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Zika virus in pregnancy

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https://www.readbyqxmd.com/read/29445153/development-of-a-chimeric-zika-vaccine-using-a-licensed-live-attenuated-flavivirus-vaccine-as-backbone
#1
Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D Davidson, Ya-Jun Song, Pei-Yong Shi, Cheng-Feng Qin
The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, while exhibiting an attenuation phenotype in multiple animal models...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29437048/development-of-infants-with-congenital-zika-syndrome-what-do-we-know-and-what-can-we-expect
#2
Anne C Wheeler
The association between Zika virus infection during pregnancy and severe birth defects in infants has led to worldwide attention focused on the mechanisms of the disease and the prevention of future exposure. Surveillance efforts around the world continue with the goal of identifying and monitoring all potentially exposed women and their newborns. For infants who were born with congenital Zika syndrome (CZS) and their families, an uncertain future awaits. As infants who were born with CZS during the most recent outbreak enter their second year of life, new developments in the outcomes of the condition continue to unfold, providing some insight into the likely long-term sequalae...
February 2018: Pediatrics
https://www.readbyqxmd.com/read/29435496/zika-virus-alters-dna-methylation-of-neural-genes-in-an-organoid-model-of-the-developing-human-brain
#3
Sylvie Janssens, Michael Schotsaert, Rahul Karnik, Vinod Balasubramaniam, Marion Dejosez, Alexander Meissner, Adolfo García-Sastre, Thomas P Zwaka
Zika virus (ZIKV) infection during early pregnancy can cause microcephaly and associated defects at birth, but whether it can induce neurologic sequelae that appear later in life remains unclear. Using a model of the developing brain based on embryonic stem cell-derived brain organoids, we studied the impact of ZIKV infection on the DNA methylation pattern across the entire genome in selected neural cell types. The virus unexpectedly alters the DNA methylome of neural progenitors, astrocytes, and differentiated neurons at genes that have been implicated in the pathogenesis of a number of brain disorders, most prominently mental retardation and schizophrenia...
January 2018: MSystems
https://www.readbyqxmd.com/read/29428987/scope-of-knowledge-about-zika-among-women-in-us-mexico-border-communities
#4
Jill A McDonald, Katherine Selchau, Bridget Acquah-Baidoo
Maternal Zika virus infection (ZIKV) has serious health consequences for unborn offspring. Knowledge about prevention is critical to reducing risk, yet what women in the high-risk US-Mexico border region know about protecting themselves and their babies from ZIKV is mostly unknown. This study aimed to assess knowledge of ZIKV among pregnant and inter-conception women and to identify sources of information that might address knowledge gaps. Clients in five federally-funded, border region Healthy Start programs (N = 326) were interviewed in late 2016 about their knowledge of ZIKV prevention methods and whether they believed themselves or their babies to be at risk...
February 10, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29421625/microglia-the-missing-link-in-maternal-immune-activation-and-fetal-neurodevelopment-and-a-possible-link-in-preeclampsia-and-disturbed-neurodevelopment
#5
Jelmer R Prins, Sharon Eskandar, Bart J L Eggen, Sicco A Scherjon
Disturbances in fetal neurodevelopment have extensively been related to neurodevelopmental disorders in early and later life. Fetal neurodevelopment is dependent on adequate functioning of the fetal immune system. During pregnancy, the maternal immune system is challenged to both tolerate the semi-allogenic fetus and to protect the mother and fetus from microbes. The fetal immune system is influenced by maternal immune disturbances; therefore, perturbations in maternal immunity likely do not only alter pregnancy outcome but also alter fetal neurodevelopment...
January 31, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29416874/optimization-of-commercially-available-zika-virus-antibodies-for-use-in-a-laboratory-developed-immunohistochemical-assay
#6
Brigid C Bollweg, Luciana Silva-Flannery, Pamela Spivey, Gillian L Hale
Zika virus (ZIKV) infection during pregnancy can cause adverse fetal outcomes and severe irreversible congenital birth defects including microcephaly. Immunohistochemistry (IHC) is a valuable diagnostic tool for detecting ZIKV antigens in tissues from cases of fetal loss in women infected with ZIKV, and for providing insights into disease pathogenesis. As a result, there is increasing demand for commercially available ZIKV antibodies for use in IHC assays. ZIKV antibodies were selected and obtained from commercial sources to include both mouse and rabbit hosts, and a variety of antigenic targets...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29415586/what-we-know-and-what-we-don-t-know-about-perinatal-zika-virus-infection-a-systematic-review
#7
Antoni Soriano-Arandes, Irene Rivero-Calle, Eleni Nastouli, Maria Espiau, M A Frick, Ana Alarcon, Federico Martinón-Torres
Zika virus (ZIKV) infection has caused the most challenging worldwide infectious epidemic outbreak in recent months. ZIKV causes microcephaly and other congenital malformations. There is a need to perform updated systematic reviews on ZIKV infection periodically because this epidemic is bringing up new evidence with extraordinary speed. Areas covered: Evidence related to ZIKV infection in the gestational, perinatal, and early infant periods covering epidemiology, virology, pathogenesis, risk factors, time of infection during pregnancy, newborn symptoms, treatment, and vaccines...
February 8, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29412347/microcephaly-in-piau%C3%A3-brazil-descriptive-study-during-the-zika-virus-epidemic-2015-2016
#8
Igor Gonçalves Ribeiro, Marcia Regina de Andrade, Janaína de Moraes Silva, Zenira Martins Silva, Maria Amélia de Oliveira Costa, Marcelo Adriano da Cunha E Silva Vieira, Francisca Miriane de Araújo Batista, Herlon Guimarães, Marcelo Yoshito Wada, Eduardo Saad
OBJECTIVE: to describe the occurrence and characteristics of microcephaly cases in Piauí, Brazil, during an epidemic of Zika virus infection in 2015-2016. METHODS: descriptive study using data of live births from January/2015 to January/2016, obtained from the Information System on Live Births (Sinasc), the Public Health Events Registry (RESP) and the active search for medical records; mothers and live births were tested for dengue, chikungunya, and Zika, besides syphilis, toxoplasmosis, rubella, cytomegalovirus, and herpes (STORCH)...
February 1, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29406461/zika-virus-a-public-health-perspective
#9
Nahida Chakhtoura, Rohan Hazra, Catherine Y Spong
PURPOSE OF REVIEW: Zika virus' impact on pregnancy became widely known in 2015 with a dramatic increase in the number of babies born with microcephaly in Recife, Brazil. A mosquito-borne virus resulting in congenital anomalies is unique, and Zika's ability to cause neurological defects on a large scale was a grim reminder of the Rubella epidemic in the 1950s. Over the past 2 years, studies have provided insight on how Zika virus (ZIKV) infects cells and causes disease, but much remains unknown about the long-term risks of Zika exposure on infant growth and development...
February 5, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29401460/zika-virus-like-particles-elicit-protective-antibodies-in-mice
#10
Mauricio A Salvo, Brock Kingstad-Bakke, Cristhian Salas-Quinchucua, Erwin Camacho, Jorge E Osorio
Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of congenital abnormalities. To date, no vaccines or antivirals are publicly available. We developed Zika virus-like particles (VLPs) and evaluated their immunogenicity and protective efficacy in mouse models. ZIKV VLPs (ZIKVLPs) formulated with alum were injected into 6-8-week-old interferon deficient AG129 mice as well as wild type BALB/c mice...
February 5, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29390455/cerebral-injuries-associated-with-zika-virus-in-utero-exposure-in-children-without-birth-defects-in-french-guiana-case-report
#11
Arthur Felix, Edouard Hallet, Anne Favre, Rémi Kom-Tchameni, Antoine Defo, Olivier Fléchelles, Jean-Marc Rosenthal, Maylis Douine, Mathieu Nacher, Narcisse Elenga
RATIONALE: A major epidemic of Zika virus (ZIKV) infection occurred in French Guiana and West Indies. French national epidemiological surveillance estimated that 1650 pregnant women contracted the ZIKV during epidemic period from January 2016 to October 2016 in French Guiana. PATIENT CONCERNS: ZIKV infection during pregnancy is a cause of microcephaly and birth defects. DIAGNOSES: In this report, we describe 2 children with proven in utero ZIKV exposure...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388670/zika-virus-outbreaks-and-treatment-in-pregnant-women-in-ho-chi-minh-city-vietnam
#12
Thuong C Bui, Xuan V Huynh, Hoang Nguyen, Kieu T Nguyen, Chuong D Nguyen, Nguyen D Pham
The present study includes two case reports of pregnant patients with Zika virus (ZIKV) infections in Vietnam. Both patients provided written consent for the publication of the case reports. In the first, a Southern Vietnamese women (G1 P2 ) aged 30 years who was in the 21st week of pregnancy and was living with her husband in District 8 of Ho Chi Minh City, Vietnam, approximately 9.9 km from Tu Du Hospital, Ho Chi Minh City, presented for treatment. One week prior to presentation, the patient became ill with ocular pain, myalgia, and mild fever (maximum 37...
February 1, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29381706/ocular-and-uteroplacental-pathology-in-a-macaque-pregnancy-with-congenital-zika-virus-infection
#13
Emma L Mohr, Lindsey N Block, Christina M Newman, Laurel M Stewart, Michelle Koenig, Matthew Semler, Meghan E Breitbach, Leandro B C Teixeira, Xiankun Zeng, Andrea M Weiler, Gabrielle L Barry, Troy H Thoong, Gregory J Wiepz, Dawn M Dudley, Heather A Simmons, Andres Mejia, Terry K Morgan, M Shahriar Salamat, Sarah Kohn, Kathleen M Antony, Matthew T Aliota, Mariel S Mohns, Jennifer M Hayes, Nancy Schultz-Darken, Michele L Schotzko, Eric Peterson, Saverio Capuano, Jorge E Osorio, Shelby L O'Connor, Thomas C Friedrich, David H O'Connor, Thaddeus G Golos
Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Significant pathology at the maternal-fetal interface included acute chorioamnionitis, placental infarcts, and leukocytoclastic vasculitis of the myometrial radial arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29372233/birth-defects-potentially-related-to-zika-virus-infection-during-pregnancy-in-the-united-states
#14
Brenda Fitzgerald, Coleen Boyle, Margaret A Honein
No abstract text is available yet for this article.
January 25, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29371100/the-zika-contraception-access-network-a-feasibility-programme-to-increase-access-to-contraception-in-puerto-rico-during-the-2016-17-zika-virus-outbreak
#15
Eva Lathrop, Lisa Romero, Stacey Hurst, Nabal Bracero, Lauren B Zapata, Meghan T Frey, Maria I Rivera, Erin N Berry-Bibee, Margaret A Honein, Judith Monroe, Denise J Jamieson
BACKGROUND: Prevention of unintended pregnancy is a primary strategy to reduce adverse pregnancy and birth outcomes related to Zika virus infection. The Zika Contraception Access Network (Z-CAN) aimed to build a network of health-care providers offering client-centred contraceptive counselling and the full range of reversible contraception at no cost to women in Puerto Rico who chose to prevent pregnancy during the 2016-17 Zika virus outbreak. Here, we describe the Z-CAN programme design, implementation activities, and baseline characteristics of the first 21 124 participants...
January 19, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29370577/maternal-fetal-transmission-of-the-zika-virus-an-intriguing-interplay
#16
Camila Zanluca, Lucia de Noronha, Claudia Nunes Duarte Dos Santos
In this review, we give an overview of aspects related to the congenital transmission of the Zika virus (ZIKV). Although we acknowledge that important advances in research on ZIKV pathogenesis have come from studies using animal models, particularly non-human primates, this review emphasizes studies using ex-vivo human cells and tissues as well as natural infections in pregnant women. The possible routes used by ZIKV to cross or breach the placental barrier and infect the fetal central nervous system are presented...
November 6, 2017: Tissue Barriers
https://www.readbyqxmd.com/read/29370151/population-based-surveillance-of-birth-defects-potentially-related-to-zika-virus-infection-15-states-and-u-s-territories-2016
#17
Augustina Delaney, Cara Mai, Ashley Smoots, Janet Cragan, Sascha Ellington, Peter Langlois, Rebecca Breidenbach, Jane Fornoff, Julie Dunn, Mahsa Yazdy, Nancy Scotto-Rosato, Joseph Sweatlock, Deborah Fox, Jessica Palacios, Nina Forestieri, Vinita Leedom, Mary Smiley, Amy Nance, Heather Lake-Burger, Paul Romitti, Carrie Fall, Miguel Valencia Prado, Jerusha Barton, J Michael Bryan, William Arias, Samara Viner Brown, Jonathan Kimura, Sylvia Mann, Brennan Martin, Lucia Orantes, Amber Taylor, John Nahabedian, Amanda Akosa, Ziwei Song, Stacey Martin, Roshan Ramlal, Carrie Shapiro-Mendoza, Jennifer Isenburg, Cynthia A Moore, Suzanne Gilboa, Margaret A Honein
Zika virus infection during pregnancy can cause serious birth defects, including microcephaly and brain abnormalities (1). Population-based birth defects surveillance systems are critical to monitor all infants and fetuses with birth defects potentially related to Zika virus infection, regardless of known exposure or laboratory evidence of Zika virus infection during pregnancy. CDC analyzed data from 15 U.S. jurisdictions conducting population-based surveillance for birth defects potentially related to Zika virus infection...
January 26, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29369018/vector-competence-of-some-mosquito-species-from-canada-for-zika-virus
#18
Antonia Dibernardo, Michael J Turell, L Robbin Lindsay, Courtney Loomer, Mahmood Iranpour
The recent introduction of Zika virus (ZIKV) into the Americas and the occurrence of birth defects associated with infection during pregnancy have created a concern about the spread of this virus into more northern countries in the Americas. Therefore, we examined several species of mosquitoes found in southern Manitoba, Canada, for their susceptibility to infection and their ability to transmit ZIKV. Aedes cinereus, Ae. euedes, Ae. fitchii, Ae. sticticus, Ae. vexans, Coquillettidia perturbans, Culex restuans, and Cx...
December 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/29359251/can-vaccination-save-a-zika-virus-epidemic
#19
Wencel Valega-Mackenzie, Karen R Ríos-Soto
Zika virus (ZIKV) is a vector-borne disease that has rapidly spread during the year 2016 in more than 50 countries around the world. If a woman is infected during pregnancy, the virus can cause severe birth defects and brain damage in their babies. The virus can be transmitted through the bites of infected mosquitoes as well as through direct contact from human to human (e.g., sexual contact and blood transfusions). As an intervention for controlling the spread of the disease, we study a vaccination model for preventing Zika infections...
January 22, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29357209/travel-during-pregnancy-results-from-an-ultrasound-unit-based-questionnaire
#20
Kathleen M Antony, Vivek K Gupta, Kara K Hoppe, Tracy Quamme, Nora Feldman, Katharina Stewart
BACKGROUND: The frequency of domestic and international travel among women residing in the United States, and specifically Wisconsin, during pregnancy is not known. Given the recent epidemic of Zika virus disease, clinicians should be aware of the frequency of travel during pregnancy and should inquire about travel by pregnant women, women of reproductive age, and their sexual partners. METHODS: Due to the Zika epidemic, our obstetric ultrasound center added questions about international and domestic travel to a general health form that is routinely distributed to all patients presenting for anatomic ultrasounds...
December 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
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