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https://www.readbyqxmd.com/read/28719388/what-is-new-in-managing-patients-with-food-allergy-almost-everything
#1
Brian Schroer, Jaclyn Bjelac, Mandy Leonard
PURPOSE OF REVIEW: This review aims to describe current concepts in managing patients with food allergy. There have been many recent advances in the management of patients with IgE-mediated reactions to food, including diagnosis, prevention, management, and ongoing research in the field. Food allergy is increasing in prevalence and may be life threatening. This review aims to highlight changes in recommended practice when diagnosing and managing patients with food allergy. RECENT FINDINGS: Early introduction of highly allergenic foods, particularly peanut, has been shown to decrease the risk for development of food allergy in patients who are at elevated risk...
July 14, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28717851/multidrug-resistant-salmonellae-isolated-in-japanese-quails-reared-in-abeokuta-nigeria
#2
Ezekiel O Omoshaba, F O Olufemi, O E Ojo, A O Sonibare, M Agbaje
Salmonellosis is a major bacterial disease causing huge economic losses in the poultry industry worldwide. This study was carried out to determine the period prevalence and antimicrobial susceptibility of Salmonella enterica in Japanese quails in Abeokuta, Nigeria. Four hundred cloacal swabs of quail birds were collected from 4 locations within Abeokuta. Salmonella was isolated from the samples using conventional methods for selective isolation of Salmonella and biochemical identification. Isolates were confirmed by polymerase chain reaction assays for the amplification and detection of Salmonella-associated virulence genes (invA and stn) using specific primers...
July 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28717845/proteomics-in-inflammatory-bowel-disease-approach-using-animal-models
#3
REVIEW
Fadi H Mourad, Yunki Yau, Valerie C Wasinger, Rupert W Leong
Recently, proteomics studies have provided important information on the role of proteins in health and disease. In the domain of inflammatory bowel disease, proteomics has shed important light on the pathogenesis and pathophysiology of inflammation and has contributed to the discovery of some putative clinical biomarkers of disease activity. By being able to obtain a large number of specimens from multiple sites and control for confounding environmental, genetic, and metabolic factors, proteomics studies using animal models of colitis offered an alternative approach to human studies...
July 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28717327/virulence-gene-profiles-of-arcobacter-species-isolated-from-animals-foods-of-animal-origin-and-humans-in-andhra-pradesh-india
#4
M Soma Sekhar, S R Tumati, B K Chinnam, V S Kothapalli, N Mohammad Sharif
AIM: This study aimed to detect putative virulence genes in Arcobacter species of animal and human origin. MATERIALS AND METHODS: A total of 41 Arcobacter isolates (16 Arcobacter butzleri, 13 Arcobacter cryaerophilus, and 12 Arcobacter skirrowii) isolated from diverse sources such as fecal swabs of livestock (21), raw foods of animal origin (13), and human stool samples (7) were subjected to a set of six uniplex polymerase chain reaction assays targeting Arcobacter putative virulence genes (ciaB, pldA, tlyA, mviN, cadF, and cj1349)...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28716358/the-ability-of-lizards-to-identify-an-artificial-batesian-mimic
#5
Josef Beneš, Petr Veselý
Birds are usually considered the main predators shaping the evolution of aposematic signals and mimicry. Nevertheless, some lizards also represent predominately visually oriented predators, so they may also play an important role in the evolution of aposematism. Despite this fact, experimental evidence regarding the responses of lizards to aposematic prey is very poor compared to such evidence in birds. Lizards possess very similar sensory and cognitive abilities to those of birds and their response to aposematic prey may thus be affected by very similar processes...
June 3, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28716098/awakening-sleeping-beauty-production-of-propionic-acid-in-escherichia-coli-through-the-sbm-operon-requires-the-activity-of-a-methylmalonyl-coa-epimerase
#6
Ricardo Axayacatl Gonzalez-Garcia, Tim McCubbin, Annalena Wille, Manuel Plan, Lars Keld Nielsen, Esteban Marcellin
BACKGROUND: Propionic acid is used primarily as a food preservative with smaller applications as a chemical building block for the production of many products including fabrics, cosmetics, drugs, and plastics. Biological production using propionibacteria would be competitive against chemical production through hydrocarboxylation of ethylene if native producers could be engineered to reach near-theoretical yield and good productivity. Unfortunately, engineering propionibacteria has proven very challenging...
July 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28711269/development-of-an-isothermal-amplification-based-assay-for-the-rapid-visual-detection-of-salmonella-bacteria
#7
Hai-Bin Liu, Yu-Xuan Zang, Xin-Jun Du, Ping Li, Shuo Wang
The efficient and timely detection of pathogens is a major concern worldwide. The aim of this study was to establish a rapid detection method for Salmonella bacteria in food samples to facilitate timely treatment. Widely used detection methods currently include culture-based methods and PCR-based methods. The former are time consuming, requiring 2 to 3 d, whereas the latter have higher accuracy but are typically complicated, requiring expertise and expensive instruments. In this study, a sensitive and rapid approach for the visual and point-of-use detection of Salmonella bacteria based on recombinase polymerase amplification (RPA) and a lateral-flow (LF) nucleic acid strip was established...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711194/factors-associated-with-epinephrine-administration-for-anaphylaxis-in-children-before-arrival-to-the-emergency-department
#8
Melissa Robinson, Matthew Greenhawt, David R Stukus
BACKGROUND: Epinephrine is the first-line treatment for anaphylaxis but may be underused by patients and medical personnel. OBJECTIVE: To evaluate factors associated with anaphylaxis management before arrival at the emergency department (ED) or urgent care center (UCC). METHODS: We performed a retrospective review of electronic medical records for all patients aged 0 to 25 years presenting with anaphylaxis to the ED or UCC at a pediatric academic referral center during 2009 to 2013...
June 30, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28709885/modeling-of-acetate-type-fermentation-of-sugar-containing-wastewater-under-acidic-ph-conditions
#9
Liang Huang, Xin-Rong Pan, Ya-Zhou Wang, Chen-Xuan Li, Chang-Bin Chen, Quan-Bao Zhao, Yang Mu, Han-Qing Yu, Wen-Wei Li
In this study, a kinetic model was developed based on Anaerobic Digestion Model No. 1 to provide insights into the directed production of acetate and methane from sugar-containing wastewater under low pH conditions. The model sufficiently described the dynamics of liquid-phase and gaseous products in an anaerobic membrane bioreactor by comprehensively considering the syntrophic bioconversion steps of sucrose hydrolysis, acidogenesis, acetogenesis and methanogenesis under acidic pH conditions. The modeling results revealed a significant pH-dependency of hydrogenotrophic methanogenesis and ethanol-producing processes that govern the sucrose fermentative pathway through changing the hydrogen yield...
June 16, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28707278/daclizumab-development-clinical-trials-and-practical-aspects-of-use-in-multiple-sclerosis
#10
REVIEW
Laura E Baldassari, John W Rose
Daclizumab is a humanized monoclonal antibody directed towards CD25, the alpha subunit of the high-affinity interleukin (IL)-2 receptor. Daclizumab exerts its effects via multiple mechanisms, including reduction of IL-2-mediated lymphocyte activation and upregulation of CD56-bright natural killer cells. Intravenous daclizumab (Zenapax™) was initially approved for prevention of rejection in renal transplant. In subsequent early testing, followed by larger-scale phase II and phase III trials, both intravenous and subcutaneous daclizumab have demonstrated clinical efficacy in the treatment of multiple sclerosis...
July 13, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28707051/application-of-transgalactosylation-activity-of-%C3%AE-galactosidase-from-kluyveromyces-lactis-for-the-synthesis-of-ascorbic-acid-galactoside
#11
Aleksandra Wojciechowska, Robert Klewicki, Michał Sójka, Katarzyna Grzelak-Błaszczyk
In view of a commonly known beneficial role and low stability of ascorbic acid, many efforts are constantly undertaken to produce its improved derivatives. This paper presents results on the synthesis of ascorbic acid galactoside using transgalactosylation properties of β-galactosidase from Kluyveromyces lactis and lactose as a donor of galactosyl moiety. The purpose of this study was to determine the influence of selected factors (concentration and molar ratio of substrates, amount of the enzyme preparation, pH of the solution, presence of different ions) on the course of transgalactosylation reaction...
July 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28703957/lactose-free-frozen-yogurt-production-and-characteristics
#12
Katarzyna Skryplonek, David Gomes, Jorge Viegas, Carlos Pereira, Marta Henriques
BACKGROUND: Nowadays, consumer demand is driving better and more nutritious dairy products. Changing from traditional to new lactose-free products poses technological challenges for the food industry in order to maintain or improve their food characteristics and consumer preferences. METHODS: This study investigates the production of lactose-free frozen yogurt by enzymati- cally hydrolysis of lactose, and its influence on the final product characteristics. In the case of lactose-free products, commercial Ha-lactase® was used for hydrolysis, and the reaction occurred simultaneously with fermentation...
April 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28703279/lactulose-production-by-a-thermostable-glycoside-hydrolase-from-the-hyperthermophilic-archaeon-caldivirga-maquilingensis-ic-167
#13
Rebaone Letsididi, Hinawi A M Hassanin, Marwa Y F Koko, Tao Zhang, Bo Jiang, Wanmeng Mu
BACKGROUND: Lactulose has various uses in the food and pharmaceutical fields. Thermostable enzymes have many advantages for industrial exploitation, including high substrate solubilities as well as reduced risk of process contamination. RESULTS: Enzymatic synthesis of lactulose employing a transgalactosylation reaction by a recombinant thermostable GH1 from the hyperthermophilic archaeon Caldivirga maquilingensis IC-167 was investigated and its optimum pH for lactulose production was found to be 4...
July 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28701697/peptidomics-of-an-in-vitro-digested-%C3%AE-gal-carrying-protein-revealed-ige-reactive-peptides
#14
D Apostolovic, M Krstic, J Mihailovic, M Starkhammar, T Cirkovic Velickovic, C Hamsten, M van Hage
The mammalian carbohydrate galactose-α1,3-galactose (α-Gal) causes a novel form of food allergy, red meat allergy, where patients experience severe allergic reactions several hours after red meat consumption. Here we explored gastric digestion of α-Gal glycoproteins using an in vitro model. Bovine thyroglobulin (BTG), a typical α-Gal carrying glycoprotein, was digested with pepsin. The resulting peptides were characterised by SDS PAGE, immunoblot and ImmunoCAP using sera from 20 red meat allergic patients...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701647/the-case-of-a-14-year-old-boy-who-experienced-anaphylaxis-due-to-jellyfish-mastigias-papua-ingestion
#15
Shohei Kubota, Asako Nozawa, Takanori Yanai, Koji Ozasa, Satomi Mori, Kazuyuki Kurihara
We report a case of jellyfish allergy diagnosed via an oral food challenge. A 14-year-old boy had no history of jellyfish stings and had been eating commercially available jellyfish products twice yearly for the past 5-6 years. Five minutes after eating a commercially available boiled jellyfish product (100g), he experienced nausea, wheezing, and erythema and had visited our hospital. We suspected an anaphylactic reaction and treated him with intramuscular adrenaline injection, corticosteroid and antihistamine infusions, volume resuscitation, and salbutamol sulfate inhalation, which resulted in an improvement of the symptoms...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28701646/an-adult-case-of-anaphylaxis-caused-by-allergy-to-jellyfish
#16
Shintaro Suzuki, Yoshito Miyata, Megumi Jinno, Yasunari Kishino, Tetsuya Homma, Shin Ota, Akihiko Tanaka, Takuya Yokoe, Tsukasa Ohnishi, Hironori Sagara, Naomi Kurata, Kuniyoshi Shimakura, Kouichi Kurose
A 35-year-old female, professional diver, reported nausea, vomiting, and systemic hives 20 to 30 minutes after ingestion of antipasto made with jellyfish. Patient reported prior episodes of swelling after stings from several different creatures, including jelly fish. She also developed a systemic allergic reaction after sting from an unknown creature while diving. On the initial visit to our hospital, serum total IgE level was 545IU/ml. We extracted crude allergen from jellyfish and evaluated allergen specific IgE antibody levels using ELISA...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28701251/recognition-and-management-of-anaphylaxis-in-older-adults
#17
Anastasiya Plagova, Diane Nykamp
OBJECTIVES: To discuss medications that cause anaphylaxis in older adults and its treatment, with a focus on epinephrine. DATA SOURCE: A search of PubMed using the terms "anaphylaxis," "drug-induced anaphylaxis," "epinephrine autoinjectable," "anaphylaxis diagnosis," "anaphylaxis treatment," and "epinephrine cost" was performed. English-language articles from January 2000 to August 2016 appearing in these searches were reviewed. STUDY SELECTION/DATA EXTRACTION: Relevant review articles, consensus statements, practice parameters, task force recommendations, and original articles were assessed for recognition and treatment of drug-induced anaphylaxis...
July 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28700928/molecular-state-of-the-membrane-active-antibiotic-daptomycin
#18
Ming-Tao Lee, Wei-Chin Hung, Meng-Hsuan Hsieh, Hsiung Chen, Yu-Yung Chang, Huey W Huang
Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved by the U.S. Food and Drug Administration so far. The drug interacts with the cytoplasmic membranes of Gram-positive pathogens, causing membrane permeabilization to ions and cell death. The antibiotic activity is calcium-ion dependent and correlates with the target membrane's content of phosphatidylglycerol (PG). For such a complex reaction with membranes, it has been difficult to uncover the molecular process that underlies its antibacterial activity...
July 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28700218/response-of-soil-microbial-communities-to-elevated-antimony-and-arsenic-contamination-indicates-the-relationship-between-the-innate-microbiota-and-contaminant-fractions
#19
Weimin Sun, Enzong Xiao, Tangfu Xiao, Valdis Krumins, Qi Wang, Max M Haggblom, Yiran Dong, Song Tang, Min Hu, Baoqin Li, Bingqing Xia, Wei Liu
Mining of sulfide ore deposits containing metalloids, such as antimony and arsenic, has introduced serious soil contamination around the world, posing severe threats to food safety and human health. Hence, it is important to understand the behavior and composition of the microbial communities that control the mobilization or sequestration of these metal(loid)s. Here, we selected two sites in Southwest China with different levels of Sb and As contamination to study interactions among various Sb and As fractions and the soil microbiota, with a focus on the microbial response to metalloid contamination...
July 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28697661/safety-of-a-proteoliposome-from-neisseria-meningitides-as-adjuvant-for-a-house-dust-mite-allergy-vaccine
#20
Wendy Ramírez, Virgilio Bourg, Damaris Torralba, Elisa Facenda, Beatriz Tamargo, Bárbara O González, Gustavo Sierra, Oliver Pérez, Yordanis Perez-Llano, Alexis Labrada
The proteoliposome (PL) of Neisseria meningitidis serogroup B has been reported as a safe and potent vaccine adjuvant, inducing a TH1-skewed response. The present study describes a pre-clinical safety evaluation of an allergy therapeutic vaccine candidate based on purified allergens from Dermatophagoides siboney house dust mite and PL as adjuvant, both components adsorbed onto aluminum hydroxide gel. Two separate studies of acute toxicity evaluation were performed in mice and rabbits, and two repeat-dose studies were conducted in non-sensitized and allergen-sensitized Balb/c mice, respectively...
December 2017: Journal of Immunotoxicology
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