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Zika virus in pregnancy

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https://www.readbyqxmd.com/read/29049277/update-interim-guidance-for-the-diagnosis-evaluation-and-management-of-infants-with-possible-congenital-zika-virus-infection-united-states-october-2017
#1
Tolulope Adebanjo, Shana Godfred-Cato, Laura Viens, Marc Fischer, J Erin Staples, Wendi Kuhnert-Tallman, Henry Walke, Titilope Oduyebo, Kara Polen, Georgina Peacock, Dana Meaney-Delman, Margaret A Honein, Sonja A Rasmussen, Cynthia A Moore
CDC has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection (1) in response to recently published updated guidance for health care providers caring for pregnant women with possible Zika virus exposure (2), unknown sensitivity and specificity of currently available diagnostic tests for congenital Zika virus infection, and recognition of additional clinical findings associated with congenital Zika virus infection. All infants born to mothers with possible Zika virus exposure* during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit including a comprehensive physical examination, age-appropriate vision screening and developmental monitoring and screening using validated tools (3-5), and newborn hearing screen at birth, preferably using auditory brainstem response (ABR) methodology (6)...
October 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29048293/long-term-viruria-in-zika-virus-infected-pregnant-women-brazil-2016
#2
Ana Carolina B Terzian, Cássia Fernanda Estofolete, Rafael Alves da Silva, Denise Cristina Mós Vaz-Oliani, Antonio Hélio Oliani, Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos, Paula Rahal, Maurício L Nogueira
During the 2016 Zika virus outbreak in Brazil, we detected Zika virus RNA in urine samples collected from Zika virus-positive pregnant women during different stages of pregnancy. Women had positive and negative intervals of viruria; 3 newborns had adverse outcomes. Further research is needed to clarify the relationship between viruria and outcomes for newborns.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29039229/exposure-to-allethrin-based-mosquito-coil-smoke-during-gestation-and-postnatal-development-affects-reproductive-function-in-male-offspring-of-rat
#3
Golla Madhubabu, Suresh Yenugu
The threat of zika virus looms throughout the world and the use of allethrin-based mosquito coils to prevent mosquito bites during and postpregnancy is on the rise. The aim of this study was to analyze the toxic effects of exposure to allethrin-based mosquito coil smoke in rats under conditions that reflect human settings. Pregnant female rats were exposed to mosquito coil smoke and same was continued to the male pups up to 111 days postparturition (21-day weaning plus up to 90 days postweaning). Increased oxidative stress, distorted antioxidant enzyme status, downregulation of genes involved in spermatogenesis, sperm maturation and steroidogenesis was observed...
July 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29026637/a-review-of-selected-arboviruses-during-pregnancy
#4
REVIEW
Penélope Saldanha Marinho, Antonio José Cunha, Joffre Amim Junior, Arnaldo Prata-Barbosa
Arboviruses are emerging infectious diseases with the ability to expand geographically and rapidly affect large populations. The recent epidemic caused by the Zika virus in the Americas and congenital Zika syndrome associated with maternal infection has called out attention to the importance of studying arboviruses during pregnancy. This is a review on selected arboviruses infections during gestation, including Zika, Chikungunya, Dengue and Yellow Fever viruses. Issues such as historical overview, pathogenesis, transmission, clinical conditions, diagnosis, treatment and prevention are addressed...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29020159/distinguishing-secondary-dengue-virus-infection-from-zika-virus-infection-with-previous-dengue-by-a-combination-of-three-simple-serological-tests
#5
Wen-Yang Tsai, Han Ha Youn, Carlos Brites, Jih-Jin Tsai, Jasmine Tyson, Celia Pedroso, Jan Felix Drexler, Mars Stone, Graham Simmons, Michael P Busch, Marion Lanteri, Susan L Stramer, Angel Balmaseda, Eva Harris, Wei-Kung Wang
Background: The explosive spread of Zika virus (ZIKV) and associated microcephaly present an urgent need for sensitive and specific serodiagnostic tests, particularly for pregnant women in dengue virus (DENV)-endemic regions. Recent reports of enhanced ZIKV replication by dengue-immune sera have raised concerns about the role of previous DENV infection on the risk and severity of microcephaly and other ZIKV complications. Methods: Enzyme-linked immunosorbent assays (ELISAs) based on ZIKV and DENV non-structural protein 1 (NS1) were established to test acute, convalescent-phase and post-convalescent-phase serum/plasma samples from reverse-transcription polymerase-chain reaction-confirmed-cases including 20 primary ZIKV, 25 ZIKV with previous dengue, 58 secondary DENV, and 16 primary DENV1 infections...
July 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28980148/the-pathogenesis-of-microcephaly-resulting-from-congenital-infections-why-is-my-baby-s-head-so-small
#6
REVIEW
L D Frenkel, F Gomez, F Sabahi
The emergence of Zika-virus-associated congenital microcephaly has engendered renewed interest in the pathogenesis of microcephaly induced by infectious agents. Three of the original "TORCH" agents are associated with an appreciable incidence of congenital microcephaly: cytomegalovirus, rubella virus, and Toxoplasma gondii. The pathology of congenital microcephaly is characterized by neurotropic infectious agents that involve the fetal nervous system, leading to brain destruction with calcifications, microcephaly, sensorineural hearing loss, and ophthalmologic abnormalities...
October 5, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28976853/brain-mri-in-infants-after-maternal-zika-virus-infection-during-pregnancy
#7
LETTER
Mehdi Mejdoubi, Alice Monthieux, Tiphaine Cassan, Catherine Lombard, Olivier Flechelles, Clara Adenet
New England Journal of Medicine, Volume 377, Issue 14, Page 1399-1400, October 2017.
October 5, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28961800/zika-virus-and-reproduction-facts-questions-and-current-management
#8
Sylvie Epelboin, Emmanuel Dulioust, Loïc Epelboin, Alexandra Benachi, Françoise Merlet, Catherine Patrat
BACKGROUND: Zika virus (ZIKV) is an arthropod-borne virus of the family Flaviviridae, genus Flavivirus. ZIKV is currently the focus of an ongoing pandemic and worldwide public health emergency. Although originally isolated in 1947, its pathogenesis was poorly known and very few documented infections were published until recently. Its route of transmission and its impact on reproduction and pregnancy have only recently begun to be disclosed. OBJECTIVE AND RATIONALE: This review summarizes the most recent knowledge about ZIKV infection and pathogenesis and focuses on its impacts on male and female genital tracts, including the risks of sexual transmission and to pregnancy...
August 9, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28954927/rapid-antigen-tests-for-dengue-virus-serotypes-and-zika-virus-in-patient-serum
#9
Irene Bosch, Helena de Puig, Megan Hiley, Marc Carré-Camps, Federico Perdomo-Celis, Carlos F Narváez, Doris M Salgado, Dewahar Senthoor, Madeline O'Grady, Elizabeth Phillips, Ann Durbin, Diana Fandos, Hikaru Miyazaki, Chun-Wan Yen, Margarita Gélvez-Ramírez, Rajas V Warke, Lucas S Ribeiro, Mauro M Teixeira, Roque P Almeida, José E Muñóz-Medina, Juan E Ludert, Mauricio L Nogueira, Tatiana E Colombo, Ana C B Terzian, Patricia T Bozza, Andrea S Calheiros, Yasmine R Vieira, Giselle Barbosa-Lima, Alexandre Vizzoni, José Cerbino-Neto, Fernando A Bozza, Thiago M L Souza, Monique R O Trugilho, Ana M B de Filippis, Patricia C de Sequeira, Ernesto T A Marques, Tereza Magalhaes, Francisco J Díaz, Berta N Restrepo, Katerine Marín, Salim Mattar, Daniel Olson, Edwin J Asturias, Mark Lucera, Mohit Singla, Guruprasad R Medigeshi, Norma de Bosch, Justina Tam, Jose Gómez-Márquez, Charles Clavet, Luis Villar, Kimberly Hamad-Schifferli, Lee Gehrke
The recent Zika virus (ZIKV) outbreak demonstrates that cost-effective clinical diagnostics are urgently needed to detect and distinguish viral infections to improve patient care. Unlike dengue virus (DENV), ZIKV infections during pregnancy correlate with severe birth defects, including microcephaly and neurological disorders. Because ZIKV and DENV are related flaviviruses, their homologous proteins and nucleic acids can cause cross-reactions and false-positive results in molecular, antigenic, and serologic diagnostics...
September 27, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28945787/rapid-colorimetric-detection-of-zika-virus-from-serum-and-urine-specimens-by-reverse-transcription-loop-mediated-isothermal-amplification-rt-lamp
#10
Amanda E Calvert, Brad J Biggerstaff, Nathan A Tanner, Molly Lauterbach, Robert S Lanciotti
Zika virus (ZIKV) has emerged as a major global public health concern in the last two years due to its link as a causative agent of human birth defects. Its rapid expansion into the Western Hemisphere as well as the ability to be transmitted from mother to fetus, through sexual transmission and possibly through blood transfusions has increased the need for a rapid and expansive public health response to this unprecedented epidemic. A non-invasive and rapid ZIKV diagnostic screening assay that can be performed in a clinical setting throughout pregnancy is vital for prenatal care of women living in areas of the world where exposure to the virus is possible...
2017: PloS One
https://www.readbyqxmd.com/read/28939807/a-single-dose-live-attenuated-vaccine-prevents-zika-virus-pregnancy-transmission-and-testis-damage
#11
Chao Shan, Antonio E Muruato, Brett W Jagger, Justin Richner, Bruno T D Nunes, Daniele B A Medeiros, Xuping Xie, Jannyce G C Nunes, Kaitlyn M Morabito, Wing-Pui Kong, Theodore C Pierson, Alan D Barrett, Scott C Weaver, Shannan L Rossi, Pedro F C Vasconcelos, Barney S Graham, Michael S Diamond, Pei-Yong Shi
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916522/viral-infection-sensitizes-human-fetal-membranes-to-bacterial-lipopolysaccharide-by-mertk-inhibition-and-inflammasome-activation
#12
Sarah N Cross, Julie A Potter, Paulomi Aldo, Ja Young Kwon, Mary Pitruzzello, Mancy Tong, Seth Guller, Carla V Rothlin, Gil Mor, Vikki M Abrahams
Chorioamnionitis, premature rupture of fetal membranes (FMs), and subsequent preterm birth are associated with local infection and inflammation, particularly IL-1β production. Although bacterial infections are commonly identified, other microorganisms may play a role in the pathogenesis. Because viral pandemics, such as influenza, Ebola, and Zika, are becoming more common, and pregnant women are at increased risk for associated complications, this study evaluated the impact that viral infection had on human FM innate immune responses...
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28914749/raised-frequency-of-microcephaly-related-to-zika-virus-infection-in-two-birth-defects-surveillance-systems-in-bogot%C3%A3-and-cali-colombia
#13
Paula Hurtado-Villa, Angie K Puerto, Salomé Victoria, Gloria Gracia, Lesly Guasmayán, Patricia Arce, Gilberto Álvarez, Esperanza Blandón, Nubia Rengifo, Jorge A Holguín, Alexander Durán, Ignacio Zarante
Zika virus infection during pregnancy is now known to cause congenital microcephaly and severe brain defects. In 2016, rates of microcephaly appeared to start increasing around May, peaking in July, and declining through December. The occurrence of microcephaly appears to have increased nearly 4-fold in 2 large cities in Colombia, concurrently with the reported Zika virus epidemic in the country.
October 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28910635/gestational-stage-and-ifn-%C3%AE-signaling-regulate-zikv-infection-in-utero
#14
Brett W Jagger, Jonathan J Miner, Bin Cao, Nitin Arora, Amber M Smith, Attila Kovacs, Indira U Mysorekar, Carolyn B Coyne, Michael S Diamond
Although Zika virus (ZIKV)-induced congenital disease occurs more frequently during early stages of pregnancy, its basis remains undefined. Using established type I interferon (IFN)-deficient mouse models of ZIKV transmission in utero, we found that the placenta and fetus were more susceptible to ZIKV infection at earlier gestational stages. Whereas ZIKV infection at embryonic day 6 (E6) resulted in placental insufficiency and fetal demise, infections at midstage (E9) resulted in reduced cranial dimensions, and infection later in pregnancy (E12) caused no apparent fetal disease...
September 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28887877/epidemiological-and-ecological-determinants-of-zika-virus-transmission-in-an-urban-setting
#15
José Lourenço, Maricelia Maia de Lima, Nuno Rodrigues Faria, Andrew Walker, Moritz Ug Kraemer, Christian Julian Villabona-Arenas, Ben Lambert, Erenilde Marques de Cerqueira, Oliver G Pybus, Luiz Cj Alcantara, Mario Recker
The Zika virus has emerged as a global public health concern. Its rapid geographic expansion is attributed to the success of Aedes mosquito vectors, but local epidemiological drivers are still poorly understood. Feira de Santana played a pivotal role in the Chikungunya epidemic in Brazil and was one of the first urban centres to report Zika infections. Using a climate-driven transmission model and notified Zika case data, we show that a low observation rate and high vectorial capacity translated into a significant attack rate during the 2015 outbreak, with a subsequent decline in 2016 and fade-out in 2017 due to herd-immunity...
September 9, 2017: ELife
https://www.readbyqxmd.com/read/28878742/zika-virus-what-have-we-learnt-since-the-start-of-the-recent-epidemic
#16
REVIEW
Juan-Carlos Saiz, Miguel A Martín-Acebes, Rubén Bueno-Marí, Oscar D Salomón, Luis C Villamil-Jiménez, Jorg Heukelbach, Carlos H Alencar, Paul K Armstrong, Tania M Ortiga-Carvalho, Rosalia Mendez-Otero, Paulo H Rosado-de-Castro, Pedro M Pimentel-Coelho
Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28878071/zika-virus-escapes-nk-cell-detection-by-upregulating-mhc-class-i-molecules
#17
Ariella Glasner, Esther Oiknine-Djian, Yiska Weisblum, Mohammad Diab, Amos Panet, Dana G Wolf, Ofer Mandelboim
NK cells are innate lymphocytes that participate in many immune processes encompassing cancer, bacterial and fungal infection, autoimmunity and even pregnancy and are specialize in anti-viral defense. NK cells express inhibitory and activating receptors and kill their targets when activating signals overpower the inhibitory ones. The NK cell inhibitory receptors compose of a uniquely diverse array of proteins named Killer-cell immunoglobulin-like receptors (KIRs) the CD94 family and the leukocyte immunoglobulin like receptor family (LIR)...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28877754/association-between-suspected-zika-virus-disease-during-pregnancy-and-giving-birth-to-a-newborn-with-congenital-microcephaly-a-matched-case-control-study
#18
Ticiane Henriques Santa Rita, Renata Barcelos Barra, Gisele Pasquali Peixoto, Pedro Goes Mesquita, Gustavo Barcelos Barra
OBJECTIVE: In early 2015, an outbreak of an acute exanthematous illness with dengue-like symptoms occurred in northeastern Brazil. By the end of the same year, an unexpected increase in the number of cases of microcephaly was observed in the region. The microcephaly outbreak cause was unknown and rumors pointing to various potential causes arose. Since we were unaware at the time if this scenario would attract the interest of the broader scientific community, due to the neglected regions associated and as often happens with many others health conditions related to infectious diseases in Latin America...
September 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28837029/zika-virus-outbreak-should-assisted-reproduction-patients-avoid-pregnancy
#19
Edson Borges, Daniela Paes de Almeida Ferreira Braga, Bianca Ferrarini Zanetti, Amanda Souza Setti, Rodrigo Rosa Provenza, Assumpto Iaconelli
OBJECTIVE: To discuss the requirement from the National Health Surveillance Agency (ANVISA), for assisted reproduction treatment patients to undergo laboratory tests for ZIKV detection, and if the public health authorities and government leaders' recommendations to women simply avoid pregnancy is prudent. METHODS: This study was performed in a university-affiliated in vitro fertilization center in Brazil. We present a critical discussion on the risk of microcephaly due to ZIKV infection and the prevalence of other harmful pathogens to vulnerable pregnant women and infants...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28835931/t-cell-responses-in-individuals-infected-with-zika-virus-and-in-those-vaccinated-against-dengue-virus
#20
Dominic Paquin-Proulx, Fabio E Leal, Cassia G Terrassani Silveira, Alvino Maestri, Claudia Brockmeyer, Shannon M Kitchen, Vinicius D Cabido, Esper G Kallas, Douglas F Nixon
BACKGROUND: The outbreak of Zika virus (ZIKV) infection in Brazil has raised concerns that infection during pregnancy could cause microcephaly and other severe neurodevelopmental malformations in the fetus. The mechanisms by which ZIKV causes fetal abnormalities are largely unknown. The importance of pre-infection with dengue virus (DENV), or other flaviviruses endemic to Brazil, remains to be investigated. It has been reported that antibodies directed against DENV can increase ZIKV infectivity by antibody dependent enhancement (ADE), suggesting that a history of prior DENV infection might worsen the outcome of ZIKV infection...
2017: Pathogens & Immunity
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