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tumor budding colorectal

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https://www.readbyqxmd.com/read/29731961/macrophages-induce-budding-in-aggressive-human-colon-cancer-subtypes-by-protease-mediated-disruption-of-tight-junctions
#1
Kari Trumpi, Nicola Frenkel, Timo Peters, Nicoline M Korthagen, Jennifer M J Jongen, Daniëlle Raats, Helma van Grevenstein, Yara Backes, Leon M Moons, Miangela M Lacle, Jan Koster, Danny Zwijnenburg, Inne H M Borel Rinkes, Onno Kranenburg
Primary human colorectal tumors with a high stromal content have an increased capacity to metastasize. Cancer-associated fibroblasts (CAFs) promote metastasis, but the contribution of other stromal cell types is unclear. Here we searched for additional stromal cell types that contribute to aggressive tumor cell behavior. By making use of the 'immunome compendium'-a collection of gene signatures reflecting the presence of specific immune cell-types-we show that macrophage signatures are most strongly associated with a high CAF content and with poor prognosis in multiple large cohorts of primary tumors and liver metastases...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29626253/interobserver-variability-in-the-h-e-based-assessment-of-tumor-budding-in-pt3-4-colon-cancer-does-it-affect-the-prognostic-relevance
#2
Benedikt Martin, Eva Schäfer, Elzbieta Jakubowicz, Patrick Mayr, Regina Ihringer, Matthias Anthuber, Gerhard Schenkirsch, Tina Schaller, Bruno Märkl
Tumor budding is a mostly accepted adverse prognostic factor in colorectal carcinoma. It is on the cusp of a widespread use after agreement was reached recently on uniform assessment criteria. We investigated whether the interobserver variability has a direct influence on the prognostic relevance in pT3/4 colon cancer in the background of different levels of experience of the investigators. In total, six investigators with different levels of experience evaluated tumor budding on H&E slides in 244 cases with primary diagnosed (2002-2011) colon carcinoma (pT3/4, N+/-, M0)...
April 6, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29448312/prognostic-significance-of-poorly-differentiated-clusters-and-tumor-budding-in-colorectal-liver-metastases
#3
Gilton M Fonseca, Evandro S de Mello, Sheila F Faraj, Jaime A P Kruger, Fabricio F Coelho, Vagner B Jeismann, Renato M Lupinacci, Ivan Cecconello, Venancio A F Alves, Timothy M Pawlik, Paulo Herman
BACKGROUND: Histomorphological features have been described as prognostic factors after resection of colorectal liver metastases (CLM). The objectives of this study were to assess the prognostic significance of tumor budding (TB) and poorly differentiated clusters (PDC) among CLM, and their association with other prognostic factors. METHODS: We evaluated 229 patients who underwent a first resection of CLM. Slides stained by HE were assessed for TB, PDC, tumor border pattern, peritumoral pseudocapsule, peritumoral, and intratumoral inflammatory infiltrate...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29447923/the-significance-of-tumor-budding-in-t1-colorectal-carcinoma-the-most-reliable-predictor-of-lymph-node-metastasis-especially-in-endoscopically-resected-t1-colorectal-carcinoma
#4
So Jeong Lee, Ahrong Kim, Young Keum Kim, Won Young Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Geum Am Song, Do Youn Park
Endoscopic resection is widely recognized as a first-line treatment for T1 colorectal cancers (CRC), although additional surgical intervention may be indicated based on the risk of lymph node (LN) metastasis. However, risk factors for LN metastasis in T1 CRC not fully established. We investigated the clinicopathological features of T1 CRC and evaluated their association with lymph node metastasis in 133 cases of T1 CRC, consisting of 87 cases with first-line endoscopic resection (EMR) followed by additional surgery and 46 cases with primary surgical resection...
February 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29445855/-treatment-strategy-for-early-stage-rectal-cancer-t1-carcinoma
#5
REVIEW
G Liebig-Hörl, C Puchner, M Gerken, M Klinkhammer-Schalke, A Fürst
BACKROUND: A common consensus for the definition for early rectal cancer does not exist. This item is used in cases of histological findings including pTis, pT1 or pT2 tumors. The term early rectal cancer is not mentioned in the German S3 guidelines on colorectal cancer. The pTis tumors are located at the mucosa level of the intestinal wall and they have nearly no tendency to develop metastases but pT2 tumors have a high risk of local metastases; therefore, the term early rectal cancer is not adequate for pT2 tumors...
February 14, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29416940/tumor-associated-macrophages-remodeling-emt-and-predicting-survival-in-colorectal-carcinoma
#6
Si Li, Fangying Xu, Jing Zhang, Lili Wang, Yang Zheng, Xuesong Wu, Jing Wang, Qiong Huang, Maode Lai
The immune contexture, a composition of the tumor microenvironment, plays multiple important roles in cancer stem cell (CSC) and epithelial-mesenchymal transition (EMT), and hence critically influences tumor initiation, progression and patient outcome. Tumor-associated macrophages (TAMs) are abundant in immune contexture, however their roles in CSC, EMT and prognosis of colorectal cancer (CRC) have not been elucidated. In 419 colorectal carcinomas, immune cell types (CD68+ macrophages, CD3+ , CD4+ or CD8+ T lymphocytes, CD20+ B lymphocytes), EMT markers (E-cadherin and Snail) as well as the stem cell marker (CD44v6) were detected in tumor center (TC) and tumor invasive front (TF) respectively by immunohistochemistry...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29403085/tumor-budding-as-a-standardized-parameter-in-gastrointestinal-carcinomas-more-than-just-the-colon
#7
REVIEW
Kyra B Berg, David F Schaeffer
Tumor budding, defined as single cells or clusters of less than five cells, is thought to be a histomorphologic marker of an aggressive tumor behavior mimicking the embryologic epithelial-mesenchymal transition, and has been well established in the past two decades as a poor prognostic factor in colorectal carcinoma. Slow uptake in routine reporting of this important pathologic prognostic feature was in part due to differing methods of assessment of budding reported in the literature, but has recently been clarified at a consensus conference on tumor budding in colorectal carcinoma...
February 6, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29391881/sialyl-lewis-x-expression-at-the-invasive-front-as-a-predictive-marker-of-liver-recurrence-in-stage-ii-colorectal-cancer
#8
Masato Yamadera, Eiji Shinto, Hitoshi Tsuda, Yoshiki Kajiwara, Yoshihisa Naito, Kazuo Hase, Junji Yamamoto, Hideki Ueno
Sialyl Lewisx (SLX) is a carbohydrate ligand for endothelial selectin that participates in cell adhesion, proliferation and scattering. It plays an important role in cancer cell adhesion to vascular endothelial cells, leading to hematogenous metastasis. The prognostic significance of SLX expression level at the invasive front in patients with stage II colorectal cancer (CRC) was examined. A total of 209 patients with stage II CRC curatively resected between 1997 and 2000 were enrolled. The preoperative serum SLX levels measured by radioimmunoassay and SLX immunoexpression levels at the invasive front, and at the non-invasive frontal region determined by tissue microarray were analyzed...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29366842/histologic-factors-associated-with-need-for-surgery-in-patients-with-pedunculated-t1-colorectal-carcinomas
#9
Yara Backes, Sjoerd G Elias, John N Groen, Matthijs P Schwartz, Frank H J Wolfhagen, Joost M J Geesing, Frank Ter Borg, Jeroen van Bergeijk, Bernhard W M Spanier, Wouter H de Vos Tot Nederveen Cappel, Koen Kessels, Cornelis A Seldenrijk, Mihaela G Raicu, Paul Drillenburg, Anya N Milne, Marjon Kerkhof, Tom C J Seerden, Peter D Siersema, Frank P Vleggaar, G Johan A Offerhaus, Miangela M Lacle, Leon M G Moons
BACKGROUND & AIMS: Most patients with pedunculated T1 colorectal tumors referred for surgery are not found to have lymph node metastases, and were therefore unnecessarily placed at risk for surgery-associated complications. We aimed to identify the factors associated with need for surgery in patients with pedunculated T1 colorectal tumors. METHODS: We performed a cohort-nested matched case-control study of 708 patients diagnosed with pedunculated T1 colorectal tumors at 13 hospitals in The Netherlands, from January 1, 2000 through December 31, 2014, followed for a median of 44 months (interquartile range, 20-80 months)...
January 31, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29344167/analysis-of-imp3-expression-in-primary-tumor-and-stromal-cells-in-patients-with-colorectal-cancer
#10
Xiaoping Huang, Qingzhu Wei, Jianghuan Liu, Hongling Niu, Gang Xiao, Lixin Liu
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein upregulated in tumor cells during carcinogenesis. The aim of the present study was to investigate the expression status of IMP3 in colorectal cancer (CRC) tissues and its clinical significance. Immunostaining was performed in 130 CRC samples, the association of IMP3 expression with clinicopathological characteristics was assessed and 58 patients were selected for survival analysis. To the best of our knowledge, the present study describes for the first time the expression of IMP3 in tumor stromal components of CRC...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112018/tumor-budding-and-pdc-grade-are-stage-independent-predictors-of-clinical-outcome-in-mismatch-repair-deficient-colorectal-cancer
#11
Éanna Ryan, Yi Ling Khaw, Ben Creavin, Robert Geraghty, Elizabeth J Ryan, David Gibbons, Ann Hanly, Sean T Martin, P Ronan O'Connell, Desmond C Winter, Kieran Sheahan
Mismatch repair deficient (dMMR) colorectal cancer (CRC) despite its association with poor histologic grade often has improved prognosis compared with MMR proficient CRC. Tumor budding and poorly differentiated clusters (PDCs) may predict metastatic potential of colorectal adenocarcinoma (CRC). In addition, their assessment may be more reproducible than the evaluation of other histopathologic parameters. Therefore, we wished to determine their potential as prognostic indicators in a cohort of dMMR CRC patients relative to histologic grade...
January 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29044503/clinical-significance-of-programmed-cell-death-ligand-1-expression-and-the-immune-microenvironment-at-the-invasive-front-of-colorectal-cancers-with-high-microsatellite-instability
#12
Shotaro Korehisa, Eiji Oki, Makoto Iimori, Yu Nakaji, Mototsugu Shimokawa, Hiroshi Saeki, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara
Immunotherapy is reportedly effective in colorectal cancers (CRCs) with high microsatellite instability (MSI-H); however, the specific cell types that respond to immune checkpoint therapy are unclear. Herein, we aimed to examine the expression of programmed cell death-ligand 1 (PD-L1) and related proteins in MSI-H and microsatellite-stable (MSS) CRCs to investigate the immune microenvironment at the tumor's invasive front. The MSI status was retrospectively assessed in 499 patients undergoing surgical resection of primary CRC; of these, 48 were classified as MSI-H...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29040282/colorectal-carcinoma-tumour-budding-and-podia-formation-in-the-xenograft-microenvironment
#13
Friedrich Prall, Claudia Maletzki, Maja Hühns, Mathias Krohn, Michael Linnebacher
Tumour budding and podia formation are well-appreciated in surgical pathology as an aggressive invasion phenotype of colorectal carcinoma cells that is attained in the microenvironment of the invasive margin. In this study, we addressed how tumour budding and podia formation feature in xenografts. Primary colorectal carcinomas (N = 44) of various molecular types (sporadic standard type, high-degree microsatellite-unstable, CpG island methylator phenotype) were transplanted subcutaneously into T and B cell-deficient NSG mice, making possible immunohistochemistry with routine surgical pathology antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/29036423/invasive-micropapillary-carcinoma-component-is-an-independent-prognosticator-of-poorer-survival-in-stage-iii-colorectal-cancer-patients
#14
Hiroki Kitagawa, Masanori Yoshimitsu, Mayumi Kaneko, Yuta Ibuki, Manabu Emi, Toshihiko Kohashi, Hidenori Mukaida, Hiroo Matsuura, Hiroki Ohge, Hideki Ohdan, Naoki Hirabayashi
Background: Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in colorectal cancer leads to poorer prognosis than conventional colorectal cancer; however, the influence of IMPC on outcomes remains unclear. The present study aimed to identify the clinicopathological characteristics of colorectal cancers with IMPCs, and to evaluate the prognostic significance of IMPCs per se. Methods: We retrospectively analyzed data from 837 patients with colorectal cancer who underwent surgical treatment...
December 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28968818/deletions-at-slc18a1-increased-the-risk-of-crc-and-lower-slc18a1-expression-associated-with-poor-crc-outcome
#15
Dandan Zhang, Zhenli Li, Xiaohong Xu, Dan Zhou, Shunli Tang, Xiaoyang Yin, Fangying Xu, Hui Li, Yuan Zhou, Tao Zhu, Hong Deng, Shuai Zhang, Qiong Huang, Jing Wang, Wei Yin, Yimin Zhu, Maode Lai
Copy number variations (CNVs) contribute to the development of colorectal cancer (CRC). We conducted a two-stage association study to identify CNV risk loci for CRC. We performed a gene-based rare CNV study on 694 sporadic CRC and 1641 controls using Illumina Human-OmniExpress-12v1.0 BeadChips, and further replicated in 934 CRC cases and 2680 controls for risk CNVs by using TaqMan Copy Number Assay. Tumor buddings, cancer cells in the center of primary tumor and normal intestinal epithelial cells were captured using laser capture microdissection (LCM) and were assayed using AffymetrixGeneChip® Human Genome U133 Plus 2...
October 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28962043/a-novel-ability-of-endocytoscopy-to-diagnose-histological-grade-of-differentiation-in-t1-colorectal-carcinomas
#16
Tomoya Sako, Shin-Ei Kudo, Hideyuki Miyachi, Kunihiko Wakamura, Kenta Igarashi, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Takemasa Hayashi, Atsushi Katagiri, Fumio Ishida, Takeshi Azuma, Haruhiro Inoue, Shigeharu Hamatani
BACKGROUND AND STUDY AIMS:  Endocytoscopic images closely resemble histopathology. We assessed whether endocytoscopy could be used to determine T1 colorectal cancer histological grade. PATIENTS AND METHODS:  Endocytoscopic images of 161 lesions were divided into three types: tubular gland lumens, unclear gland lumens, and fused gland formations on endocytoscopy (FGFE). We retrospectively compared endocytoscopic findings with histological grade in the resected specimen superficial layer, and examined the incidence of risk factors for lymph node metastasis...
January 2018: Endoscopy
https://www.readbyqxmd.com/read/28932085/novel-predictors-for-lymph-node-metastasis-in-submucosal-invasive-colorectal-carcinoma
#17
Kwangil Yim, Daeyoun David Won, In Kyu Lee, Seong-Taek Oh, Eun Sun Jung, Sung Hak Lee
AIM: To evaluate a novel grading system to predict lymph node metastasis (LNM) in patients with submucosal invasive colorectal carcinoma (SICRC). METHODS: We analyzed the associations between LNM and various clinicopathological features in 252 patients with SICRC who had undergone radical surgery at the Seoul Saint Mary's hospital between 2000 and 2015. RESULTS: LNM was observed in 31 patients (12.3%). The depth and width of the submucosal invasion, lymphatic invasion, tumor budding, and the presence of poorly differentiated clusters (PDCs) were significantly associated with the incidence of LNM...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28875602/poorly-differentiated-clusters-in-colorectal-adenocarcinomas-share-biological-similarities-with-micropapillary-patterns-as-well-as-tumor-buds
#18
Mineui Hong, Jeong Won Kim, Mi Kyung Shin, Byung Chun Kim
In colorectal carcinoma, poorly differentiated clusters (PDCs) are a poor prognostic indicator and show morphological continuity and behavioral similarities to micropapillary patterns (MPPs) as well as tumor buds (TBs). Epithelial-mesenchymal transition (EMT) and inhibition of cancer-stromal interactions may contribute to the development of PDCs. To clarify the biological nature of PDCs, we examined immunohistochemical stainings for β-catenin, Ki-67, E-cadherin, epithelial cell adhesion molecule (EpCAM), MUC1, and epithelial membrane antigen (EMA), which are associated with EMT and cancer-stromal interactions...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28863773/down-regulation-of-mirna-148a-and-mirna-625-3p-in-colorectal-cancer-is-associated-with-tumor-budding
#19
Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis, Eduardas Aleknavicius
BACKGROUND: MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptosis and may serve as prognostic and predictive markers. In this study we aimed to evaluate the role of miRNA-148a and miRNA-625-3p in metastatic colorectal cancer. METHODS: Fifty-four patients with a first-time diagnosed CRC receiving FOLFOX ± Bevacizumab were involved in the study...
September 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28836256/-risk-factors-analysis-of-the-early-colorectal-carcinoma-after-endoscopic-non-curative-resection-a-retrospective-clinical-study-of-56-cases
#20
Ruigang Wang, Yueming Zhang, Lizhou Dou, Yong Liu, Shun He, Xiao Liu, Xinying Yu, Guiqi Wang
OBJECTIVE: To explore the risk factors contributing to the progression-free survival rate of patients undergoing endoscopic non-curative resection. METHODS: Clinicopathological data of patients with early colorectal carcinoma and intraepithelial neoplasia undergoing endoscopic resection in our department from January 2009 to January 2015 were collected. Associated factors affecting the progression-free survival rate of the early colorectal carcinoma after endoscopic non-curative resection were analyzed...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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