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https://www.readbyqxmd.com/read/29048376/new-methods-of-esterification-of-nanodiamonds-in-fighting-breast-cancer-a-density-functional-theory-approach
#1
Linda-Lucila Landeros-Martinez, Daniel Glossman-Mitnik, Erasmo Orrantia-Borunda, Norma Flores-Holguín
The use of nanodiamonds as anticancer drug delivery vehicles has received much attention in recent years. In this theoretical paper, we propose using different esterification methods for nanodiamonds. The monomers proposed are 2-hydroxypropanal, polyethylene glycol, and polyglicolic acid. Specifically, the hydrogen bonds, infrared (IR) spectra, molecular polar surface area, and reactivity parameters are analyzed. The monomers proposed for use in esterification follow Lipinski's rule of five, meaning permeability is good, they have good permeation, and their bioactivity is high...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29046328/genetic-support-for-a-causal-role-of-insulin-resistance-on-circulating-branched-chain-amino-acids-and-inflammation
#2
Qin Wang, Michael V Holmes, George Davey Smith, Mika Ala-Korpela
OBJECTIVE: Insulin resistance has deleterious effects on cardiometabolic disease. We used Mendelian randomization analyses to clarify the causal relationships of insulin resistance (IR) on circulating blood-based metabolites to shed light on potential mediators of the IR to cardiometabolic disease relationship. RESEARCH DESIGN AND METHODS: We used 53 single nucleotide polymorphisms associated with IR from a recent genome-wide association study (GWAS) to explore their effects on circulating lipids and metabolites...
October 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29045936/anti-diabetic-potential-of-the-leaves-of-anisomeles-malabarica-in-streptozotocin-induced-diabetic-rats
#3
Peddanna Kotha, Kameswara Rao Badri, Ramya Nagalapuram, Rajasekhar Allagadda, Appa Rao Chippada
BACKGROUND/AIMS: Diabetes mellitus is a pandemic metabolic disorder that is affecting a majority of populations in recent years. There is a requirement for new drugs that are safer and cheaper due to the side effects associated with the available medications. METHODS: We investigated the anti-diabetic activity of leaves of Anisomeles malabarica following bioactivity guided fractionation. The different solvent (hexane, ethyl acetate, methanol and water) extracts of A...
October 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29045788/the-importance-of-surface-irox-in-stabilizing-ruo2-for-oxygen-evolution
#4
Maria Escudero-Escribano, Anders F Pedersen, Elisa A Paoli, Rasmus Frydendal, Daniel Friebel, Paolo Malacrida, Jan Rossmeisl, Ifan E L Stephens, Ib Chorkendorff
The high precious metal loading and high overpotential of the oxygen evolution reaction (OER) prevents the widespread utilization of polymer electrolyte membrane (PEM) water electrolyzers. Herein we explore the OER activity and stability in acidic electrolyte of a combined IrOx/RuO2 system consisting of RuO2 thin films with sub-monolayer (1, 2 and 4 Å) amounts of IrOx deposited on top. Operando extended X-ray absorption fine structure (EXAFS) on the Ir L-3 edge revealed a rutile type IrO2 structure with some Ir sites occupied by Ru, IrOx being at the surface of the RuO2 thin film...
October 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29045027/step-up-synthesis-of-periodic-mesoporous-organosilicas-with-the-framework-of-tyrosine-tyr-pmos-and-performance-on-horseradish-peroxidase-immobilization
#5
Jianqiang Wang, Wenqi Zhang, Changqing Gu, Wenpei Zhang, Man Zhou, Zhiwei Wang, Cheng Guo, Linbing Sun
A new amino-acid bridged periodic mesoporous organosilicas (PMOs) have been constructed via hydrolysis and condensation reactions under acid condition in the presence of template. The tyrosine bissilylated organic precursor (TBOS) was first prepared through multi-step reaction using tyrosine (natural amino acid) as starting material. The PMOs with the framework of tyrosine (Tyr-PMOs) were architected by simultaneously using TBOS and TEOS as complex silicon source in the condensation process. All the Tyr-PMOs materials were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM, SEM and 29Si solid-state NMR to confirm the structure...
October 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29044866/high-susceptibility-of-histidine-to-charge-solvation-revealed-by-cold-ion-spectroscopy
#6
Alexandr Y Pereverzev, Vladimir Kopysov, Oleg V Boyarkin
Histidine remained the last aromatic amino acid for which the intrinsic spectroscopic properties and structures were obscure. We measured the UV and IR spectra of protonated histidine, isolated in the gas phase, using photofragmentation cold ion spectroscopy. Unexpectedly, the UV absorption appears strongly redshifted relative to that of the cation in aqueous solutions. In investigating this phenomenon, we solved the geometries of all abundant conformers using IR conformer-selective spectroscopy and ab initio quantum chemical calculations...
October 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29044312/effect-of-carbon-source-on-production-characterization-and-bioactivity-of-exopolysaccharide-produced-by-phellinus-vaninii-ljup
#7
Chunping Xu, Jinwei Yu, Shanshan Zhao, Shungshung Wu, Peixin He, Xuewei Jia, Yanqi Liu, Duobin Mao
The effect on different three carbon source (i.e. glucose, fructose and sucrose) on production, chemical characterization and antioxidant activity of exopolysaccharide (EPS) produced by Phellinus vaninii Ljup was investigated in this study. Amongst carbon sources examined, glucose and sucrose were favorable for the mycelia growth, while the maximum EPS yield was achieved when sucrose was employed. The predominant carbohydrate compositions in EPSs identified were gluconic acid, glucose, mannose and galactose acid...
October 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29044183/direct-production-of-furfural-in-one-pot-fashion-from-raw-biomass-using-br%C3%A3-nsted-acidic-ionic-liquids
#8
Babasaheb M Matsagar, Shahriar A Hossain, Tofazzal Islam, Hatem R Alamri, Zeid A Alothman, Yusuke Yamauchi, Paresh L Dhepe, Kevin C-W Wu
The conversion of raw biomass into C5-sugars and furfural was demonstrated with the one-pot method using Brønsted acidic ionic liquids (BAILs) without any mineral acids or metal halides. Various BAILs were synthesized and characterized using NMR, FT-IR, TGA, and CHNS microanalysis and were used as the catalyst for raw biomass conversion. The remarkably high yield (i.e. 88%) of C5 sugars from bagasse can be obtained using 1-methyl-3(3-sulfopropyl)-imidazolium hydrogen sulfate ([C3SO3HMIM][HSO4]) BAIL catalyst in a water medium...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043930/associations-among-fatty-acids-desaturase-and-elongase-and-insulin-resistance-in-children
#9
Lori M Beccarelli, Rachel Erin Scherr, John W Newman, Alison G Borkowska, Ira J Gray, Jessica D Linnell, Carl L Keen, Heather M Young
OBJECTIVES: Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and identify relationships with markers of metabolic health. It was hypothesized that these lipid markers would be correlated to adiposity and metabolic disease. METHODS: This study was a cross-sectional analysis of fourth- and fifth-grade children (n = 86, aged 9-12) participating in a comprehensive nutrition program...
October 18, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29043802/sporothriolide-related-compounds-from-the-fungus-hypoxylon-monticulosum-cll-205-isolated-from-a-sphaerocladina-sponge-from-the-tahiti-coast
#10
Charlotte Leman-Loubière, Géraldine Le Goff, Pascal Retailleau, Cécile Debitus, Jamal Ouazzani
Two sporothriolide-related compounds were obtained from an extract of the fungus Hypoxylon monticulosum CLL-205, isolated from a Sphaerocladina sponge collected from the Tahiti coast. Compound 2 is a deoxy analogue of sporothric acid (4). Compound 3 is a newly reported unusual scaffold combining sporothriolide (1) and trienylfuranol A (5) moieties, through a Diels-Alderase-type reaction. Various experimental and analytical arguments supported the biocatalytic origin of compound 3. The structures of the isolated compounds were elucidated using 1D and 2D NMR, HRMS, and IR data...
October 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29043340/cfa-13-a-bifunctional-perfluorinated-metal-organic-framework-featuring-active-cu-i-and-cu-ii-sites
#11
J Fritzsche, D Denysenko, M Grzywa, D Volkmer
The synthesis and crystal structure of the mixed-valent perfluorinated metal-organic framework (Me2NH2)[CFA-13] (Coordination Framework Augsburg University-13), (Me2NH2)[CuCu(tfpc)4] (H2-tfpc = 3,5-bis(trifluoromethyl)-1H-pyrazole-4-carboxylic acid) is described. The copper-containing MOF crystallizes in the monoclinic crystal system within the space group P21/n (no. 14) and the unit cell parameters are as follows: a = 22.3887(19), b = 13.6888(8), c = 21.1804(13) Å, β = 90.495(3)°, V = 6491.0(8) Å(3). (Me2NH2)[CFA-13] features a porous 3-D structure constructed from two types of secondary building units (SBUs)...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29040025/effect-of-chronic-consumption-of-pistachios-pistacia-vera-l-on-glucose-metabolism-in-pre-diabetics-and-type-2-diabetics-a-systematic-review
#12
Priscila Vaz de Melo Ribeiro, Alessandra da Silva, Alinne Paula de Almeida, Helen Hermana Miranda Hermsdorff, Rita de Cássia Gonçalves Alfenas
Pistachio is a nut with high polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), polyphenols and carotenoids content, and the synergism between these compounds appears to affect glucose metabolism. In this systematic review we analyzed studies in which the effect of chronic consumption of pistachio on markers of glucose metabolism was evaluated in pre-diabetic and type 2 diabetics. We used the PubMed, Scopus, Cochrane and Lilacs databases. The research terms used were pistachio, pre-diabetes, type 2 diabetes mellitus, insulin resistance, blood glucose, hyperglycemia and glycated hemoglobin (HbA1c)...
October 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29039933/porous-uranium-diphosphonate-frameworks-with-trinuclear-units-templated-by-organic-ammonium-hydrolyzed-from-amine-solvents
#13
Zhi-Hui Zhang, Ganna A Senchyk, Yi Liu, Tyler Spano-Franco, Jennifer E S Szymanowski, Peter C Burns
By varying solvent systems, the solvothermal treatment of uranyl nitrate and methylenediphosphonic acid (H4PCP) afforded three new porous uranyl-organic frameworks (UOFs). All were structurally characterized by single-crystal X-ray diffraction and formulated as (Et2NH2)2[(UO2)3(PCP)2](H2O)2.5 (1), (MeNH3)(H3O)[(UO2)3(PCP)2(H2O)3] (2), and [Na(H2O)4](H3O)[(UO2)3(PCP)2(H2O)2](H2O)5 (3). These compounds crystallize with three-dimensional anionic frameworks containing U(VI) and distinct cationic species due to in situ solvent hydrolysis...
October 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29039911/halide-re-shelled-quantum-dot-inks-for-infrared-photovoltaics
#14
James Z Fan, Mengxia Liu, Oleksandr Voznyy, Bin Sun, Larissa Levina, Rafael Quintero-Bermudez, Min Liu, Olivier Ouellette, F Pelayo Garcia de Arquer, Sjoerd Hoogland, Edward H Sargent
Colloidal quantum dots are promising materials for tandem solar cells that complement to silicon and perovskites. These devices are fabricated from solution phase; however, existing methods for making infrared-bandgap CQD inks suffer agglomeration and fusion during solution exchange. Here we develop a ligand exchange that provides robust surface protection and thereby avoids aggregation. First, we exchanged long oleic acid ligands to a mixed system comprised of medium-chain ammonium and anionic chloride ligands; then, we re-shelled the surface using short halides and pseudohalide ligands that enabled transfer to a polar solvent...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29039324/synthesis-pharmacological-screening-and-computational-analysis-of-some-2-1h-indol-3-yl-n-un-substituted-phenylmethylidene-acetohydrazides-and-2-1h-indol-3-yl-n-un-substituted-benzoyl-2-thienylcarbonyl-acetohydrazides
#15
Kaniz Rubab, Muhammad Athar Abbasi, Azizur Rehman, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, Muhammad Ashraf, Quratul Ain, Irshad Ahmad, Muhammad Arif Lodhi, Mehreen Ghufran, Muhammad Shahid, Hina Fatima
The undertaken research was initiated by transforming 2-(1H-Indol-3-yl)acetic acid (1) in catalytic amount of sulfuric acid and ethanol to ethyl 2-(1H-Indol-3-yl)acetate (2), which was then reacted with hydrazine monohydrate in methanol to form 2-(1H-Indol-3-yl)acetohydrazide (3). Further, The reaction scheme was designed into two pathways where, first pathway involved The reaction of 3 with substituted aromatic aldehydes (4a-o) in methanol with few drops of glacial acetic acid to generate 2-(1H-Indol-3-yl)-N'-[(un)substitutedphenylmethylidene]acetohydrazides (5a-o) and in second pathway 3 was reacted with acyl halides (6a-e) in basic aqueous medium (pH 9-10) to afford 2-(1H-Indol-3-yl)-N'-[(un)substitutedbenzoyl/2-thienylcarbonyl]acetohydrazides (7a-e)...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29038536/hydrogen-sulphide-treatment-increases-insulin-sensitivity-and-improves-oxidant-metabolism-through-the-camkkbeta-ampk-pathway-in-pa-induced-ir-c2c12-cells
#16
Xubo Chen, Xueyan Zhao, Fazhang Lan, Tao Zhou, Hua Cai, Haiying Sun, Weijia Kong, Wen Kong
Studies have reported attenuation of insulin resistance (IR) by improving phosphorylation of the insulin signalling pathway. However, the upstream molecular signalling pathway is still elusive. In this study, Western blot was used to evaluate the phosphorylation level of the insulin signalling pathway and the AMPK pathway. 2-NBDG was used to evaluate glucose uptake. Ca(2+) imaging was used to assess change of intracellular Ca(2+) concentration. We found that NaHS enhanced the intracellular Ca(2+) concentration and glucose uptake and activated the insulin signalling cascade in a palmitic acid (PA)-induced IR model in C2C12 cells...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036913/alpha-galacto-oligosaccharides-at-low-dose-improve-liver-steatosis-in-a-high-fat-diet-mouse-model
#17
Eric Chappuis, Fanny Morel-Depeisse, Bruno Bariohay, Julien Roux
Non-Alcoholic Fatty Liver Disease (NAFLD) is the major liver disease worldwide and is linked to the development of metabolic syndrome and obesity. As alpha-galacto-oligosaccharides (α-GOS) from legumes have been shown to reduce body weight and hyperphagia in overweight adults, it was hypothesized that they would exert benefits on the development of metabolic syndrome and associated NAFLD in a rodent model. C57Bl/6J mice were fed a high-fat diet until they developed metabolic syndrome and were then orally treated either with α-GOS at a physiological dose (2...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29031448/la-ce-codoped-bi2o3-composite-photocatalysts-with-high-photocatalytic-performance-in-removal-of-high-concentration-dye
#18
Shuangshuang Xue, Hongbo He, Qizhe Fan, Changlin Yu, Kai Yang, Weiya Huang, Yang Zhou, Yu Xie
A series of La/Ce-codoped Bi2O3 composite photocatalysts were fabricated via hydrothermal-calcination process. The as-prepared products were intensively characterized by some physicochemical characterizations like N2 physical adsorption, X-ray powder diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), UV-Vis diffuse reflectance (UV-Vis DRS), Fourier transform infrared spectroscopy (FT-IR), photoelectrochemical measurements, and photoluminescence (PL) spectroscopy. The characterization results indicated that La and Ce doping induced obvious crystal phase transformation in Bi2O3, from monoclinic to tetragonal phase...
October 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29031227/development-of-a-graphene-oxide-chitosan-nanocomposite-for-the-removal-of-picric-acid-from-aqueous-solutions-study-of-sorption-parameters
#19
Mona Mohseni Kafshgari, Hasan Tahermansouri
The functionalization of graphene oxide (GO) with chitosan (Chi) has been investigated to prepare a nanocomposite material (GO-Chi) for the removal of picric acid from aqueous solutions. Materials were characterized by FT-IR, TGA, DTG, FESEM, EDX, XRD and BET. Batch experiments such as solution pH, amount of adsorbents, contact time, concentration of the picric acid and temperature were achieved to study sorption process. Kinetic studies were well described by pseudo-second-order kinetic model for both adsorbents...
October 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031148/fabrication-of-charge-reversible-graphene-oxide-based-nanocomposite-with-multiple-antibacterial-modes-and-magnetic-recyclability
#20
Qiang Li, Chunyan Yong, Weiwei Cao, Xi Wang, Lina Wang, Jie Zhou, Xiaodong Xing
In this work, N-alkylated poly (4-vinylpyridine) (NPVP), a cationic polymer, was firstly applied for the surface modification of Fe3O4 nanoparticles. Then the modified Fe3O4 nanoparticles (Fe3O4@NPVP NPs) combined with graphene oxide (GO) through simple electrostatic binding. Subsequently, deposited Ag nanoparticles (Ag NPs) procedure was carried out to form the multiple antibacterial nanocomposites (GO-Fe3O4@NPVP-Ag). The synthesized nanostructures were well characterized by Transmission Electron Microscope (TEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) and Raman spectroscopy...
October 3, 2017: Journal of Colloid and Interface Science
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