keyword
MENU ▼
Read by QxMD icon Read
search

IR acid

keyword
https://www.readbyqxmd.com/read/29667690/metal-organic-frameworks-as-affinity-agents-to-enhance-the-microdialysis-sampling-efficiency-of-fatty-acids
#1
Hui Yang, Tuo Li, Lu Liu, Na Li, Ming Guan, Yangyang Zhang, Zhenpeng Wang, Zhenwen Zhao
Microdialysis (MD) has been extensively used for in vivo sampling of hydrophilic analytes such as neurotransmitters and drug metabolites. In contrast, there have been few reports on sampling of lipophilic analytes by MD. Lipophilic analytes are easily adsorbed on the surfaces of the dialysis membrane and the inner wall of tubing, which leads to a very low relative recovery (RR). In this work, a strategy to develop an enhanced MD sampling of fatty acids (FAs) by using metal-organic frameworks (MOFs) as affinity agents in the perfusion fluid was investigated...
April 18, 2018: Analyst
https://www.readbyqxmd.com/read/29667407/the-enhanced-stability-of-pt-ml-m-ml-wc-0001-multilayer-alloys-under-electrochemical-conditions-a-first-principle-study
#2
Xiaoming Zhang, Tianwei Gu, Shaodong Shi, Leyi Li, Shansheng Yu
Pt monolayer catalyst could greatly reduce the use of platinum. However, the core or subsurface transition metal could easily segregate to the surface and eventually selectively dissolve in the working conditions. In this work, a type of PtML /MML /WC multi-layer structure catalyst has been designed using DFT method. The results show that the stability of W-terminated core catalysts is lower than that of the corresponding C-terminated one. More importantly, C-terminated PtML/CoML/WC alloy could also maintain a stable platinum monolayer structure in various electrolyte solutions (eg, perchloric acid, phosphoric acid, alkaline solutions) and via different ORR pathways, in addition to the previously well-known precious alloy elements, such as Ru, Ir, etc...
April 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29666790/efficient-mechanochemical-bifunctional-nanocatalysts-for-the-conversion-of-isoeugenol-to-vanillin
#3
Somayeh Ostovar, Ana Franco, Alain R Puente-Santiago, María Pinilla-de Dios, Daily Rodríguez-Padrón, Hamid R Shaterian, Rafael Luque
A bifunctional nanocatalyst composed of iron containing SBA-15 material modified with sulfonic acid groups was synthesized by a mechanochemical approach. A full characterization of the obtained nanocatalyst was performed by N2 physisorption isotherms analysis, transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and Fourier-Infrared Spectroscopy (FT-IR). The mechanochemically synthesized nanocatalyst displays a high isoeugenol conversion to vanillin under mild conditions using H2 O2 as oxidizing agent...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29665358/hyperinsulinemic-euglycemic-clamp-over-the-first-year-of-use-of-depot-medroxyprogesterone-acetate-as-a-contraceptive
#4
Vaneska Melhado-Kimura, Gisele Almeida Batista, Aglécio Luiz de Souza, Priscilla de Nazaré Silva Dos Santos, Sarah Monte Alegre, Elizabeth João Pavin, Luis Bahamondes, Arlete Fernandes
OBJECTIVE: The literature lacks data on the use of the gold-standard hyperinsulinemic-euglycemic clamp (HEC) technique for the evaluation of insulin resistance (IR) in depot-medroxyprogesterone acetate (DMPA) users. This study assessed carbohydrate metabolism in non-obese users of DMPA using the HEC technique. STUDY DESIGN: A prospective, non-randomized, comparative study conducted at the Family Planning Clinic/Metabolic Unit, University of Campinas, Brazil. Forty-eight women aged 18-39 years underwent HEC: 30 initiating use of DMPA and 18 initiating use of a copper intrauterine device (IUD)...
April 14, 2018: Contraception
https://www.readbyqxmd.com/read/29663877/synthesis-of-3-cyclohexylamino-2-arylimidazo-1-2-a-pyridine-8-carboxylic-acids-via-an-efficient-three-component-condensation-reaction-between-cyclohexylisocyanide-and-2-aminopyridine-3-carboxylic-acid-in-the-presence-of-aromatic-aldehyde
#5
Ghasem Marandi
AIM AND OBJECTIVE: Reaction of cyclohexylisocyanide and 2-aminopyridine-3-carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. MATERIAL AND METHODS: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis...
April 16, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29663870/identification-of-some-novel-pyrazolo-1-5-a-pyrimidine-derivatives-as-inha-inhibitors-through-pharmacophore-based-virtual-screening-and-molecular-docking
#6
Palmi Modi, Shivani Patel, Mahesh T Chhabria
The InhA inhibitors play key role in mycolic acid synthesis by preventing the fatty acid biosynthesis pathway. In this present article Pharmacophore modelling and molecular docking study followed by in silico virtual screening could be considered as effective strategy to identify newer enoyl-ACP reductase inhibitors. Pyrrolidine carboxamide derivatives were opted to generate pharmacophore models using HypoGen algorithm in Discovery studio 2.1. Further it was employed to screen Zinc and Minimaybridge databases to identify and design newer potent hit molecules...
April 17, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29662989/group-3-metal-trihalide-complexes-with-neutral-n-donor-ligands-exploring-their-affinity-towards-fluoride
#7
Emily Curnock, William Levason, Mark E Light, Sajinder K Luthra, Graeme McRobbie, Francesco M Monzittu, Gillian Reid, R Nathan Williams
Fluorination of [ScCl3(Me3-tacn)] (Me3-tacn = 1,4,7-trimethyl-1,4,7-triazacyclononane) and [ScCl3(BnMe2-tacn)] (BnMe2-tacn = 1,4-dimethyl-7-benzyl-1,4,7-triazacyclononane) by Cl/F exchange with 3 mol. equiv. of anhydrous [NMe4]F in CH3CN solution yields the corresponding [ScF3(R3-tacn)] (R3 = Me3 or BnMe2). These are the first examples of scandium fluoride complexes containing neutral co-ligands. The fluorination occurs stepwise, and using a deficit of [NMe4]F produced [ScF2Cl(Me3-tacn)]. Attempts to fluorinate [YCl3(Me3-tacn)], [YI3(Me3-tacn)], [LaCl3(Me3-tacn)(OH2)] or [MCl3(terpy)] (M = Sc, Y or La; terpy = 2,2':6'2''-terpyridyl) using a similar method were unsuccessful, due to the Cl/F exchange being accompanied by loss of the neutral ligand from the metal centre...
April 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29660680/phase-composition-and-morphological-characterization-of-human-kidney-stones-using-ir-spectroscopy-scanning-electron-microscopy-and-x-ray-rietveld-analysis
#8
Paramita Chatterjee, Arup Chakraborty, Alok K Mukherjee
Pathological calcification in human urinary tract (kidney stones) is a common problem affecting an increasing number of people around the world. Analysis of such minerals or compounds is of fundamental importance for understanding their etiology and for the development of prophylactic measures. In the present study, structural characterization, phase quantification and morphological behaviour of thirty three (33) human kidney stones from eastern India have been carried out using IR spectroscopy (FT-IR), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)...
April 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29660612/perfluoroalkyl-substances-and-glycemic-status-in-pregnant-danish-women-the-odense-child-cohort
#9
Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye Kyhl, Helle Raun Andersen, Philippe Grandjean, Tina Kold Jensen, Marianne Andersen
BACKGROUND: Perfluoroalkyl substances (PFASs) are persistent chemicals with suspected endocrine disrupting abilities applied in consumer products. PFASs have potentially modulating effects on glucose homeostasis. Insulin resistance prevails during third trimester of pregnancy, and this challenge of glucose homeostasis may reveal putative effects of PFAS concentrations on glycemic status. OBJECTIVE: To investigate associations between five serum PFASs and glucose-related outcomes in pregnant Danish women based on their risk of gestational diabetes mellitus (GDM)...
April 13, 2018: Environment International
https://www.readbyqxmd.com/read/29660230/the-use-of-antimicrobials-as-adjuvant-therapy-for-the-treatment-of-obesity-and-insulin-resistance-effects-and-associated-mechanisms
#10
REVIEW
Sandra Aparecida Dos Reis, Maria do Carmo Gouveia Peluzio, Josefina Bressan
The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance. In this regard, the present manuscript aimed to review the effect of regular use of antimicrobials on the treatment of obesity and/or IR, as well as its associated mechanisms. The regular use of antimicrobials does not seem to influence the body weight and adiposity of its consumer...
April 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29660144/in-situ-growth-of-zr-based-metal-organic-framework-uio-66-nh-2-for-open-tubular-capillary-electrochromatography
#11
Pingxiu Tang, Rong Wang, Zilin Chen
The highly stability and other properties of Zr(IV)-based metal organic frameworks(MOFs) make it a promising choice for chromatographic separation, while the application in open-tubular capillary electrochromatography (OT-CEC) separation has not been explored yet. Herein, we report the first example of the in-situ growth of UiO-66-NH2 onto the capillary for open-tubular capillary electrochromatography. UiO-66-NH2 consists of ZrCl4 and 2-amino-1,4-benzenedicarboxylic acid, which is highly porous and stable in a variety of solvents...
April 16, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29659970/cholic-acid-supplementation-of-a-high-fat-obesogenic-diet-suppresses-hepatic-triacylglycerol-accumulation-in-mice-via-a-fibroblast-growth-factor-21-dependent-mechanism
#12
Siri M Ippagunta, Alexei Kharitonenkov, Andrew C Adams, F Bradley Hillgartner
Background: Supplementation of a high-fat obesogenic diet (HFD) with cholic acid (CA) suppresses the development of obesity, insulin resistance, and hepatic steatosis in mice. Objective: We investigated the role of fibroblast growth factor 21 (FGF21) in mediating the beneficial actions of CA on metabolic syndrome. Methods: Male 7-wk-old wild-type (WT) mice and FGF21 knockout (FGF21KO) mice were fed an HFD for 12 wk followed by a 4-wk period in which the mice were fed the HFD alone or supplemented with 0...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658532/changes-of-albumin-secondary-structure-after-palmitic-acid-binding-ft-ir-spectroscopic-study
#13
Adam Oleszko, Jadwiga Hartwich, Marlena Gąsior-Głogowska, Sylwia Olsztyńska-Janus
PURPOSE: Albumin is an universal transport protein. Plasma pool of free fatty acids arising from triglyceride hydrolysis, critical in energy metabolism and etiology of metabolic disorders is transported by albumin. According to various studies albumin has from seven to nine binding sites with diverse affinity to long chain fatty acids. X-ray diffraction crystallography measurements have provided data only for pure human serum albumin or albumin with fully saturated binding sites. These results have shown that amount of -helices is higher after fatty acids binding...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29657772/ph-responsive-polymeric-micelles-self-assembled-from-amphiphilic-copolymer-modified-with-lipid-used-as-doxorubicin-delivery-carriers
#14
Xin Xin Zhou, Long Jin, Rui Qun Qi, Teng Ma
In the present study, a novel pH-responsive amphiphilic copolymer, 1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)] conjugated poly(β-amino esters) (DSPE- b -PEG- b -PAE- b -PEG- b -DSPE), was designed and successfully synthesized via Michael-type step polymerization. The chemical structure of the pentablock copolymer was confirmed with proton nuclear magnetic resonance (1 H-NMR) and Fourier transform infrared (FT-IR) spectroscopy. The copolymer was able to self-assemble into core/shell polymeric micelles in aqueous solution at low concentrations, and its critical micelle concentration (CMC) value was 4...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29655751/isorenieratene-interaction-with-human-serum-albumin-multi-spectroscopic-analyses-and-docking-simulation
#15
Yashu Chen, Yufeng Zhou, Mo Chen, Bijun Xie, Jifang Yang, Jigang Chen, Zhida Sun
Isorenierantene was reported to be an aromatic carotenoid and has become a food ingredient, mainly from smear cheese, which possesses special antioxidant ability and significant photoprotective effect. In this paper, the interaction of isorenieratene with human serum albumin (HSA) was explored and compared with that of nonaromatic carotenoids using multi-spectroscopic methods and docking simulations. The results suggested isorenieratene could bind to HSA through a static quenching mechanism. The binding processes were spontaneous and exothermic, and the binding between isorenieratene and HSA was mainly driven by hydrophobic forces and electrostatic attraction...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29653099/herbacetin-a-flaxseed-flavonoid-ameliorates-high-percent-dietary-fat-induced-insulin-resistance-and-lipid-accumulation-through-the-regulation-of-hepatic-lipid-metabolizing-and-lipid-regulating-enzymes
#16
Chinnadurai Veeramani, Mohammed A Alsaif, Khalid S Al-Numair
Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored. The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyperlipidemia in 57BL/6 J mice. Obesity associated insulin resistance was induced by continuously feeding the mice with high-fat diet for 10 weeks...
April 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29651969/synthesis-characterization-of-ethyl-5-substituted-1h-pyrazole-3-carboxylate-derivative-as-potent-anti-inflammatory-agents
#17
Sujeet Kumar Gupta, Pratik Khanal, Arun Kumar, Arun Kumar, Neha Srivastava, Bhumika Yogi, Anshuman Sinha
BACKGROUND: Recently, pyrazole derivatives have shown significant anti-inflammatory activity. Non-steroidal anti-inflammatory drugs have the drawbacks of such as gastric irritation and gastric ulceration in treatment of inflammation. So the current study deals with the synthesis and pharmacological evaluation of a series of novel pyrazole derivatives as anti-inflammatory agents. METHODS: A series of novel ethyl 5-(substituted)-1H-pyrazole-3-carboxylate (2a-j) were synthesized and evaluated for anti-inflammatory activity using carrageenan-induced inflammation in rat paw edema model...
April 11, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29649536/characterization-of-momordica-charantia-l-polysaccharide-and-its-protective-effect-on-pancreatic-cells-injury-in-stz-induced-diabetic-mice
#18
Cong Zhang, Hongman Chen, Weiqi Bai
A polysaccharide with a molecular weight of 13,029 Da was isolated from Momordica charantia (MCP) fruit and purified by ion-exchange and size-exclusion chromatography. The isolated polysaccharide MCPIIa contained L-Rha, D-GalA, D-Gal, D-Xyl, L-Ara in a molar ratio of 12:3.05:19.89:5.95:56. IR spectrum and NMR studies indicated that the MCPIIa sugar units were linked, via β-glycosidic bonds, to a large number of arabinofuranose, glucuronic acid, and xylopyranosyl residues. In addition, the hypoglycemic effect of MCPIIa was investigated in streptozotocin (STZ)-induced diabetic mice...
April 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29645064/adiponectin-expression-in-visceral-adiposity-is-an-important-determinant-of-insulin-resistance-in-morbid-obesity
#19
Anca Elena Sirbu, Laura Buburuzan, Steliana Kevorkian, Sorina Martin, Carmen Barbu, Catalin Copaescu, Bogdan Smeu, Simona Fica
INTRODUCTION: Visceral adiposity is associated with decreased serum adiponectin levels, peripheral resistance to insulin and an increased risk of cardio-metabolic complications. However, the link between adiponectin expression in visceral adipose tissue (VAT), its serum levels and metabolic protection is controversial. The aim of this study was to investigate the relationship between the adiponectin gene expression in VAT and clinical and metabolic parameters in patients with severe obesity...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29643936/single-cell-assessment-of-yeast-metabolic-engineering-for-enhanced-lipid-production-using-raman-and-afm-ir-imaging
#20
Kamila Kochan, Huadong Peng, Bayden R Wood, Victoria S Haritos
Background: Biodiesel is a valuable renewable fuel made from derivatized fatty acids produced in plants, animals, and oleaginous microbes. Of the latter, yeasts are of special interest due to their wide use in biotechnology, ability to synthesize fatty acids and store large amounts of triacylglycerols while utilizing non-food carbon sources. While yeast efficiently produce lipids, genetic modification and indeed, lipid pathway metabolic engineering, is usually required for cost-effective production...
2018: Biotechnology for Biofuels
keyword
keyword
85549
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"