keyword
https://read.qxmd.com/read/38155543/colorectal-carcinoma-with-sarcomatoid-components-report-of-15-cases-and-literature-review-of-an-exceedingly-rare-carcinoma-subtype
#21
JOURNAL ARTICLE
Umamaheshwari Golconda, Kelsey E McHugh, Daniela S Allende, Katrina Collins, Patrick Henn, Maribel Lacambra, Pablo A Bejarano, Gabriel M Groisman, Maurice B Loughrey, Vidya Monappa, Xuchen Zhang, Jason L Hornick, Raul S Gonzalez
Colorectal carcinoma with sarcomatoid components (which includes so-called carcinosarcomas and sarcomatoid carcinomas) is a rare subtype with 50 reported cases in the literature and overlapping criteria with undifferentiated carcinoma. We collected and described 15 cases from 10 men and 5 women, with a mean age of 66 years. Symptoms included abdominal pain and gastrointestinal bleeding. Most tumors presented in the rectosigmoid region, with a mean size of 8.2 cm. The sarcomatoid component, on average, represented 58% of the tumors and took many forms, including spindled (10 cases), anaplastic (9 cases), and rhabdoid (3 cases); one case showed osteoid matrix...
December 29, 2023: American Journal of Surgical Pathology
https://read.qxmd.com/read/38146608/are-the-width-length-depth-and-area-of-submucosal-invasion-predictive-of-lymph-node-metastasis-in-pt1-colorectal-cancer
#22
JOURNAL ARTICLE
Olga Maynovskaia, Evgeny Rybakov, Stanislav Chernyshov, Evgeniy Khomyakov, Sergey Achkasov
PURPOSE: Submucosa-limited (pathological T1, pT1) colorectal cancers (CRCs) pose a continuing challenge in the choice of treatment options, which range from local excision to radical surgery. The aim of this study was to evaluate the morphometric and morphologic risk factors associated with regional lymph node metastasis (LNM) in pT1 CRC. METHODS: We performed a histological review of patients who underwent oncological resection between 2016 and 2022. Tumor grade, budding, poorly differentiated clusters (PDCs), cancer gland rupture, lymphovascular invasion (LVI), and presence of deep submucosal invasion (DSI), as well as width, length, total area, and area of DSI, were evaluated as potential risk factors for LNM...
December 26, 2023: Annals of Coloproctology
https://read.qxmd.com/read/38130549/utility-of-cd34-in-assessing-microvessel-density-and-its-correlation-with-clinicopathological-parameters-in-colorectal-carcinoma-patients
#23
JOURNAL ARTICLE
Shweta Pandey, Samarth Shukla, Sunita Vagha
Currently, the most commonly practiced method of reporting cases of colorectal carcinoma is done according to guidelines provided by the College of American Pathologists (8th edition) and the Royal College of Pathologists (UK). These guidelines include various histopathological parameters like tumor site, extent, histologic type, grade, margins, tumor budding, lymphovascular invasion, and perineural invasion. However, in the present guidelines, the immunohistochemistry-based marker of mean vessel density (MVD) has not been addressed as an important parameter...
November 2023: Curēus
https://read.qxmd.com/read/38108390/immunohistochemical-expression-of-immune-checkpoints-ctla-4-lag3-and-tim-3-in-cancer-cells-and-tumor-infiltrating-lymphocytes-tils-in-colorectal-carcinoma
#24
JOURNAL ARTICLE
Doaa I Abdelrahman, Ibtesam Elhasadi, Amal Anbaig, Adel Bakry, Doaa Mandour, Tamer Wasefy, Ahmed M Yehia, Mohammed Alorini, Amany M Shalaby, Amar Ibrahim Omer Yahia, Mohamed A Alabiad
BACKGROUND: Colorectal cancer is considered the third most prevalent cancer in both sexes. Immune checkpoint receptors that regulate T-cell response, stimulation, and development include lymphocyte activating gene 3 (LAG-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), and T-cell immunoglobulin and mucin domain 3 (Tim-3). In addition, they are crucial for the advancement of cancer and tumor immune escape. OBJECTIVE: This work's aim was to assess the immunohistochemistry expression of Tim-3, CTLA-4, and LAG-3 in cancer cells and tumor-infiltrating lymphocytes (TILs) in colorectal cancer (CRC) and the correlation between these markers and clinicopathological variables and survival data...
December 18, 2023: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/38108373/tumor-budding-assessment-in-colorectal-carcinoma-normalization-revisited
#25
JOURNAL ARTICLE
David P Cyr, Cherry Pun, Sameer Shivji, Bojana Mitrovic, Kai Duan, Rossi Tomin, Aysegul Sari, Amanpreet Brar, Siham Zerhouni, Mantaj S Brar, Erin D Kennedy, Carol J Swallow, Richard Kirsch, James R Conner
Tumor budding (TB) is a powerful prognostic factor in colorectal cancer (CRC). An internationally standardized method for its assessment (International Tumor Budding Consensus Conference [ITBCC] method) has been adopted by most CRC pathology protocols. This method requires that TB counts are reported by field area (0.785 mm2) rather than objective lens and a normalization factor is applied for this purpose. However, the validity of this approach is yet to be tested. We sought to validate the ITBCC method with a particular emphasis on normalization as a tool for standardization...
December 18, 2023: American Journal of Surgical Pathology
https://read.qxmd.com/read/38066805/clinicopathological-significances-of-peritumoral-budding-in-colorectal-cancer-a-detailed-analysis-based-on-mucinous-and-micropapillary-pattern
#26
JOURNAL ARTICLE
Jung-Soo Pyo, Nae Yu Kim, Kyueng-Whan Min, Dong-Wook Kang
The present study aimed to evaluate the correlations between peritumoral tumor budding (PTB) and the clinicopathological characteristics of colorectal cancer (CRC) according to histological components. The PTBs were investigated and divided into high and low groups. The clinicopathological significance and prognostic implications of PTB in CRC were evaluated. High PTB was found in 104 of 266 CRCs (39.1%). High PTB was significantly correlated with left-sided tumors, lymphatic invasion, lymph node metastasis, distant metastasis, and high pTNM stage...
November 29, 2023: Diagnostics
https://read.qxmd.com/read/38029034/histomorphological-evaluation-of-desmoplastic-tumor-stroma-in-malignant-ovarian-surface-epithelial-tumors
#27
JOURNAL ARTICLE
Sana Ahuja, Sufian Zaheer, Sunil Ranga
BACKGROUND: Ovarian cancer is the 8th most common cancer in women worldwide. Tumor budding is defined as a type of invasive growth in carcinomas with either a single tumor cell or a cluster of up to four cells at the invasive tumor front and is associated with epithelial-mesenchymal transition. A reactive stroma rich in cancer-associated fibroblasts is associated with higher tumor grade and poorer prognosis in breast, colorectal, and oral cancers. AIMS AND OBJECTIVES: The present study was conducted to highlight the prognostic significance of tumor budding and fibrotic cancer stroma in malignant ovarian surface epithelial tumors with known prognostic parameters...
2023: Journal of Mid-life Health
https://read.qxmd.com/read/38001907/prognostic-value-of-tumor-budding-for-early-breast-cancer
#28
JOURNAL ARTICLE
Diogo J Silva, Gonçalo Miranda, Teresina Amaro, Matilde Salgado, Alexandra Mesquita
BACKGROUND: Tumor budding (TB) is a dynamic process associated with the epithelial-mesenchymal transition and a well-established prognostic biomarker for colorectal cancer. As part of the tumor microenvironment, tumor buds demonstrate increased cell motility and invasiveness. Current evidence demonstrates that high levels of TB correlate with disease progression and worst outcomes across different solid tumors. Our work aims to demonstrate the clinical applicability of TB analysis and its utility as a prognostic factor for patients with early breast cancer (EBC)...
October 27, 2023: Biomedicines
https://read.qxmd.com/read/37916344/the-relationship-between-microsatellite-instability-in-colorectal-adenocarcinoma-and-tumor-budding-and-histopathological-parameters
#29
JOURNAL ARTICLE
U Topal, P Gülcan, S Yüksel, Z Teke, H Bektaş, M Duman
OBJECTIVE: This study aims to investigate the correlation between the presence of microsatellite instability (MSI) and tumor budding, as well as their relationship with histopathological parameters in patients diagnosed with colorectal adenocarcinoma. PATIENTS AND METHODS: The study encompassed patients who underwent curative surgery to treat colorectal cancer. These patients were classified into groups based on their MSI status. The International Tumor Budding Consensus Conference (ITBCC) 2016 guidelines were utilized to identify tumor budding...
October 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37893479/colorectal-carcinomas-searching-for-new-histological-parameters-associated-with-lymph-node-metastases
#30
JOURNAL ARTICLE
Aura Jurescu, Adrian Văduva, Octavia Vița, Adelina Gheju, Remus Cornea, Codruța Lăzureanu, Anca Mureșan, Marioara Cornianu, Sorina Tăban, Alis Dema
Background and Objectives : Colorectal cancer (CRC) continues to be an essential public health problem. Our study aimed to evaluate the prognostic significance of classic prognostic factors and some less-studied histopathological parameters in CRC. Materials and Methods : We performed a retrospective study on 71 colorectal carcinoma patients who underwent surgery at the "Pius Brînzeu" County Clinical Emergency Hospital in Timișoara, Romania. We analyzed the classic parameters but also tumor budding (TB), poorly differentiated clusters (PDCs) of cells, tumor-infiltrating lymphocytes (TILs), and the configuration of the tumor border on hematoxylin-eosin slides...
October 2, 2023: Medicina
https://read.qxmd.com/read/37841433/effects-of-imipramine-on-cancer-patients-over-expressing-fascin1-description-of-the-hitclif-clinical-trial
#31
JOURNAL ARTICLE
Antonio Asensi-Cantó, Edith Rodríguez-Braun, Asunción Beltrán-Videla, Ana María Hurtado, Pablo Conesa-Zamora
BACKGROUND: Tumor invasion and metastasis are responsible for the majority of cancer-related deaths. The identification of molecules involved in these processes is crucial to design effective treatments that can halt the progression of cancer. To spread and metastasize, tumor cells must restructure their cytoskeleton and emit protrusions. A key molecule in this process of creating these invading structures is Fascin1, the main protein involved in the formation of actin cytoskeleton bundles and a consistent marker of bad prognosis in several types of cancer...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37778272/clinical-significance-of-glycogen-synthase-kinase-3-gsk-3-expression-and-tumor-budding-grade-in-colorectal-cancer-implications-for-targeted-therapy
#32
JOURNAL ARTICLE
Silvia Guil-Luna, Aurora Rivas-Crespo, Carmen Navarrete-Sirvent, Ana Mantrana, Alejandra Pera, Rafael Mena-Osuna, Marta Toledano-Fonseca, María Victoria García-Ortíz, Carlos Villar, Maria Teresa Sánchez-Montero, Janna Krueger, Francisco Javier Medina-Fernández, Juan De La Haba-Rodríguez, Auxiliadora Gómez-España, Enrique Aranda, Christopher E Rudd, Antonio Rodríguez-Ariza
INTRODUCTION: Glycogen synthase kinase 3 (GSK-3) has been proposed as a novel cancer target due to its regulating role in both tumor and immune cells. However, the connection between GSK-3 and immunoevasive contexture, including tumor budding (TB) has not been previously examined. METHODS: we investigated the expression levels of total GSK-3 as well as its isoforms (GSK-3β and GSK-3α) and examined their potential correlation with TB grade and the programmed cell death-ligand 1 (PD-L1) in colorectal cancer (CRC) tumor samples...
September 28, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37760801/cellular-and-molecular-mechanisms-of-the-tumor-stroma-in-colorectal-cancer-insights-into-disease-progression-and-therapeutic-targets
#33
REVIEW
Nikolay Shakhpazyan, Liudmila Mikhaleva, Arkady Bedzhanyan, Zarina Gioeva, Nikolay Sadykhov, Alexander Mikhalev, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann, Alexander Orekhov
Colorectal cancer (CRC) is a major health burden worldwide and is the third most common type of cancer. The early detection and diagnosis of CRC is critical to improve patient outcomes. This review explores the intricate interplay between the tumor microenvironment, stromal interactions, and the progression and metastasis of colorectal cancer. The review begins by assessing the gut microbiome's influence on CRC development, emphasizing its association with gut-associated lymphoid tissue (GALT). The role of the Wnt signaling pathway in CRC tumor stroma is scrutinized, elucidating its impact on disease progression...
August 23, 2023: Biomedicines
https://read.qxmd.com/read/37746764/additional-staining-for-lymphovascular-invasion-is-associated-with-increased-estimation-of-lymph-node-metastasis-in-patients-with-t1-colorectal-cancer-systematic-review-and-meta-analysis
#34
REVIEW
Jun Watanabe, Katsuro Ichimasa, Yuki Kataoka, Atsushi Miki, Hidehiro Someko, Munenori Honda, Makiko Tahara, Takeshi Yamashina, Khay Guan Yeoh, Shigeo Kawai, Kazuhiko Kotani, Naohiro Sata
OBJECTIVES: Lymphovascular invasion (LVI) is a critical risk factor for lymph node metastasis (LNM), which requires additional surgery after endoscopic resection of T1 colorectal cancer (CRC). However, the impact of additional staining on estimating LNM is unclear. This systematic review aimed to evaluate the impact of additional staining on determining LNM in T1 CRC. METHODS: We searched five electronic databases. Outcomes were diagnostic odds ratio (DOR), assessed using hierarchical summary receiver operating characteristic curves, and interobserver agreement among pathologists for positive LVI, assessed using Kappa coefficients (κ)...
September 25, 2023: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/37697033/radiomics-and-machine-learning-analysis-by-computed-tomography-and-magnetic-resonance-imaging-in-colorectal-liver-metastases-prognostic-assessment
#35
JOURNAL ARTICLE
Vincenza Granata, Roberta Fusco, Federica De Muzio, Maria Chiara Brunese, Sergio Venanzio Setola, Alessandro Ottaiano, Claudia Cardone, Antonio Avallone, Renato Patrone, Silvia Pradella, Vittorio Miele, Fabiana Tatangelo, Carmen Cutolo, Nicola Maggialetti, Damiano Caruso, Francesco Izzo, Antonella Petrillo
OBJECTIVE: The aim of this study was the evaluation radiomics analysis efficacy performed using computed tomography (CT) and magnetic resonance imaging in the prediction of colorectal liver metastases patterns linked to patient prognosis: tumor growth front; grade; tumor budding; mucinous type. Moreover, the prediction of liver recurrence was also evaluated. METHODS: The retrospective study included an internal and validation dataset; the first was composed by 119 liver metastases from 49 patients while the second consisted to 28 patients with single lesion...
September 11, 2023: La Radiologia Medica
https://read.qxmd.com/read/37686518/clinico-pathological-features-outcomes-and-impacts-of-covid-19-pandemic-on-patients-with-early-onset-colorectal-cancer-a-single-institution-experience
#36
JOURNAL ARTICLE
Daniel Martinez-Perez, David Viñal, Jesús Peña-Lopez, Diego Jimenez-Bou, Iciar Ruiz-Gutierrez, Sergio Martinez-Recio, María Alameda-Guijarro, Antonio Rueda-Lara, Gema Martin-Montalvo, Ismael Ghanem, Ana Belén Custodio, Lucia Trilla-Fuertes, Angelo Gamez-Pozo, Antonio Barbachano, Javier Rodriguez-Cobos, Pilar Bustamante-Madrid, Asuncion Fernandez-Barral, Aurora Burgos, Maria Isabel Prieto-Nieto, Laura Guerra Pastrian, José Manuel González-Sancho, Alberto Muñoz, Jaime Feliu, Nuria Rodríguez-Salas
BACKGROUND: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC), as well as the impacts of COVID-19 pandemic. METHODS: We included all patients with pathologically confirmed diagnoses of CRC at Hospital Universitario La Paz from October 2016 to December 2021. The EOCRC cut-off age was 50 years old. RESULTS: A total of 1475 patients diagnosed with CRC were included, eighty (5...
August 24, 2023: Cancers
https://read.qxmd.com/read/37661922/intratumoral-metabolic-heterogeneity-of-colorectal-cancer
#37
REVIEW
Yoshinobu Hirose, Kohei Taniguchi
Although the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs OXPHOS) may be too simplistic and not accurately represent the metabolic characteristics of CRC...
September 4, 2023: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/37568691/endoscopic-treatment-of-t1-colorectal-cancer
#38
REVIEW
Klaus Metter, Stephanie Ellen Weißinger, Alinda Várnai-Händel, Karl-Ernst Grund, Franz Ludwig Dumoulin
Commonly accepted criteria for curative resection of T1 colorectal cancer include R0 resection with horizontal and vertical clear margins (R0), absence of lympho-vascular or vessel infiltration (L0, V0), a low to moderate histological grading (G1/2), low tumor cell budding, and limited (<1000 µm) infiltration into the submucosa. However, submucosal infiltration depth in the absence of other high-risk features has recently been questioned as a high-risk situation for lymph-node metastasis. Consequently, endoscopic resection techniques should focus on the acquisition of qualitatively and quantitively sufficient submucosal tissue...
July 30, 2023: Cancers
https://read.qxmd.com/read/37528304/postoperative-prognosis-according-to-pathologic-categorization-of-desmoplastic-reaction-in-patients-with-extrahepatic-cholangiocarcinoma
#39
JOURNAL ARTICLE
Yusuke Yoshida, Yoshitsugu Nakanishi, Tomoko Mitsuhashi, Hiroyuki Yamamoto, Mariko O Hayashi, Mitsunobu Oba, Takeo Nitta, Takashi Ueno, Toru Yamada, Masato Ono, Shota Kuwabara, Yutaka Hatanaka, Satoshi Hirano
BACKGROUND: Recent studies have demonstrated the importance of desmoplastic reaction (DR) in predicting postoperative prognosis for patients with colorectal carcinoma. However, the impact of DR on the prognosis of extrahepatic cholangiocarcinomas (EHCCs) is not established. This study aimed to clarify the associations of pathologic DR categories with clinicopathologic factors and postoperative prognosis of perihilar cholangiocarcinoma (PHCC) and distal cholangiocarcinoma (DCC). METHODS: A pathologic review of 174 patients with PHCC and 109 patients with DCC who underwent surgical resection was performed...
August 1, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37517168/analyzing-the-invasive-front-of-colorectal-cancer-by-punching-tissue-block-or-laser-capture-microdissection
#40
JOURNAL ARTICLE
Ana Pavlič, Kristian Urh, Emanuela Boštjančič, Nina Zidar
The aim of this study was to determine the advantages and limitations of two commonly used sampling techniques, i.e., punching tissue block (PTB) and laser capture microdissection (LCM) when investigating tumor cell-derived gene expression patterns at the invasive front of colorectal cancer (CRC). We obtained samples from 20 surgically removed CRCs at locations crucial for tumor progression, i.e., the central part, the expansive front and the infiltrative front exhibiting tumor budding (TB), using both sampling techniques...
July 27, 2023: Pathology, Research and Practice
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