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https://www.readbyqxmd.com/read/27874299/cooling-effectiveness-of-a-modified-cold-water-immersion-method-after-exercise-induced-hyperthermia
#1
Katherine E Luhring, Cory L Butts, Cody R Smith, Jeffrey A Bonacci, Ramon C Ylanan, Matthew S Ganio, Brendon P McDermott
CONTEXT:  Recommended treatment for exertional heat stroke includes whole-body cold-water immersion (CWI). However, remote locations or monetary or spatial restrictions can challenge the feasibility of CWI. Thus, the development of a modified, portable CWI method would allow for optimal treatment of exertional heat stroke in the presence of these challenges. OBJECTIVE:  To determine the cooling rate of modified CWI (tarp-assisted cooling with oscillation [TACO]) after exertional hyperthermia...
November 22, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27869624/surgical-outcome-and-prognostic-analysis-of-transoral-atlantoaxial-reduction-plate-system-for-basilar-invagination-a-voxel-based-morphometry-study
#2
Gejin Wei, Chenglong Shi, Zhiyun Wang, Hong Xia, Qingshui Yin, Zenghui Wu
BACKGROUND: The use of a transoral atlantoaxial reduction plate (TARP) system is an effective surgical approach for the treatment of basilar invagination. With the aim of improving the therapeutic efficacy of the TARP operation, we conducted a voxel-based morphometric study to quantitatively investigate the descent of the odontoid process and craniocervical volume changes. METHODS: We enrolled 20 patients with basilar invagination who underwent a TARP procedure...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27865532/tarp-assisted-cooling-as-a-method-of-whole-body-cooling-in-hyperthermic-individuals
#3
Yuri Hosokawa, William M Adams, Luke N Belval, Lesley W Vandermark, Douglas J Casa
STUDY OBJECTIVE: We investigated the efficacy of tarp-assisted cooling as a body cooling modality. METHODS: Participants exercised on a motorized treadmill in hot conditions (ambient temperature 39.5°C [103.1°F], SD 3.1°C [37.58°F]; relative humidity 38.1% [SD 6.7%]) until they reached exercise-induced hyperthermia. After exercise, participants were cooled with either partial immersion by the tarp-assisted cooling method (water temperature 9.20°C [48.56°F], SD 2...
November 4, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27820603/forebrain-selective-ampa-receptor-antagonism-guided-by-tarp-%C3%AE-8-as-an-antiepileptic-mechanism
#4
Akihiko S Kato, Kevin D Burris, Kevin M Gardinier, Douglas L Gernert, Warren J Porter, Jon Reel, Chunjin Ding, Yuan Tu, Douglas A Schober, Matthew R Lee, Beverly A Heinz, Thomas E Fitch, Scott D Gleason, John T Catlow, Hong Yu, Stephen M Fitzjohn, Francesca Pasqui, He Wang, Yuewei Qian, Emanuele Sher, Ruud Zwart, Keith A Wafford, Kurt Rasmussen, Paul L Ornstein, John T R Isaac, Eric S Nisenbaum, David S Bredt, Jeffrey M Witkin
Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Although efficacious, AMPA-receptor antagonists, including perampanel (Fycompa), the only approved antagonist for epilepsy, induce dizziness and motor impairment. We hypothesized that blockade of forebrain AMPA receptors without blocking cerebellar AMPA receptors would be antiepileptic and devoid of motor impairment...
December 2016: Nature Medicine
https://www.readbyqxmd.com/read/27796133/vertical-transmission-of-hepatitis-b-virus-during-pregnancy-and-delivery-in-denmark
#5
Nina Weis, Susan Cowan, Sofie Hallager, Sandra Dröse, Lena Hagelskjær Kristensen, Karin Grønbæk, Jan Gerstoft, Lone G Madsen, Mette Rye Clausen, Suzanne Lunding, Britta D Tarp, Toke S Barfod, Stine Sloth, Dorte Kinggaard Holm, Jesper Jensen, Henrik Krarup
OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission...
October 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27775461/effect-of-a-treat-to-target-cyclosporin-on-mri-assessed-synovitis-osteitis-tenosynovitis-bone-erosion-and-joint-space-narrowing-in-early-rheumatoid-arthritis-results-from-a-2-year-randomized-double-blind
#6
S Møller-Bisgaard, B J Ejbjerg, I Eshed, K Hørslev-Petersen, M L Hetland, A G Jurik, H Thomsen, T Torfing, K Stengaard-Pedersen, P Junker, N S Krogh, T Lottenburger, T Ellingsen, L S Andersen, H Skjødt, A J Svendsen, U Tarp, I T Hansen, J Pødenphant, J K Pedersen, H Lindegaard, L G Hanson, A Vestergaard, D Glinatsi, M Østergaard
OBJECTIVES: To investigate whether a treat-to-target strategy based on methotrexate (MTX) and intra-articular (IA) betamethasone suppresses magnetic resonance imaging (MRI)-determined measures of disease activity and reduces joint destruction in early rheumatoid arthritis (eRA) patients, and to investigate whether concomitant cyclosporin A (CyA) provides an additional effect. METHOD: In the 2-year randomized, double-blind, treat-to-target trial CIMESTRA, 160 patients with eRA (< 6 months) were randomized to MTX, intra-articular betamethasone and CyA, or placebo CyA...
October 24, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27769592/defining-the-optimal-biological-monotherapy-in-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomised-trials
#7
Simon Tarp, Daniel E Furst, Anna Dossing, Mikkel Østergaard, Tove Lorenzen, Michael S Hansen, Jasvinder A Singh, Ernest H Choy, Maarten Boers, Maria E Suarez-Almazor, Lars E Kristensen, Henning Bliddal, Robin Christensen
OBJECTIVES: To summarize and compare the benefits and harms of biological agents used as monotherapy for rheumatoid arthritis (RA) in order to inform decisions for patients who are intolerant to conventional DMARD therapy. METHODS: We searched MEDLINE, EMBASE, CENTRAL, and other sources for randomised trials that compared biological monotherapy with methotrexate, placebo, or other biological monotherapies. Primary outcomes were ACR50 and the number of patients who discontinued due to adverse events...
September 14, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27763814/the-rna-binding-landscape-of-rbm10-and-its-role-in-alternative-splicing-regulation-in-models-of-mouse-early-development
#8
Julie Rodor, David R FitzPatrick, Eduardo Eyras, Javier F Cáceres
Mutations in the RNA-binding protein, RBM10, result in a human syndromic form of cleft palate, termed TARP syndrome. A role for RBM10 in alternative splicing regulation has been previously demonstrated in human cell lines. To uncover the cellular functions of RBM10 in a cell line that is relevant to the phenotype observed in TARP syndrome, we used iCLIP to identify its endogenous RNA targets in a mouse embryonic mandibular cell line. We observed that RBM10 binds to pre-mRNAs with significant enrichment in intronic regions, in agreement with a role for this protein in pre-mRNA splicing...
October 20, 2016: RNA Biology
https://www.readbyqxmd.com/read/27752074/synaptic-plasticity-tarp-target
#9
Sian Lewis
No abstract text is available yet for this article.
October 18, 2016: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/27622067/tarp-vaccination-is-associated-with-slowing-in-psa-velocity-and-decreasing-tumor-growth-rates-in-patients-with-stage-d0-prostate-cancer
#10
Lauren V Wood, Antonio Fojo, Brenda D Roberson, Meghan S B Hughes, William Dahut, James L Gulley, Ravi A Madan, Philip M Arlen, Marianna Sabatino, David F Stroncek, Luciano Castiello, Jane B Trepel, Min-Jung Lee, Howard L Parnes, Seth M Steinberg, Masaki Terabe, Julia Wilkerson, Ira Pastan, Jay A Berzofsky
T-cell receptor alternate reading frame protein (TARP) is a 58-residue protein over-expressed in prostate and breast cancer. We investigated TARP peptide vaccination's impact on the rise in PSA (expressed as Slope Log(PSA) or PSA Doubling Time (PSADT)), validated tumor growth measures, and tumor growth rate in men with Stage D0 prostate cancer. HLA-A*0201 positive men were randomized to receive epitope-enhanced (29-37-9V) and wild-type (27-35) TARP peptides administered as a Montanide/GM-CSF peptide emulsion or as an autologous peptide-pulsed dendritic cell vaccine every 3 weeks for a total of five vaccinations with an optional 6th dose of vaccine at 36 weeks based on immune response or PSADT criteria with a booster dose of vaccine for all patients at 48 and 96 weeks...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27602332/targeted-disruption-of-chlamydia-trachomatis-invasion-by-in-trans-expression-of-dominant-negative-tarp-effectors
#11
Christopher J Parrett, Robert V Lenoci, Brenda Nguyen, Lauren Russell, Travis J Jewett
Chlamydia trachomatis invasion of eukaryotic host cells is facilitated, in part, by the type III secreted effector protein, Tarp. The role of Tarp in chlamydiae entry of host cells is supported by molecular approaches that examined recombinant Tarp or Tarp effectors expressed within heterologous systems. A major limitation in the ability to study the contribution of Tarp to chlamydial invasion of host cells was the prior absence of genetic tools for chlamydiae. Based on our knowledge of Tarp domain structure and function along with the introduction of genetic approaches in C...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27595750/culture-independent-genomic-characterisation-of-candidatus-chlamydia-sanzinia-a-novel-uncultivated-bacterium-infecting-snakes
#12
Alyce Taylor-Brown, Nathan L Bachmann, Nicole Borel, Adam Polkinghorne
BACKGROUND: Recent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement for culturing. We recently identified a range of novel uncultured chlamydiae in captive snakes in Switzerland, however, nothing is known about their biology. Using a metagenomics approach, the aim of this study was to characterise the genome of a novel chlamydial taxon from the choana of a captive snake...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27528545/reply-to-a-comment-on-discovery-and-characterization-of-ampa-receptor-modulators-selective-for-tarp-%C3%AE-8
#13
Michael P Maher, Michael K Ameriks, Brad M Savall, Nicholas I Carruthers, Timothy W Lovenberg
No abstract text is available yet for this article.
September 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27528544/a-comment-on-discovery-and-characterization-of-ampa-receptor-modulators-selective-for-tarp-%C3%AE-8
#14
Jeffrey M Witkin, Kevin M Gardinier
No abstract text is available yet for this article.
September 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27460575/-intubationskr%C3%A3-vende-facial-erysipelas
#15
Mads Karlsson, Britta Tarp
No abstract text is available yet for this article.
July 25, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27454049/structural-biology-of-glutamate-receptor-ion-channel-complexes
#16
Mark L Mayer
Chemical transmission at excitatory synapses in the brain is mediated by a diverse family of glutamate receptor ion channels (iGluRs), tetrameric membrane protein assemblies of molecular weight 400-600kDa. Until recently, structural information for intact iGluRs was limited to biochemically tractable homomeric receptors trapped in different conformational states. These provided key insights into the mechanisms of iGluR activation and desensitization. Structures of heteromeric AMPA and NMDA receptors, the major iGluR families in the brain, together with long awaited cryo-EM structures of an AMPA receptor TARP complex, expand this picture and reveal surprising conformational diversity, raising many fundamental and controversial questions...
July 22, 2016: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/27411667/avidity-characterization-of-genetically-engineered-t-cells-with-novel-and-established-approaches
#17
Victoria Hillerdal, Vanessa F Boura, Hanna Björkelund, Karl Andersson, Magnus Essand
BACKGROUND: Adoptive transfer of genetically engineered autologous T-cells is becoming a successful therapy for cancer. The avidity of the engineered T-cells is of crucial importance for therapy success. We have in the past cloned a T-cell receptor (TCR) that recognizes an HLA-A2 (MHC class I)-restricted peptide from the prostate and breast cancer- associated antigen TARP. Herein we perform a side-by-side comparison of the TARP-specific TCR (TARP-TCR) with a newly cloned TCR specific for an HLA-A2-restricted peptide from the cytomegalovirus (CMV) pp65 antigen...
2016: BMC Immunology
https://www.readbyqxmd.com/read/27403474/measuring-quality-of-care-in-the-context-of-sustainable-development-goal-3-a-call-for-papers
#18
EDITORIAL
Yoko Akachi, Finn Tarp, Edward Kelley, Tony Addisona, Margaret E Kruk
No abstract text is available yet for this article.
March 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27400529/-on-orbit-multispectral-sensor-characterization-based-on-spectral-tarps
#19
Xin Li, Li-ming Zhang, Hong-yao Chen, Wei-wei Xu
The multispectral remote sensing technology has been a primary means in the research of biomass monitoring, climate change, disaster prediction and etc. The spectral sensitivity is essential in the quantitative analysis of remote sensing data. When the sensor is running in the space, it will be influenced by cosmic radiation, severe change of temperature, chemical molecular contamination, cosmic dust and etc. As a result, the spectral sensitivity will degrade by time, which has great implication on the accuracy and consistency of the physical measurements...
March 2016: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/27368747/influence-of-variation-in-molar-ratio-on-co-amorphous-drug-amino-acid-systems
#20
Katrine Tarp Jensen, Flemming Hofmann Larsen, Korbinian Löbmann, Thomas Rades, Holger Grohganz
Molecular interactions were investigated within four different co-amorphous drug-amino acid systems, namely indomethacin-tryptophan (Ind-Trp), furosemide-tryptophan (Fur-Trp), indomethacin-arginine (Ind-Arg) and furosemide-arginine (Fur-Arg). The co-amorphous systems were prepared by ball milling for 90min at different molar ratios and analyzed by XRPD and DSC. Interactions within the co-amorphous samples were evaluated based on the deviation between the actual glass transition temperature (Tg) and the theoretical Tg calculated by the Gordon-Taylor equation...
October 2016: European Journal of Pharmaceutics and Biopharmaceutics
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