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https://www.readbyqxmd.com/read/28069802/genomic-profiling-of-a-large-set-of-diverse-pediatric-cancers-identifies-known-and-novel-mutations-across-tumor-spectra
#1
Juliann Chmielecki, Mark Bailey, Jie He, Julia Elvin, Jo-Anne Vergilio, Shakti Ramkissoon, James Suh, Garrett M Frampton, James X Sun, Samantha Morley, Daniel Spritz, Siraj Ali, Laurie Gay, Rachel L Erlich, Jeffrey S Ross, Joana Buxhaku, Hilary Davies, Vinny Faso, Alexis Germain, Blair Glanville, Vincent A Miller, Philip J Stephens, Katherine A Janeway, John M Maris, Soheil Meshinchi, Trevor J Pugh, Jack F Shern, Doron Lipson
Pediatric cancers are generally characterized by low mutational burden and few recurrently mutated genes. Recent studies suggest that genomic alterations may help guide treatment decisions and clinical trial selection. Here, we describe genomic profiles from 1,215 pediatric tumors representing sarcomas, extracranial embryonal tumors, brain tumors, hematologic malignancies, carcinomas, and gonadal tumors. Comparable published datasets identified similar frequencies of clinically relevant alterations, validating this dataset as biologically relevant...
January 9, 2017: Cancer Research
https://www.readbyqxmd.com/read/28060329/drug-repurposing-hypothesis-generation-using-the-re-fine-drugs-system
#2
Kelly Regan, Soheil Moosavinasab, Philip Payne, Simon Lin
The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates...
December 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059348/on-chip-asymmetric-microcavity-optomechanics
#3
Soheil Soltani, Alexa W Hudnut, Andrea M Armani
High quality factor (Q) optical resonators have enabled rapid growth in the field of cavity-enhanced, radiation pressure-induced optomechanics. However, because research has focused on axisymmetric devices, the observed regenerative excited mechanical modes are similar. In the present work, a strategy for fabricating high-Q whispering gallery mode microcavities with varying degrees of asymmetry is developed and demonstrated. Due to the combination of high optical Q and asymmetric device design, two previously unobserved modes, the asymmetric cantilever and asymmetric crown mode, are demonstrated with sub-mW thresholds for onset of oscillations...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28058114/protective-effects-of-co-enzyme-q10-on-thioacetamide-induced-acute-liver-damage-and-its-correlation-with-behavioral-biochemical-and-pathological-factors
#4
Soheil Ashkani-Esfahani, Fereshteh Bagheri, Yasaman Emami, Elmira Esmaeilzadeh, Negar Azarpira, Nazila Hassanabadi, Marzieh Keshtkar, Mojtaba Farjam, Omid Koohi-Hosseinabadi, Ali Noorafshan
BACKGROUND: Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death. OBJECTIVES: In this experimental study we determined whether coenzyme Q10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against thioacetamide (TAA)-induced liver damage and its related neurobehavioral alterations in rats...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28050181/factors-associated-with-depressive-symptoms-in-young-adults-with-coronary-artery-disease-tehran-heart-center-s-premature-coronary-atherosclerosis-cohort-thc-pac-study
#5
Seyed Hesameddin Abbasi, Seyed Ebrahim Kassaian, Saeed Sadeghian, Abbasali Karimi, Soheil Saadat, Flora Peyvandi, Arash Jalali, Tahereh Davarpasand, Shahin Akhondzadh, Nazila Shahmansouri, Masoumeh Lotfi-Tokaldany, Maryam Amiri Abchouyeh, Farah Ayatollahzade Isfahani, Frits Rosendaal
Objective: Depressed coronary artery disease (CAD) patients may experience a poorer prognosis than non-depressed patients. The aim of this study was to find the associated factors for depressive symptoms in young adults with CAD. Method: This was a cross-sectional study within Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Young adult CAD patients (men ≤ 45 year-old and women ≤ 55 year-old) were visited from March 2013 to February 2014. Demographic, clinical and laboratory data were collected and all patients were asked to fill in the Beck Depression Inventory II...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28038939/skin-fragility-in-the-wild-derived-inbred-mouse-strain-mus-pahari-eij
#6
C Herbert Pratt, Christopher S Potter, Thomas J Sproule, Raoul V Kuiper, Son Yong Karst, Soheil S Dadras, Derry C Roopenian, John P Sundberg
Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain's skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases...
December 27, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28028567/the-use-of-achilles-tendon-allograft-for-latissimus-dorsi-tendon-reconstruction-a-minimally-invasive-technique
#7
Soheil Sabzevari, Tom Chao, Jay Kalawadia, Albert Lin
Treatment of subacute, retracted latissimus dorsi and teres major tendon ruptures in young overhead athletes is challenging. This case report describes management of a subacute retracted latissimus dorsi and teres major rupture with Achilles tendon allograft reconstruction using a two-incision minimally invasive technique. Level of evidence V.
December 27, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27997128/spatial-and-temporal-trends-of-polyhalogenated-carbazoles-in-sediments-of-upper-great-lakes-insights-into-their-origin
#8
Jiehong Guo, Zhuona Li, Prabha Ranasinghe, Solidea Bonina, Soheil Hosseini, Margaret B Corcoran, Colin Smalley, Karl J Rockne, Neil C Sturchio, John P Giesy, An Li
Polyhalogenated carbazoles (PHCZs) have been increasingly detected in the environment. Their similarities in chemical structure with legacy pollutants and their potential toxicity have caused increasing concern. In this work, 112 Ponar grab and 28 core sediment samples were collected from Lakes Michigan, Superior, and Huron, and a total of 26 PHCZs were analyzed along with unsubstituted carbazole using gas chromatography coupled with single- or triple-quadrupole mass spectrometry. Our results show that the total accumulation of PHCZs in the sediments of the upper Great Lakes is >3000 tonnes, orders of magnitude greater than those of polychlorinated biphenyls (PCBs) and decabromodiphenyl ether (BDE209)...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27989662/immunoinformatics-analysis-and-in-silico-designing-of-a-novel-multi-epitope-peptide-vaccine-against-staphylococcus-aureus
#9
Nasim Hajighahramani, Navid Nezafat, Mahboobeh Eslami, Manica Negahdaripour, Seyyed Soheil Rahmatabadi, Younes Ghasemi
Staphylococcus aureus is a pathogen that causes a variety of infections in humans. Methicillin-resistant S. aureus, which is an antibiotic-resistant form, is responsible for nosocomial staphylococcal infections, whose frequency is increasing in healthy people. Thereby, the development of novel techniques is required to overcome this bacterial infection. In this context, the use of vaccines to control infections is an appropriate alternative. In this study, immunoinformatics analysis is used on three antigenic determinants as vaccine candidates, and a novel multi-epitope vaccine is designed to induce cellular, humoral, and innate immune responses against S...
December 16, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27956283/single-step-transepithelial-photorefractive-keratectomy-in-myopia-and-astigmatism-18-month-follow-up
#10
Soheil Adib-Moghaddam, Saeed Soleyman-Jahi, Bahram Salmanian, Amir-Houshang Omidvari, Fatemeh Adili-Aghdam, Farsad Noorizadeh, Medi Eslani
PURPOSE: To evaluate the long-term quantitative and qualitative optical outcomes of 1-step transepithelial photorefractive keratectomy (PRK) to correct myopia and astigmatism. SETTING: Bina Eye Hospital, Tehran, Iran. DESIGN: Prospective interventional case series. METHODS: Eyes with myopia with or without astigmatism were evaluated. One-step transepithelial PRK was performed with an aberration-free aspheric optimized profile and the Amaris 500 laser...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27943055/reproducible-segmentation-of-white-matter-hyperintensities-using-a-new-statistical-definition
#11
Soheil Damangir, Eric Westman, Andrew Simmons, Hugo Vrenken, Lars-Olof Wahlund, Gabriela Spulber
OBJECTIVES: We present a method based on a proposed statistical definition of white matter hyperintensities (WMH), which can work with any combination of conventional magnetic resonance (MR) sequences without depending on manually delineated samples. MATERIALS AND METHODS: T1-weighted, T2-weighted, FLAIR, and PD sequences acquired at 1.5 Tesla from 119 subjects from the Kings Health Partners-Dementia Case Register (healthy controls, mild cognitive impairment, Alzheimer's disease) were used...
December 9, 2016: Magma
https://www.readbyqxmd.com/read/27920824/cloning-expression-and-molecular-analysis-of-iranian-brucella-melitensis-omp25-gene-for-designing-a-subunit-vaccine
#12
Soheil Yousefi, Mojtaba Tahmoorespur, Mohammad Hadi Sekhavati
Brucellosis is a well-known domestic animal infectious disease, which is caused by Brucella bacterium. The outer membrane protein 25 kDa (Omp25) gene plays an important role in simulating of TNF-α, IFN-α, macrophage, and cytokines cells. In the current study molecular cloning and expression analysis of Omp25 gene for designing a subunit vaccine against Brucella was investigated. Amplifying the full length of candidate gene was performed using specific primers. Sub-cloning of this gene conducted using pTZ57R/T vector in TOP10F strain of Escherichia coli(E...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27917279/minocycline-attenuates-cirrhotic-cardiomyopathy-and-portal-hypertension-in-a-rat-model-possible-involvement-of-nitric-oxide-pathway
#13
Seyyedeh Elaheh Mousavi, Seyed Mahdi Rezayat, Maliheh Nobakht, Seyed Soheil Saeedi Saravi, Iraj Yazdani, Amir Rashidian, Ahmad Reza Dehpour
OBJECTIVES: An increase in nitric oxide (NO) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO overproduction, we aimed to examine its role in a rat model of CCl4-induced cirrhotic cardiovascular complications. MATERIALS AND METHODS: Portal pressure and inotropic responsiveness of isolated papillary muscles to isoproterenol were measured in cirrhotic rats, following minocycline (50 mg/kg/day for 8 weeks) treatment...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27904583/the-role-of-intravenous-immunoglobulin-in-treatment-of-mucous-membrane-pemphigoid-a-review-of-literature
#14
REVIEW
Soheil Tavakolpour
BACKGROUND: Mucous membrane pemphigoid (MMP) is considered an autoimmune blistering disease that predominantly affects mucous membranes. Various treatments are available for controlling the diseases, but not all of them may respond. MATERIALS AND METHODS: PubMed and Google Scholar were searched for all the associated studies until 2015, using the keywords such as "cicatricial pemphigoid" or "ocular pemphigoid" or "mucous membrane pemphigoid" or "MMP" and "intravenous immunoglobulin" or "IVIg" to find all the relevant studies...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903291/erratum-to-high-expression-of-myocyte-enhancer-factor-2c-mef2c-is-associated-with-adverse-risk-features-and-poor-outcome-in-pediatric-acute-myeloid-leukemia-a-report-from-the-children-s-oncology-group
#15
George S Laszlo, Todd A Alonzo, Chelsea J Gudgeon, Kimberly H Harrington, Alex Kentsis, Robert B Gerbing, Yi-Cheng Wang, Rhonda E Ries, Susana C Raimondi, Betsy A Hirsch, Alan S Gamis, Soheil Meshinchi, Roland B Walter
No abstract text is available yet for this article.
November 30, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27883937/atorvastatin-protected-from-paraquat-induced-cytotoxicity-in-alveolar-macrophages-via-down-regulation-of-tlr-4
#16
Nazli Alizadeh-Tabrizi, Hassan Malekinejad, Soheil Varasteh, Hadi Cheraghi
The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat in the presence and absence of atorvastatin for 24h. Cell viability, myeloperoxidase activity; nitric oxide generation and total antioxidant capacity were assessed. Expression of TLR-4 at mRNA and protein levels were studied by using PCR and western blot methods Atorvastatin enhanced the paraquat-reduced cell viability and reduced the paraquat-induced myeloperoxidase activity and nitric oxide production...
November 18, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27867552/prognostic-value-of-on-admission-arterial-pco2-in-hospitalized-patients-with-community-acquired-pneumonia
#17
Zeynab Yassin, Mohammad Saadat, Hamidreza Abtahi, Abbas Rahimi Foroushani, Soheil Peiman
BACKGROUND: There is little data about the correlation between the outcome of community acquired pneumonia (CAP) and the hypercapnic type respiratory failure. In this study we prospectively investigated the prognostic significance of first arterial CO2 tension in patients hospitalized with CAP. METHODS: In this prospective study patients with CAP, admitted to a general hospital were included. PaCO2 was measured for each subject in an arterial blood sample drawn in the first 2 hours and its correlations with three major outcomes were evaluated: intensive care unit (ICU) admission, duration of admission and mortality in 30 days...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27862562/management-of-pemphigus-disease-in-pregnancy
#18
REVIEW
Soheil Tavakolpour, Hajar Sadat Mirsafaei, Saeid Delshad
Pemphigus can cause complications during pregnancy and may cause serious harm to a fetus. For this study, a comprehensive review of common treatments of pemphigus and their adverse effects associated with pregnancy and male fertility was conducted. We concluded that a period of remission with minimal or no therapy before conception could significantly reduce the risk of the disease flaring up, at least in the first trimester. The period of remission causes a delay in the flare-up of the disease, which means lower cumulative doses and the prevention of possible congenital abnormalities caused by corticosteroid or immunosuppressant treatments...
January 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27862074/three-dimensional-analysis-modeling-and-simulation-of-the-effect-of-static-magnetic-fields-on-neurons
#19
Soheil Hashemi, Ali Abdolali
The effect of static magnetic fields on neuron function has been studied. None of the possible explanations are decisive or fully consistent with evidence in the literature. Therefore, the purpose of this paper is to examine the different possibilities, for the first time, through a three-dimensional modeling strategy in an effort to find out which possibility or combination is effective on cell function. A full-wave analysis was employed to simulate various effects of magnetic fields. The possibilities included force exerted on mobile ions, magnetophoretic force exerted on ions with permeability different from intracellular or extracellular fluids, magnetophoretic force exerted on sensor proteins in ion channels, and magnetophoretic pressure exerted on the membrane and spatial rotation of anisotropic diamagnetic particles...
November 14, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/27855302/the-possible-role-of-interleukin-35-and-its-therapeutic-potential-in-pemphigus
#20
REVIEW
Soheil Tavakolpour, Forough Kheiry, Hajar Sadat Mirsafaei, Meisam Akhlaghdoust
Pemphigus is an autoimmune disease that causes blistering and is life-threatening if left untreated. Nowadays, finding a promising treatment for pemphigus remains a serious challenge. Various treatments are currently recommended to treat this disease, but they rarely lead to complete and durable remission. Regulatory cells appear to have a critical role in numerous autoimmune diseases, so it is possible that promotion of these cells may induce remission. This study presents a new approach to treating pemphigus that has not been discussed to date...
January 2017: International Immunopharmacology
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