Ildefonso M De la Fuente, Jose Carrasco-Pujante, Borja Camino-Pontes, Maria Fedetz, Carlos Bringas, Alberto Pérez-Samartín, Gorka Pérez-Yarza, José I López, Iker Malaina, Jesus M Cortes
Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements remains an unresolved question. Here, we have addressed the systemic processes driving the directed locomotion of cells. Specifically, we have performed an exhaustive study analyzing the trajectories of 700 individual cells belonging to three different species ( Amoeba proteus , Metamoeba leningradensis , and Amoeba borokensis ) in four different scenarios: in absence of stimuli, under an electric field (galvanotaxis), in a chemotactic gradient (chemotaxis), and under simultaneous galvanotactic and chemotactic stimuli...
May 2024: PNAS Nexus