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https://www.readbyqxmd.com/read/29774755/radiographic-progression-in-non-radiographic-axial-spondyloarthritis
#1
Mikhail Protopopov, Denis Poddubnyy
Non-radiographic axial spondyloarthritis (nr-axSpA) represents a subtype of axial spondyloarthritis (axSpA) with no significant structural damage in sacroiliac joints and spine. Despite that, patients with nr-axSpA demonstrate a substantial burden of illness, and a considerable share of them might progress to radiographic axSpA (r-axSpA) over time. The amount and quality of published data allows crude estimation of progression rate and factors related to a higher risk of progression. Areas covered: This review discusses the available data reporting the rates and predictors of radiographic progression in the sacroiliac joints and in the spine in patients with nr-axSpA as well as predisposing factors for such a progression...
May 18, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29772953/anterior-center-edge-angle-on-sagittal-ct-a-comparison-of-normal-hips-to-dysplastic-hips
#2
Shafagh Monazzam, Karly Ann Williams, Trevor J Shelton, Arash Calafi, Brian M Haus
PURPOSE: The anterior center-edge angle (ACEA) describes anterior acetabular coverage on false profile radiographs. Variability associated with pelvic tilt, radiographic projection, and identifying the true anterior edge, causes discrepancies in measuring an accurate ACEA. Computed tomography (CT) has the potential of improving the accuracy of ACEA. However, because the ACEA on sagittal CT has been shown to not be equivalent to ACEA on false profile radiographs, the normal range of ACEA on CT currently remains unknown and cannot reliably be used to determine over/under coverage...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29765257/spotlight-on-certolizumab-pegol-in-the-treatment-of-axial-spondyloarthritis-efficacy-safety-and-place-in-therapy
#3
REVIEW
Josefina Marin, María Laura Acosta Felquer, Enrique R Soriano
Certolizumab pegol (CZP) is a pegylated humanized tumor necrosis factor-α inhibitor (TNFi) approved for the treatment of ankylosing spondylitis (AS) in the USA and for AS and non-radiographic axial spondyloarthritis (nr-axSpA) in Europe and in some Latin American countries. CZP lacks Fc region, preventing complement fixation and cytotoxicity mediated by antibody; CZP does not actively cross the placenta, unlike other TNFi. RAPID-axSpA study is a Phase III trial conducted in patients with AS and nr-axSpA as double blind and placebo controlled to week 24, dose blind to week 48 and open label to week 204...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29754330/gender-differences-in-axial-spondyloarthritis-women-are-not-so-lucky
#4
REVIEW
T Rusman, R F van Vollenhoven, I E van der Horst-Bruinsma
PURPOSE OF REVIEW: Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gender distribution. The purpose of this review is to aggregate the existing data on gender differences in axSpA in order to increase the awareness that female axSpA patients are still under-recognized...
May 12, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29745878/should-over-treatment-of-axial-spondyloarthritis-with-biologics-remain-a-concern-after-the-issue-of-the-new-asas-criteria-data-from-regisponserbio-spanish-register-of-biological-therapy-in-spondyloarthritides
#5
Mireia Moreno, Jordi Gratacós, Victoria Navarro-Compán, Eugenio de Miguel, Pilar Font, Teresa Clavaguera, Luis Francisco Linares, Beatriz Joven, Xavier Juanola
OBJECTIVES: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria. METHODS: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment start, disease duration, gender, HLA-B27, body mass index (BMI), BASDAI, BASFI, C-reactive protein, ESR, metrological data, ASQoL, WAPAI, extra-articular manifestations, comorbidities, radiological study, type of biological treatment and concomitant treatments...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#6
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29733988/cardiac-related-spinal-cord-tissue-motion-at-the-foramen-magnum-is-elevated-in-type-i-chiari-malformation-patients-and-decreases-post-decompression-surgery
#7
Braden J Lawrence, Mark Luciano, John Tew, Richard G Ellenbogen, John N Oshinski, Francis Loth, Amanda P Culley, Bryn A Martin
OBJECTIVE: Type 1 Chiari malformation (CM-I) is a craniospinal disorder historically defined by cerebellar tonsillar position (TP) greater than 3-5mm below the foramen magnum (FM). This definition has come under question since quantitative measurements of cerebellar herniation do not always correspond with symptom severity. Researchers have proposed several additional radiographic diagnostic criteria based on dynamic motion of fluids and/or tissues. The present study objective was to determine if cardiac-related craniocaudal spinal cord tissue displacement is an accurate indicator of the presence of CM-I and if tissue displacement is altered with decompression...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29727767/bioabsorbable-plating-in-the-treatment-of-pediatric-clavicle-fractures-a-biomechanical-and-clinical-analysis
#8
Emily J Osborn, Christine L Farnsworth, Joshua D Doan, Eric W Edmonds
BACKGROUND: Classic implants for operative intervention of mid-shaft clavicle fractures in adolescents can become symptomatic, requiring removal. This study compares 1) biomechanical properties and 2) clinical outcomes in adolescents of mid-shaft clavicle fracture fixation with bioabsorbable versus metal implants. METHODS: Six synthetic clavicles with mid-shaft fractures underwent bioabsorbable plating. A testing frame applied 10 non-destructive torsion and 10 axial compression cycles, followed by cantilever bending to failure...
April 30, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29670761/improvements-in-workplace-and-household-productivity-with-certolizumab-pegol-treatment-in-axial-spondyloarthritis-results-to-week-96-of-a-phase-iii-study
#9
Désirée van der Heijde, Jürgen Braun, Martin Rudwaleit, Oana Purcaru, Arthur F Kavanaugh
Objectives: To evaluate the effect of certolizumab pegol (CZP) on work and household productivity, and on participation in family, social and leisure activities in patients with axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic (nr-) axSpA. Methods: RAPID-axSpA (NCT01087762) was a phase III, double-blind, placebo-controlled trial to week (Wk) 24, dose-blind to Wk48 and open-label to Wk204. A total of 325 patients were randomised 1:1:1 to placebo, CZP 200 mg Q2W or CZP 400 mg Q4W...
2018: RMD Open
https://www.readbyqxmd.com/read/29595277/-the-role-of-magnetic-resonance-imaging-in-diagnostics-of-axial-spondyloarthritis
#10
Martin Žlnay
Axial spondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder that primary affects axial skeleton. It comprises wide spectrum of patients with immune mediated spine inflammation, from early, so called non-radiographic axial spondyloarthritis to clinically evident ankylosing spondylitis. Conventional radiography is still the cornerstone of diagnosis, evaluation and classification of SpA. However, it has limitations in early disease, because it can only depict the consequences of inflammation for its inability to visualize soft tissue abnormalities within bone marrow...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29595276/-axial-spondyloarthritis
#11
Leona Procházková, Vladimír Červeňák, Miroslav Souček
Axial spondyloarthritis (axSpA) is a common name for the non-radiographic form of the disease and radiographic axial spondyloarthritis, known as ankylosing spondylitis (AS). The disease is typically manifested at a young age, characterized by affection of axial skeleton, and in the most severe form can lead to complete ankylosis of the spine. Etiology of diseases have not yet been clarified, however, the genetic background, especially the binding to HLA-B27 antigen, is obvious. Clinical manifestations are dominated by chronic pain in the lower pain or buttocks that occurred in young age, in a large proportion of patients having the character of so-called inflammatory pain...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29511503/new-advances-in-the-understanding-and-treatment-of-axial-spondyloarthritis-from-chance-to-choice
#12
REVIEW
Sayam Dubash, Dennis McGonagle, Helena Marzo-Ortega
Axial spondyloarthritis (axSpA) is a chronic inflammatory condition that encompasses ankylosing spondylitis (AS) as well as non-radiographic axial disease (nr-axSpA) and can lead to chronic pain, structural damage and disability. The introduction of tumour necrosis factor inhibitor (TNFi) drugs for AS heralded a new era of drug therapeutics for what was previously a largely untreatable disease. This has now been expanded with the licensing of secukinumab, an interleukin 17A (IL-17A) inhibitor for the treatment of AS...
March 2018: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29490705/anti-cd74-antibodies-have-no-diagnostic-value-in-early-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#13
Janneke J de Winter, Marleen G van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen, Torsten Witte, Dominique L Baeten
BACKGROUND: Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA. METHODS: Anti-CD74 IgG and IgA antibodies were first measured in an exploratory cohort of patients with radiographic axSpA (138 patients with ankylosing spondyloarthritis (AS)) and 57 healthy controls and then were measured in patients with early axSpA (n = 274) and with non-SpA chronic back pain (CBP) (n = 319), participating in the spondyloarthritis caught early (SPACE) prospective cohort study of patients under 45 years old with early back pain (for ≥ 3 months, but ≤ 2 years)...
March 1, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29409213/weightbearing-ct-in-normal-hindfoot-alignment-presence-of-a-constitutional-valgus
#14
A Burssens, E Van Herzele, T Leenders, S Clockaerts, K Buedts, G Vandeputte, J Victor
BACKGROUND: The normal hindfoot angle is estimated between 2° and 6° of valgus in the general population. These results are solely based on clinical findings and plain radiographs. The purpose of this study is to assess the hindfoot alignment using weightbear CT. METHODS: Forty-eight patients, mean age of 39.6±13.2 years, with clinical and radiological absence of hindfoot pathology were included. A weightbear CT was obtained and allowed to measure the anatomical tibia axis (TAx) and the hindfoot alignment (HA)...
February 16, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29409123/characterization-of-patients-with-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-in-the-us-based-corrona-registry
#15
Philip J Mease, Désirée van der Heijde, Chitra Karki, Jacqueline B Palmer, Mei Liu, Renganayaki Pandurengan, Yujin Park, Jeffrey D Greenberg
OBJECTIVE: To describe the characteristics of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) in the United States. METHODS: Demographics, clinical characteristics, patient-reported outcomes, and treatment characteristics of patients with AS and nr-axSpA were assessed at the time of enrollment in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry. AS was defined as patients who fulfilled the 1984 modified New York criteria for AS; nr-axSpA was defined as all other patients with axSpA who did not fulfill the radiologic criterion...
February 6, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29353820/cervical-spine-fractures-in-osteopetrosis-a-case-report-and-review-of-the-literature
#16
Arjang Ahmadpour, Amir Goodarzi, Darrin J Lee, Ripul R Panchal, Kee D Kim
While management of appendicular fractures has been well described in the setting of osteopetrosis, there is limited information on managing fractures of the axial spine. Here we present an osteopetrotic patient with multiple traumatic multiple, comminuted, unstable cervical spinal fractures managed with non-operative stabilization, and provide a review of the pathophysiology, genetic characteristics, and special considerations that must be explored when determining operative versus non-operative management of spinal injury in osteopetrosis...
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353745/comparison-of-soft-tissue-artifact-and-its-effects-on-knee-kinematics-between-non-obese-and-obese-subjects-performing-a-squatting-activity-recorded-using-an-exoskeleton
#17
Julien Clément, Jaques A de Guise, Alexandre Fuentes, Nicola Hagemeister
BACKGROUND: Rigid attachment systems are one of the methods used to compensate for soft tissue artifact (STA) inherent in joint motion analyses. RESEARCH QUESTION: The goal of this study was to quantify STA of an exoskeleton design to reduce STA at the knee, and to assess the accuracy of 3D knee kinematics recorded with the exoskeleton in non-obese and obese subjects during quasi-static weight-bearing squatting activity using biplane radiography. METHODS: Nine non-obese and eight obese subjects were recruited...
March 2018: Gait & Posture
https://www.readbyqxmd.com/read/29350332/sleep-in-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-associations-with-disease-activity-gender-and-mood
#18
Alison Wadeley, Emily Clarke, Shaaron Leverment, Raj Sengupta
The study aims were to assess the prevalence of good or poor sleep in a cohort of axial spondyloarthritis patients and to investigate its correlation with a range of objectively and subjectively measured variables in order to develop a model for distinguishing good from poor sleepers. Five hundred ninety-eight patients with ankylosing spondylitis and 61 with non-radiographic axial spondyloarthritis completed the Jenkins Sleep Evaluation Questionnaire. Measures of disease activity, mobility, function, mood, fatigue, quality of life, work productivity, night-time pain and general health were gathered...
April 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29349901/inflammatory-back-pain-and-associated-disease-conditions-among-patients-with-chronic-low-back-pain-in-bangladesh
#19
Sabrina Yesmin, Syed Jamil Abdal, Aminur Rahman, Md Nazrul Islam, Alamgir Mustak Ahammad, Shamim Ahmed, Md Abu Shahin, Minhaj Rahim Chowdhury, Syed Atiqul Haq
AIM: Inflammatory back pain (IBP) is the earliest symptom of axial and other forms of spondyloarthritis (SpA). However, there are no published data on prevalence of IBP among patients suffering from chronic low back pain (CLBP) in Bangladesh. In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh. METHODS: This 1 year cross-sectional study was conducted among 240 CLBP patients in a rheumatology outpatient clinic...
January 18, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29343510/limited-radiographic-progression-and-sustained-reductions-in-mri-inflammation-in-patients-with-axial-spondyloarthritis-4-year-imaging-outcomes-from-the-rapid-axspa-phase-iii-randomised-trial
#20
Désirée van der Heijde, Xenofon Baraliakos, Kay-Geert A Hermann, Robert B M Landewé, Pedro M Machado, Walter P Maksymowych, Owen R Davies, Natasha de Peyrecave, Bengt Hoepken, Lars Bauer, Tommi Nurminen, Juergen Braun
OBJECTIVES: To report 4-year imaging outcomes in the RAPID-axSpA (NCT01087762) study of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), treated with certolizumab pegol (CZP). METHODS: This phase III, randomised trial was placebo-controlled and double-blind to week 24, dose-blind to week 48 and open-label to week 204. Patients fulfilling the Assessment of Spondyloarthritis International Society (ASAS) axSpA criteria with active disease were stratified (AS/nr-axSpA) according to the modified New York (mNY) criteria at randomisation...
May 2018: Annals of the Rheumatic Diseases
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