neuronal-damage-biomarkers-in-the-identification-of-patients-at-risk-of-long-term-postoperative-cognitive-dysfunction-after-cardiac-surgery
#16
W F Kok, J Koerts, O Tucha, T W L Scheeren, A R Absalom
Biomarkers of neurological injury can potentially predict postoperative cognitive dysfunction. We aimed to identify whether classical neuronal damage-specific biomarkers, including brain fatty acid-binding protein, neuron-specific enolase and S100 calcium-binding protein β, as well as plasma-free haemoglobin concentration as a measure of haemolysis, could be used to predict the risk of long-term cognitive decline after coronary artery bypass grafting with or without cardiopulmonary bypass. We assessed cognitive function using the CogState brief computerised cognitive test battery at 3 months and at 15 months after surgery...
December 17, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27956760/neuroinflammation-induced-by-surgery-does-not-impair-the-reference-memory-of-young-adult-mice
#17
Yanhua Zhao, Lili Huang, Huan Xu, Guangxi Wu, Mengyi Zhu, Jie Tian, Hao Wang, Xiangrui Wang, Weifeng Yu, Liqun Yang, Diansan Su
Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27940456/perioperative-cognitive-protection
#18
C Brown, S Deiner
There is significant evidence that many older surgical patients experience at least a transient decrease in cognitive function. Although there is still equipoise regarding the degree, duration, and mechanism of cognitive dysfunction, there is a concurrent need to provide best-practice clinical evidence. The two major cognitive disorders seen after surgery are postoperative delirium and postoperative cognitive dysfunction. Delirium is a public health problem; millions of dollars are spent annually on delirium-related medical resource use and prolonged hospital stays...
December 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27940378/ppar%C3%AE-activation-ameliorates-postoperative-cognitive-decline-probably-through-suppressing-hippocampal-neuroinflammation-in-aged-mice
#19
Zhijie Zhang, Hongmei Yuan, Huatang Zhao, Bin Qi, Fayin Li, Lijun An
Neuroinflammation plays a key role in many neurodegenerative disorders, including postoperative cognitive decline (POCD). Growing evidence has demonstrated that activation of the peroxisome proliferator-activated receptor-γ (PPARγ) attenuates the inflammatory response and improves cognitive dysfunction associated with many neuropsychiatric disorders. We hypothesize that down-regulation of PPARγ is linked to neuroinflammation and the subsequent cognitive deficits observed in an animal model of POCD. In the present study, the POCD animal model was established by performing an exploratory laparotomy under isoflurane anesthesia in 20-month-old male C57BL/6 mice...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27935781/the-neurotoxicity-of-general-anesthetic-drugs-emphasis-on-the-extremes-of-age
#20
Chuck Biddle, Vincent Ford
A substantial body of research suggests that anesthetic exposure to patients who are very young or very old may impair cognitive, behavioral, and emotional development or recovery. In lower animal models of pre- and postnatal age, anesthetic exposure may impact inflammation, synaptogenesis, neuronal apoptosis, and glial cell development. To date, research in humans is inconclusive regarding the long-term cognitive and behavioral sequelae of general anesthesia in the young child. In older adults, postoperative cognitive dysfunction and cognitive delirium are identified as markers of anesthetic neurotoxicity...
January 2017: Annual Review of Nursing Research
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