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https://www.readbyqxmd.com/read/28286817/epidemiological-pattern-of-injuries-in-iran-a-nationwide-review-of-seven-million-emergency-department-admissions
#1
Mohammad Haji Aghajani, Mashyaneh Haddadi, Soheil Saadat
INTRODUCTION: Globally, it is estimated that around 5.8 million people die annually as result of injuries, which causes 10% of all deaths and 16% of disability adjusted life years lost worldwide. This study aimed to determine the epidemiology of injuries in emergency departments in Iran. METHOD: This cross sectional study was carried out using national injury surveillance data registry from 21 March 2009 to 20 March 2014. RESULTS: 7,176,344 patients with the mean age of 27...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28282213/anatomic-and-histological-investigation-of-the-anterolateral-capsular-complex-in-the-fetal-knee
#2
Soheil Sabzevari, Amir Ata Rahnemai-Azar, Marcio Albers, Monica Linde, Patrick Smolinski, Freddie H Fu
BACKGROUND: There is currently disagreement with regard to the presence of a distinct ligament in the anterolateral capsular complex of the knee and its role in the pivot-shift mechanism and rotatory laxity of the knee. PURPOSE: To investigate the anatomic and histological properties of the anterolateral capsular complex of the fetal knee to determine whether there exists a distinct ligamentous structure running from the lateral femoral epicondyle inserting into the anterolateral tibia...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28274232/perilipin-polymorphisms-are-risk-factors-for-the-development-of-obesity-in-adolescents-a-case-control-study
#3
Yavuz Tokgöz, Ishak Abdurrahman Işık, Soheil Akbari, Tuncay Kume, Oya Sayın, Esra Erdal, Nur Arslan
BACKGROUND: The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines. METHODS: A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR...
March 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28260200/increased-lateral-tibial-posterior-slope-is-related-to-tibial-tunnel-widening-after-primary-acl-reconstruction
#4
Soheil Sabzevari, Amir Ata Rahnemai-Azar, Humza S Shaikh, Justin W Arner, James J Irrgang, Freddie H Fu
PURPOSE: The purpose of the study was to determine the influence of femoral and tibial bone morphology on the amount of femoral and tibial tunnel widening after primary anatomic ACL reconstruction. It was hypothesized that tibial and femoral bone morphology would be significantly correlated with tunnel widening after anatomic ACL reconstruction. METHODS: Forty-nine consecutive patients (mean age 21.8 ± 8.1 years) who underwent primary single-bundle anatomic ACL reconstruction with hamstring autograft were enrolled...
March 4, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28259097/mammalian-target-of-rapamycin-mtor-nitric-oxide-system-possibly-modulate-antidepressant-like-effect-of-17%C3%AE-ethinyl-estradiol-in-ovariectomized-mice
#5
Seyed Soheil Saeedi Saravi, Alireza Arefidoust, Seyed Sobhan Saeedi Saravi, Rahele Yaftian, Mahdi Bayati, Milad Salehi, Ahmad Reza Dehpour
Due to a close association between depressive disorders and altered estrogen levels, this study was conducted to examine the hypothesis that antidepressant-like effect of ethinyl estradiol (EE2) in ovariectomized mice is modulated by mammalian target of rapamycin (mTOR)/nitric oxide pathways. Female mice were undergone bilateral ovariectomy and different doses of EE2 were intraperitoenally injected alone and combined with specific mTOR inhibitor, rapamycin, non-specific NOS inhibitor, L-NAME, nNOS inhibitor, 7-NI, NO precursor, l-arginine, and selective PDE5I, sildenafil...
March 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28258552/isolation-and-functional-characterization-of-a-methyl-jasmonate-responsive-3-carene-synthase-from-lavandula-x-intermedia
#6
Ayelign M Adal, Lukman S Sarker, Ashley D Lemke, Soheil S Mahmoud
A methyl jasmonate responsive 3-carene synthase (Li3CARS) gene was isolated from Lavandula x intermedia and functionally characterized in vitro. Lavenders produce essential oils consisting mainly of monoterpenes, including the potent antimicrobial and insecticidal monoterpene 3-carene. In this study we isolated and functionally characterized a leaf-specific, methyl jasmonate (MeJA)-responsive monoterpene synthase (Li3CARS) from Lavandula x intermedia. The ORF excluding transit peptides encoded a 64.9 kDa protein that was expressed in E...
March 3, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28246595/fixed-full-arches-supported-by-tapered-implants-with-knife-edge-thread-design-and-nanostructured-calcium-incorporated-surface-a-short-term-prospective-clinical-study
#7
Soheil Bechara, Algirdas Lukosiunas, Giorgio Andrea Dolcini, Ricardas Kubilius
Purpose. To evaluate implant survival, peri-implant bone loss, and complications affecting fixed full-arch (FFA) restorations supported by implants with a knife-edge thread design and nanostructured, calcium-incorporated surface. Methods. Between January 2013 and December 2015, all patients referred for implant-supported FFA restorations were considered for enrollment in this study. All patients received implants with a knife-edge thread design and nanostructured calcium-incorporated surface (Anyridge®, Megagen, South Korea) were restored with FFA restorations and enrolled in a recall program...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28241201/automated-quantification-of-the-impact-of-defects-on-the-mechanical-behavior-of-deoxyribonucleic-acid-origami-nanoplates
#8
Bowen Liang, Anand Nagarajan, Michael W Hudoba, Ricardo Alvarez, Carlos E Castro, Soheil Soghrati
Deoxyribonucleic acid (DNA) origami is a method for the bottom-up self-assembly of complex nanostructures for applications, such as biosensing, drug delivery, nanopore technologies, and nanomechanical devices. Effective design of such nanostructures requires a good understanding of their mechanical behavior. While a number of studies have focused on the mechanical properties of DNA origami structures, considering defects arising from molecular self-assembly is largely unexplored. In this paper, we present an automated computational framework to analyze the impact of such defects on the structural integrity of a model DNA origami nanoplate...
April 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28222251/prognostic-methylation-markers-for-overall-survival-in-cytogenetically-normal-patients-with-acute-myeloid-leukemia-treated-on-swog-trials
#9
Xiaoyu Qu, Megan Othus, Jerry Davison, Yu Wu, Liying Yan, Soheil Meshinchi, Fabiana Ostronoff, Elihu H Estey, Jerry P Radich, Harry P Erba, Frederick R Appelbaum, Min Fang
BACKGROUND: Aberrant DNA methylation is known to occur in patients with acute myeloid leukemia (AML), whereas methylation signatures and prognostic markers have been proposed. The objective of the current study was to evaluate all CpG sites of the genome and identify prognostic methylation markers for overall survival in patients with AML with normal karyotype (AML-NK). METHODS: AML-NK samples from 7 SWOG trials were analyzed using a novel genome-wide approach called "CHARMcox" (comprehensive high-throughput array-based relative methylation analysis combined with the Cox proportional hazards model) controlling for known clinical covariates...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28218741/identification-of-micrornas-associated-with-invasive-and-aggressive-phenotype-in-cutaneous-melanoma-by-next-generation-sequencing
#10
Sankhiros Babapoor, Rong Wu, James Kozubek, Donna Auidi, Jane M Grant-Kels, Soheil S Dadras
A comprehensive repertoire of human microRNAs (miRNAs) that could be involved in early melanoma invasion into the dermis remains unknown. To this end, we sequenced small RNAs (18-30 nucleotides) isolated from an annotated series of invasive melanomas (average invasive depth, 2.0 mm), common melanocytic nevi, and matched normal skin (n=28). Our previously established bioinformatics pipeline identified 765 distinct mature known miRNAs and defined a set of top 40 list that clearly segregated melanomas into thin (0...
February 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28217647/wound-healing-effect-of-arnebia-euchroma-gel-on-excisional-wounds-in-rats
#11
Maryam Mohsenikia, Shahrzad Khakpour, Zahra Azizian, Soheil Ashkani-Esfahani, Seyyede Tahereh Razavipour, Pooya Toghiani
BACKGROUND: Wound healing is a complex process leading to regeneration of damaged skin tissue. Arnebia euchroma (AE) have many effective activities such as anti-inflammatory, antimicrobial, antioxidative, and anti-tumoral effects. The extract of AE has positive effects on burn wounds. This study is designed to investigate the healing effects of AE on excisional wounds in rats. MATERIALS AND METHODS: Thirty six rats with the age of 8 weeks divided into three groups...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28217088/a-non-parametric-approach-to-the-overall-estimate-of-cognitive-load-using-nirs-time-series
#12
Soheil Keshmiri, Hidenobu Sumioka, Ryuji Yamazaki, Hiroshi Ishiguro
We present a non-parametric approach to prediction of the n-back n ∈ {1, 2} task as a proxy measure of mental workload using Near Infrared Spectroscopy (NIRS) data. In particular, we focus on measuring the mental workload through hemodynamic responses in the brain induced by these tasks, thereby realizing the potential that they can offer for their detection in real world scenarios (e.g., difficulty of a conversation). Our approach takes advantage of intrinsic linearity that is inherent in the components of the NIRS time series to adopt a one-step regression strategy...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28203250/the-effects-of-punica-granatum-flower-extract-on-skin-injuries-induced-by-burn-in-rats
#13
Ebrahim Nasiri, Seyed Jalal Hosseinimehr, Jafar Akbari, Mohammad Azadbakht, Soheil Azizi
Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined...
2017: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/28182308/mr-enterography-in-nonresponsive-adult-celiac-disease-correlation-with-endoscopic-pathologic-serologic-and-genetic-features
#14
Amir Reza Radmard, Amir Pejman Hashemi Taheri, Elham Salehian Nik, Soheil Kooraki, Shadi Kolahdoozan, Babak Mirminachi, Masoud Sotoudeh, Golnaz Ekhlasi, Reza Malekzadeh, Bijan Shahbazkhani
PURPOSE: To assess small bowel abnormalities on magnetic resonance enterography (MRE) in adult patients with nonresponsive celiac disease (CD) and investigate their associations with endoscopic, histopathologic, serologic, and genetic features. MATERIALS AND METHODS: This prospective study was carried out between September 2012 and August 2013. After approval by the Ethics Committee of our institution, informed consent was acquired from all participants. Forty consecutive patients with nonresponsive CD, aged 17-76 years, underwent MRE using a 1...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28119160/evaluation-of-prepulse-inhibition-and-memory-impairments-at-early-stage-of-cirrhosis-may-be-considered-as-a-diagnostic-index-for-minimal-hepatic-encephalopathy
#15
Iraj Aghaei, Seyed Soheil Saeedi Saravi, Samaneh Ghotbi Ravandi, Masoumeh Nozari, Ali Roudbari, Afshin Dalili, Mohammad Shabani, Ahmad Reza Dehpour
Minimal hepatic encephalopathy (MHE), which represents the early stage of this condition, is not clinically apparent and is prevalent in up to 80% of patients. The poor outcomes of MHE encouraged us to identify more simple methods for early diagnosis of MHE. To this purpose, we evaluated the contemporary manifestations of motor, cognitive and sensorimotor gaiting deficits following bile duct-ligation (BDL). Male Wistar rats were undergone BDL to induce cirrhosis and locomotor, spatial learning and memory and sensorimotor gating were assessed 2, 3, and 4weeks after the operation by rotarod, Morris water-maze and prepulse inhibition (PPI) tests...
January 21, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28108543/disease-characteristics-and-prognostic-implications-of-cell-surface-flt3-receptor-cd135-expression-in-pediatric-acute-myeloid-leukemia-a-report-from-the-children-s-oncology-group
#16
Katherine Tarlock, Todd A Alonzo, Michael R Loken, Robert B Gerbing, Rhonda E Ries, Richard Aplenc, Lillian Sung, Susana Raimondi, Betsy A Hirsch, Samir B Kahwash, Amy McKenney, E Anders Kolb, Alan S Gamis, Soheil Meshinchi
PURPOSE: The FLT3 cell-surface receptor tyrosine kinase (CD135) is expressed in a majority of both acute lymphoid leukemia (ALL) and myeloid leukemia (AML). However, the prognostic significance of CD135 expression in AML remains unclear. We therefore evaluated the association between FLT3 surface expression and disease characteristics and outcomes in pediatric patients with AML. EXPERIMENTAL DESIGN: We analyzed FLT3 receptor expression on AML blasts by multi-dimensional flow cytometry and its association with disease characteristics, clinical outcomes, and FLT3 transcript level in 367 children with AML treated on the Children's Oncology Group trial AAML0531...
January 20, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28104991/prevalence-of-hepatitis-c-virus-infection-among-hemodialysis-patients-in-the-middle-east-a-systematic-review-and-meta-analysis
#17
Soheil Ashkani-Esfahani, Seyed Moayed Alavian, Mohammad Salehi-Marzijarani
AIM: To determine hepatitis C virus (HCV) infection prevalence in each country of the Middle-East and the overall prevalence of the region. METHODS: In this systematic review, we gathered all documents related to HCV infection prevalence among hemodialysis patients in 17 middle-east countries from April 2006 to March 2016. We selected only cross-sectional studies that had proper sampling and measurement methods as well as a valid statistical analysis. RESULTS: After screening of 7311 documents, 56 studies were selected reporting the prevalence of HCV infection among hemodialysis patients from 10 countries of the region...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28097099/comparison-of-vitamin-d-levels-in-naive-treated-and-inactive-carriers-with-chronic-hepatitis-b-virus
#18
Shahnaz Sali, Soheil Tavakolpour, Baharan Farkhondemehr
Background and Aims: During recent years, the relationship between vitamin D levels and chronic hepatitis B (CHB) infection has attracted many researchers' attention. However, the results relating to the association of vitamin D levels and HBV infection have been conflicting and there remains a lack of knowledge about the effects of antiviral treatments on vitamin D level. Methods: Eighty-four patients with CHB were assessed and divided into three groups: inactive carriers (n = 28), treated (n = 34), and new (treatment-naïve) cases (n = 22)...
December 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28069802/genomic-profiling-of-a-large-set-of-diverse-pediatric-cancers-identifies-known-and-novel-mutations-across-tumor-spectra
#19
Juliann Chmielecki, Mark Bailey, Jie He, Julia Elvin, Jo-Anne Vergilio, Shakti Ramkissoon, James Suh, Garrett M Frampton, James X Sun, Samantha Morley, Daniel Spritz, Siraj Ali, Laurie Gay, Rachel L Erlich, Jeffrey S Ross, Joana Buxhaku, Hilary Davies, Vinny Faso, Alexis Germain, Blair Glanville, Vincent A Miller, Philip J Stephens, Katherine A Janeway, John M Maris, Soheil Meshinchi, Trevor J Pugh, Jack F Shern, Doron Lipson
Pediatric cancers are generally characterized by low mutational burden and few recurrently mutated genes. Recent studies suggest that genomic alterations may help guide treatment decisions and clinical trial selection. Here, we describe genomic profiles from 1,215 pediatric tumors representing sarcomas, extracranial embryonal tumors, brain tumors, hematologic malignancies, carcinomas, and gonadal tumors. Comparable published datasets identified similar frequencies of clinically relevant alterations, validating this dataset as biologically relevant...
January 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28060329/drug-repurposing-hypothesis-generation-using-the-re-fine-drugs-system
#20
Kelly Regan, Soheil Moosavinasab, Philip Payne, Simon Lin
The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates...
December 11, 2016: Journal of Visualized Experiments: JoVE
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