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M1a AND lung cancer

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https://www.readbyqxmd.com/read/27867003/prognostic-impact-of-newly-proposed-m-descriptors-in-tnm-classification-of-non-small-cell-lung-cancer
#1
Junghoon Shin, Bhumsuk Keam, Miso Kim, Young Sik Park, Tae Min Kim, Dong-Wan Kim, Young Whan Kim, Dae Seog Heo
INTRODUCTION: The International Association for the Study of Lung Cancer recently proposed new M descriptors for the next edition of the TNM classification for NSCLC, subdividing the current M1b category into two subcategories: M1b, which indicates a solitary extrathoracic metastasis in a single organ, and M1c, which indicates multiple extrathoracic metastasis. The purpose of this study was to validate the prognostic value of the newly proposed M descriptors in an independent cohort with multivariate and subgroup analysis...
November 17, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27567989/does-lymph-node-metastasis-have-a-negative-prognostic-impact-in-patients-with-nsclc-and-m1a-disease
#2
Chenyang Dai, Yijiu Ren, Dong Xie, Hui Zheng, Yunlang She, Ke Fei, Gening Jiang, Chang Chen
OBJECTIVES: Patients with NSCLC with M1a disease regardless of lymph node status were categorized as stage IV. This study aims to investigate whether the N descriptors in M1a patients could provide clinical information. METHODS: Overall, 39,731 patients with NSCLC with M1a disease were identified from the Surveillance, Epidemiology, and End Results database during 2005-2012. Lung cancer-specific survival (LCSS) was compared among M1a patients stratified by N stage...
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27502712/prospective-assessment-of-a-gene-signature-potentially-predictive-of-clinical-benefit-in-metastatic-melanoma-patients-following-mage-a3-immunotherapeutic-predict
#3
P Saiag, R Gutzmer, P A Ascierto, M Maio, J-J Grob, P Murawa, B Dreno, M Ross, J Weber, A Hauschild, P Rutkowski, A Testori, E Levchenko, A Enk, L Misery, C Vanden Abeele, I Vojtek, O Peeters, V G Brichard, P Therasse
BACKGROUND: Genomic profiling of tumor tissue may aid in identifying predictive or prognostic gene signatures (GS) in some cancers. Retrospective gene expression profiling of melanoma and non-small-cell lung cancer led to the characterization of a GS associated with clinical benefit, including improved overall survival (OS), following immunization with the MAGE-A3 immunotherapeutic. The goal of the present study was to prospectively evaluate the predictive value of the previously characterized GS...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27339719/-comparison-of-the-masaoka-koga-and-the-iaslc-itmig-proposal-for-the-tnm-%C3%A2-staging-systems-based-on-the-chinese-alliance-for-research-in-thymomas-chart-%C3%A2-retrospective-database
#4
Guanghui Liang, Zhitao Gu, Yin Li, Jianhua Fu, Yi Shen, Yucheng Wei, Lijie Tan, Peng Zhang, Yongtao Han, Chun Chen, Renquan Zhang, Ke-Neng Chen, Hezhong Chen, Yongyu Liu, Youbing Cui, Yun Wang, Liewen Pang, Zhentao Yu, Xinming Zhou, Yangchun Liu, Yuan Liu, Wentao Fang
BACKGROUND: To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis...
July 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27227958/surgical-intervention-improves-survival-for-metastatic-non-small-cell-lung-cancer-patients
#5
Hong Shen, Ying Cao, Xiaofen Li, Yinuo Tan, Jiaqi Chen, Ziru Yang, Yiyao Kong, Ying Yuan
Surgical intervention for stage IV non-small cell lung cancer (NSCLC) is still controversial. This study sought to evaluate the clinical effects of surgical intervention on survival in patients with stage IV NSCLCs and to identify the cohort benefitting the most from surgery.A retrospective study from the Surveillance, Epidemiology, and End Results database was performed to compare the survival of stage IV NSCLC patients who had undergone surgery with those who did not undergo surgery. Overall survival (OS) was evaluated using the Kaplan-Meier method and the log-rank test...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27220062/oligometastases-in-ajcc-stage-ivc-nasopharyngeal-carcinoma-a-subset-with-better-overall-survival
#6
Yun-Hong Tian, Wen-Hui Zou, Wei-Wei Xiao, Lei Zeng, Xia Yuan, Li Bai, Taixiang Lu, Yunming Tian, Fei Han
BACKGROUND: The purpose of this study was to analyze the patterns of metastasis and therapeutic approaches in American Joint Committee on Cancer (AJCC) stage IVc nasopharyngeal carcinoma (NPC). METHODS: A retrospective analysis of 263 patients with stage IVc NPC revealed the incidence of bone, liver, and lung metastases was 67.7%, 32.3%, and 16.0%, respectively. All patients received chemotherapy; 160 patients received radiotherapy (RT) to the primary tumor. RESULTS: The factors associated with poor overall survival (OS) were Karnofsky Performance Scale (KPS) ≤70, liver metastasis, multiple-organ metastasis, ≥6 lesions, no RT to the primary tumor, and <4 chemotherapy cycles...
August 2016: Head & Neck
https://www.readbyqxmd.com/read/27160353/distant-metastases-in-colorectal-carcinoma-a-proposal-for-a-new-m1-subclassification
#7
S Merkel, K Weber, R S Croner, H Golcher, J Göhl, A Agaimy, S Semrau, J Siebler, A Wein, W Hohenberger, C Wittekind
INTRODUCTION: In 2010, the seventh Tumour-Node-Metastasis (TNM) cancer staging system of the International Union for Cancer Control (UICC) and the American Joint Committee of Cancer (AJCC) introduced a subdivision of M1 in the TNM classification of colorectal carcinomas. For the eighth TNM edition which will be released in the autumn of 2016 and will become effective in January 2017 new proposals are appreciated. The aim of our study was to define a new and better proposal for M1 subclassification...
September 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27114841/comparison-of-the-masaoka-koga-staging-and-the-international-association-for-the-study-of-lung-cancer-the-international-thymic-malignancies-interest-group-proposal-for-the-tnm-staging-systems-based-on-the-chinese-alliance-for-research-in-thymomas-retrospective
#8
Guanghui Liang, Zhitao Gu, Yin Li, Jianhua Fu, Yi Shen, Yucheng Wei, Lijie Tan, Peng Zhang, Yongtao Han, Chun Chen, Renquan Zhang, Keneng Chen, Hezhong Chen, Yongyu Liu, Youbing Cui, Yun Wang, Liewen Pang, Zhentao Yu, Xinming Zhou, Yangchun Liu, Yuan Liu, Wentao Fang
BACKGROUND: To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis...
April 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27057627/the-prognosis-after-contraindicated-surgery-of-nsclc-patients-with-malignant-pleural-effusion-m1a-may-be-better-than-expected
#9
Yijiu Ren, Chenyang Dai, Jianfei Shen, Yang Liu, Dong Xie, Hui Zheng, Jiaxi He, Wenhua Liang, Gening Jiang, Ke Fei, Ping Yang, Jianxing He, Chang Chen
Although non-small cell lung cancer (NSCLC) with malignant pleural effusion (M1a) is generally contraindicated for surgery, several reports have demonstrated favorable prognosis. This study aimed to describe the results of surgical intervention in this disease. In this retrospective study, we evaluated NSCLC patients with ipsilateral malignant pleural effusion selected from Surveillance Epidemiology and End-Results database (SEER). Primary tumor resection was compared to no tumor resection in the overall survival (OS) and lung cancer-specific survival (LCSS)...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27023116/image-based-multilevel-subdivision-of-m1-category-in-tnm-staging-system-for-metastatic-nasopharyngeal-carcinoma
#10
Lujun Shen, Wang Li, Siyang Wang, Guofeng Xie, Qi Zeng, Chen Chen, Feng Shi, Ying Zhang, Ming Wu, Wanhong Shu, Changchuan Pan, Yunfei Xia, Peihong Wu
Purpose To establish an image-based M1 category subdivision system for personalized prognosis prediction and treatment planning in patients with metastatic nasopharyngeal carcinoma (NPC). Materials and Methods A total of 1172 patients with metachronous metastasic NPC were retrospectively enrolled (the dataset is from Sun Yat-sen University Cancer Center for derivation, and the combined datasets are from Guangzhou Medical University Cancer Center and the Fifth Affiliated Hospital of Sun Yat-sen University for validation)...
September 2016: Radiology
https://www.readbyqxmd.com/read/26940530/the-iaslc-lung-cancer-staging-project-background-data-and-proposals-for-the-classification-of-lung-cancer-with-separate-tumor-nodules-in-the-forthcoming-eighth-edition-of-the-tnm-classification-for-lung-cancer
#11
Frank C Detterbeck, Vanessa Bolejack, Douglas A Arenberg, John Crowley, Jessica S Donington, Wilbur A Franklin, Nicolas Girard, Edith M Marom, Peter J Mazzone, Andrew G Nicholson, Valerie W Rusch, Lynn T Tanoue, William D Travis, Hisao Asamura, Ramón Rami-Porta
INTRODUCTION: Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors can be classified to inform the eighth edition of the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses. METHODS: Survival of patients with separate tumor nodules in the International Association for the Study of Lung Cancer database were analyzed...
May 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26940528/the-iaslc-lung-cancer-staging-project-summary-of-proposals-for-revisions-of-the-classification-of-lung-cancers-with-multiple-pulmonary-sites-of-involvement-in-the-forthcoming-eighth-edition-of-the-tnm-classification
#12
Frank C Detterbeck, Andrew G Nicholson, Wilbur A Franklin, Edith M Marom, William D Travis, Nicolas Girard, Douglas A Arenberg, Vanessa Bolejack, Jessica S Donington, Peter J Mazzone, Lynn T Tanoue, Valerie W Rusch, John Crowley, Hisao Asamura, Ramón Rami-Porta
INTRODUCTION: Patients with lung cancer who harbor multiple pulmonary sites of disease have been challenging to classify; a subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee was charged with developing proposals for the eighth edition of the tumor, node, and metastasis (TNM) classification to address this issue. METHODS: A systematic literature review and analysis of the International Association for the Study of Lung Cancer database was performed to develop proposals for revision in an iterative process involving multispecialty international input and review...
May 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26940527/the-iaslc-lung-cancer-staging-project-background-data-and-proposals-for-the-application-of-tnm-staging-rules-to-lung-cancer-presenting-as-multiple-nodules-with-ground-glass-or-lepidic-features-or-a-pneumonic-type-of-involvement-in-the-forthcoming-eighth-edition
#13
Frank C Detterbeck, Edith M Marom, Douglas A Arenberg, Wilbur A Franklin, Andrew G Nicholson, William D Travis, Nicolas Girard, Peter J Mazzone, Jessica S Donington, Lynn T Tanoue, Valerie W Rusch, Hisao Asamura, Ramón Rami-Porta
INTRODUCTION: Application of tumor, node, and metastasis (TNM) classification is difficult in patients with lung cancer presenting as multiple ground glass nodules or with diffuse pneumonic-type involvement. Clarification of how to do this is needed for the forthcoming eighth edition of TNM classification. METHODS: A subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee conducted a systematic literature review to build an evidence base regarding such tumors...
May 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26904216/predilection-of-contralateral-upper-lung-metastasis-in-upper-lobe-lung-adenocarcinoma-patients
#14
Yen-Hsiang Huang, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Kun-Chieh Chen, Kang-Yi Su, Hsuan-Yu Chen, Chi-Sheng Chang, Jeremy J W Chen, Sung-Liang Yu, Huei-Wen Chen, Tsung-Ying Yang, Gee-Chen Chang
BACKGROUND: Lung cancer with lung to lung metastasis is common. The objective of this study was to investigate the association among the distribution of contralateral lung metastases versus primary lung tumor location, clinical characteristics, and epidermal growth factor receptor (EGFR) mutations status. METHODS: The study included treatment-naïve stage IV lung adenocarcinoma with contralateral lung metastases from 2012 through 2013. RESULTS: In total, 103 patients were enrolled after excluding lung cancer with histology other than adenocarcinoma, synchronous multiple primary lung cancers, or other active malignancy...
January 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26654941/egfr-kinase-domain-mutation-positive-lung-cancers-are-sensitive-to-intrapleural-perfusion-with-hyperthermic-chemotherapy-iphc-complete-treatment
#15
Hongjuan Zhang, Cheng Zhan, Ji Ke, Zhiqiang Xue, Aiqun Zhang, Kaifeng Xu, Zhirong Shen, Lei Yu, Liang Chen
Lung cancer is the global leading cause of cancer-related deaths. A significant portion of lung cancer patients harbor kinase domain mutations in the epidermal growth factor receptor (EGFR). While EGFR tyrosine kinase inhibitors (TKI) effectively shrink tumors harboring mutant EGFR, clinical efficacy is limited by the development of TKI resistance. Effective alternatives are desperately needed in clinic for treating EGFR kinase domain mutation positive lung cancer. In our clinic in treating M1a lung cancer patients through intrapleural perfusion with hyperthermic chemotherapy (IPHC) followed by cycles of systemic chemotherapy (we termed this procedure IPHC complete treatment, IPHC-CT), we found dramatic tumor shrinkage in mutant EGFR-positive patients...
January 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26557992/accidental-invisible-intrathoracic-disseminated-pt4-m1a-a-distinct-lung-cancer-with-favorable-prognosis
#16
Wen-Zhao Zhong, Wei Li, Xue-Ning Yang, Ri-Qiang Liao, Qiang Nie, Song Dong, Hong-Hong Yan, Xu-Chao Zhang, Hai-Yan Tu, Bin-Chao Wang, Jian Su, Jin-Ji Yang, Qing Zhou, Yi-Long Wu
OBJECTIVE: In the 7(th) edition of the TNM classification of malignant tumors, the prognosis for pT4-M1a stage IV lung cancer is better than for stage pIIIB. Subgroups of lung cancer patients who underwent incomplete resection (R1/R2) have a favorable prognosis. This study compares the prognosis between cases of invisible local residual disease and intrathoracic disseminated pT4-M1aIV. METHODS: Patient characteristics and histological and molecular profiles were retrospectively collected for lung cancer patients who underwent resection intended to be curative but were accidentally incomplete...
July 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26543638/erratum-to-accidental-invisible-intrathoracic-disseminated-pt4-m1a-a-distinct-lung-cancer-with-favorable-prognosis
#17
(no author information available yet)
[This corrects the article on p. 1205 in vol. 7.].
September 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26536193/the-iaslc-lung-cancer-staging-project-proposals-for-the-revision-of-the-m-descriptors-in-the-forthcoming-eighth-edition-of-the-tnm-classification-of-lung-cancer
#18
Wilfried E E Eberhardt, Alan Mitchell, John Crowley, Haruhiko Kondo, Young Tae Kim, Andrew Turrisi, Peter Goldstraw, Ramon Rami-Porta
INTRODUCTION: The aim of this study is to analyze all metastatic (M) categories of the current tumor, node, and metastasis (TNM) classification of lung cancer with the objective of providing suggestions for modifications of the M component in the next edition of the TNM classification for lung cancer. METHODS: The new International Association for the Study of Lung Cancer lung cancer database was created from 94,708 patients diagnosed as having lung cancer between 1999 and 2010...
November 2015: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26317917/impact-of-a-contralateral-tumor-nodule-on-survival-in-non-small-cell-lung-cancer
#19
Zachary S Morris, Donald M Cannon, Brett A Morris, Søren M Bentzen, Kevin R Kozak
INTRODUCTION: Contralateral lung tumors in non-small-cell lung cancer (NSCLC) are classified as stage M1a yet may represent hematogenous metastases or synchronous primary tumors. The impact of these tumors on overall survival (OS) is poorly understood. Here, we aim to determine whether NSCLC patients with M1a disease due only to a contralateral tumor nodule exhibit a favorable prognosis relative to other M1a or M1b patients. METHODS: Retrospective evaluation of the impact of contralateral tumor nodules on OS in NSCLC stratified by primary tumor size and N stage attained from Surveillance, Epidemiology, and End Results database...
November 2015: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/25893920/survival-of-m1a-non-small-cell-lung-cancer-treated-surgically-a-retrospective-single-center-study
#20
Tieqin Liu, Hongxu Liu, Gebang Wang, Chenlei Zhang, Bingbing Liu
BACKGROUND: Stage IV non-small cell lung cancer (NSCLC) is always associated with a poor outcome and is rarely treated with surgical resection. The aim of this study was to retrospectively analyze the effectiveness of surgical treatments. METHODS: We have retrospectively analyzed the records of NSCLC patients with local thoracic metastatic disease (M1a) who had been treated with surgical resection. The impact on survival of eight variables (age, gender, smoking status, current drinking status, site of metastasis, pathology classifications, resection status, and presence of adjuvant treatment) were further assessed...
October 2015: Thoracic and Cardiovascular Surgeon
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