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Liver trauma

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https://www.readbyqxmd.com/read/29908646/an-unusual-case-of-suicide-by-methanol-ingestion
#1
Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi, Shin-Ichi Kubo
A female in her late teens purposely ingested alcohol fuel containing methanol to commit suicide, which she admitted on social media. She was found in distress by her parents and died at the hospital some hours later. Autopsy revealed swelling of the brain and edematous and congestive lungs. No other trauma or unusual findings were revealed at autopsy. Methanol was detected upon routine screening for alcohols by headspace gas chromatography with flame-ionization detection. To confirm the presence of methanol and its metabolite formic acid, a method with detection by mass spectrometry was used...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29907210/nonoperative-management-of-penetrating-abdominal-solid-organ-injuries-in-children
#2
Reid Sakamoto, Kazuhide Matsushima, Amory de Roulet, Kristine Beetham, Aaron Strumwasser, Damon Clark, Kenji Inaba, Demetrios Demetriades
BACKGROUND: Nonoperative management (NOM) of penetrating solid organ injuries (SOI) has not been well described in the pediatric population. The objective of this study was to characterize the epidemiology, injury patterns, and factors associated with trial and failure of NOM. METHODS: This is a retrospective cohort analysis of the National Trauma Data Bank for the period of 2007-2014. The study population included patients ≤18 y with penetrating injury to the liver, spleen, or kidney...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29882101/preliminary-report-of-percutaneous-cholecystostomy-as-diagnosis-and-treatment-of-biliary-tract-trauma
#3
Jean-Baptiste Cazauran, Arnaud Muller, Baptiste Hengy, Pierre-Jean Valette, Laurent Gruner, Olivier Monneuse
BACKGROUND: Biliary leak following severe blunt liver injuries is a complex problem becoming more frequent with improvements in non-operative management. Standard treatment requires main bile duct drainage usually performed by endoscopic sphincterotomy and stent placement. We report our experience with cholecystostomy as a first minimally invasive diagnostic and therapeutic approach. METHODS: We performed a retrospective analysis of consecutive patients with post-traumatic biliary leak between 2006 and 2015...
June 7, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29879513/a-case-report-of-idiopathic-spinal-subdural-hematoma-and-literature-review
#4
Yongli Wang, Hua Zheng, Yafeng Ji, Qian Lu, Xiongfeng Li, Xue-Sheng Jiang
STUDY DESIGN: This article reported a case of idiopathic spinal subdural hematoma (SDH) and made a review of this disease. OBJECTIVE: To make a review of idiopathic spinal subdural hematoma. SUMMARY OF BACKGROUND DATA: To the best of our knowledge, there are 20 cases idiopathic SDH only 1 case which reported the idiopathic SDH located in cervical region. METHODS: A 43-year-old man had a sudden onset of needle-like and continuous neck pain for 3 days with paresthesias and paraplegia...
June 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29852169/txnip-knockdown-alleviates-hepatocyte-ischemia-reperfusion-injury-through-preventing-p38-jnk-pathway-activation
#5
Yong Zhang, Liang-Sheng Miao, Ying-Min Cai, Jia-Xuan He, Zhen-Ni Zhang, Gang Wu, Juan Zheng
Hepatic ischemia and reperfusion (I/R) injury is a major cause of liver damage during liver transplantation, resection surgery, shock, and trauma. It has been reported that TXNIP expression was upregulated in a rat model of hepatic I/R injury. However, the role of TXNIP in the hepatic I/R injury is little known. In our study, we investigated the biological role of TXNIP and its potential molecular mechanism in the human hepatic cell line (HL7702 cells). Using oxygen-glucose deprivation and reoxygenation (OGD/R) to create a cell model of hepatic I/R injury, we found that the mRNA and protein expression levels of TXNIP were upregulated in HL7702 cells exposed to OGD/R...
May 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29851904/high-dose-fxiii-administration-induces-effective-hemostasis-for-trauma-associated-coagulopathy-tac-both-in-vitro-and-in-rat-hemorrhagic-shock-in-vivo-models
#6
Futoshi Nagashima, Satoshi Inoue, Hiroyuki Koami, Toru Miike, Yuichiro Sakamoto, Keita Kai
BACKGROUND: Trauma associated coagulopathy (TAC) is an early and primary complication in severe trauma patients. FXIII is reported to stabilize a clot in the late phase of the coagulation cascade. The goal of this study was to investigate whether the administration of FXIII improves the condition of TAC both in vitro and in vivo. METHODS: We evaluated the effects of different doses, including a very high dose of FXIII (3.6- 32.4 IU/ml) on tissue-plasminogen activator (t-PA) induced hyperfibrinolysis and the combined condition of dilutional coagulopathy and t-PA induced hyperfibrinolysis in vitro...
May 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29849508/the-impact-of-septic-stimuli-on-the-systemic-inflammatory-response-and-physiologic-insult-in-a-preclinical-non-human-primate-model-of-polytraumatic-injury
#7
Diego A Vicente, Matthew J Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A Elster, Thomas A Davis
Background: Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant non-human primate (NHP) trauma models. Methods: Mauritian Cynomolgus Macaques underwent either a laparoscopic closed abdomen liver injury (laparoscopic 60% left-lobe hepatectomy) in an established uncontrolled severe hemorrhage model (THM), or a polytrauma hemorrhage model (PHM) involving combined liver and bowel injury, uncontrolled severe hemorrhage as well as an open full-thickness cutaneous flank wound...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29848342/spontaneous-omental-bleeding-a-case-report-and-literature-review
#8
Yun-Xiao Lyu, Yun-Xiao Cheng, Ting Li
BACKGROUND: Spontaneous rupture of omental vessels is an infrequent medical condition possibly causing severe intra-abdominal hemorrhage. Omental bleeding results from trauma associated injury and irritation, neoplasia, arterial aneurysm rupture, and anticoagulant treatment. Idiopathic omental bleeding rarely causes acute abdominal bleeding which has been reported to occur in previous studies. Here we reported a case with idiopathic omental hemorrhage due to vascular malformation. A systematic review of literature is provided...
May 30, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29847540/patients-at-high-risk-of-intervention-for-pediatric-traumatic-liver-injury
#9
Katie A Donnelly, Kristen Breslin, Karen J OʼConnell
OBJECTIVES: Nonoperative management of hemodynamically stable liver lacerations in pediatric trauma patients is a safe and effective management strategy for pediatric patients; approximately 90% will be successfully managed nonoperatively. No study has specifically identified risk criteria for the need for intervention versus observation alone. Our objective for this study was to determine risk factors from the physical examination, computed tomography scan, and laboratory results associated with intervention for liver laceration...
May 25, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29806813/management-of-intra-abdominal-vascular-injury-in-trauma-laparotomy-a-south-african-experience
#10
Ross Weale, Victor Kong, Vassil Manchev, Wanda Bekker, George Oosthuizen, Petra Brysiewicz, Grant Laing, John Bruce, Damian Clarke
BACKGROUND: Intra-abdominal vascular injury (IAVI) is uncommon but continues to be associated with high mortality rates despite technological advances in the past decades. In light of these ongoing developments, we reviewed our contemporary experience with IAVI in an attempt to clarify and refine our management strategies and the outcome of these patients. METHODS: We retrospectively reviewed the charts of all patients admitted between January 2011 and December 2014 at a major trauma centre in South Africa who were found to have an IAVI during laparotomy for trauma...
June 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29769109/valproate-induced-hyperammonemia-uncovering-an-underlying-inherited-metabolic-disorder-a-case-report
#11
Shaine Mehta, Sarrah Tayabali, Robin Lachmann
BACKGROUND: Sodium valproate is a commonly used anticonvulsant. It is widely recognized that valproate can cause hyperammonemia, particularly in people with underlying liver disease. Patients with urea cycle disorders are genetically predisposed to this adverse event and can develop severe hyperammonemia if given valproate. This can occur even if liver functions tests and plasma concentration of valproate are normal, highlighting the importance of checking ammonia levels in any patient presenting with encephalopathy...
May 17, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29769030/in-silico-simulation-of-liver-crack-detection-using-ultrasonic-shear-wave-imaging
#12
Erwei Nie, Jiao Yu, Debaditya Dutta, Yanying Zhu
BACKGROUND: Liver trauma is an important source of morbidity and mortality worldwide. A timely detection and precise evaluation of traumatic liver injury and the bleeding site is necessary. There is a need to develop better imaging modalities of hepatic injuries to increase the sensitivity of ultrasonic imaging techniques for sites of hemorrhage caused by cracks. In this study, we conduct an in silico simulation of liver crack detection and delineation using an ultrasonic shear wave imaging (USWI) based method...
May 16, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29765226/whole-body-computed-tomography-in-trauma-patients-optimization-of-the-patient-scanning-position-significantly-shortens-examination-time-while-maintaining-diagnostic-image-quality
#13
Tilman Hickethier, Kamal Mammadov, Bettina Baeßler, Thorsten Lichtenstein, Jochen Hinkelbein, Lucy Smith, Patrick Sven Plum, Seung-Hun Chon, David Maintz, De-Hua Chang
Background: The study was conducted to compare examination time and artifact vulnerability of whole-body computed tomographies (wbCTs) for trauma patients using conventional or optimized patient positioning. Patients and methods: Examination time was measured in 100 patients scanned with conventional protocol (Group A: arms positioned alongside the body for head and neck imaging and over the head for trunk imaging) and 100 patients scanned with optimized protocol (Group B: arms flexed on a chest pillow without repositioning)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29763851/pancreaticoduodenal-arcades-as-salvage-route-for-transarterial-embolization-of-life-threatening-hepatic-hemorrhage-in-patients-with-severe-celiac-axis-stenosis-case-series
#14
Ali Barah, Ahmed Omar, Ayman El-Menyar, Omran Almokdad, Ahmed Sayedin, Ala Alsherbini, Ahmed Almuzrakshi, Hatem Khalaf, Hassan Al-Thani
INTRODUCTION: Various transarterial embolotherapies for different hepatic etiologies are performed through the celiac axis (CA). However, this pathway is not always patent due to the extensive stenosis or occlusion of the origin of CA. In such situations, the pancreaticoduodenal arcades (PDAs) catheterization is the main alternative to gain access to the hepatic arteries as demonstrated in clinical studies. PRESENTATION OF CASE: We report two cases of life-threating hepatic hemorrhage indicated for emergency transarterial embolization (TAE)...
April 11, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29758989/the-double-hazard-of-bleeding-and-thrombosis-in-hemostasis-from-a-clinical-point-of-view-a-global-assessment-by-rotational-thromboelastometry-rotem
#15
Olga Meltem Akay
Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29758975/design-of-liver-functional-reserve-monitor-based-on-three-wavelength-from-ir-to-nir
#16
Fuli Ye, Huimiao Zhan, Guilian Shi
BACKGROUND: The preoperative evaluation of liver functional reserve is very important to determine the excision of liver lobe for the patients with liver cancer. There already exist many effective evaluation methods, but these ones have many disadvantages such as large trauma, complicated process and so on. OBJECTIVE: Therefore, it is essential to develop a fast, accurate and simple detection method of liver functional reserve for the practical application in the clinical engineering field...
May 4, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29755574/branched-chain-amino-acids-in-health-and-disease-metabolism-alterations-in-blood-plasma-and-as-supplements
#17
REVIEW
Milan Holeček
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a number of muscle wasting disorders for more than 50 years. However, until today, there is no consensus regarding their therapeutic effectiveness. In the article is demonstrated that the crucial roles in BCAA metabolism play: (i) skeletal muscle as the initial site of BCAA catabolism accompanied with the release of alanine and glutamine to the blood; (ii) activity of branched-chain keto acid dehydrogenase (BCKD); and (iii) amination of branched-chain keto acids (BCKAs) to BCAAs...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29740988/suppression-of-the-interleukin-1%C3%A3-induced-inflammatory-response-of-human-chang-liver-cells-by-acute-and-subacute-exposure-to-alcohol-an-in-vitro-study
#18
Katharina Mörs, Shinwan Kany, Jason-Alexander Hörauf, Nils Wagner, Claudia Neunaber, Mario Perl, Ingo Marzi, Borna Relja
AIM: To evaluate protective immunosuppressive dose and time-dependent effects of ethanol in an in vitro model of acute inflammation in human Chang liver cells. METHOD: The study was performed in 2016 and 2017 in the research laboratory of the Department of Trauma, Hand and Reconstructive Surgery, the University Hospital of the Goethe-University Frankfurt. Chang liver cells were stimulated with either interleukin (IL)-1β or IL-6 and subsequently treated with low-dose ethanol (85 mmol/L) or high-dose ethanol (170 mmol/L) for one hour (acute exposure) or 72 hours (subacute exposure)...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29731163/predictors-of-organ-donation-among-patients-with-brain-death-in-the-intensive-care-unit
#19
M T Nakamura, G E Rodio, C Tchaicka, E F Padilha, A C Jorge, P A D Duarte
INTRODUCTION: Despite the improved care of potential organ donors with probable brain death (BD) in the intensive care unit (ICU), few epidemiologic and clinical data are available in developing countries. OBJECTIVES: To evaluate ICU patients with suspected BD aiming to identify factors possibly related to success (organ donation) or failure (nondonation). METHODS: Retrospective cohort study, from the patient records of an adult ICU of a Brazilian teaching hospital for 12 months...
March 9, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29710288/the-drug-overdose-epidemic-and-deceased-donor-transplantation-in-the-united-states-a-national-registry-study
#20
Christine M Durand, Mary G Bowring, Alvin G Thomas, Lauren M Kucirka, Allan B Massie, Andrew Cameron, Niraj M Desai, Mark Sulkowski, Dorry L Segev
Background: The epidemic of drug overdose deaths in the United States has led to an increase in organ donors. Objective: To characterize donors who died of overdose and to analyze outcomes among transplant recipients. Design: Prospective observational cohort study. Setting: Scientific Registry of Transplant Recipients, 1 January 2000 to 1 September 2017. Participants: 138 565 deceased donors; 337 934 transplant recipients at 297 transplant centers...
April 17, 2018: Annals of Internal Medicine
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