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Non radiographic axial

Joachim Sieper, Tim Holbrook, Christopher M Black, Robert Wood, Xiaohan Hu, Sumesh Kachroo
OBJECTIVES: To assess the impact of non-radiographic axial spondyloarthritis (nr-axSpA) on patients and society based on real-world evidence from the Adelphi nr-axSpA Disease Specific Programme, a cross-sectional survey of rheumatologists and their patients in Germany, France, Spain, Italy and the UK. METHODS: Physicians completed patient record forms for the next two patients consulting with nr-axSpA (diagnosis at the physician's judgement); patients were invited to complete a patient self-completion form...
August 31, 2016: Clinical and Experimental Rheumatology
Kei Wong, Alex B Troncoso, Diane P Calello, David Salo, Fred Fiesseler
BACKGROUND: Radial head subluxation (RHS) is a common complaint seen in the pediatric emergency department in children ages 6 months to 4 years. Classically, injury occurs due to axial traction on the arm, but this mechanism is not universal. Some patients will have recurrent RHS; some may undergo x-ray (XR) evaluation for alternative diagnosis. OBJECTIVES: To determine factors associated with recurrences and radiographic evaluations in RHS. METHODS: A retrospective study with inclusion criteria: under 10 years of age with discharge diagnosis "nursemaid," "radial head," or "subluxation...
September 26, 2016: Journal of Emergency Medicine
Stephanie Teboul-Coré, Caroline Rey-Jouvin, Anne Miquel, Camille Vatier, Jacqueline Capeau, Jean-Jacques Robert, Thao Pham, Olivier Lascols, Francis Berenbaum, Jean-Denis Laredo, Corinne Vigouroux, Jérémie Sellam
OBJECTIVE: To describe the bone imaging features of lipodystrophies in the largest cohort ever published. MATERIALS AND METHODS: We retrospectively examined bone imaging data in 24 patients with lipodystrophic syndromes. Twenty-two had genetic lipodystrophy: 12/22 familial partial lipodystrophy (FPLD) and 10/22 congenital generalized lipodystrophy (CGL), 8 with AGPAT2-linked CGL1 and 2 with seipin-linked CGL2. Two patients had acquired generalized lipodystrophy (AGL) in a context of non-specific autoimmune disorders...
November 2016: Skeletal Radiology
L T Hermansen, A G Loft, A A Christiansen, H L Munk, L Gilbert, A G Jurik, B Arnbak, C Manniche, U Weber, M Østergaard, S J Pedersen, T Barington, P Junker, K Hørslev-Petersen, O Hendricks
OBJECTIVES: To investigate whether antibody response patterns against Klebsiella pneumoniae capsular serotypes can discriminate patients with axial spondyloarthritis (axSpA) from patients with non-specific low back pain (LBP). METHOD: Immunoglobulin (Ig)G and IgA antibodies against K. pneumoniae capsular serotypes K2, K26, K36, and K50 were measured, and antibody seropositivity compared between groups and analysed for patient correlation in five different groups: (a) 96 patients fulfilling the Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axSpA; (b) 38 patients with either a positive magnetic resonance imaging (MRI) scan as defined by ASAS or a positive human leucocyte antigen (HLA)-B27 status plus one clinical SpA feature, characterized as 'non-axSpA'; (c) 82 non-specific LBP patients; (d) 40 healthy blood donors and (e) 43 patients with diagnosed ankylosing spondylitis (AS) served as the negative and positive control groups...
September 7, 2016: Scandinavian Journal of Rheumatology
Janneke J de Winter, Leonieke J van Mens, Désirée van der Heijde, Robert Landewé, Dominique L Baeten
BACKGROUND: Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). So far, however, summary data on the prevalence are lacking. The objective of this meta-analysis was to assess the prevalence of peripheral and extra-articular manifestations in ankylosing spondylitis (AS) and nr-axSpA. METHODS: We performed a systematic literature search to identify publications describing the prevalence of peripheral and extra-articular disease manifestations in patients with AS and nr-axSpA...
September 1, 2016: Arthritis Research & Therapy
Sadaaki Tsutsui, Keikichi Kawasaki, Ken-Ichi Yamakoshi, Eiichi Uchiyama, Mitsuhiro Aoki, Katsunori Inagaki
BACKGROUND: The present study compared the changes in biomechanical and radiographic properties under cyclic axial loadings between the 'double-tiered subchondral support' (DSS) group (wherein two rows of screws were used) and the 'non-DSS' (NDSS) group (wherein only one row of distal screws was used) using cadaveric forearm models of radius fractures fixed with a polyaxial locking plate. MATERIAL AND METHODS: Fifteen fresh cadaveric forearms were surgically operated to generate an Arbeitsgemeinschaft für Osteosynthesefragen (AO) type 23-C2 fracture model with the fixation of polyaxial volar locking plates...
September 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Celeste B Burness, Sean T Duggan
Etanercept (SB4) [Benepali(®)], a tumour necrosis factor inhibitor that is a biosimilar of reference etanercept (Enbrel(®)), is approved in the EU for use in all adult indications for which reference etanercept is approved, namely rheumatoid arthritis, axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis), psoriatic arthritis, and plaque psoriasis. The approval of etanercept (SB4) was based on the results of stringent comparability exercises designed to demonstrate similarity to reference etanercept in terms of quality, biological activity, efficacy, safety, and immunogenicity...
August 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Eric Toussirot, Charline Vauchy, Delphine Binda, Fabrice Michel
Axial spondyloarthritis (Ax SpA) refers to chronic inflammatory rheumatic diseases that mainly affect the axial skeleton, leading to erosions and new bone formation in the sacroiliac joints and/or the spine. Ax SpA includes the radiographic form of the disease, ie, ankylosing spondylitis (AS), and the nonradiographic Ax SpA (non-Rx Ax SpA) forms. Anti-tumor necrosis factor alpha (TNFα) agents are used in the treatment of Ax SpA in patients who do not respond to or are intolerant to nonsteroidal anti-inflammatory drugs...
2016: Drug Design, Development and Therapy
Joachim Sieper, Martin Rudwaleit, Jan Lenaerts, Jürgen Wollenhaupt, Leysan Myasoutova, Sung-Hwan Park, Yeong W Song, Ruji Yao, Susan Huyck, Marinella Govoni, Denesh Chitkara, Nathan Vastesaeger
OBJECTIVES: To evaluate partial remission during treatment with infliximab (IFX) + naproxen (NPX) vs NPX alone in patients from the two subgroups of SpA and explore baseline predictors of partial remission. METHODS: Infliximab as First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial was a double-blind, randomised controlled trial of IFX in biologic-naïve patients with early, active axial SpA. Patients were randomised (2:1) to receive 28 weeks of treatment with i...
July 13, 2016: Rheumatology
Ignazio Olivieri, Caterina Fanizza, Michele Gilio, Roberto Ravasio
Anti-tumour necrosis factor (TNF) agents are recommended as second-line therapy for patients with axial spondyloarthropathies. This analysis reviewed data on studies investigating the efficacy and tolerability of anti-TNF agents in patients with non-radiographic axial spondyloarthritis (nr-axSpA) who had failed first-line non-steroidal anti-inflammatory (NSAID) treatment. Efficacy data from RCTs were used to calculate the number needed to treat (NNT) for individual anti-TNFs and then the cost per responder was determined to provide an indication of the value of each therapy...
July 4, 2016: Clinical and Experimental Rheumatology
Julianna Desmarais, Secia Beier, Atul Deodhar
INTRODUCTION: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the spine and sacroiliac (SI) joints. The spectrum of axSpA includes ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA). Evidence has supported the use of TNF alpha inhibitors (TNFi) in treating these diseases, with good efficacy and tolerable safety profiles. Certolizumab pegol (CZP) is an anti-TNF alpha (TNFa) agent with data to support its use in both AS and nr-axSpA. AREAS COVERED: The pharmacologic properties of CZP were reviewed...
August 2016: Expert Opinion on Biological Therapy
Gamze Kilic, Erkan Kilic, Salih Ozgocmen
AIM: To assess the validity of Assessment in Spondyloarthritis International Society (ASAS) endorsed Ankylosing Spondylitis Disease Activity Score (ASDAS) C-reactive protein (-CRP) and ASDAS erythrocyte sedimentation rate (-ESR) in axial spondyloarthritis (axSpA) and to estimate the cut-off values for male and female patients with axSpA. METHODS: Patients with axSpA were assessed for disease activity, functions, mobility and AS Quality of Life (ASQoL) and pain. The discriminant ability of ASDAS versions was assessed using standardized mean differences...
June 16, 2016: International Journal of Rheumatic Diseases
H Varela, E Villamañán, C Plasencia, J A Romero, M Ruano, A Balsa, A Herrero
WHAT IS KNOWN AND OBJECTIVE: The appearance of antitumor necrosis factor drugs (ATDs) has been a major advance in the management of these patients. However, due to the immunosuppressive effect of these therapies, side effects that require treatment discontinuations can appear. The purpose of this study was to evaluate the frequency of ATD discontinuation due to adverse drug effects (ADEs) and the influence of different factors such as diagnosis, ATD prescribed and concomitant disease-modifying antirheumatic drugs (DMARDs)...
June 2016: Journal of Clinical Pharmacy and Therapeutics
Denis Poddubnyy, Mikhail Protopopov, Hildrun Haibel, Jürgen Braun, Martin Rudwaleit, Joachim Sieper
OBJECTIVE: The aim of this work was to investigate the association between disease activity measured by the Ankylosing Spondylitis Disease Activity Score (ASDAS) and radiographic spinal progression in patients with early axial spondyloarthritis (axSpA). METHODS: Altogether, 178 patients with definite axSpA (100 with ankylosing spondylitis and 78 with non-radiographic axSpA) were included. Spinal radiographs (baseline and year 2) were assessed according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) and for the presence of syndesmophytes...
April 28, 2016: Annals of the Rheumatic Diseases
Nurullah Akkoc, Muhammad A Khan
The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being debated. The Food and Drug Agency (FDA) had criticized the ASAS criteria and the studies which used these criteria to enroll patients in a clinical trial of certolizumab and adalimumab for the treatment of non-radiographic axial spondyloarthritis...
June 2016: Clinical Rheumatology
Nicolò Cavalli, Clotilde Austoni, Stefano Corbella, Silvio Taschieri, Bruno Barbaro, Francesco Azzola, Luca Francetti
BACKGROUND: The objective of the study was to evaluate the prevalence of peri-implant mucositis and peri-implantitis in non-smoking patients rehabilitated with a fixed prosthesis supported by two axial and two tilted implants. METHODS: Forty-three patients with a total of 49 rehabilitations were included in the study. Each patient was included in a follow-up schedule consisting in a visit every six months during the first two years and every year thereafter in which professional oral hygiene was performed and data about bleeding on probing, probing depth and bone resorption were collected...
June 2016: Minerva Stomatologica
Vanesa Calvo-Río, Ricardo Blanco, Montserrat Santos-Gómez, Esteban Rubio-Romero, Miguel Cordero-Coma, Adela Gallego-Flores, Raúl Veroz, Ignacio Torre, Félix Francisco Hernández, Antonio Atanes, Javier Loricera, M C González-Vela, Natalia Palmou, José L Hernández, Miguel A González-Gay
OBJECTIVE: To assess the efficacy of golimumab (GLM) in refractory uveitis associated to spondyloarthritis (SpA). METHODS: Multicenter study of SpA-related uveitis refractory to at least 1 immunosuppressive drug. The main outcome variables were degree of anterior and posterior chamber inflammation, visual acuity, and macular thickness. RESULTS: A total of 15 patients (13 men/2 women; 18 affected eyes; mean age 39 ± 6 years) were evaluated...
August 2016: Seminars in Arthritis and Rheumatism
Joachim Sieper, Denis Poddubnyy
Non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for patients with symptomatic axial spondyloarthritis (SpA), who seem to respond best if treated early in the course of disease. The effect of NSAIDs on radiographic disease progression is less clear. Conventional disease-modifying antirheumatic drugs (DMARDs) are not recommended in the treatment of axial SpA, either alone or in combination with TNF blockers. Patients with nonradiographic axial SpA (nr-axSpA) seem to respond as well to TNF blockers as do patients with radiographic axial SpA (ankylosing spondylitis (AS))...
May 2016: Nature Reviews. Rheumatology
Maxime Dougados, Christophe Demattei, Rosaline van den Berg, Viet Vo Hoang, Fabrice Thevenin, Monique Reijnierse, Damien Loeuille, Antoine Feydy, Pascal Claudepierre, Désirée van der Heijde
OBJECTIVE: To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years. METHODS: Patients with recent-onset axial SpA (from the Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a radiographic SI joint score according to the modified New York criteria...
August 2016: Arthritis & Rheumatology
Dong Sun, Michael McCarthy, Adam C Dooley, Raghu H Ramakrishnaiah, R Shane Shelton, Sandra G McLaren, Robert A Skinner, Larry J Suva, Richard E McCarthy
Current convex tethering techniques for treatment of scoliosis have centered on anterior convex staples or polypropylene tethers. We hypothesized that an allograft tendon tether inserted via the costo-transverse foramen would correct an established spinal deformity. In the pilot study, 6 eight week old pigs underwent allograft tendon tethering via the costo-transverse foreman or sham to test the strength of the transplanted tendon to retard spine growth. After 4 months, spinal deformity in three planes was induced in all animals with allograft tendons...
March 18, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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