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https://www.readbyqxmd.com/read/28294602/surface-cleaning-and-disinfection-efficacy-assessment-of-four-chlorine-types-using-e-coli-and-the-ebola-surrogate-phi6
#1
Karin Gallandat, Marlene K Wolfe, Daniele S Lantagne
In the 2014 West African Ebola outbreak, international organizations provided conflicting recommendations for disinfecting surfaces contaminated by uncontrolled patient spills. We compared the efficacy of four chlorine solutions (sodium hypochlorite, sodium dichloroisocyanurate, high-test hypochlorite, and generated hypochlorite) for disinfection of three surface types (stainless steel, heavy duty tarp, and nitrile), with and without pre-cleaning practices (pre-wiping and/or covering) and soil load. The test organisms were E...
March 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28279361/tarps-and-ampa-receptors-function-follows-form
#2
James E Huettner
In this issue of Neuron, Ben-Yaacov et al. (2017) dissect the interaction between AMPA receptors and auxiliary (TARP) subunits, revealing essential roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellular EX2 loop.
March 8, 2017: Neuron
https://www.readbyqxmd.com/read/28262796/dynamics-of-cancerous-tissue-correlates-with-invasiveness
#3
Ann-Katrine Vransø West, Lena Wullkopf, Amalie Christensen, Natascha Leijnse, Jens Magelund Tarp, Joachim Mathiesen, Janine Terra Erler, Lene Broeng Oddershede
Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259844/cyanotic-congenital-heart-disease-and-atherosclerosis
#4
REVIEW
Julie Bjerre Tarp, Annette Schophuus Jensen, Thomas Engstrøm, Niels-Henrik Holstein-Rathlou, Lars Søndergaard
Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis...
March 4, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28258844/temporal-changes-of-new-onset-atrial-fibrillation-in-patients-randomized-to-surgical-or-transcatheter-aortic-valve-replacement
#5
Troels Højsgaard Jørgensen, Hans Gustav Hørsted Thyregod, Julie Bjerre Tarp, Jesper Hastrup Svendsen, Lars Søndergaard
BACKGROUND: Temporal development of new-onset atrial fibrillation (NOAF) after aortic valve replacement is unclear, and opportunistic screening has limited diagnostic accuracy. This is the first study to investigate the incidence and temporal development of NOAF detected by implantable loop recorder (ILR) in patients with aortic stenosis, randomized to surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). METHOD: An ILR was implanted in a subgroup of patients without pre-procedural atrial fibrillation (AF), randomized to SAVR or TAVR in the NOTION trial...
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28240629/commentary-on-response-to-a-troubled-asset-relief-program-for-the-patient-centered-medical-home-tarp-or-the-new-deal-the-case-for-medical-home-repairs
#6
Foster Gesten
No abstract text is available yet for this article.
April 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28240627/a-troubled-asset-relief-program-for-the-patient-centered-medical-home
#7
John Wasson
The patient-centered medical home (PCMH) costs a lot to build and maintain. Deficiencies have become apparent: it has provided few of its advertised benefits and is becoming a troubled asset. A troubled asset relief program for the PCHM is needed (PCMH-TARP). This report presents a PCMH-TARP that places patients' interests first. The PCMH-TARP addresses regulatory barriers and greatly simplifies the complexity of the PCMH blueprint. A disruptively renovated PCMH will stand on a foundation of measures that matter to patients...
April 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28238551/molecular-mechanism-of-ampa-receptor-modulation-by-tarp-stargazin
#8
Anat Ben-Yaacov, Moshe Gillor, Tomer Haham, Alon Parsai, Mohammad Qneibi, Yael Stern-Bach
AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain and critically contribute to synaptic plasticity and pathology. AMPAR trafficking and gating are tightly controlled by auxiliary transmembrane AMPAR regulatory proteins (TARPs). Here, using systematic domain swaps with the TARP-insensitive kainate receptor GluK2, we show that AMPAR interaction with the prototypical TARP stargazin/γ2 primarily involves the AMPAR membrane domains M1 and M4 of neighboring subunits, initiated or stabilized by the AMPAR C-tail, and that these interactions are sufficient to enable full receptor modulation...
February 17, 2017: Neuron
https://www.readbyqxmd.com/read/28219485/acute-antipsychotic-treatment-of-children-and-adolescents-with-schizophrenia-spectrum-disorders-a-systematic-review-and-network-meta-analysis
#9
REVIEW
Anne Katrine Pagsberg, Simon Tarp, Dorte Glintborg, Anne Dorte Stenstrøm, Anders Fink-Jensen, Christoph Ulrich Correll, Robin Christensen
OBJECTIVE: To determine the comparative efficacy and safety of antipsychotics for youth with early-onset schizophrenia using network meta-analytic methods combining direct and indirect trial data. METHOD: The authors systematically searched MEDLINE, the Cochrane Library, and clinicaltrials.gov and selected randomized controlled trials allocating youth with schizophrenia spectrum disorders to a (non-clozapine) antipsychotic versus placebo or another antipsychotic...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28157851/cp-tensor-based-compression-of-hyperspectral-images
#10
Leyuan Fang, Nanjun He, Hui Lin
In this paper, an effective CANDECOMP/PARAFAC tensor-based compression (CPTBC) approach is proposed for on-ground hyperspectral images (HSIs). By considering the observed HSI cube as a whole three-order tensor, the proposed CPTBC method utilizes the CANDECOMP/PARAFAC tensor decomposition to decompose the original HSI data into the sum of R rank-1 tensors, which can simultaneously exploit both the spatial and spectral information of HSIs. Specifically, compared with the original HSI data, the R rank-1 tensors have fewer non-zero entries...
February 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28153567/elevated-tarp-promotes-proliferation-and-metastasis-of-salivary-adenoid-cystic-carcinoma
#11
Haitang Yue, Yu Cai, Yaling Song, Liuyan Meng, Xinming Chen, Mingwei Wang, Zhuan Bian, Rong Wang
OBJECTIVE: This study aims to analyze the expression of T-cell receptor γ chain alternate reading frame protein (TARP) in salivary adenoid cystic carcinoma (SACC) and its distant metastases and to investigate its influences on the development and progression of SACC. STUDY DESIGN: TARP expression was analyzed in 50 primary SACCs, 13 specimens of metastatic adenoid cystic carcinoma of salivary gland origin, and 20 noncancerous tissues around SACC via immunohistochemistry...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28135041/inflammatory-bowel-disease-and-venous-thromboembolism-during-pregnancy-and-the-postpartum-period
#12
A T Hansen, R Erichsen, E Horváth-Puhó, H T Sørensen
Essentials Risk of pregnancy-related venous thromboembolism may be increased in inflammatory bowel disease. We performed a study on inflammatory bowel disease and pregnancy-related venous thromboembolism. Inflammatory bowel disease is a risk factor for pregnancy-related venous thromboembolism. Proper disease control before conception is pivotal to avoid venous thromboembolism. SUMMARY: Background The incidence of inflammatory bowel disease (IBD) increases, and thus is more common, in pregnant women...
January 30, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28112485/patients-in-haemodialysis-experienced-uraemic-pruritus-as-a-dual-phenomenon
#13
Helene Tarp, Malene Bonde-Petersen, Jeanette Finderup
BACKGROUND: Uraemic pruritus (UP) is one of the most frequent symptoms for patients in haemodialysis. Studies show that UP decreases quality of life including sleep. Patients find it difficult to describe the symptoms of UP to healthcare professionals. OBJECTIVES: To explore how patients in haemodialysis experience the phenomenon of UP. METHODS: A qualitative phenomenological-hermeneutic framework was used. Fifteen semi-structured interviews were undertaken at a Danish university hospital in November 2015...
March 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28112333/-chlamydia-trachomatis-infection-in-patients-of-a-health-institution-of-bogota-and-medellin-2012-2015
#14
Jaiberth Antonio Cardona-Arias, Luz Helena Gallego-Atehortúa, Leonardo Alberto Ríos-Osorio
INTRODUCTION: Chlamydia trachomatis presents clinical consequences and it is barely studied in Colombia. OBJECTIVE: To compare the C. trachomatis infection in Bogotá and Medellín with specific frequencies by gender and age group, between 2012-2015. METHODS: Descriptive study of multiple groups, with 1,660 people in Bogotá and 1,087 in Medellin. Anti-Chlamydia trachomatis test with recombinant antigens MOMP, TARP and CPAF was applied; 100% sensitivity and 99...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28099766/high-salinity-relaying-to-reduce-vibrio-parahaemolyticus-and-vibrio-vulnificus-in-chesapeake-bay-oysters-crassostrea-virginica
#15
Salina Parveen, Michael Jahncke, Sara Elmahdi, Helen Crocker, John Bowers, Chanelle White, Stephanie Gray, Amanda C Morris, Kathy Brohawn
Cases of Vibrio infections in the United States have tripled from 1996 to 2009 and these infections are most often associated with the consumption of seafood, particularly oysters (Crassostrea virginica). Information is needed on how to reduce numbers of Vibrio parahaemolyticus and Vibrio vulnificus in bi-valve molluscan shellfish (for example, oysters). The purpose of this study was to evaluate the effectiveness of high salinity relaying or treatment in recirculating aquaculture systems (RASs) as methods to reduce the abundance of V...
January 18, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28073842/expression-of-cd14-il-10-and-tolerogenic-signature-in-dendritic-cells-inversely-correlate-with-response-to-tarp-vaccination-in-prostate-cancer-patients
#16
Luciano Castiello, Marianna Sabatino, Jiaqiang Ren, Masaki Terabe, Hanh Khuu, Lauren V Wood, Jay A Berzofsky, David F Stroncek
PURPOSE: Despite the vast number of clinical trials conducted so far, Dendritic cell (DC)-based cancer vaccines have mostly shown unsatisfactory results. Factors and manufacturing procedures essential for these therapeutics to induce effective anti-tumor immune responses have yet to be fully characterized. We here aimed to identify DC markers correlating with clinical and immunological response in a prostate carcinoma vaccination regimen. EXPERIMENTAL DESIGN: We performed an extensive characterization of DCs used to vaccinate 18 prostate carcinoma patients enrolled in a pilot trial of TCR gamma alternate reading frame protein (TARP) peptide vaccination (NCT00908258)...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28067815/marine-oil-supplements-for-arthritis-pain-a-systematic-review-and-meta-analysis-of-randomized-trials
#17
REVIEW
Ninna K Senftleber, Sabrina M Nielsen, Jens R Andersen, Henning Bliddal, Simon Tarp, Lotte Lauritzen, Daniel E Furst, Maria E Suarez-Almazor, Anne Lyddiatt, Robin Christensen
Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of all marine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis...
January 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28056115/a-tiered-approach-to-retinopathy-of-prematurity-screening-tarp-using-a-weight-gain-predictive-model-and-a-telemedicine-system
#18
Jaclyn Gurwin, Lauren A Tomlinson, Graham E Quinn, Gui-Shuang Ying, Agnieshka Baumritter, Gil Binenbaum
Importance: The Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study telemedicine system of remote fundus image grading and The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP-ROP) postnatal weight gain predictive model are 2 approaches for improving ROP screening efficiency. Current screening has low specificity for severe ROP. Objective: To describe a tiered approach to ROP screening (TARP) for identifying children who develop severe ROP using telemedicine and a predictive model synergistically...
January 5, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28027935/cross-sectional-associations-of-objectively-measured-physical-activity-with-brain-derived-neurotrophic-factor-in-adolescents
#19
Tao Huang, Anne Kær Gejl, Jakob Tarp, Lars Bo Andersen, Lone Peijs, Anna Bugge
OBJECTIVE: The purpose of this study was to examine the associations between objectively measured physical activity and serum brain-derived neurotrophic factor (BDNF) in adolescents. METHODS: Cross-sectional analyses were performed using data from 415 adolescents who participated in the 2015 follow-up of the Childhood Health Activity and Motor Performance School Study Denmark (the CHAMPS-study DK). Physical activity was objectively measured by accelerometry monitors...
December 24, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28013201/risk-of-serious-adverse-effects-of-biological-and-targeted-drugs-in-patients-with-rheumatoid-arthritis-a-systematic-review-meta-analysis
#20
Simon Tarp, Daniel Eric Furst, Maarten Boers, George Luta, Henning Bliddal, Ulrik Tarp, Karsten Heller Asmussen, Birgitte Brock, Anna Dossing, Tanja Schjødt Jørgensen, Steffen Thirstrup, Robin Christensen
OBJECTIVES: To determine possible differences in serious adverse effects among the 10 currently approved biological and targeted synthetic DMARDs (b/ts-DMARDs) for RA. METHODS: Systematic review in bibliographic databases, trial registries and websites of regulatory agencies identified randomized trials of approved b/ts-DMARDs for RA. Network meta-analyses using mixed-effects Poisson regression models were conducted to calculate rate ratios for serious adverse events (SAEs) and deaths between each of the 10 drugs and control (i...
December 24, 2016: Rheumatology
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