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Atopic eczema

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https://www.readbyqxmd.com/read/29668088/atopic-dermatitis-risk-estimates-for-hand-eczema
#1
S Kezic
No abstract text is available yet for this article.
April 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29665062/phase-1-studies-to-assess-the-safety-tolerability-and-pharmacokinetics-of-jte-052-a-novel-janus-kinase-inhibitor-ointment-in-japanese-healthy-volunteers-and-patients-with-atopic-dermatitis
#2
Hidemi Nakagawa, Osamu Nemoto, Hiroyuki Yamada, Takeshi Nagata, Noriko Ninomiya
The purpose of the present two phase 1 studies was to assess the safety, tolerability and pharmacokinetics for topical application of a novel Janus kinase (JAK) inhibitor, JTE-052, in Japanese healthy adult male volunteers and Japanese adult patients with atopic dermatitis (AD). Additionally, exploratory investigation was performed on the efficacy for disease severity and pruritus score in AD patients. In the QBX1-1 study, the cutaneous safety of JTE-052 ointment by a patch test and a photo patch test was assessed in an intra-individual comparative study using placebo ointment, white petrolatum and non-application as comparators...
April 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29620611/bleach-for-atopic-dermatitis-beyond-antimicrobials
#3
Melody Maarouf, Vivian Y Shi
Individuals with atopic dermatitis (AD) have used bleach baths to treat superinfections, although their mechanism of action is not well understood. The ClinicalTrials.gov, National Eczema Association, and PubMed databases were searched for studies that investigate the role bleach plays in modulating AD. Fifteen studies were included in this review. Bleach bath improves clinical symptoms of AD and restores surface microbiome by eradicating bacteria, most notably Staphylococcus aureus. Many studies have noted that this antimicrobial effect has reduced the need for topical corticosteroids or topical antibiotics...
April 3, 2018: Dermatitis
https://www.readbyqxmd.com/read/29606816/antibiotic-susceptibility-and-treatment-response-in-bacterial-skin-infection
#4
Ji Soo Lim, Hyun-Sun Park, Soyun Cho, Hyun-Sun Yoon
Background: Bacterial skin infections occur secondarily in conditions involving a vulnerable skin barrier such as atopic eczema, as well as primarily such as impetigo. They are mainly caused by Staphylococcus aureus and Streptococci . Recently, the prevalence of methicillin-resistant S. aureus has been increasing. Objective: To determine the characteristics of community-acquired bacterial skin infections, to observe their antibiotic susceptibility patterns, and to evaluate factors contributing to the treatment response...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29606814/topical-tacrolimus-for-the-treatment-of-atopic-dermatitis-with-truncal-lesion
#5
Hyun Chang Ko, Woo Il Kim, Sang Hyun Cho, Young Lip Park, Eung Ho Choi, Sang Wook Son, Bark Lynn Lew, Yang Won Lee, Young Jun Seo, Gyong Moon Kim, Joon Hong Min, Chan Ho Na, Chong Hyun Won, Hyoseung Shin, Kwang Hoon Lee, Joo Young Roh, Young Min Park, Yong Hyun Jang, Seok Kweon Yun, You Chan Kim, Gyeong Hun Park, Chun Wook Park
Background: Topical tacrolimus is an effective anti-inflammatory therapy for acute and chronic states of atopic dermatitis (AD) in both adults and children. Topical tacrolimus has particular use at sensitive areas such as the face, anogenitals, and skin folds of neck and extremities. However, many AD patients also experience aggravated symptoms on trunk. Objective: The aim of this study was to investigate the efficacy and safety of topical tacrolimus for AD patients with truncal lesions...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29601982/quantitation-of-peptides-from-non-invasive-skin-tapings-using-isotope-dilution-and-tandem-mass-spectrometry
#6
Nichole Reisdorph, Michael Armstrong, Roger Powell, Kevin Quinn, Kevin Legg, Donald Leung, Rick Reisdorph
Previous work from our laboratories utilized a novel skin taping method and mass spectrometry-based proteomics to discover clinical biomarkers of skin conditions; these included atopic dermatitis, Staphylococcus aureus colonization, and eczema herpeticum. While suitable for discovery purposes, semi-quantitative proteomics is generally time-consuming and expensive. Furthermore, depending on the method used, discovery-based proteomics can result in high variation and inadequate sensitivity to detect low abundant peptides...
March 21, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29595231/habit-reversal-therapy-quickly-and-significantly-contributes-to-the-management-of-children-with-atopic-eczema
#7
A Bewley
No abstract text is available yet for this article.
March 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29593534/east-indian-sandalwood-oil-is-a-phosphodiesterase-inhibitor-a-new-therapeutic-option-in-the-treatment-of-inflammatory-skin-disease
#8
Manju Sharma, Corey Levenson, John C Browning, Emily M Becker, Ian Clements, Paul Castella, Michael E Cox
Cyclic adenosine monophosphate phosphodiesterases (PDEs) regulate pro-inflammatory cytokine production. One isoform, PDE4, is overactive in chronic relapsing inflammatory skin diseases: psoriasis and eczema/atopic dermatitis, and in several cancers. East Indian sandalwood oil (EISO) has significant anti-inflammatory properties. Here, we report that 75% of pediatric eczema/atopic dermatitis patients treated with topical EISO formulations achieved a >50% reduction in their Eczema Area and Severity Index score...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29575273/who-will-treat-inflammatory-skin-diseases-in-the-year-2020
#9
Wolf-Henning Boehncke, Hòpitaux Universitaires de Genève
Psoriasis is a good example on how therapeutic options have increased over the last decade (figure 1)1 . This development is about to repeat itself in atopic eczema and may cause a (paradoxic) loss of interest amongst dermatologists to manage these diseases:Most innovations are systemics, necessitating monitoring and managing adverse events; but dermatologists are not necessarily used to this. This article is protected by copyright. All rights reserved.
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29540642/dual-factors-may-be-necessary-for-development-of-atopic-march-in-early-infancy
#10
Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Masaya Takahashi, Hirotaka Minami
The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29537454/dupilumab-in-the-treatment-of-dyshidrosis-a-report-of-two-cases
#11
Gillian K Weston, Jette Hooper, Bruce E Strober
Dupilumab (Dupixent, Regeneron Pharmaceuticals and Sanofi Genzyme) is a novel biologic medication recently approved by the FDA for the treatment of moderate-to-severe atopic dermatitis in adults who have not achieved adequate control with topical medications. Dyshidrotic eczema is a distinct entity, often considered on the spectrum of atopic dermatitis, that primarily effects the palms and soles; it is often associated with considerable morbidity yet is frequently challenging to treat. We report two cases of recalcitrant dyshidrotic eczema treated successfully with dupilumab at standard dosing...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29537405/a-review-of-photodiagnostic-investigations-over-26-years-experience-of-the-national-scottish-photobiology-service-1989-2015
#12
H Nassan, R S Dawe, H Moseley, S H Ibbotson
Background The Scottish Photobiology Service is the national referral pathway for patients with cutaneous photosensitivity diseases in Scotland. We reviewed the pattern of diagnosis of photosensitivity diseases and investigations performed between 1989 and 2015. Methods and Results Data were collected from the Photodiagnostic Database, annual reports and paper records. The total number of patients assessed each year was stable over the period studied (median 242 [range 231-266]), with most being new patients (median 69 [range 62-73]%)...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29536938/not-all-that-vesicles-is-herpes
#13
Robert R Gruhl, Andrew Wu, Micah Niermann, Andrew Olson
BACKGROUND: Eczema coxsackium (EC) can manifest in patients with underlying atopic dermatitis (AD) as a diffuse vesicular rash in a febrile child. The presentation overlaps clinically with the feared diagnosis of eczema herpeticum (EH), which makes differentiating between the conditions very important. CASE PRESENTATION: A 6-month-old girl with known AD presented with fever and rapidly spreading vesicular rash. The patient had multiple exposures including a new antibiotic prescription, introduction of new foods, 6-month vaccinations and a sick contact...
November 27, 2017: Diagnosis
https://www.readbyqxmd.com/read/29533490/effects-of-a-protein-free-oat-plantlet-extract-on-microinflammation-and-skin-barrier-function-in-atopic-dermatitis-patients
#14
REVIEW
A Wollenberg, R Fölster-Holst, M Saint Aroman, F Sampogna, C Vestergaard
Atopic dermatitis (AD) is a common, highly pruritic, chronic inflammatory skin disease. Dysfunction of the epidermal barrier is witnessed by an increased transepidermal water loss in lesional and non-lesional AD skin. The inflammation in lesional AD skin is well characterized. Non-lesional skin of AD patients shows histological signs of a subclinical inflammation and a pro-inflammatory cytokine milieu. This microinflammation is present even in seemingly healed skin and must be taken into account regarding treatment of AD...
April 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29532579/editorial-comments-on-this-issue-of-the-journal
#15
Philippe A Eigenmann
Skin diseases related to allergy are common in childhood and pediatric allergists are commonly faced with atopic eczema, treatment schemes for which include calcineurin inhibitors: commonly used topical drugs which control inflammatory skin flares. In the first review of this issue, Nakahira et al provide mechanistic insights, among others, into modulation of the immune response by tacrolimus (1). Prevention of atopic eczema is addressed by Wickens et al. This article is protected by copyright. All rights reserved...
March 13, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29530123/-a-meta-analysis-of-risk-factors-for-asthma-in-chinese-children
#16
Shu-Jun Liu, Ting-Ting Wang, Shi-Yu Cao, Ya-Qing Tan, Li-Zhang Chen
OBJECTIVE: To investigate the main risk factors for asthma in Chinese children, and to provide a reference for the prevention and treatment of asthma. METHODS: The databases including CNKI, Wanfang Data, China Biology Medicine disc, VIP Database for Chinese Technical Periodicals, Web of Science, and PubMed were searched for studies on risk factors for asthma in Chinese children published up to September 2017. Stata 12.0 was used for the Meta analysis. RESULTS: A total of 24 case-control studies were included, with 5 309 cases in the case group and 6 404 cases in the control group...
March 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29529048/swimming-pool-exposure-is-associated-with-autonomic-changes-and-increased-airway-reactivity-to-a-beta-2-agonist-in-school-aged-children-a-cross-sectional-survey
#17
João Cavaleiro Rufo, Inês Paciência, Diana Silva, Carla Martins, Joana Madureira, Eduardo de Oliveira Fernandes, Patrícia Padrão, Pedro Moreira, Luís Delgado, André Moreira
BACKGROUND: Endurance swimming exercises coupled to disinfection by-products exposure has been associated with increased airways dysfunction and neurogenic inflammation in elite swimmers. However, the impact of swimming pool exposure at a recreational level on autonomic activity has never been explored. Therefore, this study aimed to investigate how swimming pool attendance is influencing lung and autonomic function in school-aged children. METHODS: A total of 858 children enrolled a cross sectional survey...
2018: PloS One
https://www.readbyqxmd.com/read/29527033/autosomal-recessive-hyper-ige-syndrome
#18
Mohapatra Liza, Dash Gaurav, Mohanty Prasenjeet, Jena Swapna, Behera Binodini
The hyper-IgE syndrome (HIES) is a rare group of primary immunodeficiency characterised by recurrent infections, eczema, and elevated serum levels of IgE. Autosomal dominant HIES is caused by mutations in transcription factor - signal transducer and activator of transcription-3. Autosomal-recessive (AR) HIES was described in 2004 due to mutation of tyrosine kinase 2 gene, and subsequently, another mutation in dedicator of cytokinesis 8 gene was discovered in 2009. Although both the forms have many common clinical features, few characteristic findings help in differentiating them...
January 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29513367/the-familial-aggregation-of-atopic-diseases-and-depression-or-anxiety-in-children
#19
Bronwyn K Brew, Cecilia Lundholm, Tong Gong, Henrik Larsson, Catarina Almqvist
BACKGROUND: Children with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases have strong genetic and environmental components, therefore it seems likely that there is a shared liability rather than causative risk. OBJECTIVE: To investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety. METHODS: Participants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n= 14197...
March 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29500077/protective-role-of-6-formylindolo-3-2-b-carbazole-ficz-an-endogenous-ligand-for-arylhydrocarbon-receptor-in-chronic-mite-induced-dermatitis
#20
Mari Kiyomatsu-Oda, Hiroshi Uchi, Saori Morino-Koga, Masutaka Furue
BACKGROUND: Chronic eczema such as atopic dermatitis imposes significant socio-econo-psychologic burdens on the affected individuals. In addition to conventional topical treatments, phototherapy is recommended for patients with extensive lesions. Although immunosuppression is believed to explain its primary effectiveness, the underlying mechanisms of phototherapy remain unsolved. Ultraviolet irradiation generates various tryptophan photoproducts including 6-formylindolo[3,2-b]-carbazole (FICZ)...
February 21, 2018: Journal of Dermatological Science
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