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Dendritic cell vaccine

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https://www.readbyqxmd.com/read/29915600/vaccine-designs-utilizing-invariant-nkt-licensed-antigen-presenting-cells-provide-nkt-or-t-cell-help-for-b-cell-responses
#1
REVIEW
Shin-Ichiro Fujii, Satoru Yamasaki, Yusuke Sato, Kanako Shimizu
Vaccines against a variety of infectious diseases have been developed and tested. Although there have been some notable successes, most are less than optimal or have failed outright. There has been discussion about whether either B cells or dendritic cells (DCs) could be useful for the development of antimicrobial vaccines with the production of high titers of antibodies. Invariant (i)NKT cells have direct antimicrobial effects as well as adjuvant activity, and iNKT-stimulated antigen-presenting cells (APCs) can determine the form of the ensuing humoral and cellular immune responses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915023/enhancement-of-peptide-vaccine-immunogenicity-by-increasing-lymphatic-drainage-and-boosting-serum-stability
#2
Kelly D Moynihan, Rebecca L Holden, Naveen K Mehta, Chensu Wang, Mark R Karver, Jens Dinter, Simon Liang, Wuhbet Abraham, Mariane B Melo, Angela Q Zhang, Na Li, Sylvie Le Gall, Bradley Pentelute, Darrell J Irvine
Antitumor T-cell responses have the potential to be curative in cancer patients, but the induction of potent T-cell immunity through vaccination remains a largely unmet goal of immunotherapy. We previously reported that the immunogenicity of peptide vaccines could be increased by maximizing delivery to lymph nodes (LNs), where T-cell responses are generated. This was achieved by conjugating the peptide to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-PEG (DSPE-PEG) to promote albumin binding, which resulted in enhanced lymphatic drainage and improved T-cell responses...
June 18, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29914156/-listeria-monocytogenes-a-model-pathogen-continues-to-refine-our-knowledge-of-the-cd8-t-cell-response
#3
REVIEW
Zhijuan Qiu, Camille Khairallah, Brian S Sheridan
Listeria monocytogenes ( Lm ) infection induces robust CD8 T cell responses, which play a critical role in resolving Lm during primary infection and provide protective immunity to re-infections. Comprehensive studies have been conducted to delineate the CD8 T cell response after Lm infection. In this review, the generation of the CD8 T cell response to Lm infection will be discussed. The role of dendritic cell subsets in acquiring and presenting Lm antigens to CD8 T cells and the events that occur during T cell priming and activation will be addressed...
June 16, 2018: Pathogens
https://www.readbyqxmd.com/read/29912184/isolation-protocol-of-mouse-monocyte-derived-dendritic-cells-and-their-subsequent-in-vitro-activation-with-tumor-immune-complexes
#4
Nadine Santana-Magal, Diana Rasoulouniriana, Corey Saperia, Amit Gutwillig, Peleg Rider, Edgar G Engleman, Yaron Carmi
Dendritic cells (DC) are heterogeneous cell populations that differ in their cell membrane markers, migration patterns and distribution, and in their antigen presentation and T cell activation capacities. Since most vaccinations of experimental tumor models require millions of DC, they are widely isolated from the bone marrow or spleen. However, these DC significantly differ from blood and tumor DC in their responses to immune complexes (IC), and presumably to other Syk-coupled lectin receptors. Importantly, given the sensitivity of DC to danger-associated molecules, the presence of endotoxins or antibodies that crosslink activation receptors in one of the isolating steps could result in the priming of DC and thus affect the parameters, or at least the dosage, required to activate them...
May 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911996/altered-immune-cell-follicular-dynamics-in-hiv-infection-following-influenza-vaccination
#5
Eirini Moysi, Suresh Pallikkuth, Leslie R De Armas, Louis E Gonzalez, David Ambrozak, Varghese George, David Huddleston, Rajendra Pahwa, Richard A Koup, Constantinos Petrovas, Savita Pahwa
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral therapy (cART) are not clear. We obtained LN biopsies before and 10 to 14 days after trivalent seasonal influenza immunization from healthy controls (HCs) and HIV+ volunteers on cART to investigate CD4+ T follicular helper (Tfh) and B cell dynamics by flow cytometry and quantitative imaging analysis...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29910795/predictors-of-response-to-autologous-dendritic-cell-therapy-in-glioblastoma-multiforme
#6
Chia-Ing Jan, Wan-Chen Tsai, Horng-Jyh Harn, Woei-Cherng Shyu, Ming-Chao Liu, Hsin-Man Lu, Shao-Chih Chiu, Der-Yang Cho
Background: Glioblastoma (GBM) is the most common and lethal primary malignant glioma in adults. Dendritic cell (DC) vaccines have demonstrated promising results in GBM clinical trials. However, some patients do not respond well to DC therapy, with survival rates similar to those of conventional therapy. We retrospectively analyzed clinical and laboratory data to evaluate the factors affecting vaccine treatment. Methods: Forty-seven patients with de novo GBM were enrolled at China Medical University Hospital between 2005 and 2010 and divided into two subgroups...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29909133/tuberculin-skin-test-reaction-is-related-to-memory-but-not-naive-cd4-t-cell-responses-to-mycobacterial-stimuli-in-bcg-vaccinated-young-adults
#7
Magdalena Kowalewicz-Kulbat, Piotr Szpakowski, Camille Locht, Franck Biet, Paulina Kaplonek, Krzysztof T Krawczyk, Joël Pestel, Wieslawa Rudnicka
Bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis and the tuberculin skin test (TST) is the most widely used method to detect BCG take. However, subjects may remain TST-negative, even after several BCG administrations. To investigate some of the potential reasons underlying this inability of developing tuberculin sensitivity in response to BCG we compared the effect of different mycobacterial stimuli in the groups differently responding to tuberculin. TST was performed on 71 healthy adults aged 25-30 years, who had received BCG in their childhood, and considered TST-positive at ≥10 mm...
June 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29908893/post-pegylated-and-crosslinked-polymeric-ssrna-nanocomplexes-as-adjuvants-targeting-lymph-nodes-with-increased-cytolytic-t-cell-inducing-properties
#8
Bo Lou, Ans De Beuckelaer, George R Dakwar, Katrien Remaut, Johan Grooten, Kevin Braeckmans, Bruno G De Geest, Enrico Mastrobattista, Stefaan De Koker, Wim E Hennink
Potent adjuvants are highly demanded for most protein and peptides based vaccine candidates in clinical development. Recognition of viral single stranded (ss)RNA by innate toll-like receptors 7/8 in dendritic cells results in a cytokine environment supportive to the establishment of long lasting antibody responses and Th1 oriented T cell immunity. To fully exploit the immunestimulatory properties of ssRNA, it needs to be adequately formulated to ensure its optimal delivery to dendritic cells in the vaccine draining lymph nodes...
June 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29907693/exosomes-shuttle-trex1-sensitive-ifn-stimulatory-dsdna-from-irradiated-cancer-cells-to-dendritic-cells
#9
Julie M Diamond, Claire Vanpouille-Box, Sheila Spada, Nils-Petter Rudqvist, Jessica Chapman, Beatrix Ueberheide, Karsten A Pilones, Yasmeen Sarfraz, Silvia C Formenti, Sandra Demaria
Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell-derived IFN-I is required to recruit BATF3-dependent dendritic cells (DCs) to poorly immunogenic tumors and trigger antitumor T-cell responses in combination with immune checkpoint blockade. We have previously demonstrated that the exonuclease TREX1 regulates radiation immunogenicity by degrading cytosolic dsDNA...
June 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29906623/gene-expression-analysis-of-isolated-salmonid-galt-leucocytes-in-response-to-pamps-and-recombinant-cytokines
#10
A Attaya, T Wang, J Zou, T Herath, A Adams, C J Secombes, S Yoon
Increased knowledge of the immune response of the intestine, a physiologically critical organ involved in absorption, secretion and homeostasis in a non-sterile environment, is needed to better understand the mechanisms involved in the induction of long-lasting immunity and, subsequently, the development of efficacious gastrointestinal immunization approaches. To this end, analysis of isolated gut cells will give an insight into the cell types present and their immune capability. Hence, in this study we first optimised a method for salmonid gut leucocyte isolation and characterised the cells on the basis of their expression of a range of selected cell markers associated with T & B cells and dendritic cells...
June 12, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29904904/ilixadencel-an-allogeneic-cell-based-anticancer-immune-primer-for-intratumoral-administration
#11
Alex Karlsson-Parra, Juliana Kovacka, Emilia Heimann, Margareth Jorvid, Sijme Zeilemaker, Sharon Longhurst, Peter Suenaert
Intratumoral administration of an immune primer is a therapeutic vaccine strategy aimed to trigger dendritic cell (DC)-mediated cross-presentation of cell-associated tumor antigens to cytotoxic CD8+ T cells without the need for tumor antigen characterization. The prevailing view is that these cross-presenting DCs have to be directly activated by pathogen-associated molecular patterns (PAMPS), including Toll-like receptor ligands or live microbial agents like oncolytic viruses. Emerging data are however challenging this view, indicating that the cross-presenting machinery in DCs is suboptimally activated by direct PAMP recognition, and that endogenous inflammatory factors are the main drivers of DC-mediated cross-presentation within the tumor...
June 14, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29904582/development-of-a-novel-mechanism-based-glycolipid-adjuvant-for-vaccination
#12
REVIEW
Jordana Grazziela Coelho-Dos-Reis, Xiangming Li, Moriya Tsuji
The inability to elicit strong and durable cellular responses is a major obstacle in the development of successful vaccines, in particular those against malaria. In this regard, the generation of novel adjuvants that will potently boost cell-mediated immunity induced by candidate vaccines is helpful. We and others have found a glycolipid, called α-galactosylceramide (α-GalCer), which could be presented on CD1d expressed by antigen-presenting cells (APCs) and stimulate natural killer T (NKT) cells. This triggers the activation/maturation of APCs, particularly dendritic cells (DCs)...
2018: F1000Research
https://www.readbyqxmd.com/read/29901978/in-vivo-imaging-tracking-and-immune-responses-to-nanovaccines-involving-combined-antigen-nanoparticles-with-a-programmed-delivery
#13
Xia Dong, Jie Liang, Afeng Yang, Chun Wang, Deling Kong, Feng Lv
Combined nanovaccine can generate robust and persistent antigen-specific immune responses. A combined nanovaccine was developed based on antigen loaded genipin-crosslinked-polyethyleneimine-antigen nanoparticles and in vivo multispectral fluorescence imaging tracked the antigen delivery of combined nanovaccine. The inner layer antigen nanoparticles carried abundant antigens by self-crosslinking for persistent immune response, while the outer antigen on the surface of antigen nanoparticles provided initial antigen exposure...
June 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29900058/optimized-dendritic-cell-vaccination-induces-potent-cd8-t-cell-responses-and-anti-tumor-effects-in-transgenic-mouse-melanoma-models
#14
Mareike Grees, Adi Sharbi-Yunger, Christos Evangelou, Daniel Baumann, Gal Cafri, Esther Tzehoval, Stefan B Eichmüller, Rienk Offringa, Jochen Utikal, Lea Eisenbach, Viktor Umansky
Despite melanoma immunogenicity and remarkable therapeutic effects of negative immune checkpoint inhibitors, a significant fraction of patients does not respond to current treatments. This could be due to limitations in tumor immunogenicity and profound immunosuppression in the melanoma microenvironment. Moreover, insufficient tumor antigen processing and presentation by dendritic cells (DC) may hamper the development of tumor-specific T cells. Using two genetically engineered mouse melanoma models ( RET and BRAFV600E transgenic mice), in which checkpoint inhibitor therapy alone is not efficacious, we performed proof-of-concept studies with an improved, multivalent DC vaccination strategy based on our recently developed genetic mRNA cancer vaccines...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899819/development-of-a-preclinical-humanized-mouse-model-to-evaluate-acute-toxicity-of-an-influenza-vaccine
#15
Eita Sasaki, Haruka Momose, Yuki Hiradate, Keiko Furuhata, Takuo Mizukami, Isao Hamaguchi
Safety evaluation of a human vaccine is critical for vaccine development and for preventing an unexpected adverse reaction in humans. Nonetheless, to date, very few systems have been described for preclinical studies of human adverse reactions in vivo . Previously, we have identified biomarker genes expressed in the lungs for evaluation of influenza vaccine safety, and their usefulness in rodent models and for adjuvant-containing vaccines has already been reported. Here, our purpose was to develop a novel humanized mouse model retaining human innate-immunity-related cells to assess the safety of influenza vaccines using the previously identified biomarker genes...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29896795/bridging-systemic-immunity-with-gastrointestinal-immune-responses-via-oil-in-polymer-capsules
#16
Yufei Xia, Jie Wu, Yiqun Du, Chunyu Miao, Zhiguo Su, Guanghui Ma
As peripheral lymphocytes are typically excluded from the gastrointestinal lymph tissues, current parenteral vaccinations fail to simultaneously induce systemic and mucosal responses. To break the natural barrier, "immunoticket" capsules are developed and heralded, which are designed with positive charged shells and oily core to spatiotemporally deliver antigens and all-trans retinoic acid (RA). After intramuscular vaccinations, these capsules function as an immunoticket to cultivate peripheral dendritic cells (DCs) with gut-homing receptors (CCR9)...
June 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29895501/tumor-lysate-loaded-bacterial-ghosts-as-a-tool-for-optimized-production-of-therapeutic-dendritic-cell-based-cancer-vaccines
#17
N Dobrovolskienė, V Pašukonienė, A Darinskas, J A Kraśko, K Žilionytė, A Mlynska, Ž Gudlevičienė, E Mišeikytė-Kaubrienė, V Schijns, W Lubitz, P Kudela, M Strioga
Cancer immunotherapy with dendritic cell (DC)-based vaccines has been used to treat various malignancies for more than two decades, however generally showed a limited clinical success. Among various factors responsible for their modest clinical activity is the lack of universally applied, standardized protocols for the generation of clinical-grade DC vaccines, capable of inducing effective anti-tumor immune responses. We investigated Bacterial Ghosts (BGs) - empty envelopes of Gram-negative bacteria - as a tool for optimized production of DC vaccines...
June 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29895156/the-influence-of-therapeutic-vaccine-candidate-against-hbeag-pegfp-n1-c-472-507-ecdcd40l-on-dendritic-cells
#18
J Zheng, H Xue, H Zhang, L Wang, L Zheng, X Wang, X Lin, S Jin, J Wu
Hepatitis B virus (HBV) infection is a major public health problem and immune tolerance is responsible for persistent HBV infection. HBV therapeutic vaccines targeting HBV e antigen (HBeAg) may have an excellent effect in overcoming HBV immune tolerance. Thus, there is urgency for designing therapeutic vaccine candidates that target HBeAg. In this research, we fused the C (472-507) gene sequence of HBV with the extracellular domain of human CD40 ligand sequence and ligated this fused sequence into the pEGFP-N1 vector to construct the recombinant plasmid pEGFP-N1-C (472-507)-ecdCD40L...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29894721/physiological-factors-leading-to-a-successful-vaccination-a-computational-approach
#19
Dominic L Maderazo, Jennifer A Flegg, Melanie R Neeland, Michael J de Veer, Mark B Flegg
The immune system mounts a response to an infection by activating T cells. T cell activation occurs when dendritic cells, which have already interacted with the pathogen, scan a T cell that is cognate for (responsive to) the pathogen. This often occurs inside lymph nodes. The time it takes for this scanning event to occur, indeed the probability that it will occur at all, depends on many factors, including the rate that T cells and dendritic cells enter and leave the lymph node as well as the geometry of the lymph node and of course other cellular and molecular parameters...
June 9, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29894719/soluble-pd-1-based-vaccine-targeting-muc1-vntr-and-survivin-improves-anti-tumor-effect
#20
Chenlu Liu, Zhenzhen Lu, Yu Xie, Qianqian Guo, Fei Geng, Bo Sun, Hui Wu, Bin Yu, Jiaxin Wu, Haihong Zhang, Xianghui Yu, Wei Kong
Soluble PD-1 (sPD1) can bind with ligands PD-L1/PD-L2 on the surface of dendritic cells (DCs). Therefore, a sPD1 vaccine fused with an immunogen can increase T cell activation against cancer. Here, we constructed a MUC1 and survivin (MS) combination gene tumor vaccine expressing MS fused with soluble PD-1 (sPD1/MS). To investigate whether the sPD1/MS fusion vaccine could enhance tumor-specific immune responses, its immunogenicity and anti-tumor activity were examined after intramuscular immunization in mice...
June 9, 2018: Immunology Letters
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