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Ilexgenin A

Zong-Yang Liu, Wen-Wen Zhao, Jing-Yue Wu, Xia Wu, Xiao-Qing Chen, Ke Zan
The present study is to develop an HPLC-ELSD method for simultaneous determination of three pairs of triterpenoid isomers, Ilexsaponin A₁, Ilexhainanoside D, Ilexgenin A, 3β, 19α-dihydroxyolean-12-ene-24, 28-dioic acid (ilexhainanin E) ursolic acid and oleanic acid in the leaf of Ilex hainanensis, which could provide evidence to the quality control of this herb. The six constituents were measured on a Waters XBridge C₁₈ column (4.6 mm×250 mm, 5 μm), with a mobile phase consisting of methanol (A)- 0...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Guojun Kuang, Huan Yi, Mingjuan Zhu, Jie Zhou, Xueying Shang, Zhongxiang Zhao, Chenchen Zhu, Qiongfeng Liao, Shixia Guan, Lei Zhang
In contrast to the extensively reported therapeutic activities, far less attention has been paid to the intestinal absorption of the total saponins from Radix Ilicis Pubescentis (in Chinese Mao-Dong-Qing, MDQ). This study aimed to investigate the intestinal absorption characteristics of ilexgenin A (C1), ilexsaponin A1 (C2), ilexsaponin B1 (C3), ilexsaponin B2 (C4), ilexsaponin B3 (DC1), and ilexoside O (DC2) when administrated with the total saponins from MDQ (MDQ-TS). An UPLC method for simultaneous determination of C1, C2, C3, C4, DC1, and DC2 in intestinal outflow perfusate was developed and validated...
November 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lan-Zhu Li, Tong Zhang, Lan Yang, Lijuan Zhang, Lulu Wang, Baolin Liu, Kang Liu
Adipose dysfunction links tightly to hepatic insulin resistance and gluconeogenesis. Ilexgenin A is reported with the ability to regulate lipid profile and protect the liver against high fat diet (HFD) -induced impairment. Here, we propose that ilexgenin A ameliorates hepatic insulin signaling and gluconeogenesis by regulating lipolysis in white adipose tissue (WAT). Pyruvate tolerance test and biochemical analysis coupled with the ex vivo siRNA knockdown and co-culture studies demonstrate that ilexgenin A suppresses inflammation-associated lipolysis in epididymal fat pad via 5'-AMP-activated protein kinase (AMPK) activation, thus inhibits diacylglycerol (DAG) accumulation and protein kinase C ε (PKCε) translocation in liver, leading to the improvement of insulin sensitivity and hepatic glucose production...
July 21, 2017: European Journal of Pharmacology
Weidong Sun, Chang Liu, Yaqi Zhang, Xia Qiu, Li Zhang, Hongxia Zhao, Yi Rong, Yun Sun
Ilexgenin A (IA) is a novel pentacyclic triterpenoid, which extracted from leaves of Ilex hainanensis Merr. In the present study, we aim to explore anti-inflammatory activity of IA on LPS-induced peritonitis and its underlying molecular mechanism. The results determined that IA was capable of suppressing peritonitis in mice induced by intraperitoneal (i.p.) injection of lipopolysaccaride (LPS). Furthermore, the results showed that IA dramatically inhibited levels of inflammatory cells infiltration in peritoneal cavity and serum in LPS-induced mice peritonitis model...
February 15, 2017: European Journal of Pharmacology
Hao Yang, Juan Wang, Jin-Hong Fan, Ya-Qi Zhang, Jun-Xian Zhao, Xiao-Jun Dai, Qi Liu, Yan-Jun Shen, Chang Liu, Wei-Dong Sun, Yun Sun
Recently, we reported that Ilexgenin A exhibits anti-cancer activities and induces cell arrest. Here, we investigated the effect of Ilexgenin A on the inflammation, angiogenesis and tumor growth of hepatocellular carcinoma (HCC). Our current study revealed that Ilexgenin A significantly inhibited the inflammatory cytokines TNF-α and IL-6 levels and downregulated pro-angiogenic factor VEGF production and transcription in HepG2 cells. The underlying mechanism for Ilexgenin A effects appears to be through inhibiting STAT3 and PI3K pathways...
January 15, 2017: Toxicology and Applied Pharmacology
Chang Liu, Junxian Zhao, YunXing Liu, Yi Huang, Yanjun Shen, Juan Wang, Weidong Sun, Yun Sun
Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr. In this study, we explored the efficacy of IA on atherosclerosis and its underlying mechanism. We determined that treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs...
November 2016: International Immunopharmacology
Yi Li, Jie Yang, Mei-Hong Chen, Qiang Wang, Min-Jian Qin, Tong Zhang, Xiao-Qing Chen, Bao-Lin Liu, Xiao-Dong Wen
Ilexgenin A is a natural triterpenoid with beneficial effects on lipid disorders. This study aimed to investigate the effects of ilexgenin A on endothelial homeostasis and its mechanisms. Palmitate (PA) stimulation induced endoplasmic reticulum stress (ER stress) and subsequent thioredoxin-interacting protein (TXNIP)/NLRP3 inflammasome activation in endothelial cells, leading to endothelial dysfunction. Ilexgenin A enhanced LKB1-dependent AMPK activity and improved ER stress by suppression of ROS-associated TXNIP induction...
September 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Hao Yang, Chang Liu, Ya-Qi Zhang, Ling-Tian Ge, Jun Chen, Xiao-Qin Jia, Rui-Xia Gu, Yun Sun, Wei-Dong Sun
The present study aimed to investigate the anti-tumor activity of Ilexgenin A in B16-F10 murine melanoma and to evaluate its effect on the production of tumor-associated inflammatory cytokines. In vitro, our study showed that Ilexgenin A inhibited the proliferation of B16-F10 murine melanoma cells in a dose- and time-dependent manner, and this effect could be ascribed to the arrest of the cell cycle at G0/G1. In vivo, we evaluated the anti-tumor activity of Ilexgenin A in a tumor-bearing mouse model. The results showed that Ilexgenin A reduced the tumor weight by 51...
February 2015: International Immunopharmacology
Zhen Fan, Lian Zhou, Tianqin Xiong, Jinsong Zhou, Qingguo Li, Qinglong Tan, Zhongxiang Zhao, Jing Jin
Four new triterpene saponins, rotundinosides A-D (1-4) and seven known triterpene saponins (5-11) were isolated from a methanol extract of the barks of Ilex rotunda Thunb. The new saponins were characterized as 3-O-β-d-glucopyranosy1-(1→2)-β-d-xylopyranosyl siaresinolic acid 28-O-β-d-glucopyranoside (1), 3-O-[β-d-glucopyranosy1-(1→2)-β-d-xylopyranosyl]-3β,19α-dihydroxyurs-12-en-28-oic-O-β-d-glucopranosy1ester (2), 3-O-[α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosy1-(1→2)-α-l-arabinopyranosyl]-3β,19α-dihydroxyurs-12-en-28-oic-O-β-d-glucopyranosy1 ester (3), and 3-O-α-l-rhamanopyranosyl-(1→2)-β-d-glucopyranosy1-(1→2)-α-l-arabinopyranosyl ilexgenin B 28-O-β-d-glucopyranosy1 ester (4), respectively...
March 2015: Fitoterapia
Lu Tang, Xi-Feng Li, Sheng-Xiang Yang, Yan Qiu, Ke Yuan
The present work is to investigate the chemical constitutions of Hyptis rhomboidea and their antifungal activities. The compounds were isolated by Toyopearl HW-40, Sephadex LH-20, MCI-Gel CHP-20, RP-18, PTLC and silica column chromatographic methods and subjected to evaluate some monomers antifungal activity of eight kinds of plant pathogenic bacteria. Eleven compounds were isolated and identified as ethyl caffeate (1), ursolic acid (2), oleanolic acid (3), vanillactic acid (4), methyl rosmarinate (5), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 --> 6) -beta-D-glucopyranoside (6), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 --> 6)-beta-D-glucopyranoside (7), ilexgenin A (8), beta-amyrin (9), kaempferol 3-O-beta-D-glucopyranoside (astrgalin, 10) and cholest-5-ene-3beta, 4beta-diol (11)...
June 2014: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Chang Liu, Wang Zhang, Qiang Wang, Yun Sun, Guo-wang Diao
A new water-soluble inclusion complex of ilexgenin A (IGA) with β-cyclodextrin polymer (CDP) was prepared by a facile strategy and characterized by (1)H NMR , FT-IR, and UV-vis spectroscopy. Compared with IGA and the inclusion complex of IGA with β-cyclodextrin (IGA-CD), the solubility of IGA-β-cyclodextrin polymer (IGA-CDP) was greatly enhanced due to the water-soluble CDP host. The ratio of β-cyclodextrin (β-CD) units in CDP to IGA was determined as 2 : 1. KD of the inclusion complex was evaluated as 2...
August 14, 2013: Organic & Biomolecular Chemistry
Bo Peng, Chun-Feng Qiao, Jing Zhao, Wei-Hua Huang, De-Jun Hu, Hua-Gang Liu, Shao-Ping Li
A high performance liquid chromatography coupled with diode array and evaporative light scattering detection (HPLC-DAD-ELSD) method for simultaneous determination of eight major bioactive compounds including two flavonoids (rutin and eriodictyol-7-O-β-D-glucopyranoside), two isochlorogenic acids (isochlorogenic acid A and isochlorogenic acid C) and four triterpenoids (ilexhainanoside D, ilexsaponin A1, ilexgenin A and ursolic acid) in Ilex hainanensis has been developed for the first time. The 283 nm wavelength was chosen for determination of two flavonoids and two isochlorogenic acids...
2013: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jie Yang, Fang Lv, Xiao-qing Chen, Wei-xi Cui, Li-hong Chen, Xiao-dong Wen, Qiang Wang
Ilex hainanensis Merr. is commonly used as a folk remedy for treating hypertension, dyslipidemia and inflammation in Traditional Chinese Medicine (TCMs) and it also has great potential to treat non-alcoholic fatty liver disease (NAFLD). Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A are three major bioactive components in I. hainanensis extract. In this study, a rapid, sensitive and convenient LC-MS method was developed for their simultaneous determination in the plasma of normal and NAFLD rats...
April 15, 2013: Journal of Pharmaceutical and Biomedical Analysis
Bo Peng, Wei-Hua Huang, Jing Zhao, Hua-Gang Liu
OBJECTIVE: To investigate the chemical constituents from Ilex hainanensis. METHODS: The compounds were isolated and purified by various chromatographic techniques. The structures were identified by mass and NMR spectral data. RESULTS: Ten compounds were isolated and identified as Ilexgenin A (1), 3beta, 19alpha-dihydroxyolean-12-ene-24,28-Dioicacid-28-O-beta-D-glucopyranoside (2), Ilexsaponin A1 (3), 2-(Caffeoyloxy) methyl-3-hydroxy-1-butane-4-O-beta-D-glucopyranoside (4), Dibutyl phthalate (5), Rutin (6), Eriodictyol-7-O-beta-D-glucopyranoside (7), Syringaresinol-4-O-beta-D-glucopyranoside (8), (2E) -2-methyl-2-butene-1, 4-diol-4-O-beta-D-(6"-O- caffeoyl) -glucopyranoside (9), 1-O-caffeoyl-(2E) -2-methyl-2-butene-1, 4-diol-4-O-beta-D- glucopyranoside (10), respectively...
August 2012: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Che Yan-Yun, Zhang Liang, Li Ning, Zeng Ke-Wu, Tu Peng-Fei
Two new triterpenoid saponins, ilemaminosides A and B (1 and 2) along with six known saponins (3-8) were isolated from 70% ethanolic extract of the leaves of Ilex mamillata C.Y. Wu ex C.J. Tseng. The new saponins were characterised as 3-O-α-L-arabinopyranosyl-ilexgenin B (1) and 3-O-β-D-glucopyranosyl-(1 → 3)-α-L-arabinopyranosyl-ilexgenin B (2). The structures of compounds 1 and 2 were elucidated on the basis of the chemical and spectroscopic methods, and the structures of known compounds were identified by comparison of their spectroscopic data with those reported in the literature...
November 2012: Natural Product Research
Wen-Yuan Liu, Feng Feng, Cheng-Xia Yu, Ning Xie
A sensitive and selective high performance liquid chromatographic method coupled with DAD detection is presented for quality control of Radix Ilicis Pubescentis. By means of this analytical procedure the major individual constituents (ilexoside O, ilexgenin A, ilexsaponin A1, ilexsaponin B1, liriodendin and acanthoside B) could be quantified simultaneously. LC-ESI-MS was applied for identification of the six compounds in the plant by comparing their m/z value and retention times with those of selected standards...
January 2010: Natural Product Communications
V S Pires, G Gosmann, D Guillaume, E P Schenkel
Two new saponins were isolated from the leaves of Ilex psammophila. Their structure was established by chemical and spectroscopic methods as 28-O-beta-D-glucopyranosylester of 20(S)-ilexgenin A ([structure: see text]) and 28-O-beta-D-glucopyranosylester of 20(S)-3beta,19alpha,24-trihydroxyurs-12-ene-23, 28-dioic acid ([structure: see text]).
December 2002: Natural Product Letters
D Wen, X Zheng, K Inoue
OBJECTIVE: To further probe into the chemical composition of Ilex hainanensis. METHOD: Compound isolation was affected on the basis of the EtOAc soluble fraction of the ethanolic extract from the leaves of the plant. RESULT: Four compounds were obtained and by physico-chemical and spectroscopic methods identified as ursolic acid, ilexgenin A, ilexsaponin A1 and beta-sitosterol-3-O-beta-D-glucoside. CONCLUSION: All the four compounds were isolated from the plant for the first time...
April 1999: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
M A Ouyang, Y Q Liu, H Q Wang, C R Yang
Three new triterpenoid saponins, latifolosides F, G, H were isolated from the leaves of Ilex latifolia. Their structures were elucidated on the basis of chemical and spectral evidence. Latifoloside F was determined to be 3-O-[alpha-L-rhamnopyranosyl(1-2)]-[beta-D-glucopyranosyl(1-3)-]- alpha-L-arabinopyranosyl ilexgenin B 28-O-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside. Latifoloside G was 3-O-[alpha-L-rhamnopyranosyl(1-2)]-[beta-D-glucopyranosyl(1-3)-]- alpha-L-arabinopyranosyl pomolic acid 28-O-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside...
December 1998: Phytochemistry
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