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Fiona C Brown, Paolo Cifani, Esther Drill, Jie He, Eric Still, Shan Zhong, Sohail Balasubramanian, Dean Pavlick, Bahar Yilmazel, Kristina M Knapp, Todd A Alonzo, Soheil Meshinchi, Richard M Stone, Steven M Kornblau, Guido Marcucci, Alan S Gamis, John C Byrd, Mithat Gonen, Ross L Levine, Alex Kentsis
Cure rates of children and adults with acute myeloid leukaemia (AML) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP1, ASXL1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML, together with distinct genes that were significantly overexpressed in therapy-resistant AML. Defined gene mutations were sufficient to explain primary induction failure in only a minority of cases...
October 21, 2016: British Journal of Haematology
Michael R Loken, Andrew P Voigt, Lisa Eidenschink Brodersen, Wayne Fritschle, Andrew J Menssen, Soheil Meshinchi, Denise A Wells
Five reference populations in bone marrow specimens were identified by flow cytometry using specific combinations of reagents in order define the variation of gene product expression intensities both within and between individuals. Mature lymphocytes, uncommitted progenitor cells, promyelocytes, mature monocytes and mature neutrophils can be reproducibly identified as distinct clusters of events in heterogeneous, maturing bone marrow specimens. Support Vector Machines were used to identify the reference populations in order to reduce subjective bias in manually defining boundaries of these populations since they were not discretely separated from the remainder of the cells...
October 18, 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
Amir Reza Radmard, Mohammad Sadegh Rahmanian, Alireza Abrishami, Ali Yoonessi, Soheil Kooraki, Mehrdad Dadgostar, Amir Pejman Hashemi Taheri, Marjan Gerami Seresht, Hossein Poustchi, Elham Jafari, Reza Malekzadeh, Shahin Merat
BACKGROUND: To investigate the association between non-alcoholic fatty liver disease (NAFLD) and quantitative measures of central adiposity in the general population using a semi-automated method on magnetic resonance imaging (MRI) data. METHODS: Subjects were recruited from Golestan Cohort Study. Two groups of 120 individuals with and without fatty liver were randomly selected based on findings of ultrasound. Non-invasive diagnosis of NAFLD was made by combination of ultrasound and MRI...
October 2016: Archives of Iranian Medicine
Marco Esposito, Konstantinos Siormpas, Miltiadis Mitsias, Soheil Bechara, Anna Trullenque-Eriksson, Roberto Pistilli
PURPOSE: To compare the clinical outcome of single, partial and full fixed implant-supported prostheses immediately loaded (within 48 h), early loaded at 6 weeks and conventionally loaded at 3 months (delayed loading). MATERIALS AND METHODS: Eighty-one patients (27 requiring single implants, 27 requiring partial fixed prostheses and 27 requiring total fixed cross-arch prostheses) were randomised in equal numbers in three private practices to immediate loading (27 patients), early loading (27 patients) and conventional loading (27 patients) according to a parallel group design with three arms...
2016: European Journal of Oral Implantology
Ali Mohammadzadeh, Vahid Mohammadzadeh, Soheil Kooraki, Houman Sotoudeh, Sakineh Kadivar, Madjid Shakiba, Bahman Rasuli, Ali Borhani, Maryam Mohammadzadeh
Glioma is considered the most common type of primary central nervous system (CNS) tumor. Imaging is crucial for diagnosis, characterization, grading, and therapeutic planning of CNS gliomas. Along with a brief description of conventional computed tomography and magnetic resonance imaging techniques, this article reviews the ever-developing role of modern imaging techniques in preoperative management of CNS gliomas. It discusses current clinical applications, promising features, and limitations of each imaging method...
November 2016: Neuroimaging Clinics of North America
Eunice Song, Jane M Grant-Kels, Helen Swede, Jody L D'Antonio, Avery Lachance, Soheil S Dadras, Arni K Kristjansson, Katalin Ferenczi, Hanspaul S Makkar, Marti J Rothe
BACKGROUND: Several technologies have been developed to aid dermatologists in the detection of melanoma in vivo including dermoscopy, multispectral digital skin lesion analysis (MDSLA), and reflectance confocal microscopy (RCM). To our knowledge, there have been no studies directly comparing MDSLA and RCM. OBJECTIVE: We conducted a repeated measures analysis comparing the sensitivity and specificity of MDSLA and RCM in the detection of melanoma (n = 55 lesions from 36 patients)...
September 29, 2016: Journal of the American Academy of Dermatology
Athena Jalalian, Francis E H Tay, Soheil Arastehfar, Gabriel Liu
Load-displacement relationships of spinal motion segments are crucial factors in characterizing the stiffness of scoliotic spine models to mimic the spine responses to loads. Although nonlinear approach to approximation of the relationships can be superior to linear ones, little mention has been made to deriving personalized nonlinear load-displacement relationships in previous studies. A method is developed for nonlinear approximation of load-displacement relationships of spinal motion segments to assist characterizing in vivo the stiffness of spine models...
September 26, 2016: Medical & Biological Engineering & Computing
Soheil Tavakolpour, Seyed Moayed Alavian, Shahnaz Sali
BACKGROUND: Identification of effective treatments in hepatitis B virus (HBV) infection remains a controversial topic. Although the currently approved drugs for HBV control the disease's progression and also limit associated outcomes, these drugs may not fully eradicate HBV infection. In addition to better managing patients with chronic hepatitis B (CHB) infection, the induction of seroclearance by these drugs has been a commonly discussed topic in recent years. OBJECTIVES: In this study, we focused on treating CHB infection via the manipulation of T cells' responses to identify possible approaches to cure CHB...
June 2016: Hepatitis Monthly
Mahsa Mirdamadi, Besharat Rahimi, Enayat Safavi, Hamidreza Abtahi, Soheil Peiman
BACKGROUND: The precise head to head relationships between Cardio-pulmonary exercise testing (CPET) parameters and patients' daily symptoms/activities and the disease social/emotional impact are less well defined. In this study, the correlation of COPD daily symptoms and quality of life [assessed by St. George's Respiratory Questionnaire (SGRQ)] and COPD severity index (BODE-index) with CPET parameters were investigated. METHODS: Symptom-limited CPET was performed in 37 consecutive COPD (GOLD I-III) subjects during non-exacerbation phase...
August 2016: Journal of Thoracic Disease
Rahim Hobbenaghi, Paria Mahboub, Siamak Saifzadeh, Javad Javanbakht, Javad Yaghoobi Yeganeh Manesh, Rasool Mortezaee, Seyed Rashid Touni, Ehsan Hosseini, Shahin Aghajanshakeri, Milad Moloudizargari, Soheil Javaherypour
No abstract text is available yet for this article.
2016: Diagnostic Pathology
Hasti Karimi, Saeed Soleyman-Jahi, Nima Hafezi-Nejad, Afarin Rahimi-Movaghar, Masoumeh Amin-Esmaeili, Vandad Sharifi, Ahmad Hajebi, Soheil Saadat, Ali Akbari Sari, Vafa Rahimi-Movaghar
OBJECTIVES: To assess the incidence rate as well as direct and indirect costs of non-fatal road traffic injuries (RTIs) in Iran in 2011. METHODS: Data of the 2011 national household survey was used. In this survey, data on demographics, history and costs of injury were obtained in two steps; first, direct face-to-face interview and second, telephone calls. We estimated the incidence rate of non-fatal RTIs in this year. The direct costs included medical care as well as non-medical costs paid by the patient or insurance services...
August 30, 2016: Traffic Injury Prevention
Fatemeh Mehravar, Soheil Rafiee, Behnaz Bazrafshan, Mahmoud Khodadost
Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6-7 and 13-14 years in Northeast Iran. The prevalence rate was compared according to age group (aged 6-7 years vs. aged 13-14 years) and gender (male vs. female). In this cross-sectional study, 1706 Iranian schoolchildren aged 6-7 and 13-14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014...
September 2016: Frontiers of Medicine
Soheil Sabzevari, Adel Ebrahimpour, Mostafa Khalilipour Roudi, Amir R Kachooei
High tibia osteotomy is a common procedure in orthopedic surgery. A precise overview on indications, patients selection, pre-operative planning, surgical technique, methods of fixation, and complications have been presented. This paper focused on the points that should be considered to achieve good long-term outcomes.
June 2016: Archives of Bone and Joint Surgery
Sarvenaz Zand, Elizabeth Buzney, Lyn M Duncan, Soheil S Dadras
OBJECTIVES: Histologic and molecular heterogeneity is well recognized in malignant melanoma; however, the diversity of expression of new and classic melanoma markers has not been correlated in serial sections of metastases. METHODS: We examined and correlated the expression of microphthalmia transcription factor (MITF) with its transcriptional targets, including melastatin (MLSN1/TRPM1), pigment epithelium-derived factor (SERPINF1/PEDF), SILV/PMEL17/GP100 (human melanoma black 45 [HMB-45]), and melanoma antigen recognized by T cells 1 (MART-1)/MLANA, in 13 melanoma metastases in lymph nodes of 13 patients...
September 2016: American Journal of Clinical Pathology
Soheil Rastgou Talemi, Carl-Fredrik Tiger, Mikael Andersson, Roja Babazadeh, Niek Welkenhuysen, Edda Klipp, Stefan Hohmann, Jörg Schaber
Adaptation is an important property of living organisms enabling them to cope with environmental stress and maintaining homeostasis. Adaptation is mediated by signaling pathways responding to different stimuli. Those signaling pathways might communicate in order to orchestrate the cellular response to multiple simultaneous stimuli, a phenomenon called crosstalk. Here, we investigate possible mechanisms of crosstalk between the High Osmolarity Glycerol (HOG) and the Cell Wall Integrity (CWI) pathways in yeast, which mediate adaptation to hyper- and hypo-osmotic challenges, respectively...
2016: Scientific Reports
Soheil Safarian, Yadollah Azarmi, Ali Jahanban-Esfahlan, Hasan Jahanban-Esfahlan
BACKGROUND/AIM: Almond hull is produced in high amounts and mostly used as livestock feed. This study was designed to examine the impact of almond hull powder (AHP) administration on lipid profile and antioxidant activities in plasma and liver in hyperlipidemic rats. MATERIALS AND METHODS: As the first step, the antioxidant capacity and radical scavenging activity of AHP were determined using calorimetric methods. Then 36 adult male Wistar rats were randomly divided into 6 groups: group 1 with oral administration of 10% AHP, group 2 with oral administration of 20% AHP, group 3 with oral administration of 30% AHP, group 4 as a positive control with a high cholesterol diet, group 5 as a negative control with a normal diet, and group 6 as a sham group with a normal diet and 20% AHP...
2016: Turkish Journal of Medical Sciences
Ranjani Ramamurthy, Maya Hughes, Valerie Morris, Hamid Bolouri, Robert B Gerbing, Yi-Cheng Wang, Michael R Loken, Susana C Raimondi, Betsy A Hirsch, Alan S Gamis, Vivian G Oehler, Todd A Alonzo, Soheil Meshinchi
BACKGROUND: Aberrant expression of microRNA-155 (miR-155) has been implicated in acute myeloid leukemia (AML) and associated with clinical outcome. PROCEDURE: We evaluated miR-155 expression in 198 children with normal karyotype AML (NK-AML) enrolled in Children's Oncology Group (COG) AML trial AAML0531 and correlated miR-155 expression levels with disease characteristics and clinical outcome. Patients were divided into quartiles (Q1-Q4) based on miR-155 expression level, and disease characteristics were then evaluated and correlated with miR-155 expression...
August 11, 2016: Pediatric Blood & Cancer
Soheil Hor, Mehdi Moradi
Incomplete and inconsistent datasets often pose difficulties in multimodal studies. We introduce the concept of scandent decision trees to tackle these difficulties. Scandent trees are decision trees that optimally mimic the partitioning of the data determined by another decision tree, and crucially, use only a subset of the feature set. We show how scandent trees can be used to enhance the performance of decision forests trained on a small number of multimodal samples when we have access to larger datasets with vastly incomplete feature sets...
December 2016: Medical Image Analysis
Soheil Malekghasemi, Enver Kahveci, Memed Duman
A major application of microfluidic paper-based analytical devices (µPADs) includes the field of point-of-care (POC) diagnostics. It is important for POC diagnostics to possess properties such as ease-of-use and low cost. However, µPADs need multiple instruments and fabrication steps. In this study, two different chemicals (Hexamethyldisilazane and Tetra-ethylorthosilicate) were used, and three different methods (heating, plasma treatment, and microwave irradiation) were compared to develop µPADs. Additionally, an inkjet-printing technique was used for generating a hydrophilic channel and printing certain chemical agents on different regions of a modified filter paper...
October 1, 2016: Talanta
Soheil Tavakolpour
BACKGROUND: Multiple sclerosis (MS) is considered as the most common chronic inflammatory neurologic disorder diagnosed in young adults. Both environmental and genetic factors may influence risk of MS development. Interleukin 7 receptor (IL7R) is one of the most studied gene polymorphism on MS that may play a possible role in MS development. The most studied polymorphism of IL7R gene is "rs6897932" polymorphism on IL7Rα gene (IL7RA). METHODS: PubMed, Scopus, and Google scholar databases were searched for all of related studies on the association of IL7RA polymorphism with single nucleotide polymorphism (SNP) ID of "rs6897932" and the risk of MS through August 07, 2015...
July 2016: Multiple Sclerosis and related Disorders
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