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https://www.readbyqxmd.com/read/27901470/sinomenine-prevents-the-development-of-cardiomyopathy-in-diabetic-rats-by-inhibiting-inflammatory-responses-and-blocking-activation-of-nf-%C3%AE%C2%BAb
#1
Cheng Jiang, Yun-Long Tong, Dan Zhang, Li-Zhi Liu, Ju-Fei Wang
Diabetic cardiomyopathy is a severe complication of diabetes mellitus (DM). The goal of current work was to study the effects of sinomenine on streptozotocin-induced cardiomyopathy in rats. DM in rats was induced by intraperitoneal injection of streptozotocin. Cardiac function was evaluated by measuring left ventricle end-diastolic diameter, left ventricle end-systolic diameter and ejection fraction. Cardiac inflammation was evaluated by the degree of infiltration of T lymphocytes and the levels of pro-inflammatory cytokines...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27080266/-hydrogen-sulfide-in-cartilage-and-its-inhibitory-effect-on-matrix-metalloproteinase-13-expression-in-chondrocytes-induced-by-interlukin-1%C3%AE
#2
L P Pan, Y P Cao, L C Wen, W B Chai, J B DU, H F Jin, J Liu, X Yang, Z C Meng, H Liu, Y P Cui, R Wang, H Wu, X T Zhou, X Li, Z Y Li, M Talatibaike
OBJECTIVE: To investigate whether endogenous hydrogen sulfide (H2S) was involved in the pathogenesis of osteoarthritis (OA) and its underlying mechanism, to detect H2S and its synthases expression in knee cartilage in patients diagnosed with different severity of OA, and to explore the transcription and expression of gene MMP-13 in chondrocytes treated with IL-1β or H2S. METHODS: Synovial fluids of the in-patients with different severity of OA hospitalized in Peking University First Hospital were collected for measurement of H2S content using methylene blue assay...
April 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/26913549/protective-effect-of-adansonia-digitata-against-isoproterenol-induced-myocardial-injury-in-rats
#3
Mona A M Ghoneim, Amal I Hassan, Manal G Mahmoud, Mohsen S Asker
The baobab fruit (Adansonia digitata) was analyzed for proximate composition, amino acids, and minerals. The fruit pulp was found to be a good source of carbohydrates, proteins, phenols, and substantial quantities of K, Ca, and Mg. Amino acid analyses revealed high glutamic and aspartic acid, but the sulfur amino acids were the most limited. The present study was designed to investigate the role of Adansonia digitata (Baobab fruit pulp) against isoproterenol induced myocardial oxidative stress in experimental rats by demonstrating the changes in tissue cardiac markers, some antioxidant enzymes, interleukin-1 β (IL-1 β), monocyte chemoattractant protein-1(MCP-1), myeloperoxidase (MPO), Collagen-1, galectin-3, and serum corticosterone...
2016: Animal Biotechnology
https://www.readbyqxmd.com/read/26708749/lithium-attenuated-the-depressant-and-anxiogenic-effect-of-juvenile-social-stress-through-mitigating-the-negative-impact-of-interlukin-1%C3%AE-and-nitric-oxide-on-hypothalamic-pituitary-adrenal-axis-function
#4
A Haj-Mirzaian, S Amiri, N Kordjazy, M Momeny, A Razmi, M Rahimi-Balaei, H Amini-Khoei, A Haj-Mirzaian, H Marzban, S E Mehr, S H Ghaffari, A R Dehpour
The neuroimmune-endocrine dysfunction has been accepted as one of fundamental mechanisms contributing to the pathophysiology of psychiatric disorders including depression and anxiety. In this study, we aimed to evaluate the involvement of hypothalamic-pituitary-adrenal (HPA) axis, interleukin-1β, and nitrergic system in mediating the negative behavioral impacts of juvenile social isolation stress (SIS) in male mice. We also investigated the possible protective effects of lithium on behavioral and neurochemical changes in socially isolated animals...
February 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/26679676/bilirubin-modulated-cytokines-growth-factors-and-angiogenesis-to-improve-cutaneous-wound-healing-process-in-diabetic-rats
#5
Mahendra Ram, Vishakha Singh, Sanjay Kumawat, Vinay Kant, Surendra Kumar Tandan, Dinesh Kumar
Bilirubin has shown cutaneous wound healing potential in some preliminary studies. Here we hypothesize that bilirubin facilitates wound healing in diabetic rats by modulating important healing factors/candidates and antioxidant parameters in a time-dependent manner. Diabetes was induced in male Wistar rats by streptozotocin. In all diabetic rats wounds were created under pentobarbitone anesthesia. All the rats were divided into two groups, of which one (control) was treated with ointment base and other with bilirubin ointment (0...
January 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/26231971/clematichinenoside-protects-blood-brain-barrier-against-ischemic-stroke-superimposed-on-systemic-inflammatory-challenges-through-up-regulating-a20
#6
Dan Han, Weirong Fang, Rui Zhang, Jie Wei, Nandani Darshika Kodithuwakku, Lan Sha, Wenhuan Ma, Lifang Liu, Fengwen Li, Yunman Li
Suppression of excessive inflammation can ameliorate blood brain barrier (BBB) injury, which shows therapeutic potential for clinical treatment of brain injury induced by stroke superimposed on systemic inflammatory diseases. In this study, we investigated whether and how clematichinenoside (AR), an anti-inflammatory triterpene saponin, protects brain injury from stroke superimposed on systemic inflammation. Lipopolysaccharide (LPS) was intraperitoneally injected immediately after middle cerebral artery occlusion (MCAO) in rats...
January 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/26138240/inflammatory-response-of-cultured-rat-synoviocytes-challenged-with-synovial-fluid-from-osteoarthritis-patients-correlates-with-their-radiographic-grading-a-pilot-study
#7
Soumya J Koppikar, Priya G Kulkarni, Dhanashri R Ingale, Dattatray Shinde, NarendraKumar Wagh, Shantanu Deshpande, Alpana S Moghe, Prabhakar K Ranjekar, Abhay M Harsulkar
The inflammatory nature of synovial fluid (SF) of varying grade osteoarthritis (OA) patients was estimated by measuring pro-inflammatory factors and through a unique cell-challenge experiment. SF samples were collected from six OA and one non-OA patient; spanning Kellgren-Lawrence (KL) grades were analyzed for interlukin-1-beta (IL-1β), nitric oxide (NO) and its derivatives, and glycosaminoglycan (GAG). Levels of IL-1β, NO, and GAG in SF did not correlate with KL grades of the patients studied. In the cell-challenge experiment, cultured rat synoviocyte fibroblasts (RSFs) were challenged by the patient's SFs with and without pre-treatment of IL-1β and lipopolysaccharide (LPS)...
September 2015: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/26037399/nalp3-inflammasome-activation-in-protein-misfolding-diseases
#8
REVIEW
Fushan Shi, Mohammed Kouadir, Yang Yang
Protein-misfolding diseases, such as Alzheimer's disease, type 2 diabetes, Prion diseases, and Parkinson's disease, are characterized by inflammatory reactions. In all these diseases, IL-1β (Interlukine-1β) has been shown to be an important regulator, and the misfolded proteins are proved to be triggers of the release of IL-1β. Recently, several reports demonstrated that the inflammasome activation is involved in the progress of the misfolded protein diseases, and that the inflammasome can recognize pathogenic proteins leading to the release of IL-1β...
August 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/25894680/differential-effects-of-pioglitazone-in-the-hippocampal-ca1-region-following-transient-forebrain-ischemia-in-low-and-high-fat-diet-fed-gerbils
#9
Seung Myung Moon, Goang-Min Choi, Dae Young Yoo, Hyo Young Jung, Hee Sun Yim, Dae Won Kim, In Koo Hwang, Byung Moon Cho, In Bok Chang, Sung-Min Cho, Moo-Ho Won
In the present study, we investigated the effects of pioglitazone (PGZ) in the hippocampal CA1 region of low- or high-fat diet (LFD or HFD) fed gerbils after transient forebrain ischemia. After 8 weeks of LFD or HFD feeding, PGZ (30 mg/kg) was intraperitoneally administered to the gerbils, following which ischemia was induced by occlusion of the bilateral common carotid arteries for 5 min. Administration of PGZ significantly reduced the ischemia-induced hyperactivity 1 day after ischemia/reperfusion in both LFD- and HFD-fed gerbils...
May 2015: Neurochemical Research
https://www.readbyqxmd.com/read/25335965/effects-of-polycaprolactone-based-scaffolds-on-the-blood-brain-barrier-and-cerebral-inflammation
#10
Vincent Diong Weng Nga, Jing Lim, David Kim Seng Choy, Mya Aye Nyein, Jia Lu, Ning Chou, Tseng Tsai Yeo, Swee-Hin Teoh
Severe pathoanatomical and mechanical injuries compromise patient recovery and survival following penetrating brain injury (PBI). The realization that the blood-brain barrier (BBB) plays a major role in dictating post-PBI events has led to rising interests in possible therapeutic interventions through the BBB. Recently, the choroid plexus has also been suggested as a potential therapeutic target. The use of biocompatible scaffolds for the delivery of therapeutic agents, but little is known about their interaction with cerebral tissue, which has important clinical implications...
February 2015: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/25152589/beneficial-effect-of-butyrate-lactobacillus-casei-and-l-carnitine-combination-in-preference-to-each-in-experimental-colitis
#11
COMPARATIVE STUDY
Mahsa Moeinian, Seyedeh Farnaz Ghasemi-Niri, Shilan Mozaffari, Amir Hossein Abdolghaffari, Maryam Baeeri, Mona Navaea-Nigjeh, Mohammad Abdollahi
AIM: To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model. METHODS: Rats were divided into seven groups. Four groups received oral butyrate, L-carnitine, Lactobacillus casei and the combination of three agents for 10 consecutive days. The remaining groups included negative and positive controls and a sham group. Macroscopic, histopathological examinations, and biomarkers such as tumor necrosis factor-alpha (TNF-α) and interlukin-1β (IL-1β), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), and ferric reduced ability of plasma (FRAP) were determined in the colon...
August 21, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24972270/regulatory-effects-of-fisetin-on-microglial-activation
#12
Jing-Yuan Chuang, Pei-Chun Chang, Yi-Chun Shen, Chingju Lin, Cheng-Fang Tsai, Jia-Hong Chen, Wei-Lan Yeh, Ling-Hsuan Wu, Hsiao-Yun Lin, Yu-Shu Liu, Dah-Yuu Lu
Increasing evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play a key role in neurodegeneration. Fisetin, a plant flavonol commonly found in fruits and vegetables, is frequently added to nutritional supplements due to its antioxidant properties. In the present study, treatment with fisetin inhibited microglial cell migration and ROS (reactive oxygen species) production. Treatment with fisetin also effectively inhibited LPS plus IFN-γ-induced nitric oxide (NO) production, and inducible nitric oxide synthase (iNOS) expression in microglial cells...
June 26, 2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/24858944/tlr4-inhibitor-resatorvid-provides-neuroprotection-in-experimental-traumatic-brain-injury-implication-in-the-treatment-of-human-brain-injury
#13
Dingding Zhang, Hua Li, Tao Li, Mengliang Zhou, Shuangying Hao, Huiying Yan, Zhuang Yu, Wei Li, Kuanyu Li, Chunhua Hang
Toll-like receptor 4 (TLR4) is considered to play an important role in neuronal death in animal models and could be an important therapeutic target following traumatic brain injury (TBI). Resatorvid is a small molecule, commonly accepted to inhibit TLR4-mediated pathway. The purpose of this study was to investigate the neuroprotective effect of resatorvid after TBI. Our data revealed that inhibition of TLR4 by resatorvid attenuated the development of TBI in mouse model. And we found that resatorvid administration dramatically reduced neuronal apoptosis...
September 2014: Neurochemistry International
https://www.readbyqxmd.com/read/24847951/catechins-inhibit-vascular-endothelial-growth-factor-production-and-cyclooxygenase-2-expression-in-human-dental-pulp-cells
#14
T Nakanishi, K Mukai, Y Hosokawa, D Takegawa, T Matsuo
AIM: To investigate the effect of catechins on vascular endothelial growth factor (VEGF) production and cyclooxygenase-2 (COX-2) expression in human dental pulp cells (HDPC) stimulated with bacteria-derived factors or pro-inflammatory cytokines. METHODOLOGY: Morphologically fibroblastic cells established from explant cultures of healthy human dental pulp tissues were used as HDPC. HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1β (IL-1β) or tumour necrosis factor-α (TNF-α)...
March 2015: International Endodontic Journal
https://www.readbyqxmd.com/read/24630682/cruciferous-vegetable-intake-is-inversely-correlated-with-circulating-levels-of-proinflammatory-markers-in-women
#15
Yu Jiang, Sheng-Hui Wu, Xiao-Ou Shu, Yong-Bing Xiang, Bu-Tian Ji, Ginger L Milne, Qiuyin Cai, Xianglan Zhang, Yu-Tang Gao, Wei Zheng, Gong Yang
BACKGROUND: Higher intakes of cruciferous vegetables or their constituents have been shown to lower inflammation in animal studies. However, evidence for this anti-inflammatory effect of cruciferous vegetable consumption in humans is scarce. OBJECTIVE/DESIGN: In this cross-sectional analysis, we evaluated associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women. Dietary intake of foods was assessed by a food frequency questionnaire...
May 2014: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/24494070/anti-aging-effects-of-some-selected-iranian-folk-medicinal-herbs-biochemical-evidences
#16
Azadeh Mohammadirad, Fatemeh Aghamohammadali-Sarraf, Simin Badiei, Zakie Faraji, Reza Hajiaghaee, Maryam Baeeri, Mahdi Gholami, Mohammad Abdollahi
OBJECTIVE(S): In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS: Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/kg/day for 6 weeks). A positive control group was assigned that received vitamin E (200 mg/kg/day). The extract of herbs was prepared, lyophilized, and used in this study...
November 2013: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/24386599/suppression-of-in-vitro-murine-t-cell-proliferation-by-human-adipose-tissue-derived-mesenchymal-stem-cells-is-dependent-mainly-on-cyclooxygenase-2-expression
#17
Jin-Hee Kim, Yong-Taek Lee, Jun Man Hong, Young-Il Hwang
Mesenchymal stem cells (MSCs) of human origin have been frequently applied to experimental animal models to evaluate their immunomodulatory functions. MSCs are known to be activated by cytokines from T cells, predominantly by interferon-γ (IFN-γ), in conjunction with other cytokines such as tumor necrosis factor-α (TNF-α) and interlukin-1β. Because IFN-γ is not cross-reactive between human and mouse species, the manner in which human MSCs administered in experimental animals are activated and stimulated to function has been questioned...
December 2013: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/24363660/dna-methyltransferases-and-tets-in-the-regulation-of-differentiation-and-invasiveness-of-extra-villous-trophoblasts
#18
REVIEW
Philip C Logan, Murray D Mitchell, Peter E Lobie
Specialized cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation or invasion potentially affects the future health of the child and adult. Recently, the field of epigenetics has been applied to understand differentiation of trophoblast lineages and embryonic stem cells (ESC), from fertilization of the oocyte onward. Each trophoblast cell-type has a distinctive epigenetic profile and we will concentrate on the epigenetic mechanism of DNA methyltransferases and TETs that regulate DNA methylation...
2013: Frontiers in Genetics
https://www.readbyqxmd.com/read/24121215/propofol-limits-microglial-activation-after-experimental-brain-trauma-through-inhibition-of-nicotinamide-adenine-dinucleotide-phosphate-oxidase
#19
Tao Luo, Junfang Wu, Shruti V Kabadi, Boris Sabirzhanov, Kelsey Guanciale, Marie Hanscom, Juliane Faden, Katherine Cardiff, Charles Jeremy Bengson, Alan I Faden
BACKGROUND: Microglial activation is implicated in delayed tissue damage after traumatic brain injury (TBI). Activation of microglia causes up-regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, with the release of reactive oxygen species and cytotoxicity. Propofol appears to have antiinflammatory actions. The authors evaluated the neuroprotective effects of propofol after TBI and examined in vivo and in vitro whether such actions reflected modulation of NADPH oxidase...
December 2013: Anesthesiology
https://www.readbyqxmd.com/read/23828697/-hsv-1-based-vector-mediated-il-1r%C3%AE-gene-for-knee-osteoarthritis-in-rabbits
#20
Yi Wu, Jianming Li, Ying Kong, Ding Chen, Bo Liu, Wanchun Wang
OBJECTIVE: To investigate the effect and mechanism of herpes simplex virus type 1 (HSV-1) based vector mediated interlukin-1 receptor antagonist (IL-1Rα) gene for knee osteoarthritis in rabbits. METHODS: HSV-1 vectors containing IL-1Rα genes were constructed and injected into the joint space of the osteoarthritis knee in rabbits for 4 weeks. The rabbits were sacrificed, and the knees were lavaged, dissected and the effect of transgene expression was analyzed. Levels of IL-1Rα and IL-1 expression in the recovered lavage fluids were measured with a cytokine ELISA kit...
June 2013: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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