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Madaras Balázs, Horváth Zsolt, Gráf László, Gálffy Gabriella, Tamási Lilla, Ostoros Gyula, Döme Balázs, Mórocz Éva, Bártfai Zoltán, Prohászka Zoltán, Kocsis Judit
The 70 kDa heat shock protein (Hsp70) is a highly conservative molecular chaperone, that has important role in cell integrity. Recently considerable amount of data are accumulating on the potential role of Hsp70 in carcinogenesis and tumor progression. Most papers are focusing on intracellular or membrane bound protein, however very limited data exist on serum Hsp70, that can also induce innate and adaptive immune response. Previously we have published data on the correlation between coloretal cancer progression and serum Hsp70 concentration...
April 2017: Pathology Oncology Research: POR
Lajos Döbrőssy, Attila Kovács, Agnes Cornides, András Budai
Participation of the target population in coloretal screening is generally low. In addition to demographic and socio-economic factors, the health care system and- in particular - family doctors play an important role. Further, the rate of participation is influenced by psychological, cognitive and behavioural factors, too. The paper analyses factors related to colorectal screening behaviour and potential interventions designed to screening uptake.
July 6, 2014: Orvosi Hetilap
Huiqin Guo, De-Shen Wang, Ghazala H Rizwani, Mansoor Ahmed, Maryam Ahmed, Amir Hassan, Rui-Hua Xu, Najia Mansoor, Amit K Tiwari, Zhe-Sheng Chen
Cancer remains the major public health concern with a number of cancer patients relying on chemotherapy as a treatment option. Although, advances in biomedical research have led to increased anticancer agents in recent years, the treatment is not always effective due to resistance, toxicity or other factors. Phytochemicals and their active components isolated from plants have provided diversified effective drugs many of them are currently used against cancer and other diseases. Holoptelea integrifolia (Roxb) Planch (Ulmaceae) is a widely distributed plant in many parts of the world, also grown in gardens of Pakistan...
November 2013: Pakistan Journal of Pharmaceutical Sciences
Eun Mi Je, Sung Soo Kim, Nam Jin Yoo, Sug Hyung Lee
AIMS AND BACKGROUND: Myeloid differentiation primary response gene 88 (MYD88) is a protein involved in hematopoietic differentiation and innate immunity. Recent studies revealed MYD88 mutation in hematological malignancies and MYD88 overexpression in some solid cancers. The aim of this study was to see whether alterations of MYD88 protein expression and somatic mutation of MYD88 gene are features of common solid cancers. METHODS: We analyzed MYD88 mutation in 45 gastric, 45 colorectal, 45 breast, 45 hepatocellular, 45 prostate and 45 lung carcinomas by single-strand conformation polymorphism (SSCP)...
September 2012: Tumori
Xiao-feng Wang, Hei-ying Jin, Yi-jiang Ding, Zhi-min Fan, Xiu-fang Liu, Jian-xiang Gen
OBJECTIVE: To investigate the role of microsatellite instability(MSI) in Chinese sporadic coloretal cancer. METHODS: A total of 146 patients with colorectal cancer were treated surgically from August 2004 to September 2006 in the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine. Data were collected prospectively. Univariate and multivariable analyses were performed for parameters such as age, gender, tumor location, differentiation, MSI, tumor type, lymph node metastasis, TNM stage, and survival...
July 2011: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Durado D Brooks, Sidney J Winawer, Douglas K Rex, Ann G Zauber, Charles J Kahi, Robert A Smith, Bernard Levin, Richard Wender
This article describes a joint update of guidelines by the American Cancer Society and the U.S. Multi-Society Task Force on Colorectal Cancer delineating evidence-based surveillance recommendations for patients after polypectomy and colorectal cancer resection. Although there are some qualifying conditions, the following general guidelines apply: after colonoscopic polypectomy, patients with hyperplastic polyps should be considered to have normal colonoscopies, and subsequent colonoscopy is recommended at 10 years...
April 1, 2008: American Family Physician
Christian Pox, Wolff Schmiegel
Colorectal cancer (CR) is the second leading cause of cancer-related deaths in Germany. Screening strategies have been shown to be effective in reducing CRC mortality. One priority has to be identifying persons at increased risk of developing CRC. Family history is one important factor. Persons at risk of developing hereditary forms of CRC have to be included in specially-adapted surveillance schemes. To increase the efficacy of the surveillance programs the co-operation of the population at large must be improved...
May 2002: Zeitschrift Für ärztliche Fortbildung und Qualitätssicherung
B Quaresima, C Grandinetti, F Baudi, P Tassone, V Barbieri, S Conforti, E V Avvedimento, F Costanzo, S Venuta
Hereditary nonpolyposis colon cancer results from heritable defects in the MLH1, MSH2, PMS1 and PMS2 genes, which encode proteins involved in the mismatch repair process. In this work we report the identification of two novel germline mutations in the MLH1 gene from two unrelated HNPCC families. The two affected families do not fulfill the Amsterdam criteria. In family 1 we found a missense S93G mutation, which lies in a MLH1 domain critical for its MMR functions. In family 2 we found a two nucleotide insertion (AG) in position 523 from the AUG which determines an early stop codon at position 606 (codon 203)...
1998: Human Mutation
J Ward, F Chen, J A Guthrie, D Wilson, J P Lodge, J I Wyatt, P J Robinson
PURPOSE: To compare the accuracy of five T2-weighted sequences in the detection of liver lesion at magnetic resonance (MR) imaging after superparamagnetic iron oxide (SPIO) enhancement. MATERIALS AND METHODS: Forty-nine candidates for hepatic resection with known coloretal metastases were examined. Before SPIO enhancement, fast spin-echo (SE) images were obtained. After enhancement, the same fast SE sequence and long; TR/short TE, short TE, long TR/TE, and T2-weighted fast low-angle shot (FLASH) sequences were used...
January 2000: Radiology
J Huang, S Zheng, S Jin
APC gene, responsible for familial adenomatous polyposiscoli, is one of the tumor suppressor genes involved in tumorigenesis of sporadic colorectal cancer. Because the majority of APC mutations are located in the 5' end of exon 15 and 95% of them generate stop codon, a coupled in vitro transcription and translation system (IVSP) was used to detect somatic APC mutation of exon 15 in sporadic colorectal cancer. Forty-nine mutated sporadic cases containing 59 truncated bands (9 cases with 2 bands) were identified...
November 1996: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
K Kurihara, F Konishi, K Kanazawa, T Fujii, K Saito
We report herein the rare case of a 67-year-old man in whom alpha-feto-protein (AFP)-producing carcinoma originated in the transverse colon, describing the clinical course of the patient and the histological features of the tumor. At the age of 63, the patient had been diagnosed as having sigmoid colon carcinoma, and surgery was carried out. However, 4 years later, his fecal occult blood test was positive, and further investigation revealed a transverse colon carcinoma with liver metastasis. The serum AFP measured preoperatively was 10978 ng/ml...
1997: Surgery Today
J Norum, B Vonen, J A Olsen, A Revhaug
BACKGROUND: Adjuvant chemotherapy (5-fluorouracil, levamisole) is now standard practice in the treatment of Dukes' B and C coloretal carcinoma (CRC), and this has increased the financial burden on health care systems world-wide. PATIENTS AND METHODS: Between 1993 and 1996, 95 patients in northern Norway were included in a national randomised CRC study, and assigned to surgery plus adjuvant chemotherapy or surgery alone. In April 1996, 94 of the patients were evaluable and 82 were still alive...
January 1997: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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