Zhi-Yun Wang, Dong-Rui Ma, Meng-Jie Li, Yuan-Yuan Liang, Zheng-Wei Hu, Shuang-Jie Li, Chun-Yan Zuo, Chen-Wei Hao, Yan-Mei Feng, Meng-Nan Guo, Xiao-Yan Hao, Yuan-Li Guo, Ke-Ke Ma, Li-Na Guo, Chan Zhang, Yu-Ming Xu, Cheng-Yuan Mao, Chang-He Shi
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD) utilizing prospective cohort study and Mendelian randomization. The dataset contained a substantial cohort of 426,911 participants from the UK Biobank, discussing the association between IBS and PD with Cox proportional hazards models and case-control analysis while adjusting for covariates such as age, gender, ethnicity and education level. In univariate Cox regression model, the risk of PD was reduced in IBS patients (HR: 0...
March 28, 2024: NPJ Parkinson's Disease