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trombolysis in infarction

Sebastiaan T Roos, Leo Timmers, Paul S Biesbroek, Robin Nijveldt, Otto Kamp, Albert C van Rossum, Gerardus P J van Hout, Pieter R Stella, Pieter A Doevendans, Paul Knaapen, Birgitta K Velthuis, Niels van Royen, Michiel Voskuil, Alex Nap, Yolande Appelman
OBJECTIVES: This double blinded, placebo controlled randomized clinical trial studies the effect of exenatide on myocardial infarct size. The glucagon-like peptide-1 receptor agonist exenatide has possible cardioprotective properties during reperfusion after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. METHODS: 191 patients were randomly assigned to intravenous exenatide or placebo initiated prior to percutaneous coronary intervention using 10μg/h for 30min followed by 0...
October 1, 2016: International Journal of Cardiology
Jaume Figueras, Magda Heras, Francisco Baigorri, Roberto Elosua, Ignacio Ferreira, Miquel Santaló
BACKGROUND AND OBJECTIVE: To analyze the use of reperfusion therapy in patients with ST elevation myocardial infarction (STEMI) in Catalonia in a registry performed in 2006 (IAM CAT III) and its comparison with 2 previous registries PATIENTS AND METHODS: Frequency of reperfusion therapy and time intervals between symptom onset - reperfusion therapy were the principal variables investigated. The IAM CAT I (June-December 2000) included 1,450 patients, the IAM CAT II (October 2002-April 2003) 1,386, and the IAM CAT III (October-December 2006) 367...
November 14, 2009: Medicina Clínica
Astrid Juhl Terkelsen, Jens Erik Nielsen-Kudsk, Henning Rud Andersen, Jens Flensted Lassen
Mortality in untreated pulmonary embolism is high and short-term outcome depends on a timely diagnosis. In this case telemedicine involving 12-lead ECG and GSM-based communication between the patient in the ambulance and the telemedical staff resulted in remote pre-hospital suspicion of acute pulmonary embolism. The ambulance was referred directly to the nearest department of cardiology where acute CT and echocardiography confirmed the diagnosis. Acute trombolysis was successful. Telemedicine may be beneficial in other medical emergencies than acute myocardial infarction...
February 25, 2008: Ugeskrift for Laeger
Jaroslaw Zalewski, Krzysztof Zmudka, Piotr Musialek, Wojciech Zajdel, Piotr Pieniazek, Andrzej Kadzielski, Tadeusz Przewlocki
BACKGROUND: In a significant proportion of patients with acute myocardial infarction (AMI), successful opening of the infarct related artery (IRA) does not translate into adequate perfusion at the tissue level. We hypothesised that deterioration of epicardial blood flow in early reperfusion may identify early signs of coronary microvascular injury. METHODS: In 272 consecutive patients (age 56.9+/-10.4 years) with AMI treated by primary angioplasty (PCI), coronary blood flow (Trombolysis in Myocardial Infarction (TIMI) scale and corrected TIMI frame count (cTFC)) was evaluated before [B], immediately after [O] and 15 min after [O15] opening of the IRA...
September 2004: International Journal of Cardiology
L Carlos Passos, A da Silva Rodrigues, C Leal Costa, S Ledoux, C M de Souza, J Péricles Esteves
PURPOSE: To describe the use of myocardial reperfusion strategies (percutaneous transluminal coronary angioplasty-PTCA and intravenous trombolysis) whenever it is possible to use emergency cinecoronariography in acute myocardial infarction (AMI). METHODS: The records of patients admitted with initial diagnosis of AMI, until six hours after the beginning of symptoms, were reviewed retrospectively, between March/92 and December/93. RESULTS: One hundred forty-three patients were admitted with suspected AMI...
October 1995: Arquivos Brasileiros de Cardiologia
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