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https://www.readbyqxmd.com/read/29039581/shikonin-induces-apoptosis-and-g0-g1%C3%A2-phase-arrest-of-gallbladder-cancer-cells-via-the-jnk-signaling-pathway
#1
Tianyu Zhai, Zhenyu Hei, Qiang Ma, Haibin Liang, Yi Xu, Yichi Zhang, Longyang Jin, Chao Han, Jiandong Wang
Shikonin, a natural product isolated from the roots of Lithospermum erythrorhizon, is considered to have antitumor effects. Gallbladder cancer (GBC) is a prevalent biliary tract malignancy with few curative therapeutic stragegies and poor prognosis. In the present study, we detected the effects of shikonin on GBC cells as well as the underlying molecular mechanisms. The results demonstrated that GBC cell proliferation was inhibited by shikonin as determined by MTT and colony formation assays. Flow cytometry results demonstrated that shikonin treatment enhanced apoptosis and promoted G0/G1 phase arrest in the GBC cells...
October 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29038848/ca19-9-kinetics-during-systemic-chemotherapy-in-patients-with-advanced-or-recurrent-biliary-tract-cancer
#2
Naminatsu Takahara, Yousuke Nakai, Hiroyuki Isayama, Takashi Sasaki, Kei Saito, Kensaku Noguchi, Tatsunori Suzuki, Tomoka Nakamura, Tatsuya Sato, Kazunaga Ishigaki, Ryunosuke Hakuta, Tsuyoshi Takeda, Rie Uchino, Suguru Mizuno, Hirofumi Kogure, Minoru Tada, Kazuhiko Koike
PURPOSE: The role of carbohydrate antigen 19-9 (CA19-9) kinetics in patients with biliary tract cancer (BTC) receiving chemotherapy remains to be elucidated. METHODS: A total of 185 advanced or recurrent BTC patients receiving a first line chemotherapy between January 2006 and March 2016, were retrospectively studied. Serum CA19-9 was measured at baseline and after two cycles of chemotherapy, and patients were categorized based on CA19-9 response: CA19-9 decrease group (≥ 30% decrease), stable group (< 30% decrease and < 20% increase) and increase group (≥ 20% increase)...
October 16, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29038677/newly-diagnosed-idiopathic-liver-abscess-colonoscopy-required
#3
Priyanka Makkar, Tagore Sunkara, Manan Jhaveri, Judith Berger, Vinaya Gaduputi, Jay P Babich
Liver abscess is the most common type of visceral abscess reported in the United States. Biliary tract disease is the most common cause of the development of liver abscess. In the last decade, many cases of liver abscesses silently manifesting as colon cancer have been reported in East Asian countries. We herein describe a case of an immunocompetent man who immigrated from East Africa to Unites States and presented with a suspicion of colon mass with metastasis to the liver, and who was later diagnosed to have a colonic malignancy with a concomitant liver abscess...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29033254/nodal-areas-of-potential-geographic-error-in-adjuvant-radiotherapy-for-biliary-tract-cancer
#4
Joanna Socha, Maciej Michalak, Grzegorz Wołąkiewicz, Lucyna Kepka
PURPOSE: To determine the areas of potential geographic error in adjuvant radiotherapy (RT) for biliary-tract cancer (BTC) by comparing pathological-surgical data on the pattern of nodal spread with the extent of elective nodal CTV used in published RT studies in this setting. MATERIAL/METHODS: A literature search was performed to select articles on: 1/adjuvant RT for BTC, that provided information on the lymph node stations (LNS) included in the CTV; 2/the pathological-surgical data on the patterns of nodal involvement/recurrence in BTC...
October 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29024931/brain-metastases-from-biliary-tract-cancer-a-monocentric-retrospective-analysis-of-450-patients
#5
Giorgio Frega, Ingrid Garajová, Andrea Palloni, Maria Aurelia Barbera, Marco Trossello Pastore, Luca Faccioli, Luca Spinardi, Stefania De Lorenzo, Marta Cubelli, Maria Abbondanza Pantaleo, Guido Biasco, Giovanni Brandi
OBJECTIVE: Brain metastases (BMs) from biliary tract cancer (BTC) are extremely rare. The aim of our study was to report the incidence of BMs in patients with BTC. METHODS: We retrospectively analyzed a series of 450 patients with BTC. Presence of brain lesions was investigated only when symptoms were evident. Cumulative incidence, median overall survival (OS) from detection of BMs, median OS from cancer diagnosis, and median time from cancer diagnosis to detection of BMs were evaluated...
October 13, 2017: Oncology
https://www.readbyqxmd.com/read/29024814/anti-tumor-effects-of-nvp-bkm120-alone-or-in-combination-with-mek162-in-biliary-tract-cancer
#6
Ling Jin, Mei-Hua Jin, Ah-Rong Nam, Ji-Eun Park, Ju-Hee Bang, Do-Youn Oh, Yung-Jue Bang
There are currently no clinically validated therapeutic targets for biliary tract cancer (BTC). Despite promising results in other cancers, compounds targeting the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, alone or in combination with Ras/Raf/MEK pathway inhibitors, have not been evaluated in BTC. Here, we examined the effects of a pan-PI3K inhibitor (BKM120) with or without a MEK inhibitor (MEK162), on eight human BTC cell lines carrying mutations in K-Ras and/or the PI3K catalytic subunit, PI3KCA...
October 9, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29018181/perineural-infiltration-as-a-prognostic-factor-in-surgically-treated-gallbladder-cancer-a-single-center-experience-and-literature-review
#7
Claudio Francesco Feo, Maria Laura Cossu, Giorgio Carlo Ginesu, Alessandro Fancellu, Antonio Mario Scanu, Nadia Piras, Giuseppe Cherchi, Antonio Cossu, Giovanni Sotgiu, Marco Pazzona, Alberto Porcu
INTRODUCTION: Gallbladder cancer (GBC) is the most incident cancer of the biliary tract with only 5-13% of the sufferers surviving for five years. The aim of this study was to evaluate the prognostic role of perineural invasion (PNI) and its association with several clinicopathological variables in a cohort of surgically treated patients, and through a comprehensive review of the scientific literature. MATERIALS AND METHODS: Twenty-five consecutive patients submitted to curative surgery for GBC from 2008 through 2016 were enrolled...
October 4, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29017161/prognostic-factors-for-survival-in-patients-with-advanced-intrahepatic-cholangiocarcinoma-treated-with-gemcitabine-plus-cisplatin-as-first-line-treatment
#8
Utako Ishimoto, Shunsuke Kondo, Akihiro Ohba, Mitsuhito Sasaki, Yasunari Sakamoto, Chigusa Morizane, Hideki Ueno, Takuji Okusaka
OBJECTIVES: Intrahepatic cholangiocarcinoma (ICC) is a rare type of liver cancer. No clinically useful prognostic factors have been reported for patients with advanced ICC. In the present study, we aimed to evaluate the clinical prognostic factors of patients with advanced ICC receiving gemcitabine plus cisplatin combination therapy (GC) as standard first-line chemotherapy. METHODS: A retrospective analysis was performed of the data of patients with ICC treated at our institution from March 2011 to January 2016...
October 11, 2017: Oncology
https://www.readbyqxmd.com/read/28988016/characterisation-of-the-immune-related-transcriptome-in-resected-biliary-tract-cancers
#9
Michele Ghidini, Luciano Cascione, Pietro Carotenuto, Andrea Lampis, Francesco Trevisani, Maria Chiara Previdi, Jens C Hahne, Ian Said-Huntingford, Maya Raj, Alessandro Zerbi, Claudia Mescoli, Umberto Cillo, Massimo Rugge, Massimo Roncalli, Guido Torzilli, Lorenza Rimassa, Armando Santoro, Nicola Valeri, Matteo Fassan, Chiara Braconi
Although biliary tract cancers (BTCs) are known to have an inflammatory component, a detailed characterisation of immune-related transcripts has never been performed. In these studies, nCounter PanCancer Immune Profiling Panel was used to assess the expression of 770 immune-related transcripts in the tumour tissues (TTs) and matched adjacent tissues (ATs) of resected BTCs. Cox regression analysis and Kaplan-Meier methods were used to correlate findings with relapse-free survival (RFS). The first analysis in the TT and AT of an exploratory set (n = 22) showed deregulation of 39 transcripts associated with T-cell activation...
October 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28987259/primary-sclerosing-cholangitis-what-the-gastroenterologist-and-hepatologist-needs-to-know
#10
REVIEW
Andrea A Gossard, Gregory J Gores
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease. Abrupt changes in liver biochemistries, pain, and/or cholangitis may suggest a dominant stricture amenable to endoscopic therapy or the development of cholangiocarcinoma. Patients with PSC are at increased risk of cholangiocarcinoma. There is a strong association with inflammatory bowel disease, and an associated increased risk of colorectal cancer...
November 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28951229/effect-of-nucleos-t-ide-analogue-therapy-on-risk-of-intra-hepatic-cholangioarcinoma-in-patients-with-chronic-hepatitis-b
#11
Teng-Yu Lee, Yao-Chun Hsu, Shi-Hang Yu, Jaw-Town Lin, Ming-Shiang Wu, Chun-Ying Wu
BACKGROUND & AIMS: Chronic infection with hepatitis B virus (HBV) increases risk of intrahepatic cholangiocarcinoma (ICC), but it is not clear whether antiviral therapy reduces risk. We investigated the association between nucleos(t)ide analogue therapy and ICC risk. METHODS: We performed a nationwide long-term cohort study using Taiwan's National Health Insurance Research Database to obtain data on 185,843 patients with chronic HBV infection from October 1, 2003 through December 31, 2012...
September 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28944047/novel-biomarkers-and-endoscopic-techniques-for-diagnosing-pancreaticobiliary-malignancy
#12
REVIEW
Margaret G Keane, Amar Shah, Stephen P Pereira, Deepak Joshi
The UK incidence of pancreatic ductal adenocarcinoma is 9 per 100,000 population, and biliary tract cancer occurs at a rate of 1-2 per 100,000. The incidence of both cancers is increasing annually and these tumours continue to be diagnosed late and at an advanced stage, limiting options for curative treatment. Population-based screening programmes do not exist for these cancers, and diagnosis currently is dependent on symptom recognition, but often symptoms are not present until the disease is advanced. Recently, a number of promising blood and urine biomarkers have been described for pancreaticobiliary malignancy and are summarised in this review...
2017: F1000Research
https://www.readbyqxmd.com/read/28930749/efficacy-and-safety-of-capecitabine-irinotecan-gemcitabine-and-bevacizumab-as-second-line-treatment-in-advanced-biliary-tract-cancer-a-phase-ii-study
#13
Finn Ole Larsen, Alice Markussen, Laura V Diness, Dorte Nielsen
OBJECTIVE: Since 2010, gemcitabine and cisplatin have been considered standard first-line treatment in patients with advanced biliary tract cancer. Many centers have replaced cisplatin with oxaliplatin, which seems to obtain similar results. While first-line treatment has been well established, there are no phase III trials supporting second-line treatment, and the phase II trials with chemotherapy do not show any clear benefit. In this study, we investigated the effect of adding bevacizumab to chemotherapy in second-line treatment...
September 21, 2017: Oncology
https://www.readbyqxmd.com/read/28910999/infection-with-opisthorchis-felineus-induces-intraepithelial-neoplasia-of-the-biliary-tract-in-a-rodent-model
#14
Maria João Gouveia, Maria Y Pakharukova, Thewarach Laha, Banchob Sripa, Galina A Maksimova, Gabriel Rinaldi, Paul J Brindley, Viatcheslav A Mordvinov, Teresina Amaro, Lucio Lara Santos, José Manuel Correia da Costa, Nuno Vale
The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28905105/diagnostic-and-prognostic-role-of-18-fdg-pet-ct-in-the-management-of-resectable-biliary-tract-cancer
#15
Ka Wing Ma, Tan To Cheung, Wong Hoi She, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Wan Hang Chiu, Chung Mau Lo
OBJECTIVES: Role of 18-FDG PET/CT had been well established in other more prevalent malignancies such as colorectal and lung cancer; however, this is not as well defined in cholangiocarcinoma. Literature focusing on the prognostic values of preoperative PET/CT for resectable cholangiocarcinoma is scarce. METHOD: This is a retrospective cohort of 66 consecutive patients who had received curative resection for cholangiocarcinoma from 2010 to 2015. All patients had preoperative 18-FDG PET/CT performed...
September 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28903023/platelet-to-lymphocyte-ratio-in-biliary-tract-cancer-review-and-meta-analysis
#16
REVIEW
Lin-Hua Zhou, Xiao-Feng Luo
BACKGROUND: The platelet to lymphocyte ratio (PLR) has been found to predict clinical outcomes in multiple malignancies. The aim of this study was to assess the prognostic value of pretreatment PLR in biliary tract cancer (BTC). METHODS: We searched the MEDLINE, EMBASE, and Cochrane databases to identify studies evaluating the prognostic significance of pretreatment PLR in BTC. The end points were overall survival (OS), recurrence-free survival (RFS). Pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed-effects/random-effects models...
November 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28885493/systematic-review-and-meta-analysis-of-posttransplant-hepatic-artery-and-biliary-complications-in-patients-treated-with-transarterial-chemoembolization-before-liver-transplantation
#17
Dimitri Sneiders, Thymen Houwen, Liset H M Pengel, Wojciech G Polak, Frank J M F Dor, Hermien Hartog
BACKGROUND: Hepatic artery complications are feared complications after liver transplantation and may compromise the biliary tract, graft and patient survival. The objective of this systematic review and meta-analysis was to compare risk of hepatic artery and biliary complications after liver transplantation in patients who underwent neoadjuvant transarterial chemoembolization (TACE) vs. no TACE. METHODS: Comprehensive searches were performed in Embase, MEDLINE OvidSP, Web of Science, Google Scholar and Cochrane databases to identify studies concerning hepatocellular cancer patients undergoing preliver transplantation TACE...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28882957/5-aminolevulinic-acid-mediated-photodynamic-diagnosis-enhances-the-detection-of-peritoneal-metastases-in-biliary-tract-cancer-in-mice
#18
Toshihiro Kushibiki, Takehiro Noji, Yuma Ebihara, Koji Hontani, Masato Ono, Shota Kuwabara, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Masahiro Ishizuka, Satoshi Hirano
BACKGROUND/AIM: Previous studies on the accuracy of 5-aminolevulinic-acid-mediated photodynamic diagnosis (5-ALA PDD) have been reported for various cancers and brain surgery. However, biliary tract cancer is rare. Therefore, 5-ALA PDD has not been fully evaluated in biliary tract cancers. Small biliary tract cancer lesions such as peritoneal dissemination, liver metastases, and lymph node metastases are negative prognosticators in patients with biliary cancer. The purpose of this exploratory study was to determine if 5-ALA PDD could detect small biliary tract cancer lesions in murine models of biliary cancers...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28857137/weekday-of-cancer-surgery-in-relation-to-prognosis
#19
J Lagergren, F Mattsson, P Lagergren
BACKGROUND: Later weekday of surgery seems to affect the prognosis adversely in oesophageal cancer, whereas any such influence on other cancer sites is unknown. This study aimed to test whether weekday of surgery influenced prognosis following commonly performed cancer operations. METHODS: This nationwide Swedish population-based cohort study from 1997 to 2014 analysed weekday of elective surgery for ten major cancers in relation to disease-specific and all-cause mortality...
August 31, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28856225/development-of-a-sandwich-elisa-for-the-thrombin-light-chain-identified-by-serum-proteome-analysis
#20
Kazuyuki Sogawa, Kana Kobayashi, Shintaro Kikkawa, Shigetsugu Takano, Hideyuki Yoshitomi, Hirotaka Takizawa, Masayuki Ohtsuka, Hiroaki Shimizu, Katsunori Furuhata, Masaru Miyazaki, Osamu Yokosuka, Fumio Nomura
We previously identified novel biomarker candidates in biliary tract cancer (BTC) using serum proteome analysis. Among several candidates, we focused on thrombin light chain which is a 4204 Da peptide as the most promising biomarker for BTC. To move thrombin light chain toward potential diagnostic use, we developed an enzyme immunoassay that enables to measure serum thrombin light chain levels. Both one monoclonal antibody specific to the N-termini and one polyclonal antibody were used to develop a sandwich ELISA for thrombin light chain...
August 2017: Pract Lab Med
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