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https://www.readbyqxmd.com/read/28219485/acute-antipsychotic-treatment-of-children-and-adolescents-with-schizophrenia-spectrum-disorders-a-systematic-review-and-network-meta-analysis
#1
REVIEW
Anne Katrine Pagsberg, Simon Tarp, Dorte Glintborg, Anne Dorte Stenstrøm, Anders Fink-Jensen, Christoph Ulrich Correll, Robin Christensen
OBJECTIVE: To determine the comparative efficacy and safety of antipsychotics for youth with early-onset schizophrenia using network meta-analytic methods combining direct and indirect trial data. METHOD: The authors systematically searched MEDLINE, the Cochrane Library, and clinicaltrials.gov and selected randomized controlled trials allocating youth with schizophrenia spectrum disorders to a (non-clozapine) antipsychotic versus placebo or another antipsychotic...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28157851/cp-tensor-based-compression-of-hyperspectral-images
#2
Leyuan Fang, Nanjun He, Hui Lin
In this paper, an effective CANDECOMP/PARAFAC tensor-based compression (CPTBC) approach is proposed for on-ground hyperspectral images (HSIs). By considering the observed HSI cube as a whole three-order tensor, the proposed CPTBC method utilizes the CANDECOMP/PARAFAC tensor decomposition to decompose the original HSI data into the sum of R rank-1 tensors, which can simultaneously exploit both the spatial and spectral information of HSIs. Specifically, compared with the original HSI data, the R rank-1 tensors have fewer non-zero entries...
February 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28153567/elevated-tarp-promotes-proliferation-and-metastasis-of-salivary-adenoid-cystic-carcinoma
#3
Haitang Yue, Yu Cai, Yaling Song, Liuyan Meng, Xinming Chen, Mingwei Wang, Zhuan Bian, Rong Wang
OBJECTIVE: This study aims to analyze the expression of T-cell receptor γ chain alternate reading frame protein (TARP) in salivary adenoid cystic carcinoma (SACC) and its distant metastases and to investigate its influences on the development and progression of SACC. STUDY DESIGN: TARP expression was analyzed in 50 primary SACCs, 13 specimens of metastatic adenoid cystic carcinoma of salivary gland origin, and 20 noncancerous tissues around SACC via immunohistochemistry...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28135041/inflammatory-bowel-disease-and-venous-thromboembolism-during-pregnancy-and-the-postpartum-period
#4
Anette Tarp Hansen, Rune Erichsen, Erzsébet Horváth-Puhó, Henrik Toft Sørensen
BACKGROUND: The incidence of inflammatory bowel disease (IBD) increases, thus becoming more common also among pregnant women. IBD is a risk factor for venous thromboembolism (VTE), but it is not clear whether IBD infers an excess risk of VTE during pregnancy and the postpartum period. METHODS: A nationwide population-based cohort study of all deliveries during 1980-2013 in Denmark, using data from two nationwide health registries: the Danish National Patient Registry and the Medical Birth Registry...
January 30, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28112485/patients-in-haemodialysis-experienced-uraemic-pruritus-as-a-dual-phenomenon
#5
Helena Tarp, Malene Bonde-Petersen, Jeanette Finderup
BACKGROUND: Uraemic pruritus (UP) is one of the most frequent symptoms for patients in haemodialysis. Studies show that UP decreases quality of life including sleep. Patients find it difficult to describe the symptoms of UP to healthcare professionals. OBJECTIVES: To explore how patients in haemodialysis experience the phenomenon of UP. METHODS: A qualitative phenomenological-hermeneutic framework was used. Fifteen semi-structured interviews were undertaken at a Danish university hospital in November 2015...
January 23, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28112333/-chlamydia-trachomatis-infection-in-patients-of-a-health-institution-of-bogota-and-medellin-2012-2015
#6
Jaiberth Antonio Cardona-Arias, Luz Helena Gallego-Atehortúa, Leonardo Alberto Ríos-Osorio
INTRODUCTION: Chlamydia trachomatis presents clinical consequences and it is barely studied in Colombia. OBJECTIVE: To compare the C. trachomatis infection in Bogotá and Medellín with specific frequencies by gender and age group, between 2012-2015. METHODS: Descriptive study of multiple groups, with 1,660 people in Bogotá and 1,087 in Medellin. Anti-Chlamydia trachomatis test with recombinant antigens MOMP, TARP and CPAF was applied; 100% sensitivity and 99...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28099766/high-salinity-relaying-to-reduce-vibrio-parahaemolyticus-and-vibrio-vulnificus-in-chesapeake-bay-oysters-crassostrea-virginica
#7
Salina Parveen, Michael Jahncke, Sara Elmahdi, Helen Crocker, John Bowers, Chanelle White, Stephanie Gray, Amanda C Morris, Kathy Brohawn
Cases of Vibrio infections in the United States have tripled from 1996 to 2009 and these infections are most often associated with the consumption of seafood, particularly oysters (Crassostrea virginica). Information is needed on how to reduce numbers of Vibrio parahaemolyticus and Vibrio vulnificus in bi-valve molluscan shellfish (for example, oysters). The purpose of this study was to evaluate the effectiveness of high salinity relaying or treatment in recirculating aquaculture systems (RASs) as methods to reduce the abundance of V...
January 18, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28073842/expression-of-cd14-il-10-and-tolerogenic-signature-in-dendritic-cells-inversely-correlate-with-response-to-tarp-vaccination-in-prostate-cancer-patients
#8
Luciano Castiello, Marianna Sabatino, Jiaqiang Ren, Masaki Terabe, Hanh Khuu, Lauren V Wood, Jay A Berzofsky, David F Stroncek
PURPOSE: Despite the vast number of clinical trials conducted so far, Dendritic cell (DC)-based cancer vaccines have mostly shown unsatisfactory results. Factors and manufacturing procedures essential for these therapeutics to induce effective anti-tumor immune responses have yet to be fully characterized. We here aimed to identify DC markers correlating with clinical and immunological response in a prostate carcinoma vaccination regimen. EXPERIMENTAL DESIGN: We performed an extensive characterization of DCs used to vaccinate 18 prostate carcinoma patients enrolled in a pilot trial of TCR gamma alternate reading frame protein (TARP) peptide vaccination (NCT00908258)...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28067815/marine-oil-supplements-for-arthritis-pain-a-systematic-review-and-meta-analysis-of-randomized-trials
#9
REVIEW
Ninna K Senftleber, Sabrina M Nielsen, Jens R Andersen, Henning Bliddal, Simon Tarp, Lotte Lauritzen, Daniel E Furst, Maria E Suarez-Almazor, Anne Lyddiatt, Robin Christensen
Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of all marine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis...
January 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28056115/a-tiered-approach-to-retinopathy-of-prematurity-screening-tarp-using-a-weight-gain-predictive-model-and-a-telemedicine-system
#10
Jaclyn Gurwin, Lauren A Tomlinson, Graham E Quinn, Gui-Shuang Ying, Agnieshka Baumritter, Gil Binenbaum
Importance: The Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study telemedicine system of remote fundus image grading and The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP-ROP) postnatal weight gain predictive model are 2 approaches for improving ROP screening efficiency. Current screening has low specificity for severe ROP. Objective: To describe a tiered approach to ROP screening (TARP) for identifying children who develop severe ROP using telemedicine and a predictive model synergistically...
January 5, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28027935/cross-sectional-associations-of-objectively-measured-physical-activity-with-brain-derived-neurotrophic-factor-in-adolescents
#11
Tao Huang, Anne Kær Gejl, Jakob Tarp, Lars Bo Andersen, Lone Peijs, Anna Bugge
OBJECTIVE: The purpose of this study was to examine the associations between objectively measured physical activity and serum brain-derived neurotrophic factor (BDNF) in adolescents. METHODS: Cross-sectional analyses were performed using data from 415 adolescents who participated in the 2015 follow-up of the Childhood Health Activity and Motor Performance School Study Denmark (the CHAMPS-study DK). Physical activity was objectively measured by accelerometry monitors...
December 24, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28013201/risk-of-serious-adverse-effects-of-biological-and-targeted-drugs-in-patients-with-rheumatoid-arthritis-a-systematic-review-meta-analysis
#12
Simon Tarp, Daniel Eric Furst, Maarten Boers, George Luta, Henning Bliddal, Ulrik Tarp, Karsten Heller Asmussen, Birgitte Brock, Anna Dossing, Tanja Schjødt Jørgensen, Steffen Thirstrup, Robin Christensen
OBJECTIVES: To determine possible differences in serious adverse effects among the 10 currently approved biological and targeted synthetic DMARDs (b/ts-DMARDs) for RA. METHODS: Systematic review in bibliographic databases, trial registries and websites of regulatory agencies identified randomized trials of approved b/ts-DMARDs for RA. Network meta-analyses using mixed-effects Poisson regression models were conducted to calculate rate ratios for serious adverse events (SAEs) and deaths between each of the 10 drugs and control (i...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/28007052/rotavirus-is-frequent-among-adults-hospitalised-for-acute-gastroenteritis
#13
Karen Rokkedal Lausch, Lena Westh, Lena Hagelskjær Kristensen, Jens Lindberg, Britta Tarp, Carsten Schade Larsen
INTRODUCTION: Rotavirus infection is the most common aetiology of acute gastroenteritis (AGE) among young children. In adults, diagnostics focus mainly on bacterial causes, though recent studies suggest that rotavirus is a frequent agent. The aim of this study was to examine the proportion of rotavirus in adults hospitalised with AGE and to identify possible predictors. METHODS: During a 24-month period from 1 May 2010 adults (> 15 years) with AGE admitted to one of four hospitals in the Central Denmark Region were examined for rotavirus with VIKIA Rota-Adeno rapid test in addition to routine culture for bacterial pathogens...
January 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/27989499/biological-agents-in-polyarticular-juvenile-idiopathic-arthritis-a-meta-analysis-of-randomized-withdrawal-trials
#14
Gil Amarilyo, Simon Tarp, Ivan Foeldvari, Neta Cohen, Tracy D Pope, Jennifer M P Woo, Robin Christensen, Daniel E Furst
BACKGROUND AND OBJECTIVE: Although various biological agents are in use for polyarticular juvenile idiopathic arthritis (pJIA), head-to-head trials comparing the efficacy and safety among them are lacking. We aimed to compare the efficacy and safety of biological agents in pJIA using all currently available randomized withdrawal trials (wRCTs). METHODS: A systematic search of MEDLINE, EMBASE, CENTRAL, and clinicaltrials.gov was performed. Eligible wRCTs: patients with pJIA where a biological agent was compared with another biological agent or placebo...
December 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27874299/cooling-effectiveness-of-a-modified-cold-water-immersion-method-after-exercise-induced-hyperthermia
#15
RANDOMIZED CONTROLLED TRIAL
Katherine E Luhring, Cory L Butts, Cody R Smith, Jeffrey A Bonacci, Ramon C Ylanan, Matthew S Ganio, Brendon P McDermott
CONTEXT:  Recommended treatment for exertional heat stroke includes whole-body cold-water immersion (CWI). However, remote locations or monetary or spatial restrictions can challenge the feasibility of CWI. Thus, the development of a modified, portable CWI method would allow for optimal treatment of exertional heat stroke in the presence of these challenges. OBJECTIVE:  To determine the cooling rate of modified CWI (tarp-assisted cooling with oscillation [TACO]) after exertional hyperthermia...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27869624/surgical-outcome-and-prognostic-analysis-of-transoral-atlantoaxial-reduction-plate-system-for-basilar-invagination-a-voxel-based-morphometry-study
#16
Gejin Wei, Chenglong Shi, Zhiyun Wang, Hong Xia, Qingshui Yin, Zenghui Wu
BACKGROUND: The use of a transoral atlantoaxial reduction plate (TARP) system is an effective surgical approach for the treatment of basilar invagination. With the aim of improving the therapeutic efficacy of the TARP operation, we conducted a voxel-based morphometric study to quantitatively investigate the descent of the odontoid process and craniocervical volume changes. METHODS: We enrolled 20 patients with basilar invagination who underwent a TARP procedure...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27865532/tarp-assisted-cooling-as-a-method-of-whole-body-cooling-in-hyperthermic-individuals
#17
Yuri Hosokawa, William M Adams, Luke N Belval, Lesley W Vandermark, Douglas J Casa
STUDY OBJECTIVE: We investigated the efficacy of tarp-assisted cooling as a body cooling modality. METHODS: Participants exercised on a motorized treadmill in hot conditions (ambient temperature 39.5°C [103.1°F], SD 3.1°C [5.58°F]; relative humidity 38.1% [SD 6.7%]) until they reached exercise-induced hyperthermia. After exercise, participants were cooled with either partial immersion using a tarp-assisted cooling method (water temperature 9.20°C [48.56°F], SD 2...
November 16, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27820603/forebrain-selective-ampa-receptor-antagonism-guided-by-tarp-%C3%AE-8-as-an-antiepileptic-mechanism
#18
Akihiko S Kato, Kevin D Burris, Kevin M Gardinier, Douglas L Gernert, Warren J Porter, Jon Reel, Chunjin Ding, Yuan Tu, Douglas A Schober, Matthew R Lee, Beverly A Heinz, Thomas E Fitch, Scott D Gleason, John T Catlow, Hong Yu, Stephen M Fitzjohn, Francesca Pasqui, He Wang, Yuewei Qian, Emanuele Sher, Ruud Zwart, Keith A Wafford, Kurt Rasmussen, Paul L Ornstein, John T R Isaac, Eric S Nisenbaum, David S Bredt, Jeffrey M Witkin
Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Although efficacious, AMPA-receptor antagonists, including perampanel (Fycompa), the only approved antagonist for epilepsy, induce dizziness and motor impairment. We hypothesized that blockade of forebrain AMPA receptors without blocking cerebellar AMPA receptors would be antiepileptic and devoid of motor impairment...
December 2016: Nature Medicine
https://www.readbyqxmd.com/read/27796133/vertical-transmission-of-hepatitis-b-virus-during-pregnancy-and-delivery-in-denmark
#19
Nina Weis, Susan Cowan, Sofie Hallager, Sandra Dröse, Lena Hagelskjær Kristensen, Karin Grønbæk, Janne Jensen, Jan Gerstoft, Lone G Madsen, Mette Rye Clausen, Suzanne Lunding, Britta D Tarp, Toke S Barfod, Stine Sloth, Dorte Kinggaard Holm, Jesper Jensen, Henrik Krarup
OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission...
February 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27775461/effect-of-a-treat-to-target-cyclosporin-on-mri-assessed-synovitis-osteitis-tenosynovitis-bone-erosion-and-joint-space-narrowing-in-early-rheumatoid-arthritis-results-from-a-2-year-randomized-double-blind
#20
S Møller-Bisgaard, B J Ejbjerg, I Eshed, K Hørslev-Petersen, M L Hetland, A G Jurik, H Thomsen, T Torfing, K Stengaard-Pedersen, P Junker, N S Krogh, T Lottenburger, T Ellingsen, L S Andersen, H Skjødt, A J Svendsen, U Tarp, I T Hansen, J Pødenphant, J K Pedersen, H Lindegaard, L G Hanson, A Vestergaard, D Glinatsi, M Østergaard
OBJECTIVES: To investigate whether a treat-to-target strategy based on methotrexate (MTX) and intra-articular (IA) betamethasone suppresses magnetic resonance imaging (MRI)-determined measures of disease activity and reduces joint destruction in early rheumatoid arthritis (eRA) patients, and to investigate whether concomitant cyclosporin A (CyA) provides an additional effect. METHOD: In the 2-year randomized, double-blind, treat-to-target trial CIMESTRA, 160 patients with eRA (< 6 months) were randomized to MTX, intra-articular betamethasone and CyA, or placebo CyA...
October 24, 2016: Scandinavian Journal of Rheumatology
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