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https://www.readbyqxmd.com/read/29350332/sleep-in-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-associations-with-disease-activity-gender-and-mood
#1
Alison Wadeley, Emily Clarke, Shaaron Leverment, Raj Sengupta
The study aims were to assess the prevalence of good or poor sleep in a cohort of axial spondyloarthritis patients and to investigate its correlation with a range of objectively and subjectively measured variables in order to develop a model for distinguishing good from poor sleepers. Five hundred ninety-eight patients with ankylosing spondylitis and 61 with non-radiographic axial spondyloarthritis completed the Jenkins Sleep Evaluation Questionnaire. Measures of disease activity, mobility, function, mood, fatigue, quality of life, work productivity, night-time pain and general health were gathered...
January 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29349901/inflammatory-back-pain-and-associated-disease-conditions-among-patients-with-chronic-low-back-pain-in-bangladesh
#2
Sabrina Yesmin, Syed Jamil Abdal, Aminur Rahman, Md Nazrul Islam, Alamgir Mustak Ahammad, Shamim Ahmed, Md Abu Shahin, Minhaj Rahim Chowdhury, Syed Atiqul Haq
AIM: Inflammatory back pain (IBP) is the earliest symptom of axial and other forms of spondyloarthritis (SpA). However, there are no published data on prevalence of IBP among patients suffering from chronic low back pain (CLBP) in Bangladesh. In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh. METHODS: This 1 year cross-sectional study was conducted among 240 CLBP patients in a rheumatology outpatient clinic...
January 18, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29343510/limited-radiographic-progression-and-sustained-reductions-in-mri-inflammation-in-patients-with-axial-spondyloarthritis-4-year-imaging-outcomes-from-the-rapid-axspa-phase-iii-randomised-trial
#3
Désirée van der Heijde, Xenofon Baraliakos, Kay-Geert A Hermann, Robert B M Landewé, Pedro M Machado, Walter P Maksymowych, Owen R Davies, Natasha de Peyrecave, Bengt Hoepken, Lars Bauer, Tommi Nurminen, Juergen Braun
OBJECTIVES: To report 4-year imaging outcomes in the RAPID-axSpA (NCT01087762) study of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), treated with certolizumab pegol (CZP). METHODS: This phase III, randomised trial was placebo-controlled and double-blind to week 24, dose-blind to week 48 and open-label to week 204. Patients fulfilling the Assessment of Spondyloarthritis International Society (ASAS) axSpA criteria with active disease were stratified (AS/nr-axSpA) according to the modified New York (mNY) criteria at randomisation...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29342471/extra-articular-manifestations-and-burden-of-disease-in-patients-with-radiographic-and-non-radiographic-axial-spondyloarthritis
#4
Kemal Erol, Kevser Gok, Gizem Cengiz, Gamze Kilic, Erkan Kilic, Salih Ozgocmen
OBJECTIVE: Although the prevalence of peripheral and extra-articular disease in ankylosing spondylitis (AS) has been assessed in many studies, data on non-radiographic axial spondyloarthritis (nr-axSpA) is scanty. The aim of this study was first, to compare radiographic-axSpA/AS (r-axSpA/AS) and nr-axSpA concerning peripheral arthritis and extra-articular manifestations (EAMs), and second, to assess potential differences between patient subgroups with or without EAMs regarding disease burden...
January 16, 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29303699/implication-of-osteoprotegerin-and-sclerostin-in-axial-spondyloarthritis-cardiovascular-disease-study-of-163-spanish-patients
#5
Fernanda Genre, Javier Rueda-Gotor, Sara Remuzgo-Martínez, Alfonso Corrales, Begoña Ubilla, Verónica Mijares, Carlos Fernández-Díaz, Virginia Portilla, Ricardo Blanco, José Luis Hernández, Javier Llorca, Raquel López-Mejías, Miguel Angel González-Gay
OBJECTIVES: Due to the high incidence of cardiovascular disease in axial spondyloarthritis (axSpA), the search of potential biomarkers that may help to identify patients with high cardiovascular risk is of main importance. Therefore, in this study we assessed the implication of osteoprotegerin (OPG) and sclerostin (SCL), two biomarkers associated with cardiovascular disease and bone metabolism, in the clinical spectrum and atherosclerotic disease of patients with axSpA. METHODS: OPG and SCL serum levels were determined in 163 axSpA Spanish patients (119 ankylosing spondylitis and 44 non-radiographic axSpA) and 63 healthy controls by enzyme-linked immunosorbent assay...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29299654/comparative-study-of-open-and-arthroscopic-coracoid-transfer-for-shoulder-anterior-instability-latarjet-computed-tomography-evaluation-at-a-short-term-follow-up-part-ii
#6
Bartłomiej Kordasiewicz, Maciej Kicinski, Konrad Małachowski, Janusz Wieczorek, Sławomir Chaberek, Stanisław Pomianowski
PURPOSE AND HYPOTHESIS: The aim of this study was to evaluate and to compare the radiological parameters after arthroscopic and open Latarjet technique via evaluation of computed tomography (CT) scans. Our hypothesis was that the radiological results after arthroscopic stabilisation remained in the proximity of those results achieved after open stabilisation. MATERIAL AND METHODS: CT scan evaluation results of patients after primary Latarjet procedure were analysed...
January 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29290076/risk-of-serious-infections-in-biological-treatment-of-patients-with-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-a-meta-analysis
#7
Sen Wang, Qian He, Zongwen Shuai
The objective of the study is to quantitatively assess the risk of serious infections in patients with axial spondyloarthritis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) treated by biologics enrolled in randomized controlled trials (RCTs). A systematic literature searches of MEDLINE (via PubMed), EMBASE, the Cochrane Library and abstracts archives of the annual scientific meetings of both the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) was conducted through October 2015...
December 30, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29278210/biologics-in-inflammatory-and-immunomediated-arthritis
#8
Michele Maria Luchetti, Devis Benfaremo, Armando Gabrielli
BACKGROUND: Biologic drugs, introduced in clinical practice almost twenty years ago, represent nowadays a prominent treatment option in patients with chronic inflammatory arthritis, such as Rheumatoid Arthritis, Psoriatic Arthritis and Spondyloarthritis, that include ankylosing spondylitis and non-radiographic axial spondyloarthritis. METHODS: Several compounds targeting different pathways have been marketed and approved for the treatment of inflammatory arthritis, with a significant impact on the clinical outcomes and the natural history of the diseases...
December 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29250337/how-to-address-ischiofemoral-impingement-treatment-algorithm-and-review-of-the-literature
#9
REVIEW
Hans Gollwitzer, Ingo J Banke, Johannes Schauwecker, Ludger Gerdesmeyer, Christian Suren
Ischiofemoral impingement (IFI) is a rare cause of hip pain defined by a narrowing of the space between the lateral aspect of the os ischium and the lesser trochanter of the femur. Several underlying anatomic, functional and iatrogenic pathologies have been identified for symptomatic IFI in native hip joints and after total hip arthroplasty. Clinical symptoms vary but most commonly consist of pain of the lower buttock and groin including the inner thigh, and a snapping or clunking phenomenon is often reported...
December 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29218683/comparison-of-mri-ct-dunn-45%C3%A2-and-dunn-90%C3%A2-alpha-angle-measurements-in-femoroacetabular-impingement
#10
Kevin M Smith, Brayden J Gerrie, Patrick C McCulloch, David M Lintner, Joshua D Harris
PURPOSE: To determine if a significant difference existed among alpha angle measurements between 4 imaging techniques, axial oblique CT and MRI, Dunn 45° and Dunn 90° plain radiographs, in patients with symptomatic cam femoroacetabular impingement (FAI) and labral tear. METHODS: A single-surgeon prospective radiographic analysis of consecutive non-arthritic and non-dysplastic patients with symptomatic FAI and labral tears who underwent surgery was performed. Alpha angle was measured using standard techniques as described by Nötzli...
December 4, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29185288/imaging-in-axial-spondyloarthritis
#11
REVIEW
Xenofon Baraliakos
Axial spondyloarthritis (axSpA) covers the stage of non-radiographic axial spondyloarthritis (nr-axSpA) and classic ankylosing spondylitis. The pathognomonic findings of axSpA are mainly inflammatory and osteoproliferative changes in the sacroiliac joints (SIJ) and the spine. Various imaging techniques are being used in daily practice for assessment of disease-specific changes, such as periarticular bone marrow edema, erosions, sclerosis, fat metaplasia and ankylosis in the SIJ or spondylitis, spondylodiscitis, facet joint involvement, or syndesmophytes in the spine of patients with axSpA...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29148402/incidence-and-prevalence-of-axial-spondyloarthritis-methodologic-challenges-and-gaps-in-the-literature
#12
Rhonda Bohn, Maureen Cooney, Atul Deodhar, Jeffrey R Curtis, Amanda Golembesky
OBJECTIVES: The incidence and prevalence of axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic (nr-)axSpA, have been investigated in multiple populations, though there is a paucity of population-level data. Here, we identify population-based studies in AS and nr-axSpA, and describe the methodologic challenges in conducting these, outlining potential reasons for disparate incidence and prevalence estimates. METHODS: PubMed and Embase were searched for population-based studies providing incidence and prevalence rates, published in English from 1 Jan 2000-30 Jun 2015...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28974353/growth-curves-for-intracranial-volume-in-normal-asian-children-fortify-management-of-craniosynostosis
#13
Hideaki Kamochi, Ataru Sunaga, Daekwan Chi, Rintaro Asahi, Shiho Nakagawa, Masanori Mori, Hirokazu Uda, Shunji Sarukawa, Yasushi Sugawara, Kotaro Yoshimura
BACKGROUND: Although the charting of normal intracranial volume (ICV) is fundamental for managing craniosynostosis, Asian norms in this regard are unknown. The purpose of this study was to establish a growth curve for ICVs in a large series of normal Asian children, providing reference values to guide corrective surgery. METHODS: A total of 124 normal children (male, 63; female, 61) and 41 children diagnosed with craniosynostoses were analyzed. Patients aged 0-8 years presenting to the emergency room and subjected to computed tomography (CT) for head trauma served as the reference cohort...
September 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28970212/modification-of-structural-lesions-on-mri-of-the-sacroiliac-joints-by-etanercept-in-the-embark-trial-a-12-week-randomised-placebo-controlled-trial-in-patients-with-non-radiographic-axial-spondyloarthritis
#14
RANDOMIZED CONTROLLED TRIAL
Walter P Maksymowych, Stephanie Wichuk, Maxime Dougados, Heather E Jones, Ron Pedersen, Annette Szumski, Lisa Marshall, Jack F Bukowski, Robert G Lambert
OBJECTIVE: To evaluate the impact on structural lesions observed on MRI in the sacroiliac joints (SIJ) at 12 weeks in patients with non-radiographic axial spondyloarthritis (nr-axSpA) receiving etanercept or placebo in EMBARK (Effect of Etanercept on Symptoms and Objective Inflammation in nr-axSpA, a 104 week study). METHODS: Patients were randomised to double-blind etanercept 50 mg/week or placebo for 12 weeks. Structural lesions at baseline and 12 weeks were scored by two independent readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ structural score (SSS) on T1-weighted MRI...
January 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28968885/patients-with-fibromyalgia-rarely-fulfil-classification-criteria-for-axial-spondyloarthritis
#15
Xenofon Baraliakos, Andrea Regel, Uta Kiltz, Hans-Jürgen Menne, Friedrich Dybowski, Manfred Igelmann, Ludwig Kalthoff, Dietmar Krause, Ertan Saracbasi-Zender, Elmar Schmitz-Bortz, Jürgen Braun
Background: The Assessments of Spondyloarthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) have been criticized because of insufficient differentiation towards FM. The aim of this study was to compare the performance of currently used classification criteria in patients diagnosed with axSpA or FM. Methods: Patients were prospectively included if diagnosed with axSpA or FM by the treating rheumatologist and evaluated by an independent examiner for fulfilment of the classification criteria for axSpA (ASAS criteria) and/or FM (1990 ACR classification and 2010 ACR diagnostic criteria)...
September 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/28957558/analysis-of-dedicated-sacroiliac-views-to-improve-reliability-of-conventional-pelvic-radiographs
#16
COMPARATIVE STUDY
Ahmed Omar, Ismail Sari, Mohamed Bedaiwi, David Salonen, Nigil Haroon, Robert D Inman
Objective: To compare the antero-posterior (AP) pelvis view with the Ferguson view of the SI joint in order to resolve whether one modality has a clear advantage for grading of sacroiliitis. Methods: One hundred and nine patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) criteria for axial spondyloarthritis who had AP pelvis and Ferguson views on the same day were identified from an axial spondyloarthritis clinic registry. Two rheumatologists independently scored the AP pelvis and Ferguson views according to modified New York (NY) criteria...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28940172/gp2015-an-etanercept-biosimilar
#17
Emma D Deeks
GP2015 is the second biosimilar of the reference p75 TNF receptor-Fc fusion protein etanercept. It is approved for use in all indications for which reference etanercept is approved, including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, plaque psoriasis and paediatric plaque psoriasis. GP2015 has similar physiochemical and pharmacodynamic properties to those of reference etanercept, and the pharmacokinetic biosimilarity of the agents has been shown in healthy volunteers...
September 23, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28938006/association-between-circulating-mirnas-and-spinal-involvement-in-patients-with-axial-spondyloarthritis
#18
Klára Prajzlerová, Kristýna Grobelná, Markéta Hušáková, Šárka Forejtová, Astrid Jüngel, Steffen Gay, Jiří Vencovský, Karel Pavelka, Ladislav Šenolt, Mária Filková
OBJECTIVES: Dysregulation of miRNAs and their target genes contributes to the pathophysiology of autoimmune diseases. Circulating miRNAs may serve as diagnostic/prognostic biomarkers. We aimed to investigate the association between circulating miRNAs, disease activity and spinal involvement in patients with axial spondyloarthritis (AxSpA). METHODS: Total RNA was isolated from the plasma of patients with non-radiographic (nr)AxSpA, patients with ankylosing spondylitis (AS) and healthy controls (HC) via phenol-chloroform extraction...
2017: PloS One
https://www.readbyqxmd.com/read/28933136/coexistence-of-spondyloarthritis-and-joint-hypermobility-syndrome-rare-or-unknown-association
#19
J B Pinto Carneiro, T Pinto de Souza, T M L Antunes de Oliveira, S L Euzébio Ribeiro
We report two cases of siblings presenting coexisting non-radiographic axial spondyloartrhritis and joint hypermobility syndrome, complaining of back pain with morning stiffness, enthesitis, peripheral arthralgia, high erythrocyte sedimentation rate and C-reactive protein level and positive HLA-B27. The association of these two conditions is rare, but especially interesting in view of their contrasting features, one causing axial skeleton stiffness, the other a wider range of peripheral joint movements. Coexistence of these two opposite disorders causes confusion in diagnosis and management, resulting in lower quality of life for patients, as they are in pain from the early stages...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28926392/flexible-adult-acquired-flatfoot-deformity-comparison-between-weight-bearing-and-non-weight-bearing-measurements-using-cone-beam-computed-tomography
#20
Cesar de Cesar Netto, Lew C Schon, Gaurav K Thawait, Lucas Furtado da Fonseca, Apisan Chinanuvathana, Wojciech B Zbijewski, Jeffrey H Siewerdsen, Shadpour Demehri
BACKGROUND: The 3-dimensional nature of adult acquired flatfoot deformity can be challenging to characterize using radiographs. We tested the hypothesis that measurements on weight-bearing (WB) cone-beam computed tomography (CT) images were more useful for demonstrating the severity of the deformity than non-weight-bearing (NWB) measurements. METHODS: We prospectively enrolled 12 men and 8 women (mean age, 52 years; range, 20 to 88 years) with flexible adult acquired flatfoot deformity...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
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