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Raynell Lang, Ron Read, Hartmut B Krentz, Soheil Ramazani, Mingkai Peng, Jennifer Gratrix, M John Gill
BACKGROUND: Syphilis is a global health concern disproportionately affecting HIV-infected populations. In Alberta, Canada, the incidence of syphilis in the general population has recently doubled with 25% of these infections occurring in HIV-infected patients. The Southern Alberta HIV Clinic (SAC) and Calgary STI Program (CSTI) analyzed the epidemiologic characteristics of incident syphilis infections in our well-defined, HIV-infected population over 11 years. METHODS: Since 2006, as routine practice of both the Southern Alberta Clinic (SAC) and Calgary STI Programs (CSTI), syphilis screening has accompanied HIV viral load measures every four months...
March 13, 2018: BMC Infectious Diseases
Karl Roessler, Burkhard S Kasper, Roland Coras, Soheil Arinrad, Michael Scholz, Hajo H Hamer, Ingmar Blümcke, Michael Buchfelder
BACKGROUND: Temporal lobe resection (TLR) including amygdalo-hippocampectomy (AHE) is the most frequent performed procedure in epilepsy surgery. Due to close anatomical relationship of the mesial temporal structures and the midbrain and choroidal fissure, the risk of severe complications like postoperative stroke is up to 2.5%. METHODS: We developed a modification of the classical technique for AHE by early entering the choroidal fissure for identification of crus cerebri, posterior cerebri artery and oculomotor nerve via the anterior part of the fronto- mesial temporal horn cleft...
March 7, 2018: World Neurosurgery
Majid Shojaee, Saeed Safari, Anita Sabzghabaei, Mostafa Alavi-Moghaddam, Ali Arhami Dolatabadi, Hamid Kariman, Soheil Soltani
Introduction: Pro-brain natriuretic peptide (Pro-BNP) can act as an independent predictor of mortality in septic patients. This study aimed to compare the diagnostic accuracy of pro-BNP and Mortality in Emergency Department Sepsis (MEDS) score in this regard. Method: This cross-sectional study was conducted on > 14 years old sepsis patients of an emergency department (ED), during 2 years. The level of Pro-BNP and MEDS score were measured for all eligible patients and considering one month mortality as reference, screening performance characteristics of the two tests were compared using SPSS 21 and STATS 11...
2018: Emergency (Tehran, Iran)
Xiaotu Ma, Yu Liu, Yanling Liu, Ludmil B Alexandrov, Michael N Edmonson, Charles Gawad, Xin Zhou, Yongjin Li, Michael C Rusch, John Easton, Robert Huether, Veronica Gonzalez-Pena, Mark R Wilkinson, Leandro C Hermida, Sean Davis, Edgar Sioson, Stanley Pounds, Xueyuan Cao, Rhonda E Ries, Zhaoming Wang, Xiang Chen, Li Dong, Sharon J Diskin, Malcolm A Smith, Jaime M Guidry Auvil, Paul S Meltzer, Ching C Lau, Elizabeth J Perlman, John M Maris, Soheil Meshinchi, Stephen P Hunger, Daniela S Gerhard, Jinghui Zhang
Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for adult but not paediatric cancers, which commonly occur in developing mesodermic rather than adult epithelial tissues. Here we present a pan-cancer study of somatic alterations, including single nucleotide variants, small insertions or deletions, structural variations, copy number alterations, gene fusions and internal tandem duplications in 1,699 paediatric leukaemias and solid tumours across six histotypes, with whole-genome, whole-exome and transcriptome sequencing data processed under a uniform analytical framework...
February 28, 2018: Nature
Soheil Mahdi, Nadia Ronzano, Ane Knüppel, José Carlos Dias, Ayman Albdah, Lin Chien-Ho, Omar Almodayfer, Annet Bluschke, Sunil Karande, Huei-Lin Huang, Hanna Christiansen, Mats Granlund, Petrus J de Vries, David Coghill, Rosemary Tannock, Luis Rohde, Sven Bölte
This is the fourth and final study designed to develop International Classification of Functioning, Disability and Health (ICF, and children and youth version, ICF-CY) core sets for attention-deficit hyperactivity disorder (ADHD). To investigate aspects of functioning and environment of individuals with ADHD as documented by the ICF-CY in clinical practice settings. An international cross-sectional multi-centre study was applied, involving nine units from eight countries: Denmark, Germany, India, Italy, Portugal, Saudi Arabia, Sweden and Taiwan...
February 17, 2018: European Child & Adolescent Psychiatry
Ali Khalili, Soheil Ebrahimpour, Iradj Maleki, Saeid Abediankenari, Mousa Mohammadnia Afrouzi
BACKGROUND: Regulatory T (Treg) cell play a key role in autoimmune diseases. We evaluated the regulatory function and frequency of Treg cells and secreted IL-10, IL-35 concentration in Crohn's disease (CD). METHODS: Twenty-three patients with CD and 25 healthy controls (HC) were included in this study. We analysed the alteration of Tregs frequency using flow cytometry for CD4, CD25, CD127 and FoxP3 markers. Surface expression of CD4, CD25 and CD127 markers were used for isolation of a relatively pure Treg cells...
February 16, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Sven Bölte, Soheil Mahdi, David Coghill, Susan Shur-Fen Gau, Mats Granlund, Martin Holtmann, Sunil Karande, Florence Levy, Luis A Rohde, Wolfgang Segerer, Petrus J de Vries, Melissa Selb
Attention-deficit/hyperactivity disorder (ADHD) is associated with significant impairments in social, educational, and occupational functioning, as well as specific strengths. Currently, there is no internationally accepted standard to assess the functioning of individuals with ADHD. WHO's International Classification of Functioning, Disability and Health-child and youth version (ICF) can serve as a conceptual basis for such a standard. The objective of this study is to develop a comprehensive, a common brief, and three age-appropriate brief ICF Core Sets for ADHD...
February 12, 2018: European Child & Adolescent Psychiatry
Brayan F García, Soheil Saraji
HYPOTHESIS: The relaxation time in viscoelastic surfactant solutions is a function of temperature, salt/surfactant concentrations, resting conditions, as well as shear frequency. The simplistic assumption of a single and constant relaxation time is not representative of all relaxation modes in these solutions especially at high frequencies. EXPERIMENTS: Steady-state and oscillatory measurements are carried out to study the effects of high temperature, concentration and resting condition on the rheology of surfactants/salt mixtures including a non-ionic and a zwitterionic/anionic surfactant system...
February 1, 2018: Journal of Colloid and Interface Science
Shima Nejati, Ahmad Karkhah, Hossein Darvish, Majid Validi, Soheil Ebarhimpour, Hamid Reza Nouri
Helicobacter Pylori (H. pylori) is a gram-negative bacteria infecting numerous people all over the world. It has been established that H. pylori play an important role in pathogenesis of gastritis, peptic ulcer and gastric cancer. Pathogenic features of this bacterium are mainly attributes to the existence of pathogenic islands (PAI) genes. The most known genes in these islands are cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene (VacA). Most studies demonstrated various frequency of CagA and VacA in patient with peptic ulcer or gastritis in different countries...
February 9, 2018: Microbial Pathogenesis
Soheil Mahdi, Katja Albertowski, Omar Almodayfer, Vaia Arsenopoulou, Sara Carucci, José Carlos Dias, Mohammad Khalil, Ane Knüppel, Anika Langmann, Marlene Briciet Lauritsen, Graccielle Rodrigues da Cunha, Tokio Uchiyama, Nicole Wolff, Melissa Selb, Mats Granlund, Petrus J de Vries, Lonnie Zwaigenbaum, Sven Bölte
This is the fourth international preparatory study designed to develop International Classification of Functioning, Disability and Health (ICF, and Children and Youth version, ICF-CY) Core Sets for Autism Spectrum Disorder (ASD). Examine functioning of individuals diagnosed with ASD as documented by the ICF-CY in a variety of clinical settings. A cross-sectional study was conducted, involving 11 units from 10 countries. Clinical investigators assessed functioning of 122 individuals with ASD using the ICF-CY checklist...
February 8, 2018: Journal of Autism and Developmental Disorders
Garry Codling, Soheil Hosseini, Margaret B Corcoran, Solidea Bonina, Tian Lin, An Li, Neil C Sturchio, Karl J Rockne, Kyunghee Ji, Hui Peng, John P Giesy
Current and historical concentrations of 22 poly- and perfluorinated compounds (PFASs) in sediment collected from Lake Superior and northern Lake Michigan in 2011 and Lake Huron in 2012 are reported. The sampling was performed in two ways, Ponar grabs of surface sediments for current spatial distribution across the lake and dated cores for multi-decadal temporal trends. Mean concentrations of the sum of PFASs (∑PFASs) were 1.5, 4.6 and 3.1 ng g-1 dry mas (dm) in surface sediments for Lakes Superior, Michigan and Huron, respectively...
February 3, 2018: Environmental Pollution
Ahmad Karkhah, Mostafa Javanian, Soheil Ebrahimpour
Two hepatotropic viruses hepatitis C virus (HCV) and hepatitis B virus (HBV) have been considered as the main cause of chronic viral infections. In addition, human immunodeficiency virus (HIV) attacks the immune system by eradication of some white blood cell (T-helper cell). The role of Tregs in HCV, HBV and HIV infections ranges from suppressing antiviral T cell responses to protecting tissues as liver and immune cells from immune mediated injury. In this review, we discuss the influence of regulatory T cells in immunopathology of specific viral infections including HCV, HBV and HIV by focusing on targeting Tregs as novel approach in vaccinology against viral infections...
January 29, 2018: Infection, Genetics and Evolution
Muhammad Torequl Islam, Eunüs S Ali, Shaikh Jamal Uddin, Md Amirul Islam, Subrata Shaw, Ishaq N Khan, Seyed Soheil Saeedi Saravi, Saheem Ahmad, Shahnawaz Rehman, Vijai Kumar Gupta, Mihnea-Alexandru Găman, Amelia Maria Gaman, Santosh Yele, Asish Kumar Das, João Marcelo de Castro E Sousa, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S Mubarak, Nagendra Sastry Yarla, Jamil A Shilpi, Siddhartha Kumar Mishra, Atanas G Atanasov, Mohammad Amjad Kamal
The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, and neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases, such as Parkinson's disease, rheumatoid arthritis, and colitis. This systematic review aims to highlight andrographolide as a promising agent in cancer treatment...
February 2, 2018: Cancer Letters
Bahram Naderinabi, Soheil Soltanipour, Shadman Nemati, Alia Saberi, Sepideh Parastesh
Background: There is challenge to find an effective treatment for tinnitus. Few studies were done on the effects of acupuncture on tinnitus. This study evaluated the effect of acupuncture on chronic non-pulsatile tinnitus. Methods: This randomized double-blind clinical trial was conducted from December 2014 to September 2015 . Patients suffering from chronic non-pulsatile tinnitus were randomly allocated into two groups: acupuncture vs. placebo. They were treated in 15 sessions and at the end of the fifteenth sessions and 3 weeks after completion of the treatment, visual analog scale (VAS) for tinnitus loudness and tinnitus severity index (TSI) questionnaires were completed...
2018: Caspian Journal of Internal Medicine
Sven Bölte, Soheil Mahdi, Petrus J de Vries, Mats Granlund, John E Robison, Cory Shulman, Susan Swedo, Bruce Tonge, Virginia Wong, Lonnie Zwaigenbaum, Wolfgang Segerer, Melissa Selb
Autism spectrum disorder is associated with diverse social, educational, and occupational challenges. To date, no standardized, internationally accepted tools exist to assess autism spectrum disorder-related functioning. World Health Organization's International Classification of Functioning, Disability and Health can serve as foundation for developing such tools. This study aimed to identify a comprehensive, a common brief, and three age-appropriate brief autism spectrum disorder Core Sets. Four international preparatory studies yielded in total 164 second-level International Classification of Functioning, Disability and Health candidate categories...
January 1, 2018: Autism: the International Journal of Research and Practice
Sonal Muzumdar, Melissa Argraves, Arni Kristjansson, Katalin Ferenczi, Soheil S Dadras
Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun-damaged skin is challenging. The first-line immunostain is usually MART-1/Melan-A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART-1 and SOX10 immunostaining, we scored the percentage of epidermal melanocytes per 2-mm diameter fields in pigmented actinic keratosis (n=16), lichenoid keratosis (n=7), junctional melanocytic nevus (n=6), keratosis with atypical melanocytic proliferation (AMP, n=17) and MIS (n=10)...
January 26, 2018: Journal of Cutaneous Pathology
Marcin Kowalczuk, Kevin Kohut, Soheil Sabzevari, Jan-Hendrik Naendrup, Albert Lin
PURPOSE: To investigate whether acute rupture of the proximal long head biceps is a harbinger of disease of the nearby supraspinatus and subscapularis tendons. METHODS: A retrospective chart review from February 1, 2008, to August 31, 2016, was performed at our institution identifying patients who presented with an acute (<12-week) history of "Popeye" deformity of the distal biceps and a magnetic resonance imaging (MRI) of the affected shoulder. MRI images were then reviewed in duplicate to determine supraspinatus and subscapularis tendon tear incidence, size, chronicity, and depth...
January 17, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Junjie Zhong, Soheil Talebi, Yi Xu, Yuanjie Pang, Farshid Mostowfi, David Sinton
Fluorescence microscopy uniquely enables physical and biological research in micro- and nanofluidic systems. However, in channels with depths below 10 nm, the limited number of fluorophores results in fluorescence intensity below the detection limit of optical microscopes. To overcome this barrier, we applied Fabry-Pérot interference to enhance fluorescence intensity with a silicon nitride layer below the sub-10 nm channel. A silicon nitride layer of suitable thickness can selectively enhance both absorption and emission wavelengths, leading to a fluorescent signal that is enhanced 20-fold and readily imaged with traditional microscopes...
January 26, 2018: Lab on a Chip
Soheil Yousefi, Tooba Abbassi-Daloii, Thirsa Kraaijenbrink, Martijn Vermaat, Hailiang Mei, Peter van 't Hof, Maarten van Iterson, Daria V Zhernakova, Annique Claringbould, Lude Franke, Leen M 't Hart, Roderick C Slieker, Amber van der Heijden, Peter de Knijff, Peter A C 't Hoen
BACKGROUND: SNP panels that uniquely identify an individual are useful for genetic and forensic research. Previously recommended SNP panels are based on DNA profiles and mostly contain intragenic SNPs. With the increasing interest in RNA expression profiles, we aimed for establishing a SNP panel for both DNA and RNA-based genotyping. RESULTS: To determine a small set of SNPs with maximally discriminative power, genotype calls were obtained from DNA and blood-derived RNA sequencing data belonging to healthy, geographically dispersed, Dutch individuals...
January 25, 2018: BMC Genomics
Jay Sarthy, Ji Zha, Daria Babushok, Archana Shenoy, Jian-Meng Fan, Gerald Wertheim, Adam Himebauch, Ashley Munchel, Agne Taraseviciute, Samuel Yang, Hirohito Shima, Satoshi Narumi, Soheil Meshinchi, Timothy S Olson
No abstract text is available yet for this article.
January 23, 2018: Blood Advances
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