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Sanne A A de Laat, Anja C Huizink, Michel H Hof, Tanja G M Vrijkotte
Background: Socioeconomically disadvantaged children often have psychosocial problems. This study examined the mediating role of maternal depressive symptoms during pregnancy, infancy and early childhood in the association between maternal education, as indicator of socioeconomic status (SES), and child's psychosocial problems. Methods: Included were 3410 children from the Amsterdam Born Children and their Development (ABCD) study. To assess the child's psychosocial problems at age 5-6 years, mothers and teachers completed the Strengths and Difficulties Questionnaire (SDQ)...
July 10, 2018: European Journal of Public Health
Pradip Kumar Saha, Rashmi Bagga, Jasvinder Kaur Kalra, Aashima Arora, Rimpi Singla, Vanita Suri, Kajal Jain, Praveen Kumar, Nalini Gupta, Ashish Jain, Tulika Singh, Ravimohan S Mavuduru
BACKGROUND: Cesarean hysterectomy for adherent placenta is associated with increased maternal morbidity due to massive hemorrhage requiring large volume blood transfusion, bladder or ureteric injury, intensive care unit (ICU) admission and prolonged hospital stay. There is an ongoing effort to improve the outcome of these women and measures to reduce blood loss. OBJECTIVE: The purpose of the present study was to develop an alternate surgical approach for performing a Cesarean hysterectomy in women with adherent placenta in order to reduce hemorrhage and urinary tract injuries, and thereby improve the maternal outcome...
July 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Anne Eskild, Lars Monkerud, Anne Marie Jukic, Bjørn Olav Åsvold, Kari Kveim Lie
BACKGROUND: Intrauterine conditions may be important in the development of cerebral palsy in the child. The hormone, human chorionic gonadotropin (hCG), is synthesized in the placenta, and hCG plays an important role in placental angiogenesis and development. Thus, maternal hCG concentrations may be an indicator of placental function and thereby the intrauterine environment for the offspring. We studied the associations of maternal concentrations of hCG during pregnancy with cerebral palsy in the child...
July 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Ligia D Prezotto, Jennifer F Thorson, Pawel P Borowicz, Jena L Peine, Michelle Bedenbaugh, Stanley M Hileman, Clay A Lents, Joel S Caton, Kendall C Swanson
Maternal nutrient restriction during gestation can exert long-term negative effects on offspring health and performance. Arginine supplementation may rescue some of the negative effects elicited by maternal nutrient restriction. We tested the hypothesis that maternal arginine supplementation during gestation would rescue deleterious effects of nutrient restriction on in vitro O2 consumption in the liver and jejunum and hypothalamic protein expression of proopiomelanocortin (POMC), neuropeptide Y (NPY), agouti-related peptide (AgRP), and neuronal nitric oxide synthase (nNOS), and the colocalization of nNOS and active phosphor-signal transducer and activator of transcription 3 (pSTAT3) in female offspring...
June 20, 2018: Domestic Animal Endocrinology
Eileen K Hutton, Mary E Hannah, Andrew R Willan, Susan Ross, Alexander C Allen, B Anthony Armson, Amiram Gafni, K S Joseph, Kathryn Mangoff, Arne Ohlsson, J Johanna Sanchez, Elizabeth V Asztalos, Jon F R Barrett
OBJECTIVE: Does planned caesarean compared with planned vaginal birth lower the risk of problematic urinary stress, fecal or flatal incontinence?. DESIGN: Women between 32 0/7 and 38 6/7 weeks gestation with twin pregnancy were randomised to planned caesarean or planned vaginal birth. SETTING: 106 centers in 25 countries. POPULATION: 2305 /2804 enrolled in the study completed questionnaires at two years (82.2%follow up): 1155 in the planned caesarean group, 1150 in the planned vaginal birth group...
July 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Yap Quin Jean, Rafidah Mazlan, Mahadir Ahmad, Nashrah Maamor
Purpose: The aim of this study was to develop a substantive theory that explains parenting stress among mothers of deaf or hard-of-hearing (D/HH) children. Method: Fifteen hearing mothers of children with severe-to-profound sensorineural hearing loss were interviewed. Interviews were transcribed verbatim, and a grounded theory approach was used to inductively analyze parental stress in mothers of D/HH children. Theory generation was achieved through triangulation of data sources and systematic organization of data into codes...
July 13, 2018: American Journal of Audiology
Betsy P Humphreys, Alan J Kurtz, Carrie Portrie, Leslie J Couse, Fatemeh Hajnaghizadeh
Purpose The current healthcare system requires Maternal and Child Health (MCH) professionals with strong interdisciplinary leadership competence. MCH training programs utilize a conceptual framework for leadership and 12 validated MCH Leadership Competencies. Examining Trainee Perceived Leadership Competence (TPLC) through the competencies has the potential to inform our understanding of leadership development. Description Five cohorts of NH-ME leadership education in neurodevelopmental disabilities trainees (n = 102) completed the MCH Leadership Competencies Self-Assessment at three time points...
July 13, 2018: Maternal and Child Health Journal
Cheryl L K Gibby, Cristina Palacios, Maribel Campos, Eunjung Lim, Jinan Banna
Objectives This study investigated the association between maternal pregravid body mass index (BMI) and breastfeeding discontinuation at 4-6 months postpartum in Hawaii and Puerto Rico participants from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Methods A secondary data analysis was conducted from a text message-based intervention in WIC participants in Hawaii and Puerto Rico. The analysis included 87 women from the control group who initiated breastfeeding and whose breastfeeding status was known at the end of the study when infants were 4-6 months old...
July 13, 2018: Maternal and Child Health Journal
Mary Guo, Michelle Quensell, Ann Chang, Jill Miyamura, Tetine Sentell
Introduction Comprehension of healthcare terminology across diverse populations is critical to patient education and engagement. Methods Women in Oahu, Hawai'i with a recent delivery were interviewed about their understanding of ten common obstetric terms. Health literacy was assessed by the rapid estimate of adult literacy in medicine (REALM). Multivariable models predicted total terms comprehended by demographic factors. Results Of 269 participants, self-reported primary race was 20.5% Japanese, 19.0% Native Hawaiian, 19...
July 13, 2018: Maternal and Child Health Journal
Stefan Kuhle, Adam Muir, Christy G Woolcott, Mary M Brown, Sarah D McDonald, Mohamed Abdolell, Linda Dodds
BACKGROUND/OBJECTIVE: The association between maternal pre-pregnancy obesity and adverse child health outcomes is well described, but there are few data on the relationship with offspring health service use. We examined the influence of maternal pre-pregnancy obesity on offspring health care utilization and costs over the first 18 years of life. METHODS: This was a population-based retrospective cohort study of children (n = 35,090) born between 1989 and 1993 and their mothers, who were identified using the Nova Scotia Atlee Perinatal Database and linked to provincial administrative health data from birth through 2014...
July 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Jennifer A Salati, Victoria H J Roberts, Matthias C Schabel, Jamie O Lo, Christopher D Kroenke, Katherine S Lewandowski, Jonathan R Lindner, Kevin L Grove, Antonio E Frias
BACKGROUND: In a Japanese macaque model of diet-induced obesity, we have previously demonstrated that consumption of a high-fat, "Western-style" diet (WSD) is associated with placental dysfunction and adverse pregnancy outcomes, independent of an obese maternal phenotype. Specifically, we have reported decreased uterine placental blood flow and increased inflammation with maternal WSD consumption. We also previously investigated the use of a promising therapeutic intervention that mitigated the adverse placental effects of a WSD but had unexpected detrimental effects on fetal pancreatic development...
July 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Olga Kirioukhova, Jubin N Shah, Danaé S Larsen, Muhammad Tayyab, Nora E Mueller, Geetha Govind, Célia Baroux, Michael Federer, Jacqueline Gheyselinck, Philippa J Barrell, Hong Ma, Stefanie Sprunck, Bruno Huettel, Helen Wallace, Ueli Grossniklaus, Amal J Johnston
Genomic imprinting confers parent-of-origin-specific gene expression, thus non-equivalent and complementary function of parental genomes. As a consequence, genomic imprinting poses an epigenetic barrier to parthenogenesis in sexual organisms. We report aberrant imprinting in Boechera, a genus in which apomicts evolved from sexuals multiple times. Maternal activation of a MADS-box gene, a homolog of which is imprinted and paternally expressed in the sexual relative Arabidopsis, is accompanied by locus-specific DNA methylation changes in apomicts where parental imprinting seems to be relaxed...
July 13, 2018: Scientific Reports
Mary O'Connell Motherway, Frances O'Brien, Tara O'Driscoll, Patrick G Casey, Fergus Shanahan, Douwe van Sinderen
The non-digestible oligosaccharide fraction of maternal milk represents an important of carbohydrate and energy source for saccharolytic bifidobacteria in the gastrointestinal tract during early life. However, not all neonatal bifidobacteria isolates can directly metabolise the complex sialylated, fucosylated, sulphated and/or N-acetylglucosamine-containing oligosaccharide structures present in mothers milk. For some bifidobacterial strains, efficient carbohydrate syntrophy or crossfeeding is key to their establishment in the gut...
July 13, 2018: Scientific Reports
Luc Joyeux, Enrico Danzer, Alan W Flake, Jan Deprest
Spina bifida aperta (SBA) is one of the most common congenital malformations. It can cause severe lifelong physical and neurodevelopmental disabilities. Experimental and clinical studies have shown that the neurological deficits associated with SBA are not simply caused by incomplete neurulation at the level of the lesion. Additional damage is caused by prolonged exposure of the spinal cord and nerves to the intrauterine environment and a suction gradient due to cerebrospinal fluid leakage, leading to progressive downward displacement of the hindbrain...
July 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Ziya Kalem, Muberra Namli Kalem, Elvan Anadol, Batuhan Bakirarar, Canan Yilmaz, Cigdem Elmas, Perihan Yalcinkaya, Halil Ruso, Timur Gurgan
This study aimed to investigate the effects of maternal unhealthy nutrition on the reproductive functions of female and male adult offspring. This was an animal study carried out with 24 virgin female Wistar rats(dams) and their male and female offspring. Rats were divided standard diet (SD) or cafeteria diet (CD) groups, after 10 weeks of feeding, all rats were paired with a Wistar stud male, and each group was again divided into CD and SD groups during the pregnancy and lactation periods. After birth, 6 female and 6 male pups in each group, were subjected to study...
July 13, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Roberto Villalobos-Labra, PabloJ Sáez, Mario Subiabre, Luis Silva, Fernando Toledo, Francisco Westermeier, Fabián Pardo, Marcelo Farías, Luis Sobrevia
Obesity associates with the endoplasmic reticulum (ER) stress-induced endothelial dysfunction. Pregnant women with pre-pregnancy maternal obesity (PGMO) may transfer this potential risk to their offspring; however, whether ER stress occurs and associates with foetoplacental endothelial dysfunction in PGMO is unknown. We studied the l-arginine transport and nitric oxide (NO) synthesis in human umbilical vein endothelial cells (HUVECs) from women with PGMO or with a normal pre-pregnancy weight. We analysed the expression and activation of the ER stress sensors protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and activating transcription factor 6 (ATF6)...
July 10, 2018: Biochimica et Biophysica Acta
Toshihiro Muraji, Hidenori Tanaka, Satoshi Ieiri
The cause of biliary atresia (BA) remains an enigma. However, an ethnic diversity in the incidence of BA is so unique that anthropological approach may provide some etiopathogenetic implications in the disease mechanism. We previously reported that an association of maternal microchimerism (MMc) in BA and a significant compatibility of HLA-A between the patient with BA and their mother. Acrossthe 10 countries (Japan, South Korea, Taiwan, Philippines, New Zealand (Maori population), UK, France, Germany, Norway, and Sweden), we determined the frequency of the most prevalentHLA haplotypes of each country from Allele Frequency Database and found that it was significantly correlated with the incidence of BA of the respective country (p =0...
July 10, 2018: Human Immunology
Cristina R Fernández, Maiko Yomogida, Yumiko Aratani, Diana Hernández
OBJECTIVE: To examine dual food and energy hardship and internalizing and externalizing behavior problems in 9 year-old children. METHODS: We conducted a cross-sectional analysis of the Fragile Families and Child Wellbeing Study, a prospective national urban birth cohort, when the children were 9 years-old. Maternal reported "food hardship" (ever hungry and/or ever received free food) and "energy hardship" (ever unable to pay utility bill and/or utility shut-off) within the past year, and child behavior using the Child Behavior Checklist/6-18 years were assessed...
July 11, 2018: Academic Pediatrics
Hassan I H El-Sayyad, Effat M F El-Shershaby, Ahmed A El-Mansi, Nermeen E El-Ashry
A high cholesterol diet is related to ovarian dysfunction and infertility which has been increased among young ages consuming processed food products. The present study was conducted to evaluate the role of a high cholesterol diet on the ovaries of young female rats via assessments of histopathology, immunohistochemistry, oxidative stress and apoptic markers. Also, mating of hypercholesterolemic female rats was carried out to measure the fertility and numbers of their offspring. At the same time, phytotherapy was carried out through supplementing the diet with barley and/ or date palm fruits (10%) during the experiment to assess the phyto-therapeutic impacts in attenuation of drastic hypercholesterolemic effects...
July 10, 2018: Reproductive Biology
Lexie Prokopuk, Jessica M Stringer, Craig R White, Rolf H A M Vossen, Stefan J White, Ana S A Cohen, William T Gibson, Patrick S Western
BACKGROUND: Investigating how epigenetic information is transmitted through the mammalian germline is the key to understanding how this information impacts on health and disease susceptibility in offspring. EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. RESULTS: In this study, we used oocyte-specific Zp3-Cre recombinase (Zp3Cre) to delete Eed specifically in mouse growing oocytes, permitting the study of EED function in oocytes and the impact of depleting EED in oocytes on outcomes in offspring...
July 13, 2018: Clinical Epigenetics
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