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neonatal EEG

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https://www.readbyqxmd.com/read/27898690/isoflurane-exposure-induces-cell-death-microglial-activation-and-modifies-the-expression-of-genes-supporting-neurodevelopment-and-cognitive-function-in-the-male-newborn-piglet-brain
#1
Kevin D Broad, Jane Hassell, Bobbi Fleiss, Go Kawano, Mojgan Ezzati, Eridan Rocha-Ferreira, Mariya Hristova, Kate Bennett, Igor Fierens, Ryan Burnett, Badr Chaban, Daniel Alonso-Alconada, Aaron Oliver-Taylor, Ilias Tachsidis, Jamshid Rostami, Pierre Gressens, Robert D Sanders, Nicola J Robertson
Exposure of the brain to general anesthesia during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex, incompletely understood and may be sexually dimorphic, but include developmentally inappropriate apoptosis, inflammation and a disruption to cognitively salient gene expression. We investigated the effects of a 6h isoflurane exposure on cell death, microglial activation and gene expression in the male neonatal piglet brain. Piglets (n = 6) were randomised to: (i) naive controls or (ii) 6h isoflurane...
2016: PloS One
https://www.readbyqxmd.com/read/27895691/prognostic-factors-of-neurological-outcomes-in-late-preterm-and-term-infants-with-perinatal-asphyxia
#2
Sun Young Seo, Gyu Hong Shim, Myoung Jae Chey, Su Jeong You
PURPOSE: This study aimed to identify prognostic factors of neurological outcomes, including developmental delay, cerebral palsy and epilepsy in late-preterm and term infants with perinatal asphyxia. METHODS: All late-preterm and term infants with perinatal asphyxia or hypoxic-ischemic insults who admitted the neonatal intensive care unit of Inje University Sanggye Paik Hospital between 2006 and 2014 and were followed up for at least 2 years were included in this retrospective study...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27891080/enhanced-burst-suppression-and-disruption-of-local-field-potential-synchrony-in-a-mouse-model-of-focal-cortical-dysplasia-exhibiting-spike-wave-seizures
#3
Anthony J Williams, Chen Zhou, Qian-Quan Sun
Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays were used to record extracellular potentials from cortical and subcortical brain regions near the FL in anesthetized mice (5-13 months old) followed by 24 h cortical electroencephalogram (EEG) recordings...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27872899/de-novo-fgf12-mutation-in-2-patients-with-neonatal-onset-epilepsy
#4
Ilaria Guella, Linda Huh, Marna B McKenzie, Eric B Toyota, E Martina Bebin, Michelle L Thompson, Gregory M Cooper, Daniel M Evans, Sarah E Buerki, Shelin Adam, Margot I Van Allen, Tanya N Nelson, Mary B Connolly, Matthew J Farrer, Michelle Demos
OBJECTIVE: We describe 2 additional patients with early-onset epilepsy with a de novo FGF12 mutation. METHODS: Whole-exome sequencing was performed in 2 unrelated patients with early-onset epilepsy and their unaffected parents. Genetic variants were assessed by comparative trio analysis. Clinical evolution, EEG, and neuroimaging are described. The phenotype and response to treatment was reviewed and compared to affected siblings in the original report. RESULTS: We identified the same FGF12 de novo mutation reported previously (c...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27857618/continuous-video-eeg-in-neonates-emerging-trends-and-paradigms
#5
Ajay Gupta
No abstract text is available yet for this article.
November 2016: Epilepsy Currents
https://www.readbyqxmd.com/read/27855152/heart-rate-variability-in-hypoxic-ischemic-encephalopathy-during-therapeutic-hypothermia
#6
Robert M Goulding, Nathan J Stevenson, Deirdre M Murray, Vicki Livingstone, Peter M Filan, Geraldine B Boylan
BACKGROUND: Therapeutic hypothermia (TH) aims to ameliorate further injury in infants with moderate and severe hypoxic ischemic encephalopathy (HIE). We aim to assess the effect of TH on heart rate variability (HRV) in infants with HIE. METHODS: Multi-channel video-electroencephalography (EEG) and electrocardiography were assessed at 6-72h after birth in full-term infants with HIE, recruited prior to (pre-TH group) and following (TH group) the introduction of TH in our neonatal unit...
November 17, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27852731/forward-and-inverse-effects-of-the-complete-electrode-model-in-neonatal-eeg
#7
Sampsa Pursiainen, Seok Lew, Carsten Hermann Wolters
This paper investigates finite element method (FEM) based modeling in the context of neonatal electroencephalography (EEG). In particular, the focus lies on electrode boundary conditions. We compare the complete electrode model (CEM) to the point electrode model (PEM), which is the current standard in EEG. In the CEM, the voltage experienced by an electrode is modeled more realistically as the integral average of the potential distribution over its contact surface, whereas the PEM relies on a point value. Consequently, the CEM takes into account the sub-electrode shunting currents which are absent in the PEM...
November 16, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27809371/abnormal-neurodevelopmental-outcomes-are-very-likely-in-cases-of-bilateral-neonatal-arterial-ischaemic-stroke
#8
Ju Hyun Jin, Jeong Eun Shin, Soonmin Lee, Ho Sun Eun, Min Soo Park, Kook In Park, Ran Namgung
AIM: Neonatal arterial ischaemic stroke (AIS) is an important cause of severe neurological disability. This study aimed to analyse the clinical manifestations and outcomes of AIS patients. METHODS: We enrolled neonates with AIS admitted to Severance Children's Hospital and Gangnam Severance Hospital between 2008 and 2015. AIS was confirmed using magnetic resonance imaging (MRI). We retrospectively reviewed the clinical manifestations, MRI findings, electroencephalography (EEG) findings and neurodevelopmental outcomes...
November 3, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27792918/nutritive-sucking-induces-age-specific-eeg-changes-in-0-24-week-old-infants
#9
Johannes Lehtonen, Minna Valkonen-Korhonen, Stefanos Georgiadis, Mika P Tarvainen, Hanne Lappi, Juha-Pekka Niskanen, Ari Pääkkönen, Pasi A Karjalainen
Little is known how the brain of the newborn infant responds to the postnatal nutrition and care. No systematic studies exist in which the effects of nutritional and non-nutritional sucking on the brain activity of the infant were compared. We recorded the EEG activity of 40 infants at the ages of 0,6,12 and 24 weeks in four successive behavioral stages: while the infants were hungry and waiting for sucking, during non-nutritional and nutritional sucking, and during satiation after completed feeding. Quantitative EEG analysis was performed using occipital, parietal and central EEG channels...
October 25, 2016: Infant Behavior & Development
https://www.readbyqxmd.com/read/27789573/a-de-novo-missense-mutation-of-gabrb2-causes-early-myoclonic-encephalopathy
#10
Atsushi Ishii, Jing-Qiong Kang, Cara C Schornak, Ciria C Hernandez, Wangzhen Shen, Joseph C Watkins, Robert L Macdonald, Shinichi Hirose
BACKGROUND: Early myoclonic encephalopathy (EME), a disease with a devastating prognosis, is characterised by neonatal onset of seizures and massive myoclonus accompanied by a continuous suppression-burst EEG pattern. Three genes are associated with EMEs that have metabolic features. Here, we report a pathogenic mutation of an ion channel as a cause of EME for the first time. METHODS: Sequencing was performed for 214 patients with epileptic seizures using a gene panel with 109 genes that are known or suspected to cause epileptic seizures...
October 27, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27763963/brief-potentially-ictal-rhythmic-discharges-b-i-rds-in-non-critically-ill-adults
#11
Ji Yeoun Yoo, Lara V Marcuse, Madeline C Fields, Jillian Rosengard, Maria Vittoria Traversa, Nicolas Gaspard, Lawrence J Hirsch
INTRODUCTION: Brief potentially ictal rhythmic discharges (B(I)RDs) have been described in neonates and critically ill adults, and their association with seizures has been demonstrated. Their significance in non-critically ill adults remains unclear. We aimed to investigate their prevalence, electrographic characteristics and clinical significance. METHODS: We identified adult patients with B(I)RDs who received long term EEG recordings either in the epilepsy monitoring unit or in the ambulatory setting...
October 19, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27753460/neonatal-eyelid-conditioning-during-sleep
#12
Amanda R Tarullo, Joseph R Isler, Carmen Condon, Kimon Violaris, Peter D Balsam, William P Fifer
Using an eyelid conditioning paradigm modeled after that developed by Little, Lipsitt, and Rovee-Collier (1984), Fifer et al. (2010) demonstrated that newborn infants learn during sleep. This study examined the role of sleep state in neonatal learning. We recorded electroencephalogram (EEG), respiratory, and cardiovascular activity from sleeping full term newborn infants during delay eyelid conditioning. In the experimental group (n = 21), a tone was paired with an air puff to the eye. Consistent with Fifer et al...
November 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27749459/detecting-neonatal-seizures-with-computer-algorithms
#13
Andriy Temko, Gordon Lightbody
It is now generally accepted that EEG is the only reliable way to accurately detect newborn seizures and, as such, prolonged EEG monitoring is increasingly being adopted in neonatal intensive care units. Long EEG recordings may last from several hours to a few days. With neurophysiologists not always available to review the EEG during unsociable hours, there is a pressing need to develop a reliable and robust automatic seizure detection method-a computer algorithm that can take the EEG signal, process it, and output information that supports clinical decision making...
October 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27749458/seizures-in-preterm-infants
#14
Julia Jacobs, Emily M Spelbrink
Infants born prematurely are highly vulnerable to brain injury and susceptible to seizures in the first weeks of life. Many neonatal seizures occur without reliable clinical signs and are detectable only on electroencephalogram (EEG); understanding EEG findings in these neonates is crucial for providing appropriate care. This can be challenging, as EEG background activity and patterns vary considerably with gestational age. Some physiologic preterm EEG patterns, such as rhythmic temporal theta activity or delta brushes, may be sharply contoured and appear similar to epileptic EEG patterns later in life...
October 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27749457/treatment-effects-on-neonatal-eeg
#15
Rawad Obeid, Tammy N Tsuchida
Conventional EEG and amplitude-integrated electroencephalography are used in neonates to assess prognosis and significant changes in brain activity. Neuroactive medications and hypothermia can influence brain activity and therefore alter EEG interpretation. There are limited studies on the effect of these therapies on neonatal EEG background activity. Medication effects on the EEG or amplitude-integrated electroencephalography include increased interburst interval duration, voltage suppression, and sleep disruption...
October 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27715482/calcified-cephalohematoma-as-an-unusual-cause-of-eeg-anomalies-case-report
#16
Vera Vigo, Domenica Immacolata Battaglia, Paolo Frassanito, Gianpiero Tamburrini, Massimo Caldarelli, Luca Massimi
Cephalohematoma, one of the most common neonatal head injuries, generally undergoes spontaneous resorption. When calcified, it may cause cranial vault distortion and depression of the inner skull layer, although it remains asymptomatic. Surgery, indeed, is usually performed for cosmetic purposes. For these reasons, the long-term effects of calcified cephalohematoma (CC) are widely unknown. The authors report the case of an 11-year-old girl with a persistent calcified CC causing skull deformity and delayed electroencephalography (EEG) anomalies...
October 7, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27679737/early-high-dose-caffeine-increases-seizure-burden-in-extremely-preterm-neonates-a-preliminary-study
#17
Zachary A Vesoulis, Christopher McPherson, Jeffrey J Neil, Amit M Mathur, Terrie E Inder
Background: Although evidence suggests that methylxanthines may lower the seizure threshold, the effect of high-dose caffeine on seizure burden in preterm infants is not known. This study reports a secondary post hoc analysis of a randomized controlled trial of early high-dose caffeine citrate therapy in preterm infants, evaluating the effect of caffeine on the seizure burden using amplitude-integrated electroencephalography (aEEG). Methods: Seventy-four preterm infants (≤30 weeks gestation) were randomized to receive high-dose (n = 37, 80 mg/kg over 36 hours) or standard-dose (n = 37, 30 mg/kg over 36 hours) caffeine citrate over the first 36 hours followed by standard maintenance therapy...
September 1, 2016: Journal of Caffeine Research
https://www.readbyqxmd.com/read/27659907/discrimination-of-sleep-states-using-continuous-cerebral-bedside-monitoring-amplitude-integrated-electroencephalography-compared-to-polysomnography-in-infants
#18
Laura Bennet, Karinna L Fyfe, Stephanie R Yiallourou, Henriette Merk, Flora Y Wong, Rosemary S C Horne
AIM: Limited two-channel electroencephalography (EEG) and amplitude-integrated EEG (aEEG) monitorings are being increasingly used; however, these measurements have not been compared with polysomnographic monitoring, the gold standard for determining infant sleep states. We aimed to determine the accuracy of two-channel EEG and aEEG recordings in defining sleep states and wakefulness in term infants compared to polysomnographic monitoring. METHODS: Sleep was assessed in eight healthy term born infants (mean: 34 ± 3 days), using simultaneous polysomnography (Compumedics S-Series) and a two-channel EEG monitor (Brainz BRM2)...
December 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27650049/early-eeg-grade-and-outcome-at-5-years-after-mild-neonatal-hypoxic-ischemic-encephalopathy
#19
Deirdre M Murray, Catherine M O'Connor, C Anthony Ryan, Irina Korotchikova, Geraldine B Boylan
OBJECTIVE: More than half of all infants with neonatal hypoxic ischemic encephalopathy (HIE) are graded as mild and do not meet current criteria for therapeutic hypothermia. These infants are often not enrolled in follow-up, and hence our knowledge of their long-term outcome is sparse. We wished to compare 5-year outcomes in a group of infants with mild, moderate, and severe HIE, graded with both early EEG and clinical assessment, none of whom were treated with therapeutic hypothermia...
September 20, 2016: Pediatrics
https://www.readbyqxmd.com/read/27648460/interplay-of-brain-structure-and-function-in-neonatal-congenital-heart-disease
#20
Ala Birca, Vasily A Vakorin, Prashob Porayette, Sujana Madathil, Vann Chau, Mike Seed, Sam M Doesburg, Susan Blaser, Dragos A Nita, Rohit Sharma, Emma G Duerden, Edward J Hickey, Steven P Miller, Cecil D Hahn
OBJECTIVE: To evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate with neuronal network dysfunction measured by analysis of EEG connectivity. METHODS: We studied a prospective cohort of 20 neonates with CHD who underwent continuous EEG monitoring before surgery to assess functional brain maturation and network connectivity, structural magnetic resonance imaging (MRI) to determine the presence of brain injury and structural brain development, and diffusion tensor MRI to assess brain microstructural development...
September 2016: Annals of Clinical and Translational Neurology
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