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Neuroendocrine neoplasm

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https://www.readbyqxmd.com/read/28430347/hypopharyngeal-squamous-cell-carcinoma-and-laryngeal-neuroendocrine-carcinoma-colliding-in-the-aryepiglottic-fold-a-case-report
#1
Roberta Marangoni, Simone Mauramati, Giulia Bertino, Antonio Occhini, Marco Benazzo, Patrizia Morbini
PURPOSE: A collision tumor consists of 2 different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck region they are rare, with only 4 cases reported in the larynx. CASE REPORT: A 60-year-old heavy smoker complained of a left submandibular lesion in October 2014. The lesion was excised and showed a poorly differentiated carcinoma, suggestive for adenocarcinoma. After a positron emission tomography-computed tomography scan showed increased metabolic activity in the left laterocervical region and right vocal cord, the patient underwent endoscopic biopsy of the lesion of the left piriform sinus, which was positive for moderately differentiated squamous cell carcinoma (SCC)...
April 14, 2017: Tumori
https://www.readbyqxmd.com/read/28428105/microcarcinoid-arising-in-patients-with-long-standing-ulcerative-colitis-histological-analysis
#2
Sachie Kanada, Akira Sugita, Tetuo Mikami, Kenichi Ohashi, Hiroyuki Hayashi
Some case reports of neuroendocrine tumors (NETs) and neuroendocrine carcinoma (NEC) associated with ulcerative colitis (UC) have been published. Most NET cases are small lesions corresponding to microcarcinoids (MCs). However, published case reports have presented findings of MCs as single-case reports. Thus, the frequency of MCs is still unclear. In this study, we described the clinical and morphological features of 14 cases of UC-associated MC and estimated the frequency of MC. Consecutive patients with UC who underwent complete removal of the large intestine were assessed, and 135 patients were selected...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28422824/pancreatic-carcinoids-serotonin-producing-pancreatic-neuroendocrine-neoplasms-report-of-5-cases-and-review-of-the-literature
#3
Nikolaos Tsoukalas, Eleftherios Chatzellis, Dimitra Rontogianni, Krystallenia I Alexandraki, Georgios Boutzios, Anna Angelousi, Gregory Kaltsas
INTRODUCTION: Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These tumors can secrete a variety of biologically active substances giving rise to distinct clinical symptoms or can be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority of functioning pNENs, some tumors may secrete serotonin presenting with the features of the carcinoid syndrome. These so-called pancreatic carcinoids are considered relatively rare tumors and are associated with increased urinary levels of 5-hydroxyindoleacetic acid (5-HIAA)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421458/surgical-management-of-pancreatic-cysts-a-shifting-paradigm-toward-selective-resection
#4
REVIEW
Jon M Gerry, George A Poultsides
Due to the widespread use of high-quality cross-sectional imaging, pancreatic cystic neoplasms are being diagnosed with increasing frequency. Clinicians are therefore asked to counsel a growing number of patients with pancreatic cysts diagnosed incidentally at an early, asymptomatic stage. Over the last two decades, accumulating knowledge on the biologic behavior of these neoplasms along with improved diagnostics through imaging and endoscopic cyst fluid analysis have allowed for a selective therapeutic approach toward these neoplasms...
April 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28417484/well-differentiated-neuroendocrine-tumors-in-skin-terminology-and-diagnostic-utility-of-cytokeratin-5-6-and-p63
#5
Gauri Panse, Shawn E Cowper, David J Leffell, Melissa Pulitzer, Christine J Ko
BACKGROUND: Well-differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK 5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK 5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28417314/prognostic-factors-for-gastroenteropancreatic-neuroendocrine-neoplasms-gep-nens-what-s-better
#6
EDITORIAL
Massimo Milione
No abstract text is available yet for this article.
April 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28414996/a-case-of-multiple-synchronous-quadruple-cancers-of-the-stomach-sigmoid-colon-rectum-and-pancreas
#7
Atsushi Nanashima, Tetsuro Tominaga, Takashi Nonaka, Kouki Wakata, Masaki Kunizaki, Shuichi Tobinaga, Yorihisa Sumida, Shigekazu Hidaka, Naoe Kinoshita, Terumitsu Sawai, Takeshi Nagayasu
INTRODUCTION: Multiple primary neoplasms are relatively rare, but their incidence has increased because of aging and improvements in diagnostic imaging. PRESENTATION OF CASE: A 67-year-old man presented with epigastric pain. On upper gastrointestinal endoscopy, an ulcer was seen at the gastric angle, and biopsy showed moderately differentiated adenocarcinoma (AC). Colonoscopy demonstrated a 15-mm lesion in the sigmoid colon and a submucosal lesion in the lower rectum...
April 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28414324/correlation-between-histone-acetylation-and-expression-of-notch1-in-human-lung-carcinoma-and-its-possible-role-in-combined-small-cell-lung-carcinoma
#8
Wael Abdo Hassan, Shin-Ichiro Takebayashi, Mohamed Osama Ali Abdalla, Kosuke Fujino, Shinji Kudoh, Yamoto Motooka, Yonosuke Sato, Yoshiki Naito, Koichi Higaki, Joeji Wakimoto, Seiji Okada, Mituyoshi Nakao, Yuichi Ishikawa, Takaaki Ito
Combined small-cell lung carcinoma (cSCLC) is composed of small-cell lung carcinoma (SCLC) admixed with non-small-cell lung carcinoma (NSCLC). Evaluating the molecular differences between SCLC and NSCLC could lead to a better understanding of the pathogenesis of such neoplasms. Therefore, in this study, we investigated the correlation between histone acetylation and Notch1 expression in lung carcinoma. Using chromatin immunoprecipitation (ChIP) assay, we measured the level of acetylated histone H3 around the promoter region of Notch1 in SCLC and NSCLC cells...
April 17, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28399532/metastatic-pituitary-carcinoma-to-cervical-lymph-node-diagnosis-by-fine-needle-aspiration-and-review-of-the-literature
#9
Huiying Wang, Jiancong Liang, William H Yong, Peggy Sullivan
BACKGROUND: Pituitary carcinomas are rare neoplasms whose designation requires demonstration of metastatic disease. No specific morphologic features can reliably distinguish pituitary carcinomas from pituitary adenomas, rendering the diagnosis particularly challenging. Furthermore, as reports of pituitary carcinoma on fine needle aspiration (FNA) biopsy are exceedingly rare in the literature, the cytological features of pituitary carcinoma are poorly characterized. CASE REPORT: Here we describe a case of pituitary carcinoma in a 67-year-old woman with history of recurrent adrenocorticotropic hormone (ACTH)-producing pituitary adenoma who presented with a persistent left cervical nodule for 2 years...
April 12, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28398409/-macrocytosis-of-red-blood-cells-and-early-arthritis-positive-for-rheumatoid-factor-such-as-initial-manifestations-of-a-neuroendocrine-gastrin-secreting-gastric-tumor
#10
Ciro Manzo, Maria Natale, Gennaro Mossetti, Aniello Piscopo
Neuroendocrine tumors (NETs) represent uncommon tumors arising from the excessive proliferation of enterochromaffin-like (ECL) cells (so-called Kulchitsky cell). Gastric NETs (GNET) represent less than 2% of all NETs and less than 1% of all stomach neoplasms. In particular, gastric NETs type 1 (associated to chronic atrophic gastritis and hypergastrinaemia) is the more frequent one, accounting for 70-80% of all GNET. A macrocytic anemia is a frequent manifestation of GNET type 1. The possibility that macrocytic anemia appear during therapy with methotrexate (MTX) is widely documented...
March 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28389504/circulating-tumor-cells-and-mirna-as-prognostic-markers-in-neuroendocrine-neoplasms
#11
Maria Chiara Zatelli, Erika Maria Grossrubatscher, Elia Guadagno, Concetta Sciammarella, Antongiulio Faggiano, Annamaria Al Colao
The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. This review summarizes the available data on the possible role of circulating tumor cells and microRNAs as prognostic markers in NENs...
April 7, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28386018/panin-neuroendocrine-cells-promote-tumorigenesis-via-neuronal-cross-talk
#12
Smrita Sinha, Ya-Yuan Fu, Adrien Grimont, Maren Ketcham, Kelly Lafaro, Joseph A Saglimbeni, Gokce Askan, Jennifer M Bailey, Jerry P Melchor, Yi Zhong, Min Geol Joo, Olivera Grbovic-Huezo, In-Hong Yang, Olca Basturk, Lindsey Baker, Young Park, Robert C Kurtz, David Tuveson, Steven D Leach, Pankaj J Pasricha
Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreatic intraepithelial neoplasms (PanIN), and describe a unique subpopulation of neuroendocrine PanIN cells that express the neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, we demonstrated that sensory neurons promoted the proliferation of PanIN organoids via SP-NK1-R signaling and STAT3 activation...
April 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/28385665/dictating-genomic-destiny-epigenetic-regulation-of-pancreatic-neuroendocrine-tumours
#13
REVIEW
Justin S Gundara, Karim Jamal, Tom Kurzawinski
Pancreatic neuroendocrine tumours are a diverse group of neoplasms with an increasingly well-defined genomic basis. Despite this, much of what drives this disease is still unknown and epigenetic influences represent the next tier of gene, and hence disease modifiers that are of unquestionable importance. Moreover, they are of arguably more significance than the genes themselves given their malleable nature and potential to be exploited for not only diagnosis and prognosis, but also therapy. This review summarises what is known regarding the key epigenetic modifiers of disease through the domains of diagnosis, prognosis and treatment...
April 4, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28380493/enets-consensus-guidelines-for-the-standards-of-care-in-neuroendocrine-neoplasms-systemic-therapy-2-chemotherapy
#14
Rocio Garcia-Carbonero, Anja Rinke, Juan W Valle, Nicola Fazio, Martyn Caplin, Vera Gorbounova, Juan O''Connor, Barbro Eriksson, Halfdan Sorbye, Matthew Kulke, Jie Chen, Jenny Falkerby, Frederico Costa, Wouter de Herder, Catherine Lombard-Bohas, Marianne Pavel
No abstract text is available yet for this article.
April 5, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28377287/may-we-challenge-the-enets-guidelines-in-pancreatic-neuroendocrine-neoplasms-a-quiz-for-french-experts
#15
Bertrand Brieau, Romain Coriat
INTRODUCTION: Recent guidelines have been published by a consensus of international experts (2016 ENETS guidelines). Nevertheless, in case of pancreatic neuroendocrine neoplasms (panNEN) the ENETS guidelines fail to propose a unique strategy in some situations, due to the lack of high-level of evidence and the absence of formal agreement between the experts drawing up the guidelines. MATERIAL AND METHODS: A survey of 25 questions on panNEN was sent to 104 French experts challenging the guidelines...
March 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28373439/characterization-of-leiomyomatoid-angiomatous-neuroendocrine-tumour-lant-like-tumour-in-the-myometrium-with-histopathological-examination
#16
Takuma Hayashi, Tomoyuki Ichimura, Mari Kasai, Kenji Sano, Dorit Zharhary, Tanri Shiozawa, Nobuo Yaegashi, Ikuo Konishi
Leiomyomatoid angiomatous neuroendocrine tumour (LANT) is possibly a new disease entity that was reported as a dimorphic neurosecretory tumour with a leiomyomatous vascular component; it was found in the pituitary. We describe uterine LANT-like malignant tumour in a 45-year-old woman with uterine mesenchymal tumour, diagnosed clinically as uterine leiomyoma. She underwent laparoscopic myomectomy. The tumour consisted of hyalinized vasculature, containing factor VIII-positive endothelium and α-smooth muscle actin-positive vascular smooth muscle cells, and stromal cells, expressing neuroadhesion molecules...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28363472/surgical-management-and-surveillance-of-pediatric-appendiceal-carcinoid-tumor
#17
Inna N Lobeck, Neelum Jeste, James Geller, Joseph Pressey, Daniel von Allmen
PURPOSE: Appendiceal carcinoid tumors are rare neuroendocrine neoplasms. The aim of this study was to determine if postoperative oncologic follow-up was necessary for this tumor. METHODS: A retrospective review was performed of patients with appendiceal carcinoid 2000-2015. RESULTS: 8382 patients underwent appendectomy 2000-2015. 30 (0.3%) had appendiceal carcinoid. 70% were female (n=21) with an average age of 13.5±2.8 years (range 8-18)...
March 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28357177/pancreatic-neuroendocrine-tumors
#18
REVIEW
Jian Sun
Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors including well differentiated pancreatic neuroendocrine tumors (pNETs) and neuroendocrine carcinomas (pNECs). The incidence of pNENs has increased over the past few decades. Although, the understanding and interest for this tumor have also increased significantly, the debate about classification and diagnosis continues. Although the primary treatment for pNENs is surgical resection, there is still a lack of effective therapeutic options for patients with advanced unresectable pNENs...
February 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28355610/thymic-neuroendocrine-neoplasms-biological-behaviour-and-therapy
#19
Jia Ru, Petra Sulentic, Jian-Ming Xu, Ashley B Grossman
No abstract text is available yet for this article.
March 30, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28355107/pathology-of-aging-in-nod-scid-gamma-female-mice
#20
Sara F Santagostino, Rodolfo J Ricart Arbona, Melissa A Nashat, Julie R White, Sebastien Monette
In the past decade, NOD.Cg- Prkdc(scid) Il2rg(tm1Wjl)/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related pathology are not currently available in the literature. The prevalence of spontaneous morbidity affecting aged NSG female breeders enrolled in a parasitology study was documented with classification of neoplastic and non-neoplastic (inflammatory, metabolic, degenerative) lesions. Malignant mammary neoplasms were most commonly diagnosed, often accompanied by pulmonary metastases, while a low frequency of lymphoma and histiocytic sarcoma was documented...
January 1, 2017: Veterinary Pathology
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