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https://www.readbyqxmd.com/read/27826556/living-donor-liver-transplantation-for-hepatocellular-carcinoma-achieves-better-outcomes
#1
REVIEW
Chih-Che Lin, Chao-Long Chen
Liver transplantation (LT) for hepatocellular carcinoma (HCC) at Kaohsiung Chang Gung Memorial Hospital mainly relies on live donor LT (LDLT). Owing to taking the risk of LD, we are obligated to adopt strict selection criteria for HCC patients and optimize the pre-transplant conditions to ensure a high disease-free survival similar to those without HCC, even better than deceased donor LT (DDLT). Better outcomes are attributed to excellent surgical results and optimal patient selection. The hospital mortality of primary and salvage LDLT are lower than 2% in our center...
October 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/27787742/-18-f-fluorocholine-pet-ct-imaging-of-liver-cancer-radiopathologic-correlation-with-tissue-phospholipid-profiling
#2
Sandi A Kwee, Miles M Sato, Yu Kuang, Adrian Franke, Laurie Custer, Kyle Miyazaki, Linda L Wong
PURPOSE: [(18)F]fluorocholine PET/CT can detect hepatocellular carcinoma (HCC) based on imaging the initial steps of phosphatidylcholine synthesis. To relate the diagnostic performance of [(18)F]fluorocholine positron emission tomography (PET)/x-ray computed tomography (CT) to the phospholipid composition of liver tumors, radiopathologic correspondence was performed in patients with early-stage liver cancer who had undergone [(18)F]fluorocholine PET/CT before tumor resection. PROCEDURES: Tumor and adjacent liver were profiled by liquid chromatography mass spectrometry, quantifying phosphatidylcholine species by mass-to-charge ratio...
October 27, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27651736/detection-of-primary-malignancy-and-metastases-with-fdg-pet-ct-in-patients-with-cholangiocarcinomas-lesion-based-comparison-with-contrast-enhanced-ct
#3
Youssef Elias, Aladin T Mariano, Yang Lu
The current National Comprehensive Cancer Network (NCCN) Guidelines consider the role of 2-deoxy-2-(18)F-fluoro-d-glucose positron emission tomography/computer tomography (FDG PET/CT) in the evaluation of cholangiocarcinoma (CCA) as "uncertain," and have recommended contrast enhanced computed tomography (CECT) but not FDG PET/CT as a routine imaging test for CCA workup. We set out to compare the diagnostic performance of FDG PET/CT and CECT in patients with CCA. The retrospective study included patients with CCA who underwent FDG PET/CT and CECT within 2-month interval between 2011 and 2013 in our hospital...
September 2016: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27593246/pet-mr-imaging-in-cancers-of-the-gastrointestinal-tract
#4
REVIEW
Raj Mohan Paspulati, Amit Gupta
PET/computed tomography (PET/CT) is an established hybrid imaging technique for staging and follow-up of gastrointestinal (GI) tract malignancies, especially for colorectal carcinoma. Dedicated hybrid PET/MR imaging scanners are currently available for clinical use. Although they will not replace regular use of PET/CT, they may have utility in selected cases of GI tract malignancies. The superior soft tissue contrast resolution and depiction of anatomy and the functional information obtained from diffusion-weighted imaging (DWI) provided by MR imaging in PET/MR imaging are advantages over CT of PET/CT for T staging and follow-up of rectal carcinoma and for better characterization of liver lesions...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27588228/colon-mass-as-a-secondary-metastasis-from-cholangiocarcinoma-a-diagnostic-and-therapeutic-dilemma
#5
Azfar Niazi, Muhammad W Saif
Cholangiocarcinoma (bile ducts cancer) is a rare and aggressive form of cancer. It metastasizes frequently to liver, peritoneum, and lungs. Colon metastasis is extremely uncommon. We report here a 70-year-old male who was diagnosed with cholangiocarcinoma for which he underwent a Whipple procedure. Fifteen months later, a CT scan revealed mural thickening in the colon; this was supplemented with a PET scan, which confirmed this mass. Histological diagnosis of metastatic cholangiocarcinoma to the colon was made and the patient was treated with chemotherapy...
2016: Curēus
https://www.readbyqxmd.com/read/27439460/cholangiocarcinoma-associated-with-limbic-encephalitis-and-early-cerebral-abnormalities-detected-by-2-deoxy-2-fluorine-18-fluoro-d-glucose-integrated-with-computed-tomography-positron-emission-tomography-a-case-report
#6
Sergio L Schmidt, Juliana J Schmidt, Julio C Tolentino, Carlos G Ferreira, Sergio A de Almeida, Regina P Alvarenga, Eunice N Simoes, Guilherme J Schmidt, Nathalie H S Canedo, Leila Chimelli
BACKGROUND: Limbic encephalitis was originally described as a rare clinical neuropathological entity involving seizures and neuropsychological disturbances. In this report, we describe cerebral patterns visualized by positron emission tomography in a patient with limbic encephalitis and cholangiocarcinoma. To our knowledge, there is no other description in the literature of cerebral positron emission tomography findings in the setting of limbic encephalitis and subsequent diagnosis of cholangiocarcinoma...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27069767/metabolic-characteristics-distinguishing-intrahepatic-cholangiocarcinoma-a-negative-pilot-study-of-18-f-fluorocholine-pet-ct-clarified-by-transcriptomic-analysis
#7
Sandi A Kwee, Gordon S Okimoto, Owen Tm Chan, Maarit Tiirikainen, Linda L Wong
PET using fluorine-18 fluorocholine ((18)F-fluorocholine) may detect malignancies that involve altered choline metabolism. While (18)F-fluorocholine PET/CT has shown greater sensitivity for detecting hepatocellular carcinoma (HCC) than (18)F-fluoro-D-deoxyglucose (FDG) PET/CT, it is not known whether it can also detect intrahepatic cholangiocarcinoma (ICC), a less common form of primary liver cancer. Clinical, radiographic, and histopathologic data from 5 patients with ICC and 23 patients with HCC from a diagnostic trial of liver (18)F-fluorocholine PET/CT imaging were analyzed to preliminarily evaluate (18)F-fluorocholine PET/CT for ICC...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26902040/use-of-18f-fdg-pet-scan-and-ultrasound-guided-biopsy-in-the-diagnosis-of-hepatic-carcinomas
#8
Hua Shao, Wen Cheng, Lijuan Yu, Yingci Li, Hui Jing
BACKGROUND/AIMS: PET is a highly specific tool in liver cancer diagnosis. However, in small hepatic lesions, typical imaging characteristics are lacking. The aim of this study was to investigate the accuracy of PET-CT and ultrasound-guided biopsy for diagnosis of liver carcinomas. METHODOLOGY: Clinical data of 58 patients who were diagnosed and treated in our hospital from January 2008 to December 2012 were retrospectively reviewed. Before surgery, patients received PET-CT assessment, ultrasound examination, and ultrasound-guided biopsy of liver tissues...
June 2015: Hepato-gastroenterology
https://www.readbyqxmd.com/read/26847022/imaging-spectrum-of-cholangiocarcinoma-role-in-diagnosis-staging-and-posttreatment-evaluation
#9
REVIEW
Winnie A Mar, Andrew M Shon, Yang Lu, Jonathan H Yu, Senta M Berggruen, Grace Guzman, Charles E Ray, Frank Miller
Cholangiocarcinoma, a tumor of biliary epithelium, is increasing in incidence. The imaging appearance, behavior, and treatment of cholangiocarcinoma differ according to its location and morphology. Cholangiocarcinoma is usually classified as intrahepatic, perihilar, or distal. The three morphologies are mass-forming, periductal sclerosing, and intraductal growing. As surgical resection is the only cure, prompt diagnosis and accurate staging is crucial. In staging, vascular involvement, longitudinal spread, and lymphadenopathy are important to assess...
March 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/26805197/-a-case-of-solitary-paraaortic-lymph-node-recurrence-after-surgical-resection-for-combined-hepatocellular-and-cholangiocarcinoma
#10
Yuki Hirose, Jun Sakata, Kizuki Yuza, Daiki Soma, Natsuru Sudo, Hirosuke Ishikawa, Kumiko Tatsuda, Kohei Miura, Kazuyasu Takizawa, Kabuto Takano, Masayuki Nagahashi, Takashi Kobayashi, Hitoshi Kameyama, Shin-ichi Kosugi, Toshifumi Wakai
A 46-year-old woman underwent right hemihepatectomy, cholecystectomy, and sampling of the hilar lymph nodes for combined hepatocellular and cholangiocarcinoma. She received oral S-1 after hepatectomy. However, her serum level of carcinoembryonic antigen gradually increased, and solitary paraaortic lymph node recurrence was detected on positron emission tomography-computed tomography 12 months after hepatectomy. The patient underwent paraaortic lymph node dissection. Histologic examination revealed solitary paraaortic lymph node metastasis composed of hepatocellular carcinoma...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26801328/evaluating-the-clinical-applicability-of-the-european-staging-system-for-perihilar-cholangiocarcinoma
#11
Hishaam Nabil Ismael, Evelyne Loyer, Harmeet Kaur, Claudius Conrad, Jean-Nicolas Vauthey, Thomas Aloia
BACKGROUND: In 2011, a new European Staging System (ESS) for perihilar cholangiocarcinoma (PHC) was proposed with the expressed purpose of comparing treatment and outcomes data between institutions. The goal of this study was to evaluate the feasibility of ESS data capture. STUDY DESIGN: Forty-seven consecutive patients who underwent surgical resection for PHC between 1999 and 2013 were studied. Demographic variables, components of various staging systems (including the ESS), preoperative and perioperative details, pathology, and outcomes were recorded...
April 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26448940/radiological-imaging-for-assessing-the-respectability-of-hilar-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#12
REVIEW
Hongchen Zhang, Jian Zhu, Fayong Ke, Mingzhe Weng, Xiangsong Wu, Maolan Li, Zhiwei Quan, Yingbin Liu, Yong Zhang, Wei Gong
Hilar cholangiocarcinoma (HCC) remains one of the most difficult tumors to stage and treat. The aim of the study was to assess the diagnostic efficiency of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computer tomography (PET/CT) in evaluating the resectability of HCC. A systematic search was performed of the PubMed, EMBASE, and Cochrane databases. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated for individual studies and pooled data as well as test for heterogeneity and public bias...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26434829/anticancer-activity-of-atractylodes-lancea-thunb-dc-in-a-hamster-model-and-application-of-pet-ct-for-early-detection-and-monitoring-progression-of-cholangiocarcinoma
#13
Tullayakorn Plengsuriyakarn, Naoki Matsuda, Juntra Karbwang, Vithoon Viyanant, Kenji Hirayama, Kesara Na-Bangchang
Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is an important cancer in the Great Mekong region, particularly in Thailand. Limitations of treatment options and the lack of an effective diagnostic tool for early detection of CCA are major concerns for the control of this type of cancer. The aim of the study was to investigate anti-CCA activity of the ethanolic extract of Atractylodes lancea (Thunb.) DC., and the applicability of positron emission tomography-computed tomography (PET-CT) as a tool for detection and monitoring the progression of CCA in Opisthorchis viverrini (OV)/dimethylnitrosamine (DMN)-induced CCA hamsters...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26172134/intrahepatic-cholangiocarcinoma-expert-consensus-statement
#14
Sharon M Weber, Dario Ribero, Eileen M O'Reilly, Norihiro Kokudo, Masaru Miyazaki, Timothy M Pawlik
An American Hepato-Pancreato-Biliary Association (AHPBA)-sponsored consensus meeting of expert panellists met on 15 January 2014 to review current evidence on the management of intrahepatic cholangiocarcinoma (ICC) in order to establish practice guidelines and to agree on consensus statements. The treatment of ICC requires a coordinated, multidisciplinary approach to optimize survival. Biopsy is not necessary if the surgeon suspects ICC and is planning curative resection, although biopsy should be obtained before systemic or locoregional therapies are initiated...
August 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/26155284/gallbladder-neck-cancer-and-perihilar-cholangiocarcinoma-siblings-cousins-or-look-alikes
#15
Vinay Kumar Kapoor
The gallbladder neck cancer and perihilar cholangiocarcinoma present as painless progressive surgical obstructive jaundice. Sometimes it becomes difficult to differentiate between them even on cross-sectional imaging studies including computed tomography and magnetic resonance imaging. Staging laparoscopy and positron emission tomography may be useful in detecting metastases in gallbladder neck cancer, but are not recommended in perihilar cholangiocarcinoma. Most patients with gallbladder neck cancer and perihilar cholangiocarcinoma require preoperative biliary drainage...
May 2015: Korean Journal of Hepato-biliary-pancreatic Surgery
https://www.readbyqxmd.com/read/26155251/metastatic-cholangiocarcinoma-as-a-cause-of-appendicitis-a-case-report-and-literature-review
#16
Sung Il Kang, Jeonghyun Kang, Heae Surng Park, Sung Ill Jang, Dong Ki Lee, Kang Young Lee, Seung-Kook Sohn
Metastatic carcinoma that causes appendicitis is extremely rare. To our knowledge, metastatic cholangiocarcinoma in the appendix has been reported in only 1 case in the English literature. We report herein the case of an 87-year-old woman who presented with abdominal pain and jaundice. Advanced cholangiocellular carcinoma and a proximal appendiceal mass with appendicitis were detected on contrast-enhanced computed tomography and positron emission tomography/computed tomography. After elective laparoscopic appendectomy and wedge resection of the cecum, pathologic results revealed metastatic adenocarcinoma from extrahepatic cholangiocellular carcinoma in the appendix...
May 2014: Korean Journal of Hepato-biliary-pancreatic Surgery
https://www.readbyqxmd.com/read/26099746/metabolic-characteristics-of-advanced-biliary-tract-cancer-using-18f-fluorodeoxyglucose-positron-emission-tomography-and-their-clinical-implications
#17
Kyoung-Min Cho, Do-Youn Oh, Tae-Yong Kim, Kyung Hun Lee, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang
BACKGROUND: In advanced biliary tract cancer (BTC), the metabolic landscape has not been evaluated by (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) yet. Furthermore, reports of the clinical implications of these metabolic features are limited. We aimed to evaluate the metabolic features and their clinical relevance in advanced BTC using (18)F-FDG PET. PATIENTS AND METHODS: We consecutively enrolled patients with advanced BTC who underwent (18)F-FDG PET prior to palliative chemotherapy between 2003 and 2013...
August 2015: Oncologist
https://www.readbyqxmd.com/read/25986701/synchronous-double-primary-squamous-cell-carcinoma-and-adenocarcinoma-of-the-extrahepatic-bile-duct-a-case-report
#18
Youngsun Yoo, Seongpyo Mun
INTRODUCTION: Synchronous double cancers of the bile duct are exceptionally rare. We here report a case of synchronous squamous cell carcinoma and adenocarcinoma of the extrahepatic bile duct. CASE PRESENTATION: A 67-year-old Asian man visited our clinic complaining of jaundice and dark urine. Direct hyperbilirubinemia and an elevated cancer antigen 19-9 level were detected. Preoperative abdominal computed tomography and positron emission tomography showed two masses at the bifurcation of the common hepatic duct and at the distal common bile duct...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/25966426/radiological-diagnosis-in-cholangiocarcinoma-application-of-computed-tomography-magnetic-resonance-imaging-and-positron-emission-tomography
#19
REVIEW
Kristina I Ringe, Frank Wacker
The purpose of radiological imaging in patients with suspected or known cholangiocarcinoma (CCA) is tumour detection, lesion characterization and assessment of resectability. Different imaging modalities are implemented complementary in the diagnostic work-up. Non-invasive imaging should be performed prior to invasive biliary procedures in order to avoid false positive results. For assessment of intraparenchymal tumour extension and evaluation of biliary and vascular invasion, MRI including MRCP and CT are the primarily used imaging modalities...
April 2015: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/25889352/intramedullary-spinal-cord-metastasis-of-cholangiocarcinoma-a-case-report
#20
Laurence Faugeras, Gaetan Cantineau, Jean-Francois Daisne, Thierry Gustin, Lionel D'hondt
BACKGROUND: Cholangiocarcinomas are rare tumors, and metastasis to the intramedullary spinal cord is also rare. To the best of our knowledge, this is the first case of simultaneous cholangiocarcinoma and intramedullary spinal cord metastasis to be described in the medical literature. CASE PRESENTATION: A 62-year-old Caucasian male with a cholangiocarcinoma presented pain around his left shoulder without any other symptoms. The results by magnetic resonance imaging and F18 fluorodeoxyglucose positron emission tomography/computer tomography revealed an intramedullary metastasis at the C4 level, with spinal cord compression, and numerous secondary parenchymal brain metastases...
February 14, 2015: BMC Research Notes
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