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https://www.readbyqxmd.com/read/27914788/claudin-6-enhances-cell-invasiveness-through-claudin-1-in-ags-human-adenocarcinoma-gastric-cancer-cells
#1
A C Torres-Martínez, J F Gallardo-Vera, A N Lara-Holguin, L F Montaño, E P Rendón-Huerta
Claudins participate in tissue barrier function. The loss of this barrier is associated to metalloproteases-related extracellular matrix and basal membranes degradation. Claudin-1 is a pro-MMP-2 activator and claudin-6 transfected AGS (AGS-Cld6) cells are highly invasive. Our aim was to determine if claudin-6 was direct or indirectly associated with MMP-2 activation and cell invasiveness. Cytofluorometry, cell fractioning, immunoprecipitation, gelatin-zymography, cell migration and invasiveness assays were performed, claudin-2, -6, -7 and -9 transfected AGS cells, anti-MMP-2, -9 and -14, anti-claudins specific antibodies and claudin-1 small interfering RNA were used...
November 30, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27880035/visible-light-promoted-au-i-to-au-iii-oxidation-in-triazol-5-ylidene-complexes
#2
Daniel Mendoza-Espinosa, David Rendón-Nava, Alejandro Alvarez-Hernández, Deyanira Angeles-Beltrán, Guillermo Enrique Negrón-Silva, Oscar Rodolfo Suárez-Castillo
Reaction of triazolium precursors [MIC(CH2)n-H+]I- (n = 1-3) with potassium hexamethyldisilazane (KHMDS) and AuCl(SMe2) generates the gold(I) complexes of the type MIC(CH2)n*AuI. Visible light exposure of the latter complexes promotes a spontaneous disproportionation process rendering gold(III) complexes of the type [{MIC(CH2)n}2*AuI2]+I-. Both the Au(I) and Au(III) complex series were tested in the catalytic hydrohydrazination of terminal alkynes using hydrazine as nitrogen source.
November 23, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27869310/trpv4-regulates-tight-junctions-and-affects-differentiation-in-a-cell-culture-model-of-the-corneal-epithelium
#3
Jacqueline Martínez-Rendón, Erika Sánchez-Guzmán, Angélica Rueda, James González, Rosario Gulias-Cañizo, Guillermo Aquino-Jarquín, Federico Castro-Muñozledo, Refugio García-Villegas
TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation feature that is concentrated in the apical membrane of the outmost cell layer of the stratified epithelia. Ca(2+) imaging experiments showed that TRPV4 activation with GSK1016790A produced an influx of calcium that was blunted by the specific TRPV4 blocker RN-1734...
November 21, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27867538/classification-of-drugs-to-treat-multidrug-resistant-tuberculosis-mdr-tb-evidence-and-perspectives
#4
EDITORIAL
Adrian Rendon, Simon Tiberi, Anna Scardigli, Lia D'Ambrosio, Rosella Centis, Jose A Caminero, Giovanni Battista Migliori
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27863251/genetic-drivers-of-epigenetic-and-transcriptional-variation-in-human-immune-cells
#5
Lu Chen, Bing Ge, Francesco Paolo Casale, Louella Vasquez, Tony Kwan, Diego Garrido-Martín, Stephen Watt, Ying Yan, Kousik Kundu, Simone Ecker, Avik Datta, David Richardson, Frances Burden, Daniel Mead, Alice L Mann, Jose Maria Fernandez, Sophia Rowlston, Steven P Wilder, Samantha Farrow, Xiaojian Shao, John J Lambourne, Adriana Redensek, Cornelis A Albers, Vyacheslav Amstislavskiy, Sofie Ashford, Kim Berentsen, Lorenzo Bomba, Guillaume Bourque, David Bujold, Stephan Busche, Maxime Caron, Shu-Huang Chen, Warren Cheung, Oliver Delaneau, Emmanouil T Dermitzakis, Heather Elding, Irina Colgiu, Frederik O Bagger, Paul Flicek, Ehsan Habibi, Valentina Iotchkova, Eva Janssen-Megens, Bowon Kim, Hans Lehrach, Ernesto Lowy, Amit Mandoli, Filomena Matarese, Matthew T Maurano, John A Morris, Vera Pancaldi, Farzin Pourfarzad, Karola Rehnstrom, Augusto Rendon, Thomas Risch, Nilofar Sharifi, Marie-Michelle Simon, Marc Sultan, Alfonso Valencia, Klaudia Walter, Shuang-Yin Wang, Mattia Frontini, Stylianos E Antonarakis, Laura Clarke, Marie-Laure Yaspo, Stephan Beck, Roderic Guigo, Daniel Rico, Joost H A Martens, Willem H Ouwehand, Taco W Kuijpers, Dirk S Paul, Hendrik G Stunnenberg, Oliver Stegle, Kate Downes, Tomi Pastinen, Nicole Soranzo
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types (CD14(+) monocytes, CD16(+) neutrophils, and naive CD4(+) T cells) from up to 197 individuals. We assess, quantitatively, the relative contribution of cis-genetic and epigenetic factors to transcription and evaluate their impact as potential sources of confounding in epigenome-wide association studies...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27846359/-o-arm-navigation-in-spinal-surgery-for-complex-cases
#6
D Pescador, D Rendón, J Blanco, R González, J M Martín, C Cano-Gala, D Pescador
The intraoperative computer-assisted navigation technique has evolved and changed the way we approach certain complex cases in the vertebral pathologies. The main advantages of this technique are that it increases the accuracy of the procedure, reduces its morbidity and invasiveness, diminishes the radiation dose and improves surgical protocols. In addition to the transpedicular fixation, the navigation system is useful in a high variety of pathologies such as spinal decompression or tumor resection. In the present study, we show several cases where navigation is used intraoperatively in different pathologies and their clinical outcomes...
March 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27830352/antioxidant-and-antihypertensive-potential-of-protein-fractions-from-flour-and-milk-substitutes-from-canary-seeds-phalaris-canariensis-l
#7
María Elena Valverde, Domancar Orona-Tamayo, Blanca Nieto-Rendón, Octavio Paredes-López
Canary seed (Phalaris canariensis) is used to feed birds but it has been recently considered a promising cereal with nutraceutical potential for humans. The aim of this work was to analyze the protein fractions from canary seed flour and from milk substitutes (prepared by soaking the seeds in water 12 and 24 h), and to evaluate antioxidant and antihypertensive capacity of peptides obtained after in vitro digestion. Prolamins were the major protein fraction, followed by glutelins. After digestion, albumins and prolamins fractions from milks presented higher levels of peptides than flour, globulins showed more peptides in flour and glutelins were found in similar concentrations in all samples; 24 h milk prolamins had the highest concentration of peptides...
November 9, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27819325/automatic-detection-and-measurement-of-viral-replication-compartments-by-ellipse-adjustment
#8
Yasel Garcés, Adán Guerrero, Paloma Hidalgo, Raul Eduardo López, Christopher D Wood, Ramón A Gonzalez, Juan Manuel Rendón-Mancha
Viruses employ a variety of strategies to hijack cellular activities through the orchestrated recruitment of macromolecules to specific virus-induced cellular micro-environments. Adenoviruses (Ad) and other DNA viruses induce extensive reorganization of the cell nucleus and formation of nuclear Replication Compartments (RCs), where the viral genome is replicated and expressed. In this work an automatic algorithm designed for detection and segmentation of RCs using ellipses is presented. Unlike algorithms available in the literature, this approach is deterministic, automatic, and can adjust multiple RCs using ellipses...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818418/uranium-workers-demonstrate-lower-lobe-predominant-irregular-pneumoconiotic-opacities-on-chest-radiographs
#9
Elizabeth Kocher, Kristi J Rendon, Denece Kesler, Tawny Wilson Boyce, Orrin Myers, Kandace Evans, Linda S Cook, Akshay Sood
BACKGROUND: There is a paucity of literature on the chest radiographic findings in uranium workers. OBJECTIVE: To characterize the chest radiographic findings of pneumoconiosis in a New Mexican cohort of uranium workers. METHODS: The most recent results from chest radiographs were abstracted in this cross-sectional study. RESULTS: Radiographs showed small pneumoconiotic opacities of profusion score of ≥ 1/0 in 155/429 (36...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27816476/sex-specific-modulation-of-the-gut-microbiome-and-behavior-in-siberian-hamsters
#10
Kristyn E Sylvia, Cathleen P Jewell, Nikki M Rendon, Emma A St John, Gregory E Demas
The gut microbiome is a diverse, host-specific, and symbiotic bacterial environment that is critical for mammalian survival and exerts a surprising yet powerful influence on brain and behavior. Gut dysbiosis has been linked to a wide range of physical and psychological disorders, including autism spectrum disorders and anxiety, as well as autoimmune and inflammatory disorders. A wealth of information on the effects of dysbiosis on anxiety and depression has been reported in laboratory model systems (e.g., germ-free mice); however, the effects of microbiome disruption on social behaviors (e...
November 2, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27812638/is-there-a-rationale-for-pulmonary-rehabilitation-following-successful-chemotherapy-for-tuberculosis
#11
Marcela Muñoz-Torrico, Adrian Rendon, Rosella Centis, Lia D'Ambrosio, Zhenia Fuentes, Carlos Torres-Duque, Fernanda Mello, Margareth Dalcolmo, Rogelio Pérez-Padilla, Antonio Spanevello, Giovanni Battista Migliori
The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the "post-tuberculosis treatment" phase, which will potentially affect several million cases every year...
September 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27811746/a-new-species-of-mesovelia-heteroptera-gerromorpha-mesoveliidae-from-south-america-with-identification-key-and-notes-on-colombian-species
#12
Carla Fernanda Burguez Floriano, Felipe Ferraz Figueiredo Moreira, Pitágoras Da Conceição Bispo, Irina Morales, Fredy Molano-Rendón
Mesovelia tuberculata sp. nov. is described and illustrated based on material from the Pacific Region of Colombia. It can be recognized by the following characters of the male: mesofemur without a row of spinules; posterior margin of abdominal tergum VIII with a weak notch; abdominal pleuron VIII with an anterodorsal tubercle; abdominal sternum VI with the posteromedian projection rounded and fringed with black spinules; and paramere with margins converging and apex single. In addition, we present data concerning M...
October 17, 2016: Zootaxa
https://www.readbyqxmd.com/read/27808431/adf-winter-school-an-exciting-concept-of-the-arbeitsgemeinschaft-dermatologische-forschung-to-connect-young-scientists-and-clinician-scientists-in-dermatology-at-the-top-of-germany
#13
Amir S Yazdi, Meltem Barlin, Katharina Böhm, Fabian Gendrisch, Saeedeh Ghorbanalipoor, Stefanie Häberle, Annamarie Hamel, Svea Hüning, Clemens Hüttner, Irina Iwanova, Theodora Kanaki, Susanne Kimeswenger, Nadine Lohmann, Saira Munir, Sukalp Muzumdar, Manuel Pedro Pereira, Patricia Peking, Kristin Plesser, Adriana Rendon, Maximilian Rentschler, Carolin Schlumprecht, Anna Smorodchenko, Martin Stock, Jessica Tillmanns, Ugur Uslu, Kamran Ghoreschi, Martin Glatz, Stephan Grabbe, Manfred Kunz, Ralf Ludwig, Karin Scharffetter-Kochanek, Karin Loser
No abstract text is available yet for this article.
November 3, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27799383/roadmap-for-tuberculosis-elimination-in-latin-american-and-caribbean-countries-a-strategic-alliance
#14
EDITORIAL
Adrian Rendon, Zhenia Fuentes, Carlos A Torres-Duque, Mirtha Del Granado, Jorge Victoria, Raquel Duarte, Giovanni Battista Migliori
No abstract text is available yet for this article.
November 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27795220/-descriptive-statistics
#15
Mario Enrique Rendón-Macías, Miguel Ángel Villasís-Keever, María Guadalupe Miranda-Novales
Descriptive statistics is the branch of statistics that gives recommendations on how to summarize clearly and simply research data in tables, figures, charts, or graphs. Before performing a descriptive analysis it is paramount to summarize its goal or goals, and to identify the measurement scales of the different variables recorded in the study. Tables or charts aim to provide timely information on the results of an investigation. The graphs show trends and can be histograms, pie charts, "box and whiskers" plots, line graphs, or scatter plots...
October 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27792813/asymmetrical-functional-deficits-of-on-and-off-retinal-processing-in-the-mdx3cv-mouse-model-of-duchenne-muscular-dystrophy
#16
Tina I Tsai, Mirella Telles Salgueiro Barboni, Balázs Vince Nagy, Michel J Roux, Alvaro Rendon, Dora Fix Ventura, Jan Kremers
Purpose: The dystrophin mouse mutant mdx3Cv exhibits scotopic electroretinograpic (ERG) abnormalities, which resemble clinical changes observed in Duchenne muscular dystrophy (DMD) patients. In the present study, ERGs obtained from mdx3Cv and their wild-type littermates under scotopic, mesopic, and photopic conditions were analyzed to provide further insight on the affected retinal pathways, and to compare them with human data. Methods: Electroretinograms of mdx3Cv (n = 9) and age-matched C57BL/6J mice (n = 10) included the scotopic full-field flash (for outer retinal deficits in rod pathway), scotopic threshold response (for inner retinal integrity), photopic flash, sinusoidal flicker (for outer retinal deficits in cone pathway), mesopic rapid-on/-off sawtooth flicker, and photopic long-duration flash measurements (for separate ON-/OFF-responses under different conditions)...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27783114/mercury-in-the-blue-marlin-makaira-nigricans-from-the-southern-gulf-of-california-tissue-distribution-and-inter-annual-variation-2005-2012
#17
B Vega-Sánchez, S Ortega-García, J Ruelas-Inzunza, M Frías-Espericueta, O Escobar-Sánchez, J Guzmán-Rendón
With the aim of knowing annual variations of Hg concentrations in muscle and liver of blue marlin (Makaira nigricans) from the southern Gulf of California, fish were collected between 2005 and 2012 in three areas. In general, Hg levels were more elevated in liver than in muscle. Variations of Hg concentrations in muscle and liver among the studied years were not significant. Hg levels in muscle and liver increased significantly with length and weight of fish. In comparison to other studies, Hg levels in muscle and liver were lower...
October 25, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27722364/synthesis-structure-and-reactivity-of-pd-and-ir-complexes-based-on-new-lutidine-derived-nhc-phosphine-mixed-pincer-ligands
#18
Práxedes Sánchez, Martín Hernández-Juárez, Eleuterio Álvarez, Margarita Paneque, Nuria Rendón, Andrés Suárez
Coordination studies of new lutidine-derived hybrid NHC/phosphine ligands (CNP) to Pd and Ir have been performed. Treatment of the square-planar [Pd(CNP)Cl](AgCl2) complex 2a with KHMDS produces the selective deprotonation at the CH2P arm of the pincer to yield the pyridine-dearomatised complex 3a. A series of cationic [Ir(CNP)(cod)](+) complexes 4 has been prepared by reaction of the imidazolium salts 1 with Ir(acac)(cod). These derivatives exhibit in the solid state, and in solution, a distorted trigonal bipyramidal structure in which the CNP ligands adopt an unusual C(axial)-N(equatorial)-P(equatorial) coordination mode...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27717622/who-strategies-for-the-management-of-drug-resistant-tuberculosis
#19
Adrián Rendon, Rosella Centis, Lia D'Ambrosio, Giovanni Battista Migliori
No abstract text is available yet for this article.
October 4, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27709461/quantification-of-vibrio-species-in-oysters-from-the-gulf-of-mexico-with-two-procedures-based-on-mpn-and-pcr
#20
Guadalupe Barrera-Escorcia, Irma Wong-Chang, Carlos Leopoldo Fernández-Rendón, Alfonso Vázquez Botello, Bruno Gómez-Gil, Marcial Leonardo Lizárraga-Partida
Oysters can accumulate potentially pathogenic water bacteria. The objective of this study was to compare two procedures to quantify Vibrio species present in oysters to determine the most sensitive method. We analyzed oyster samples from the Gulf of Mexico, commercialized in Mexico City. The samples were inoculated in tubes with alkaline peptone water (APW), based on three tubes and four dilutions (10(-1) to 10(-4)). From these tubes, the first quantification of Vibrio species was performed (most probable number (MPN) from tubes) and bacteria were inoculated by streaking on thiosulfate-citrate-bile salts-sucrose (TCBS) petri dishes...
December 0: Environmental Monitoring and Assessment
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