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https://www.readbyqxmd.com/read/28724173/a-comparative-study-between-myo-inositol-and-metformin-in-the-treatment-of-insulin-resistant-women
#1
K Nas, L Tűű
OBJECTIVE: Insulin resistance (IR) is a common disorder, which can impair female fertility and is characterized by phenotypic heterogeneity. Life-style treatment and insulin sensitizers are commonly used in the management of women with IR and consequent hyperinsulinemia, in order to restore the normal endocrinological and clinical parameters. Metformin (MET) is considered one of the first approaches to this pathology but new evidences are showing promising results using myo-inositol (MYO) in the management of this pathology...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28722040/a-new-set-of-cd-ii-coordination-polymers-with-mixed-ligands-of-dicarboxylate-and-pyridyl-substituted-diaminotriazine-selective-sorption-towards-co2-and-cationic-dyes
#2
Santanu Chand, Syed Meheboob Elahi, Arun Pal, Madhab C Das
On the basis of a mixed ligand system of L(NH2)2 (6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine) and dicarboxylic acids, three new Cd(ii) coordination polymers viz. {[Cd0.5(tdc)0.5(L(NH2)2)0.5(H2O)]·DMF·H2O}n (1), {[Cd0.5(bdc)0.5(L(NH2)2)(H2O)]·DMF·H2O}n (2), and {[Cd(ipa)(L(NH2)2)(DMF)]·H2O}n (3) (tdcH2 = thiophene-2,5-dicarboxylic acid, bdcH2 = benzene-1,4-dicarboxylic acid, ipaH2 = benzene-1,3-dicarboxylic acid) were synthesized under diverse reaction conditions and characterized by single crystal X-ray diffraction, PXRD, elemental analysis, IR spectroscopy and TGA...
July 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28720547/novel-water-soluble-morpholine-substituted-zn-ii-phthalocyanine-synthesis-characterization-dna-bsa-binding-dna-photocleavage-and-topoisomerase-i-inhibition
#3
Burak Barut, Ümit Demirbaş, Arzu Özel, Halit Kantekin
In this study, novel peripherally tetra 3-morpholinophenol substituted zinc(II) phthalocyanine (4) and its water soluble form quaternized zinc(II) phthalocyanine (ZnQ) were synthesized for the first time. These novel compounds were characterized by a combination of different spectroscopic techniques such as FT-IR, (1)H NMR, (13)C NMR, UV-Vis and mass. The DNA binding of ZnQ was investigated using UV-vis absorption titration, competitive ethidium bromide, thermal denaturation and viscosity experiments that the ZnQ bound to CT-DNA via intercalation mode...
July 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28718838/phyllanthus-niruri-standardized-extract-alleviates-the-progression-of-non-alcoholic-fatty-liver-disease-and-decreases-atherosclerotic-risk-in-sprague-dawley-rats
#4
Raghdaa Hamdan Al Zarzour, Mariam Ahmad, Mohd Zaini Asmawi, Gurjeet Kaur, Mohammed Ali Ahmed Saeed, Majed Ahmed Al-Mansoub, Sultan Ayesh Mohammed Saghir, Nasiba Salisu Usman, Dhamraa W Al-Dulaimi, Mun Fei Yam
Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different extracts of Phyllanthus niruri (P. niruri). NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28718725/ellagic-acid-enhances-apoptotic-sensitivity-of-breast-cancer-cells-to-%C3%AE-radiation
#5
Vidhula Ahire, Amit Kumar, Kaushala Prasad Mishra, Gauri Kulkarni
Herbal polyphenols have gained increased significance because of the promises they hold in the prevention and treatment of cancer. There exists an enormous opportunity for the screening and valuation of natural dietary compounds in the development of an effective chemopreventive drug and radiosensitizer that may be of practical use for patients undergoing cancer therapy. This study describes the effect of the flavonoid ellagic acid (EA) on gamma-irradiated human breast cancer MCF-7 cells in vitro when administered alone or in combination with radiation...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28717975/development-of-a-novel-polymeric-nanocomposite-complex-for-drugs-with-low-bioavailability
#6
Mduduzi N Sithole, Yahya E Choonara, Lisa C du Toit, Pradeep Kumar, Thashree Marimuthu, Pierre P D Kondiah, Viness Pillay
Semi-synthetic biopolymer complex (SSBC) nanoparticles were investigated as a potential oral drug delivery system to enhance the bioavailability of a poorly water-soluble model drug acyclovir (ACV). The SSBCs were prepared from cross-linking of hydroxyl groups on hyaluronic acid (HA) with poly(acrylic acid) (PAA) resulting in ether linkages. Thereafter, conjugation of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) onto HA-PAA was accomplished using a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS)-promoted coupling reaction...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28717974/improvement-of-oral-bioavailability-of-lopinavir-without-co-administration-of-ritonavir-using-microspheres-of-thiolated-xyloglucan
#7
Ashwini R Madgulkar, Mangesh R Bhalekar, Ashwini A Kadam
Lopinavir is a BCS Class IV drug exhibiting poor bioavailability due to P-gp efflux and limited permeation. The aim of this research was to formulate and characterize microspheres of lopinavir using thiolated xyloglucan (TH-MPs) as carrier to improve its oral bioavailability without co-administration of ritonavir. Thiomeric microspheres were prepared by ionotropic gelation between alginic acid and calcium ions. Interaction studies were performed using Fourier transform infrared spectroscopy (FT-IR). The thiomeric microspheres were characterized for its entrapment efficiency, T80, surface morphology, and mucoadhesion employing in vitro wash off test...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28715860/hemoglobin-bioconjugates-with-surface-protected-gold-nanoparticles-in-aqueous-media-the-stability-depends-on-solution-ph-and-protein-properties
#8
Rafael Del Caño, Lucia Mateus, Guadalupe Sánchez-Obrero, José Manuel Sevilla, Rafael Madueño, Manuel Blázquez, Teresa Pineda
The identification of the factors that dictate the formation and physicochemical properties of protein-nanomaterial bioconjugates are important to understand their behavior in biological systems. The present work deals with the formation and characterization of bioconjugates made of the protein hemoglobin (Hb) and gold nanoparticles (AuNP) capped with three different molecular layers (citrate anions (c), 6-mercaptopurine (MP) and ω-mercaptoundecanoic acid (MUA)). The main focus is on the behavior of the bioconjugates in aqueous buffered solutions in a wide pH range...
July 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28715691/a-quinoline-based-fluorometric-and-colorimetric-dual-modal-ph-probe-and-its-application-in-bioimaging
#9
Qin Zhu, Zhao Li, Lan Mu, Xi Zeng, Carl Redshaw, Gang Wei
The compound (E)-8-hydroxyl-2-[(E)-2-(2, 4-dihydroxyphenyl)vinyl]-quinoline (1) has been developed as a fluorometric and colorimetric dual-modal probe for pH detection in solution and in vivo. Remarkable changes in the fluorescence intensity with large Stokes shifts and colorimetric responses were observed as a function of pH. The sensing mechanisms involving protonation and deprotonation processes over the acidic and alkaline pH ranges were confirmed by (1)H NMR and IR spectroscopic analysis. Furthermore, the application of probe 1 for the imaging of live PC3 cells was successfully achieved...
July 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28715034/surface-chemistry-and-stability-of-metastable-corundum-type-in2o3
#10
Eva-Maria Köck, Michaela Kogler, Chen Zhuo, Lukas Schlicker, Maged F Bekheet, Andrew Doran, Aleksander Gurlo, Simon Penner
To account for the explanation of an eventual sensing and catalytic behavior of rhombohedral In2O3 (rh-In2O3) and the dependence of the metastability of the latter on gas atmospheres, in situ electrochemical impedance spectroscopic (EIS), Fourier-transform infrared spectroscopic (FT-IR), in situ X-ray diffraction and in situ thermogravimetric analyses in inert (helium) and reactive gases (hydrogen, carbon monoxide and carbon dioxide) have been conducted to link the gas-dependent electrical conductivity features and the surface chemical properties to its metastability towards cubic In2O3...
July 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28715030/a-chiral-binol-based-gemini-amphiphilic-gelator-and-its-specific-discrimination-of-native-arginine-by-gelation-in-water
#11
Lihua Jia, Jianxin Yin, Xiangfeng Guo, Guangzhou Cao, Xuhua Tian, Bo Zhu, Lin Pu
A novel axially chiral cationic Gemini amphiphile gelator (S1) derived from (S)-BINOL has been synthesized and characterized by (1)H NMR, (13)C NMR, ESI-MS and FT-IR analyses. The critical micelle concentration (CMC) of S1 was determined to be 0.21 mM in water at room temperature. A transparent hydrogel with S1 at 43 mM was obtained at room temperature and characterized using various methods including SEM, CD, fluorescence, (1)H NMR, FT-IR, and XRD. The results indicate that the hydrophobic effect of long alkyl chains, π-π stacking of naphthalene rings, and intermolecular hydrogen-bonding of the amide groups of S1 should be responsible for the hydrogel formation...
July 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/28715007/the-covalently-bound-diazo-group-as-an-infrared-probe-for-hydrogen-bonding-environments
#12
Min You, Liyuan Liu, Wenkai Zhang
Covalently bound diazo groups are frequently found in biomolecular substrates. The C[double bond, length as m-dash]N[double bond, length as m-dash]N asymmetric stretching vibration (νas) of the diazo group has a large extinction coefficient and appears in an uncongested spectral region. To evaluate the solvatochromism of the C[double bond, length as m-dash]N[double bond, length as m-dash]N νas band for studying biomolecules, we recorded the infrared (IR) spectra of a diazo model compound, 2-diazo-3-oxo-butyric acid ethyl ester, in different solvents...
July 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28714669/interconnected-hierarchical-zsm-5-with-tunable-acidity-prepared-by-a-dealumination-realumination-process-a-superior-mtp-catalyst
#13
Junjie Li, Min Liu, Xinwen Guo, Shutao Xu, Yingxu Wei, Zhongmin Liu, Chunshan Song
ZSM-5 that uses TPAOH as a template has an Al-rich exterior and defective Si-rich interior, thus it decouples the alkaline treatment difficulties of Al-rich and Si-rich crystals. Alkaline treatment selectively removed the Si-rich interior while the Al-rich exterior was protected, this catalyst showed no change in stability comparing with parent ZSM-5 during the MTP reaction that attributed to enclosed hollow structure and acidity-rich exterior. Pre-treatment by NH4F, however, both removed defective Si-sites and caused distortion in tetrahedral aluminum that made the outer shell susceptible to alkaline treatment...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714501/understanding-the-role-of-tyrosine-in-glycogenin
#14
Ander Camiruaga, Imanol Usabiaga, Aran Insausti, Emilio J Cocinero, Iker León, José A Fernández
We explored the molecular basis of tyrosine as the docking amino acid for the first glucose molecule during the synthesis of glycogen. The IR spectra show that the aromatic ring acts as bait to keep the position where the next glucose unit has to bind clear, by luring non-desirable molecules towards the aromatic ring. Only, α-/β-glucose shows particular affinity for the O3H and O4H moieties.
July 17, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28714233/bioinspired-size-tunable-self-assembly-of-polymer-lipid-bilayer-nanodiscs
#15
Thirupathi Ravula, Sudheer Ramadugu, Giacomo Di Mauro, Ayyalusamy Ramamoorthy
Polymer-based nanodiscs are valuable tools in biomedical research that can offer a detergent-free solubilization of membrane proteins maintaining their native lipid environment. Here, we introduce a novel ~1.6 kDa SMA-based polymer with styrene:maleic acid moieties that can form nanodiscs containing a planar lipid bilayer which are useful to reconstitute membrane proteins for structural and functional studies. The physicochemical properties and the mechanism of formation of polymer-based nanodiscs are characterized by light scattering, NMR, FT-IR, and TEM imaging experiments...
July 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28714228/polyladderane-constructed-from-gemini-monomer-via-photoreaction
#16
Zhihan Wang, Benjamin Miller, Jonathan Butz, Katelyn Randazzo, Zijun D Wang, Qianli Rick Chu
Polyladderane, the first polymer to contain the ladderane functional group, was successfully synthesized from gemini monomer through photoreaction in the solid state. The modular design of the gemini monomers used to create polyladderane allowed specific structural modification, resulting in the formation of two distinct polymer products. Monomers were synthesized by connecting two photoreactive units, either sorbic acids (monomer I) or 2-furanacrylic acids (monomer II), with a 1,4-butanediol linker. Single crystal X-ray diffraction analysis of the monomers confirmed that they packed in the desired head-to-tail orientation and within a viable distance for photoreaction by electronically-complementary interaction...
July 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28711781/the-nature-of-hydrogen-bonding-interactions-in-nonsteroidal-anti-inflammatory-drugs-revealed-by-polarized-ir-spectroscopy
#17
Barbara Hachuła
The influence of hydrogen-bonding interactions in the solid phase on the IR spectroscopic pattern of the νOH band of nonsteroidal anti-inflammatory drugs (NSAIDs) was studied experimentally by IR spectroscopy with the use of polarized light at two temperatures (293K and 77K) and in isotopic dilution. The neat and deuterated crystals of (S)-naproxen ((S)-NPX), (R)-flurbiprofen ((R)-FBP), (RS)-flurbiprofen ((RS)-FBP) and (RS)-ketoprofen ((RS)-KTP) were obtained by melt crystallization between the two squeezed CaF2 plates...
July 9, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28711706/haemolytic-activity-of-formyl-and-acetyl-derivatives-of-bile-acids-and-their-gramine-salts
#18
Weronika Kozanecka-Okupnik, Beata Jasiewicz, Tomasz Pospieszny, Monika Matuszak, Lucyna Mrówczyńska
Bile acids (lithocholic: LCA, deoxycholic: DCA and cholic: CA) and their formyl- and acetyl- derivatives can be used as starting material in chemical synthesis of compounds with different biological activity strongly depended on their chemical structures. Our previous studies showed that biological activity of bile acids salts with gramine toward human erythrocytes was significantly different from the activity of bile acids alone. Moreover, gramine effectively modified the membrane perturbing activity of other steroids...
July 12, 2017: Steroids
https://www.readbyqxmd.com/read/28710952/indices-of-insulin-resistance-and-glucotoxicity-are-not-associated-with-bipolar-disorder-or-major-depressive-disorder-but-are-differently-associated-with-inflammatory-oxidative-and-nitrosative-biomarkers
#19
Kamila Landucci Bonifácio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Coneglian de Farias, Luciana Higachi, Alissana Ester Iakmiu Camargo, Janaina Favaro Soares, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd, Michael Maes
BACKGROUND: Insulin resistance (IR) is a key factor in diabetes mellitus, metabolic syndrome (MetS) and obesity and may occur in mood disorders and tobacco use disorder (TUD), where disturbances of immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways are important shared pathophysiological pathways. METHODS: This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO&NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28710289/nutritional-modulation-of-metabolic-inflammation
#20
REVIEW
Anna M Kirwan, Yvonne M Lenighan, Marcella E O'Reilly, Fiona C McGillicuddy, Helen M Roche
Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes. Metabolic insults arising from obesity promote inflammation, which in turn impedes insulin signalling and reverse cholesterol transport (RCT). Key cells in the process are metabolically activated macrophages, which up-regulate both pro- and anti-inflammatory pathways in response to lipid spillover from adipocytes...
July 14, 2017: Biochemical Society Transactions
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