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https://www.readbyqxmd.com/read/28419968/current-insights-into-pathogenesis-of-parkinson-s-disease-approach-to-mevalonate-pathway-and-protective-role-of-statins
#1
REVIEW
Seyed Soheil Saeedi Saravi, Seyed Sobhan Saeedi Saravi, Katayoun Khoshbin, Ahmad Reza Dehpour
Although Parkinson's disease (PD) is considered as the second most common life threatening age-related neurodegenerative disorder, but the underlying mechanisms for pathogenesis of PD are remained to be fully found. However, a complex relationship between genetic and environmental predisposing factors are involved in progression of PD. Dopaminergic neuronal cell death caused by mutations and accumulation of α-synuclein in Lewy bodies and neurites was suggested as the main strategy for PD, but current studies have paid attention to the role of mevalonate pathway in incidence of neurodegenerative diseases including PD...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28411282/genomic-architecture-and-treatment-outcome-in-pediatric-acute-myeloid-leukemia-a-children-s-oncology-group-report
#2
Marijana Vujkovic, Edward F Attiyeh, Rhonda E Ries, Elizabeth K Goodman, Yang Ding, Marko Kavcic, Todd A Alonzo, Yi-Cheng Wang, Robert B Gerbing, Lillian Sung, Betsy Hirsch, Susana Raimondi, Alan S Gamis, Soheil Meshinchi, Richard Aplenc
Childhood acute myeloid leukemia (AML) is frequently characterized by chromosomal instability. Approximately 50% of patients have disease relapse, and novel prognostic markers are needed to improve risk stratification. We performed genome-wide genotyping in 446 pediatric patients with de novo AML enrolled on Children's Oncology Group (COG) studies, AAML0531 (NCT01407757), AAML03P1 (NCT00070174), and CCG2961 (NCT00003790). Affymetrix and Illumina Omni 2.5 platforms were used to evaluate copy number alterations (CNAs) and determine their associations with treatment outcome...
April 14, 2017: Blood
https://www.readbyqxmd.com/read/28393038/single-step-transepithelial-photorefractive-keratectomy-in-high-myopia-qualitative-and-quantitative-visual-functions
#3
Soheil Adib-Moghaddam, Saeed Soleyman-Jahi, Fatemeh Adili-Aghdam, Samuel Arba Mosquera, Niloofar Hoorshad, Salar Tofighi
AIM: To investigate quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TransPRK) in high myopia. METHODS: In a prospective interventional case-series, 30 eyes with high myopia (-6.00 to -8.75 D) with (up to -3.00 D) or without astigmatism were enrolled from Bina Eye Hospital, Tehran, Iran. One-step TransPRK was performed with aberration-free aspherical optimized profile and SCHWIND AMARIS 500 laser. One-year follow-up results for refraction, visual acuities, vector analysis, ocular wave-front (OWF) and corneal wave-front (CWF) higher order aberrations (HOA), contrast sensitivity (CS), and post-operative haze were assessed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28387170/incidence-and-cost-of-non-fatal-burns-in-iran-a-nationwide-population-based-study
#4
Abolfazl Abouie, Payman Salamati, Nima Hafezi-Nejad, Afarin Rahimi-Movaghar, Soheil Saadat, Masoumeh Amin-Esmaeili, Vandad Sharifi, Ahmad Hajebi, Vafa Rahimi-Movaghar
To determine the incidence and cost of non-fatal burns in Iran; this cross-sectional household survey of a nationally representative sample of 15-64 years old was conducted. Through face-to-face interviews and telephone calls, the data on the demographics, history and cost of burns were collected. The annual incidence rate of burns was estimated 129.85 per 1000 population. Burns occurred higher in younger age, female gender and urban residency. The most common burn description was as follows: unpaid work (activity during burn), home (place of burn), heat and hot substances (mechanism of burn) and upper limb (site of burn)...
April 7, 2017: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/28376966/effectiveness-of-educational-interventions-on-fireworks-related-injuries-among-schoolboys
#5
Masood Naseripour, Reza Hamidian, Gary A Smith, Soheil Saadat
OBJECTIVE: We assessed the effectiveness of educational interventions in increasing the perceived risk of fireworks and preventing fireworks-related injuries among male teenagers. METHODS: In a field trial, using a cluster sampling approach, 3 high-, middle- and low-income municipality districts were selected. In each district, 5 male middle and high schools were randomly selected and assigned into one control and 4 intervention groups: (1) distribution of a multimedia disk regarding injury victims; (2) distribution of safety brochures; (3) mailing to parents from schools discussing the risk of fireworks and limiting the fireworks budget; and (4) peer-to-peer education by trained students about the risks of fireworks...
May 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28363517/assessment-of-mechanism-type-and-severity-of-injury-in-multiple-trauma-patients-a-cross-sectional-study-of-a-trauma-center-in-iran
#6
Hamidreza Reihani, Hossein Pirazghandi, Ehsan Bolvardi, Mohsen Ebrahimi, Elham Pishbin, Koorosh Ahmadi, Mahdi Safdarian, Soheil Saadat, Vafa Rahimi-Movaghar
PURPOSE: To accurately assess the mechanism, type and severity of injury in Iranian multiple trauma patients of a trauma center. METHODS: Patients with multiple traumas referring to the emergency department of Hasheminejad University Hospital in Mashhad, Iran, entered this cross sectional study from March 2013 to December 2013. All the patients with injury severity score (ISS) > 9 were included in this study. Data analysis was performed by SPSS software (Version 11...
April 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28353182/an-international-qualitative-study-of-ability-and-disability-in-adhd-using-the-who-icf-framework
#7
Soheil Mahdi, Marisa Viljoen, Rafael Massuti, Melissa Selb, Omar Almodayfer, Sunil Karande, Petrus J de Vries, Luis Rohde, Sven Bölte
This is the third in a series of four cross-cultural empirical studies designed to develop International Classification of Functioning, Disability and Health (ICF, and Children and Youth version, ICF(-CY) Core Sets for Attention-Deficit Hyperactivity Disorder (ADHD). To explore the perspectives of individuals diagnosed with ADHD, self-advocates, immediate family members and professional caregivers on relevant areas of impairment and functional abilities typical for ADHD across the lifespan as operationalized by the ICF(-CY)...
March 28, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28351408/application-of-short-message-service-to-control-blood-cholesterol-a-field-trial
#8
Saeed Sadeghian, Mohsen Shams, Zahra Alipour, Soheil Saadat, Reza Hamidian, Maryam Shahrzad
BACKGROUND: Despite recommendations, many middle-age adults neglect to check their blood cholesterol levels. Short message service (SMS, also known as texting) has been seldom studied for preventive education. We estimated how SMS can be a cost-effective method in encouraging people to check their blood cholesterol levels. METHODS: In a field trial, 3600 cell phone users (age > 30) were randomly assigned to the intervention (N: 1200) and the control groups (N: 2400)...
March 28, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28349254/%C3%AE-lipoic-acid-prevents-the-intestinal-epithelial-monolayer-damage-under-heat-stress-conditions-model-experiments-in-caco-2-cells
#9
Soheil Varasteh, Johanna Fink-Gremmels, Johan Garssen, Saskia Braber
PURPOSE: Under conditions of high ambient temperatures and/or strenuous exercise, humans and animals experience considerable heat stress (HS) leading among others to intestinal epithelial damage through induction of cellular oxidative stress. The aim of this study was to characterize the effects of α-Lipoic Acid (ALA) on HS-induced intestinal epithelial injury using an in vitro Caco-2 cell model. METHODS: A confluent monolayer of Caco-2 cells was pre-incubated with ALA (24 h) prior to control (37 °C) or HS conditions (42 °C) for 6 or 24 h and the expression of heat shock protein 70 (HSP70), heat shock factor-1 (HSF1), and the antioxidant Nrf2 were investigated...
March 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28348613/histopathological-changes-in-dental-pulp-of-rats-following-radiotherapy
#10
Zahra Sadat Madani, Soheil Azarakhsh, Pouyan Amini Shakib, Masoomeh Karimi
BACKGROUND: Radiotherapy is one of the oral and pharyngeal cancer treatment methods that can cause damage to the tissues in the radiation area; the purpose of this study is to evaluate the effects of radiotherapy on dental pulp tissue in rats. MATERIALS AND METHODS: In this interventional, experimental double-blind study, 30 rats were studied in three groups (n = 10 each). The first group received 12 gray (Gy), the second group received 18 Gy in one session, and the third group was not exposed to radiation (control group)...
January 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28286817/epidemiological-pattern-of-injuries-in-iran-a-nationwide-review-of-seven-million-emergency-department-admissions
#11
Mohammad Haji Aghajani, Mashyaneh Haddadi, Soheil Saadat
INTRODUCTION: Globally, it is estimated that around 5.8 million people die annually as result of injuries, which causes 10% of all deaths and 16% of disability adjusted life years lost worldwide. This study aimed to determine the epidemiology of injuries in emergency departments in Iran. METHOD: This cross sectional study was carried out using national injury surveillance data registry from 21 March 2009 to 20 March 2014. RESULTS: 7,176,344 patients with the mean age of 27...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28282213/anatomic-and-histological-investigation-of-the-anterolateral-capsular-complex-in-the-fetal-knee
#12
Soheil Sabzevari, Amir Ata Rahnemai-Azar, Marcio Albers, Monica Linde, Patrick Smolinski, Freddie H Fu
BACKGROUND: There is currently disagreement with regard to the presence of a distinct ligament in the anterolateral capsular complex of the knee and its role in the pivot-shift mechanism and rotatory laxity of the knee. PURPOSE: To investigate the anatomic and histological properties of the anterolateral capsular complex of the fetal knee to determine whether there exists a distinct ligamentous structure running from the lateral femoral epicondyle inserting into the anterolateral tibia...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28274232/perilipin-polymorphisms-are-risk-factors-for-the-development-of-obesity-in-adolescents-a-case-control-study
#13
Yavuz Tokgöz, Ishak Abdurrahman Işık, Soheil Akbari, Tuncay Kume, Oya Sayın, Esra Erdal, Nur Arslan
BACKGROUND: The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines. METHODS: A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR...
March 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28260200/increased-lateral-tibial-posterior-slope-is-related-to-tibial-tunnel-widening-after-primary-acl-reconstruction
#14
Soheil Sabzevari, Amir Ata Rahnemai-Azar, Humza S Shaikh, Justin W Arner, James J Irrgang, Freddie H Fu
PURPOSE: The purpose of the study was to determine the influence of femoral and tibial bone morphology on the amount of femoral and tibial tunnel widening after primary anatomic ACL reconstruction. It was hypothesized that tibial and femoral bone morphology would be significantly correlated with tunnel widening after anatomic ACL reconstruction. METHODS: Forty-nine consecutive patients (mean age 21.8 ± 8.1 years) who underwent primary single-bundle anatomic ACL reconstruction with hamstring autograft were enrolled...
March 4, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28259097/mammalian-target-of-rapamycin-mtor-nitric-oxide-system-possibly-modulate-antidepressant-like-effect-of-17%C3%AE-ethinyl-estradiol-in-ovariectomized-mice
#15
Seyed Soheil Saeedi Saravi, Alireza Arefidoust, Seyed Sobhan Saeedi Saravi, Rahele Yaftian, Mahdi Bayati, Milad Salehi, Ahmad Reza Dehpour
Due to a close association between depressive disorders and altered estrogen levels, this study was conducted to examine the hypothesis that antidepressant-like effect of ethinyl estradiol (EE2) in ovariectomized mice is modulated by mammalian target of rapamycin (mTOR)/nitric oxide pathways. Female mice were undergone bilateral ovariectomy and different doses of EE2 were intraperitoenally injected alone and combined with specific mTOR inhibitor, rapamycin, non-specific NOS inhibitor, L-NAME, nNOS inhibitor, 7-NI, NO precursor, l-arginine, and selective PDE5I, sildenafil...
March 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28258552/isolation-and-functional-characterization-of-a-methyl-jasmonate-responsive-3-carene-synthase-from-lavandula-x-intermedia
#16
Ayelign M Adal, Lukman S Sarker, Ashley D Lemke, Soheil S Mahmoud
A methyl jasmonate responsive 3-carene synthase (Li3CARS) gene was isolated from Lavandula x intermedia and functionally characterized in vitro. Lavenders produce essential oils consisting mainly of monoterpenes, including the potent antimicrobial and insecticidal monoterpene 3-carene. In this study we isolated and functionally characterized a leaf-specific, methyl jasmonate (MeJA)-responsive monoterpene synthase (Li3CARS) from Lavandula x intermedia. The ORF excluding transit peptides encoded a 64.9 kDa protein that was expressed in E...
April 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28246595/fixed-full-arches-supported-by-tapered-implants-with-knife-edge-thread-design-and-nanostructured-calcium-incorporated-surface-a-short-term-prospective-clinical-study
#17
Soheil Bechara, Algirdas Lukosiunas, Giorgio Andrea Dolcini, Ricardas Kubilius
Purpose. To evaluate implant survival, peri-implant bone loss, and complications affecting fixed full-arch (FFA) restorations supported by implants with a knife-edge thread design and nanostructured, calcium-incorporated surface. Methods. Between January 2013 and December 2015, all patients referred for implant-supported FFA restorations were considered for enrollment in this study. All patients received implants with a knife-edge thread design and nanostructured calcium-incorporated surface (Anyridge®, Megagen, South Korea) were restored with FFA restorations and enrolled in a recall program...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28241201/automated-quantification-of-the-impact-of-defects-on-the-mechanical-behavior-of-deoxyribonucleic-acid-origami-nanoplates
#18
Bowen Liang, Anand Nagarajan, Michael W Hudoba, Ricardo Alvarez, Carlos E Castro, Soheil Soghrati
Deoxyribonucleic acid (DNA) origami is a method for the bottom-up self-assembly of complex nanostructures for applications, such as biosensing, drug delivery, nanopore technologies, and nanomechanical devices. Effective design of such nanostructures requires a good understanding of their mechanical behavior. While a number of studies have focused on the mechanical properties of DNA origami structures, considering defects arising from molecular self-assembly is largely unexplored. In this paper, we present an automated computational framework to analyze the impact of such defects on the structural integrity of a model DNA origami nanoplate...
April 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28222251/prognostic-methylation-markers-for-overall-survival-in-cytogenetically-normal-patients-with-acute-myeloid-leukemia-treated-on-swog-trials
#19
Xiaoyu Qu, Megan Othus, Jerry Davison, Yu Wu, Liying Yan, Soheil Meshinchi, Fabiana Ostronoff, Elihu H Estey, Jerry P Radich, Harry P Erba, Frederick R Appelbaum, Min Fang
BACKGROUND: Aberrant DNA methylation is known to occur in patients with acute myeloid leukemia (AML), whereas methylation signatures and prognostic markers have been proposed. The objective of the current study was to evaluate all CpG sites of the genome and identify prognostic methylation markers for overall survival in patients with AML with normal karyotype (AML-NK). METHODS: AML-NK samples from 7 SWOG trials were analyzed using a novel genome-wide approach called "CHARMcox" (comprehensive high-throughput array-based relative methylation analysis combined with the Cox proportional hazards model) controlling for known clinical covariates...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28218741/identification-of-micrornas-associated-with-invasive-and-aggressive-phenotype-in-cutaneous-melanoma-by-next-generation-sequencing
#20
Sankhiros Babapoor, Rong Wu, James Kozubek, Donna Auidi, Jane M Grant-Kels, Soheil S Dadras
A comprehensive repertoire of human microRNAs (miRNAs) that could be involved in early melanoma invasion into the dermis remains unknown. To this end, we sequenced small RNAs (18-30 nucleotides) isolated from an annotated series of invasive melanomas (average invasive depth, 2.0 mm), common melanocytic nevi, and matched normal skin (n=28). Our previously established bioinformatics pipeline identified 765 distinct mature known miRNAs and defined a set of top 40 list that clearly segregated melanomas into thin (0...
February 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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