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https://www.readbyqxmd.com/read/29785519/threshold-dynamics-of-a-temperature-dependent-stage-structured-mosquito-population-model-with-nested-delays
#1
Xiunan Wang, Xingfu Zou
Mosquito-borne diseases remain a significant threat to public health and economics. Since mosquitoes are quite sensitive to temperature, global warming may not only worsen the disease transmission case in current endemic areas but also facilitate mosquito population together with pathogens to establish in new regions. Therefore, understanding mosquito population dynamics under the impact of temperature is considerably important for making disease control policies. In this paper, we develop a stage-structured mosquito population model in the environment of a temperature-controlled experiment...
May 21, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29780943/longitudinal-ophthalmic-findings-in-a-child-with-helsmoortel-van-der-aa-syndrome
#2
Michael J Gale, Hope E Titus, Gareth A Harman, Talal Alabduljalil, Anna Dennis, Jenny L Wilson, David M Koeller, Erika Finanger, Peter A Blasco, Pei-Wen Chiang, Daniel J Karr, Paul Yang
Purpose: We present the first detailed ophthalmic description of a child with Helsmoortel-Van der Aa Syndrome (HVDAS), including longitudinal follow-up and analysis. Observations: After extensive workup, a young child with poor visual behavior, hypotonic cerebral palsy, intellectual disability, and global developmental delay was found to have a heterozygous de novo mutation in the ADNP gene and diagnosed with HVDAS. Ophthalmic findings were remarkable for progressive nystagmus, macular pigment mottling, mild foveal hypoplasia with abnormal macular laminations, persistent rod dysfunction with electronegative waveform, and progressive cone degeneration...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29774262/the-need-to-improve-fertility-awareness
#3
Joyce Harper, Jacky Boivin, Helen C O'Neill, Kate Brian, Jennifer Dhingra, Grace Dugdale, Genevieve Edwards, Lucy Emmerson, Bola Grace, Alison Hadley, Laura Hamzic, Jenny Heathcote, Jessica Hepburn, Lesley Hoggart, Fiona Kisby, Sue Mann, Sarah Norcross, Lesley Regan, Susan Seenan, Judith Stephenson, Harry Walker, Adam Balen
Women and men globally are delaying the birth of their first child. In the UK, the average age of first conception in women is 29 years. Women experience age-related fertility decline so it is important that men and women are well-informed about this, and other aspects of fertility. A group of UK stakeholders have established the Fertility Education Initiative to develop tools and information for children, adults, teachers, parents and healthcare professionals dedicated to improving knowledge of fertility and reproductive health...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29772732/observing-apod-with-the-auscope-vlbi-array
#4
Andreas Hellerschmied, Lucia McCallum, Jamie McCallum, Jing Sun, Johannes Böhm, Jianfeng Cao
The possibility to observe satellites with the geodetic Very Long Baseline Interferometry (VLBI) technique is vividly discussed in the geodetic community, particularly with regard to future co-location satellite missions. The Chinese APOD-A nano satellite can be considered as a first prototype-suitable for practical observation tests-combining the techniques Satellite Laser Ranging (SLR), Global Navigation Satellite Systems (GNSS) and VLBI on a single platform in a Low Earth Orbit (LEO). Unfortunately, it has hardly been observed by VLBI, so major studies towards actual frame ties could not be performed...
May 16, 2018: Sensors
https://www.readbyqxmd.com/read/29771760/cutaneous-manifestations-of-nutritional-deficiency
#5
Ramrada Lekwuttikarn, Joyce M C Teng
PURPOSE OF REVIEW: Childhood malnutrition is a major global health issue. It is often thought of as a developing world problem and therefore, underdiagnosed or misdiagnosed in developed countries. The delay in diagnosis and treatment can lead to increased morbidity and mortality. Cutaneous manifestations are often the initial presenting signs of nutritional deficiency. Early recognition is essential in timely initiation of the necessary interventions. This article will review pertinent cutaneous findings and systemic manifestations associated with common nutritional deficiencies...
May 15, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29769386/global-acceptance-of-biosimilars-importance-of-regulatory-consistency-education-and-trust
#6
REVIEW
Eduardo Cazap, Ira Jacobs, Ali McBride, Robert Popovian, Karol Sikora
Globally, biosimilars are expected to have a key role in improving patient access to biological therapies and addressing concerns regarding the escalating cost of health care. Indeed, in Europe, increased use of biologics and reduced drug prices have been observed after the introduction of biosimilars. Recently, several monoclonal antibody biosimilars of anticancer therapies have been approved, and numerous others are in various stages of clinical development. Biosimilars are authorized via a regulatory pathway separate from that used for generic drugs; they are also regulated separately from novel biologics...
May 16, 2018: Oncologist
https://www.readbyqxmd.com/read/29767802/sitting-together-and-reaching-to-play-start-play-protocol-for-a-multisite-randomized-controlled-efficacy-trial-on-intervention-for-infants-with-neuromotor-disorders
#7
Regina T Harbourne, Stacey C Dusing, Michele A Lobo, Sarah Westcott-McCoy, James Bovaird, Susan Sheridan, James C Galloway, Hui-Ju Chang, Lin-Ya Hsu, Natalie Koziol, Emily C Marcinowski, Iryna Babik
Background: There is limited research examining the efficacy of early physical therapy on infants with neuromotor dysfunction. In addition, most early motor interventions have not been directly linked to learning, despite the clear association between motor activity and cognition during infancy. Objective: The aim of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to advance global development in infants with motor delays or neuromotor dysfunction...
June 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29765956/transcriptomic-profiling-of-zebrafish-hair-cells-using-ribotag
#8
Maggie S Matern, Alisha Beirl, Yoko Ogawa, Yang Song, Nikhil Paladugu, Katie S Kindt, Ronna Hertzano
The zebrafish inner ear organs and lateral line neuromasts are comprised of a variety of cell types, including mechanosensitive hair cells. Zebrafish hair cells are evolutionarily homologous to mammalian hair cells, and have been particularly useful for studying normal hair cell development and function. However, the relative scarcity of hair cells within these complex organs, as well as the difficulty of fine dissection at early developmental time points, makes hair cell-specific gene expression profiling technically challenging...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29748851/a-platform-for-innovation-and-standards-evaluation-a-case-study-from-the-openmrs-open-source-radiology-information-system
#9
Judy W Gichoya, Marc Kohli, Larry Ivange, Teri S Schmidt, Saptarshi Purkayastha
Open-source development can provide a platform for innovation by seeking feedback from community members as well as providing tools and infrastructure to test new standards. Vendors of proprietary systems may delay adoption of new standards until there are sufficient incentives such as legal mandates or financial incentives to encourage/mandate adoption. Moreover, open-source systems in healthcare have been widely adopted in low- and middle-income countries and can be used to bridge gaps that exist in global health radiology...
May 10, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29735526/defects-in-the-neuroendocrine-axis-contribute-to-global-development-delay-in-a-drosophila-model-of-ngly1-deficiency
#10
Tamy Portillo Rodriguez, Joshua D Mast, Tom Hartl, Tom Lee, Peter Sand, Ethan O Perlstein
N-glycanase 1 (NGLY1) Deficiency is a rare monogenic multi-system disorder first described in 2014. NGLY1 is evolutionarily conserved in model organisms. Here we conducted a natural history study and chemical-modifier screen on the Drosophila melanogaster NGLY1 homolog, Pngl. We generated a new fly model of NGLY1 Deficiency, engineered with a nonsense mutation in Pngl at codon 420 that results in a truncation of the C-terminal carbohydrate-binding PAW domain. Homozygous mutant animals exhibit global development delay, pupal lethality and small body size as adults...
May 7, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29735480/comparative-transcriptomic-response-of-primary-and-immortalized-macrophage-to-murine-norovirus-infection
#11
Eric A Levenson, Craig Martens, Kishore Kanakabandi, Charles V Turner, Kimmo Virtaneva, Monica Paneru, Stacy Ricklefs, Stanislav V Sosnovtsev, Jordan A Johnson, Stephen F Porcella, Kim Y Green
Murine norovirus (NoV) is genetically similar to human NoV and offers both an efficient in vitro cell culture system and an animal model by which to investigate the molecular basis of replication. In this study, we present a detailed global view of host alterations to cellular pathways that occur during the progression of a NoV infection. This was accomplished for both Mus musculus BALB/c-derived RAW264.7 (RAW) cells, an immortalized cell line widely used in in vitro replication studies, and primary bone marrow-derived macrophages (BMDM), representing a permissive in vivo target cell in the host...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29731506/future-perspectives-for-management-of-stage-a-heart-failure
#12
Hidekazu Tanaka
Patients with Stage A heart failure (HF) show no HF symptoms but have related comorbid diseases with a high risk of progressing to HF. Screening for comorbid diseases warrants closer attention because of the growing interest in addressing Stage A HF as the best means of preventing eventual progression to overt HF such as Stages C and D. The identification of individuals of Stage A HF is potentially useful for the implementation of HF-prevention strategies; however, not all Stage A HF patients develop left ventricular (LV) structural heart disease or symptomatic HF, which lead to advanced HF stages...
May 7, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29722846/high-dose-vitamin-d3-in-the-treatment-of-severe-acute-malnutrition-a-multicenter-double-blind-randomized-controlled-trial
#13
Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau
Background: Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency. Objective: The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition. Design: We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6-58 mo with uncomplicated severe acute malnutrition in Pakistan...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29722482/five-year-neurodevelopment-outcomes-of-perinatally-hiv-infected-children-on-early-limited-or-deferred-continuous-antiretroviral-therapy
#14
Barbara Laughton, Morna Cornell, Martin Kidd, Priscilla Estelle Springer, Els Françoise Marie-Thérèse Dobbels, Anita Janse Van Rensburg, Kennedy Otwombe, Abdel Babiker, Diana M Gibb, Avy Violari, Mariana Kruger, Mark Fredric Cotton
INTRODUCTION: Early antiretroviral therapy (ART) has improved neurodevelopmental outcomes of HIV-infected (HIV-positive) children; however, little is known about the longer term outcomes in infants commencing early ART or whether temporary ART interruption might have long-term consequences. In the children with HIV early antiretroviral treatment (CHER) trial, HIV-infected infants ≤12 weeks of age with CD4 ≥25% were randomized to deferred ART (ART-Def); immediate time-limited ART for 40 weeks (ART-40W) or 96 weeks (ART-96W)...
May 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29722445/review-article-the-prevention-of-hepatitis-b-related-hepatocellular-carcinoma
#15
REVIEW
C-L Lin, J-H Kao
BACKGROUND: Ample evidence indicates an aetiological association of persistent hepatitis B virus (HBV) infection with hepatocellular carcinoma (HCC). Several viral, host and external risk factors for the development of HBV-related HCC have been documented. AIMS: To summarise and discuss the risk stratification and the preventive strategies of HBV-related HCC. METHODS: Recent published studies identified from PubMed were comprehensively reviewed...
May 3, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29717677/facilitating-earlier-diagnosis-of-cardiovascular-disease-through-point-of-care-biosensors-a-review
#16
Mackenzie M Honikel, Chi-En Lin, David Probst, Jeffrey T La Belle
Cardiovascular disease (CVD) accounts for 30% of all global deaths and is predicted to dominate in the coming years, despite vast improvements in medical technology. Current clinical methods of assessing an individual's cardiovascular health include blood tests to monitor relevant biomarker levels as well as varying imaging modalities such as electrocardiograms, computed tomography, and angiograms to assess vasculature. As informative as these tools are, they each require lengthy scheduling, preparation, and highly trained personnel to interpret the results before any information is accessible to patients, often leading to delayed treatment, which can be fatal...
2018: Critical Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/29685149/rationale-for-environmental-hygiene-towards-global-protection-of-fetuses-and-young-children-from-adverse-lifestyle-factors
#17
Jean-Pierre Bourguignon, Anne-Simone Parent, Jos C S Kleinjans, Tim S Nawrot, Greet Schoeters, Nicolas Van Larebeke
BACKGROUND: The regulatory management of chemicals and toxicants in the EU addresses hundreds of different chemicals and health hazards individually, one by one. An issue is that, so far, the possible interactions among chemicals or hazards are not considered as such. Another issue is the anticipated delay of several decades before effective protection of public health by regulatory decisions due to a time consuming process. Prenatal and early postnatal life is highly vulnerable to environmental health hazards with lifelong consequences, and a priority period for reduction of exposure...
April 23, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29680829/containing-diffusion-the-tobacco-industry-s-multipronged-trade-strategy-to-block-tobacco-standardised-packaging
#18
Eric Crosbie, Robert Eckford, Stella Bialous
OBJECTIVE: To analyse the tobacco industry's strategy of using trade and investment agreements to prevent the global diffusion of standardised packaging (SP) of tobacco products. METHODS: Review of tobacco industry documents, relevant government documents and media items. The data were triangulated and thematically analysed. RESULTS: Internal tobacco industry documents reveal that during the early 1990s, tobacco companies developed a multipronged trade strategy to prevent the global diffusion of progressive tobacco packaging and labelling proposals, including SP...
April 21, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29672338/effects-of-a-care-coordination-intervention-with-children-with-neurodevelopmental-disabilities-and-their-families
#19
Jeanne W McAllister, Rebecca McNally Keehn, Rylin Rodgers, Philani Brian Mpofu, Patrick O Monahan, Thomas M Lock
: Care coordination is integral to improving the health of children and families. Using a Shared Plan of Care (SPoC) as a care coordination activity is recommended, but related research on outcomes in pediatric populations with complex medical conditions is scarce. OBJECTIVE: This study explores family outcomes associated with implementation of a care coordination/SPoC intervention with a population of children with neurodevelopmental disabilities and their families. METHODS: Children aged 2 to 10 years with a neurodevelopmental disability (autism spectrum disorder: 60...
April 17, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29669027/clinic-satisfaction-tool-improves-communication-and-provides-real-time-feedback
#20
Rasheedat T Zakare-Fagbamila, Elizabeth Howell, Ashley Y Choi, Tracy Z Cheng, Mary Clement, Megan Neely, Oren N Gottfried
BACKGROUND: Patient-reported assessments of the clinic experience are increasingly important for improving the delivery of care. The Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CG-CAHPS) survey is the current standard for evaluating patients' clinic experience, but its format gives 2-mo delayed feedback on a small proportion of patients in clinic. Furthermore, it fails to give specific actionable results on individual encounters. OBJECTIVE: To develop and assess the impact of a single-page Clinic Satisfaction Tool (CST) to demonstrate real-time feedback, individualized responses, interpretable and actionable feedback, improved patient satisfaction and communication scores, increased physician buy-in, and overall feasibility...
April 14, 2018: Neurosurgery
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