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Atopic eczema

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https://www.readbyqxmd.com/read/29932162/ethanolic-extracts-of-artemisia-apiacea-hance-improved-atopic-dermatitis-like-skin-lesions-in-vivo-and-suppressed-tnf-alpha-ifn-gamma%C3%A2-induced-proinflammatory-chemokine-production-in-vitro
#1
Ju-Hye Yang, Esther Lee, BoHyoung Lee, Won-Kyung Cho, Jin Yeul Ma, Kwang-Il Park
Artemisia apiacea Hance is a traditional herbal medicine used for treating eczema and jaundice in Eastern Asia including China, Korea, and Japan. However, the biological and pharmacological actions of Artemisia apiacea Hance in atopic dermatitis (AD) are not fully understood. An ethanolic extract of Artemisia apiacea Hance (EAH) was tested in vitro and in vivo to investigate its anti-inflammatory activity and anti-atopic dermatitis effects. The results showed that EAH dose-dependence inhibited production of regulated on activation, normal T-cell expressed and secreted (RANTES), interleukin (IL)-6, IL-8, and thymus and activation-regulated chemokine (TARC)...
June 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29927316/the-burden-of-moderate-to-severe-atopic-dermatitis-in-canadian-children-a-cross-sectional-survey
#2
Alanna C Bridgman, Panteha Eshtiaghi, Amanda Cresswell-Melville, Michele Ramien, Aaron M Drucker
OBJECTIVES: Although atopic dermatitis (AD) has significant impacts on quality of life, data from Canada on the subject are limited. This survey aims to assess the burden of moderate to severe AD on quality of life and disease management for pediatric patients and their caregivers in Canada. METHODS: The Eczema Society of Canada conducted an online national cross-sectional survey in English and French. We included children with self-reported moderate to severe AD...
July 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29907748/extracellular-nanovesicles-released-from-the-commensal-yeast-malassezia-sympodialis-are-enriched-in-allergens-and-interact-with-cells-in-human-skin
#3
Henrik J Johansson, Helen Vallhov, Tina Holm, Ulf Gehrmann, Anna Andersson, Catharina Johansson, Hans Blom, Marta Carroni, Janne Lehtiö, Annika Scheynius
Malassezia sympodialis is a dominant commensal fungi in the human skin mycobiome but is also associated with common skin disorders including atopic eczema (AE). M. sympodialis releases extracellular vesicles, designated MalaEx, which are carriers of small RNAs and allergens, and they can induce inflammatory cytokine responses. Here we explored how MalaEx are involved in host-microbe interactions by comparing protein content of MalaEx with that of the parental yeast cells, and by investigating interactions of MalaEx with cells in the skin...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29906525/treatment-of-atopic-dermatitis-with-tralokinumab-an-anti-il-13-monoclonal-antibody
#4
Andreas Wollenberg, Michael D Howell, Emma Guttman-Yassky, Jonathan I Silverberg, Christopher Kell, Koustubh Ranade, Rachel Moate, René van der Merwe
BACKGROUND: Interleukin (IL)-13 has an important role in atopic dermatitis (AD) pathogenesis. Tralokinumab is a fully human monoclonal antibody that potently and specifically neutralizes IL-13. OBJECTIVE: To evaluate the efficacy and safety of tralokinumab in adults with moderate to severe AD. METHODS: In this phase 2b study (NCT02347176), 204 adults were randomized 1:1:1:1 to receive subcutaneous tralokinumab 45 mg, 150 mg, or 300 mg, or placebo, every 2 weeks for 12 weeks, with concomitant topical glucocorticoids...
June 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29895253/the-atopic-dermatitis-and-food-allergy-a-paediatric-approach
#5
Natalia Cartledge, Susan Chan
Atopic dermatitis and food allergy are common conditions of childhood that are closely linked. 30% of children with moderate to severe eczema suffer from food allergy and can present with different types of reactions: immediate or IgE-mediated reactions, delayed or non-IgE-mediated eczematous flares, or a combination of the two. A detailed history is very important when approaching such patients. The presence of IgE-mediated symptoms warrants investigation and management requires avoidance of the culprit allergen, an emergency care plan and appropriate follow up...
June 12, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29894268/atopic-eczema-research-an-update
#6
Sandra Lawton
No abstract text is available yet for this article.
June 14, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29893593/skin-problems-associated-with-insulin-pumps-and-sensors-in-adults-with-type-1-diabetes-a-cross-sectional-study
#7
Anna Korsgaard Berg, Kirsten Nørgaard, Jacob P Thyssen, Claus Zachariae, Eva Hommel, Karen Rytter, Jannet Svensson
BACKGROUND: In the future, widespread use of closed-loop infusion (artificial pancreas) systems to treat type 1 diabetes (T1D) may significantly improve glycemic control and enhance treatment flexibility. However, the infusion sets and plasters necessary for these treatments can cause dermatological complications that may hamper the spread of the new technology; few studies have investigated these complications in adults. The aim of this study was to describe the dermatological complications associated with continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) in adults...
June 12, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29879703/the-aaa-risk-factors-scale-a-new-model-to-screen-for-the-risk-of-asthma-allergic-rhinitis-and-atopic-dermatitis-in-children
#8
Souheil Hallit, Chantal Raherison, Diana Malaeb, Rabih Hallit, Nelly Kheir, Pascale Salameh
OBJECTIVE: To create an allergic disease risk factors scale score that would screen for the risk assessment of asthma, allergic rhinitis and atopic dermatitis in children from 3-17 years. METHODS: This case-control study, conducted between December 2015 and April 2016, enrolled 1274 children. The allergic disease risk factors scale was created by combining environmental, exposure to toxics during pregnancy and breastfeeding and parental history of allergic diseases...
June 7, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29876613/-pruritus-in-germany-a-google-search-engine-analysis
#9
A Zink, M Rüth, B Schuster, U Darsow, T Biedermann, S Ständer
BACKGROUND: Because affected persons often do not visit a doctor, the prevalence of chronic and acute pruritus in the general population is difficult to determine. OBJECTIVES: The aim of this study is to estimate the frequency and the most common locations of pruritus in German internet users, who-with 62.4 million persons-represent a large majority of the German population, by analysing the Google search volume. MATERIALS AND METHODS: Relevant keywords for the subject "pruritus" were identified and analysed using the Google AdWords Keyword Planner...
June 6, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29859251/pilot-study-of-the-caps-clinical-extent-area-pruritus-sleep-measure-for-atopic-dermatitis-severity-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-caps-pilot-study
#10
Aaron M Drucker, Natalie H Matthews, Jennie Muglia, Abrar A Qureshi
Eczema; Atopic dermatitis; Outcome measures; Severity; Symptoms; Itch Abbreviations: AD, atopic dermatitis; BSA, body surface area; CAPS, Clinical extent, Area, Pruritus, Sleep; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; IGA, Investigator Global Assessment; POEM, Patient-Oriented Eczema Measure.
May 30, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29843458/association-between-serum-25-hydroxy-vitamin-d-levels-and-the-prevalence-of-adult-onset-asthma
#11
Mark P C Cherrie, Christophe Sarran, Nicholas J Osborne
The major circulating metabolite of vitamin D (25(OH)D) has been implicated in the pathogenesis for atopic dermatitis, asthma and other allergic diseases due to downstream immunomodulatory effects. However, a consistent association between 25(OH)D and asthma during adulthood has yet to be found in observational studies. We aimed to test the association between 25(OH)D and asthma during adulthood and hypothesised that this association would be stronger in non-atopic participants. Using information collected on the participants of the 1958 birth cohort, we developed a novel measure of atopic status using total and specific IgE values and reported history of eczema and allergic rhinitis...
May 29, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29806218/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2015-part-2-prevention-and-treatment
#12
REVIEW
A Lloyd-Lavery, N K Rogers, E Davies, D J C Grindlay, K S Thomas
This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 26 systematic reviews that were published during 2015, and focuses on the treatment and prevention of AE. For systematic reviews on the epidemiology and methodological issues, see Part 1 of this update. Topical corticosteroid withdrawal syndrome, 'steroid addiction', has been evaluated in a high-quality systematic review, which helps better define this entity and the risk factors for it...
May 27, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29800581/financial-burden-of-emergency-department-visits-for-atopic-dermatitis-in-the-united-states
#13
Lauren Kwa, Jonathan I Silverberg
BACKGROUND: Little is known about the utilization and financial-burden of emergency care visits for atopic dermatitis or eczema (AD-E) in the US. OBJECTIVE: To determine the prevalence, risk factors and cost of emergency care for AD-E in the US METHODS: Cross-sectional study of the 2006-2012 National Emergency Department Sample (NEDS), including a 20% sample of ED visits throughout the US (n=198,102,435). RESULTS: The mean annual incidence of ED visits with a primary diagnosis of AD-E was 3368...
May 22, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29795621/willingness-to-pay-for-a-cure-of-low-risk-melanoma-patients-in-germany
#14
Matthias Augustin, Christine Blome, Andrea Forschner, Ralf Gutzmer, Axel Hauschild, Lucie Heinzerling, Elisabeth Livingstone, Carmen Loquai, Dirk Schadendorf, Jochen Utikal, Tobias Wagner, Sophia Wilden, Katharina C Kähler
Malignant melanoma is potentially life-threatening but in most cases curable if detected early. Willingness to pay (WTP) is a preference-based construct that reflects burden of disease by assessment of the monetary value for a hypothetical cure from disease. Since WTP (directly as total amount of money) has not been assessed so far in patients with low risk melanoma, it was interesting to gain insights in this patient population and then, in a second step, compare it directly with the WTP of their treating dermato-oncologists...
2018: PloS One
https://www.readbyqxmd.com/read/29794003/atopic-eczema-and-cardiovascular-disease
#15
EDITORIAL
John R Ingram
No abstract text is available yet for this article.
May 23, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29793618/research-techniques-made-simple-mass-spectrometry-for-analysis-of-proteins-in-dermatological-research
#16
Christoph M Hammers, Hsin-Yao Tang, Jing Chen, Shirin Emtenani, Qi Zheng, John R Stanley
Identifying previously unknown proteins or detecting the presence of known proteins in research samples is critical to many experiments conducted in life sciences, including dermatology. Sensitive protein detection can help elucidate new intervention targets and mechanisms of disease, such as in autoimmune blistering skin diseases, atopic eczema, or other conditions. Historically, peptides from highly purified single proteins were sequenced, with many limitations, by stepwise degradation from the N-terminus to the C-terminus with subsequent identification by UV absorbance spectroscopy of the released amino acids (i...
June 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29792314/severe-and-predominantly-active-atopic-eczema-in-adulthood-and-long-term-risk-of-cardiovascular-disease-population-based-cohort-study
#17
Richard J Silverwood, Harriet J Forbes, Katrina Abuabara, Anna Ascott, Morten Schmidt, Sigrún A J Schmidt, Liam Smeeth, Sinéad M Langan
OBJECTIVE: To investigate whether adults with atopic eczema are at an increased risk of cardiovascular disease and whether the risk varies by atopic eczema severity and condition activity over time. DESIGN: Population based matched cohort study. SETTING: UK electronic health records from the Clinical Practice Research Datalink, Hospital Episode Statistics, and data from the Office for National Statistics, 1998-2015. PARTICIPANTS: Adults with a diagnosis of atopic eczema, matched (on age, sex, general practice, and calendar time) to up to five patients without atopic eczema...
May 23, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29790104/beneficial-effects-of-antioxidant-furfuryl-palmitate-in-non-pharmacologic-treatments-prescription-emollient-devices-peds-for-atopic-dermatitis-and-related-skin-disorders
#18
REVIEW
Paolo Daniele Pigatto, Marco Diani
INTRODUCTION: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. The aim of this review was to evaluate the efficacy and tolerability of furfuryl palmitate, a new antioxidant molecule, and furfuryl derivatives. METHODS: A PubMed/Google Scholar search was conducted using the term "furfuryl palmitate" (and its derivatives, including AR-GG27® ) combined with "skin," "atopic dermatitis," and "atopic eczema...
May 22, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29786146/awareness-of-and-phobias-about-topical-corticosteroids-in-parents-of-infants-with-eczema-in-hangzhou-china
#19
Yunling Li, Ting Han, Wei Li, Yin Li, Xiaoxuan Guo, Lei Zheng
BACKGROUND/OBJECTIVES: Knowledge of and phobias about topical corticosteroids in parents of infants with eczema affect efficacy of eczema treatment. METHODS: We surveyed 300 parents of children with eczema using a questionnaire to investigate knowledge of and phobias about topical corticosteroids. RESULTS: Overall, 85.7% (n = 257) of children had used topical corticosteroids, with 12.8% (n = 33) of children having steroids applied for only 1-3 days per episode; 79...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29783275/assessment-of-likelihood-ratio-for-four-contact-dermatitis-symptoms-of-vinca-minor
#20
Suman Bagchi, Chaturbhuja Nayak, Lex Rutten, Munmun Koley, Subhranil Saha, Mousumi Roy, Sk Jahir Abbas, Simantini Ghosh, Suman Halder, Ghulam Nabi Wani, Anaitulah Ahmad Mir, Showket Ahmad Bhat
BACKGROUND:  Contact dermatitis (CD) is a frequently occurring medical condition, for which Vinca minor (VM) is one of the recommended homeopathic medicines. However, the symptoms indicating this medicine have not yet been assessed systematically. Likelihood ratio (LR), based on Bayesian statistics, may yield better estimation of a medicine's indication than the existing method of entry of symptoms into materia medica and repertories. METHODS:  We investigated LRs of four CD symptoms of VM: (1) great sensitiveness of skin, with redness and soreness from slightest rubbing; (2) weeping eczema with foul, thick crusts; (3) itching amelioration in open air; and (4) CD of scalp...
May 21, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
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