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https://www.readbyqxmd.com/read/27530507/the-dipeptidyl-peptidase-4-dpp-4-inhibitor-teneligliptin-functions-as-antioxidant-on-human-endothelial-cells-exposed-to-chronic-hyperglycemia-and-metabolic-high-glucose-memory
#1
Gemma Pujadas, Valeria De Nigris, Francesco Prattichizzo, Lucia La Sala, Roberto Testa, Antonio Ceriello
Dipeptidyl peptidase-4 inhibitors are widely used in type 2 diabetes. Endothelium plays a crucial role maintaining vascular integrity and function. Chronic exposure to high glucose drives to endothelial dysfunction generating oxidative stress. Teneligliptin is a novel dipeptidyl peptidase-4 inhibitor with antioxidant properties. This study is aimed to verify a potential protective action of teneligliptin in endothelial cells exposed to high glucose. Human umbilical vein endothelial cells were cultured under normal (5 mmol/L) or high glucose (25 mmol/L) during 21 days, or at high glucose during 14 days followed by 7 days at normal glucose, to reproduce the high-metabolic memory state...
August 16, 2016: Endocrine
https://www.readbyqxmd.com/read/27344638/biochanin-a-protects-lipopolysaccharide-d-galactosamine-induced-acute-liver-injury-in-mice-by-activating-the-nrf2-pathway-and-inhibiting-nlrp3-inflammasome-activation
#2
Xingkai Liu, Tuo Wang, Xueshibojie Liu, Lu Cai, Jun Qi, Ping Zhang, Yan Li
Biochanin A, an isoflavone existed in red clover and peanuts, has been reported to possess a wide spectrum of pharmacological activities, such as anti-inflammatory and antioxidant effects. However, the protective effects and mechanism of biochanin A on liver injury have not been reported. In this study, acute liver injury was induced by intraperitoneal injection of lipopolysaccharide (LPS) and d-galactosamine (D-GalN). Biochanin A was administrated 1h prior to LPS/D-GalN challenge. Serum ALT, AST, IL-1β, and TNF-α levels, hepatic malondialdehyde (MDA), GPx, SOD, and Catalase contents, tissue histology, IL-1β, TNF-α, NLRP3, and Nrf2 expression were detected...
September 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27274779/association-of-nuclear-factor-erythroid-2-related-factor-2-thioredoxin-interacting-protein-and-heme-oxygenase-1-gene-polymorphisms-with-diabetes-and-obesity-in-mexican-patients
#3
Angélica Saraí Jiménez-Osorio, Susana González-Reyes, Wylly Ramsés García-Niño, Hortensia Moreno-Macías, Martha Eunice Rodríguez-Arellano, Gilberto Vargas-Alarcón, Joaquín Zúñiga, Rodrigo Barquera, José Pedraza-Chaverri
UNLABELLED: The nuclear factor-erythroid 2- (NF-E2-) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress is impaired in type 2 diabetes and obesity. Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects. The rs1800566 of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene, rs7211 of thioredoxin interacting protein (TXNIP) gene, rs2071749 of heme oxygenase-1 (HMOX1) gene, and the rs6721961 and the rs2364723 from Nrf2 gene were genotyped in 627 diabetic subjects and 1020 controls...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26390842/curcumin-alleviated-the-toxic-reaction-of-rhizoma-paridis-saponins-in-a-45-day-subchronic-toxicological-assessment-of-rats
#4
Shuli Man, Jing Li, Jing Liu, Hongyan Chai, Zhen Liu, Jiaming Wang, Wenyuan Gao
Rhizoma Paridis saponins (RPS), as steroid saponins, are the main components in Paris polyphylla. Curcumin (diferuloylmethane) is the most important component in the spice turmeric. In our previous research, RPS exhibited side effects such as nausea, vomiting, diarrhea, and so forth. Combination with curcumin not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumor cells and enhanced their anticancer effect. This study evaluated subchronic toxicity of 45(th) dietary of RPS and curcumin on histopathology, biochemistry, and antioxidant index...
September 22, 2015: Environmental Toxicology
https://www.readbyqxmd.com/read/26073328/the-edaravone-and-3-n-butylphthalide-ring-opening-derivative-10b-effectively-attenuates-cerebral-ischemia-injury-in-rats
#5
Kai Hua, Xiao Sheng, Ting-ting Li, Lin-na Wang, Yi-hua Zhang, Zhang-jian Huang, Hui Ji
AIM: Compound 10b is a hybrid molecule of edaravone and a ring-opening derivative of 3-n-butylphthalide (NBP). The aim of this study was to examine the effects of compound 10b on brain damage in rats after focal cerebral ischemia. METHODS: SD rats were subjected to 2-h-middle cerebral artery occlusion (MCAO). At the onset of reperfusion, the rats were orally treated with NBP (60 mg/kg), edaravone (3 mg/kg), NBP (60 mg/kg)+edaravone (3 mg/kg), or compound 10b (70, 140 mg/kg)...
August 2015: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/22869588/redox-regulation-by-nuclear-factor-erythroid-2-related-factor-2-gatekeeping-for-the-basal-and-diabetes-induced-expression-of-thioredoxin-interacting-protein
#6
Xiaoqing He, Qiang Ma
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor activated by a range of oxidants and electrophiles. The transcriptional response to endogenous oxidative cues by Nrf2 plays an important role in mammalian redox physiology and oxidative pathology. Hyperglycemia induces oxidative stress in the heart where it leads to apoptosis and ultimately cardiomyopathy. Here we investigated the mechanism by which Nrf2 suppresses oxidative stress in diabetic mouse heart. Knockout (KO) of Nrf2 induced oxidative stress and apoptosis in KO heart; diabetes further increased oxidative damage...
November 2012: Molecular Pharmacology
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