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https://www.readbyqxmd.com/read/28804246/the-role-of-functional-social-and-mobility-dynamics-in-facilitating-older-african-americans-participation-in-clinical-research
#1
Eve T Shapiro, Jay T Schamel, Kimberly A Parker, Laura A Randall, Paula M Frew
PURPOSE: Older African Americans experience disproportionately higher incidence of morbidity and mortality related to chronic and infectious diseases, yet are significantly underrepresented in clinical research compared to other racial and ethnic groups. This study aimed to understand the extent to which social support, transportation access, and physical impediments function as barriers or facilitators to clinical trial recruitment of older African Americans. METHODS: Participants (N=221) were recruited from six African American churches in Atlanta and surveyed on various influences on clinical trial participation...
2017: Open Access Journal of Clinical Trials
https://www.readbyqxmd.com/read/28764783/preferences-and-motivation-for-weight-loss-among-knee-replacement-patients-implications-for-a-patient-centered-weight-loss-intervention
#2
Christine A Pellegrini, Gwendolyn Ledford, Sara A Hoffman, Rowland W Chang, Kenzie A Cameron
BACKGROUND: Most knee replacement patients are overweight/obese, yet are commonly excluded from evidence-based weight loss programs due to mobility limitations and barriers faced around the time of surgery. The purpose of this study was to identify knee replacement patient preferences for weight loss programs and qualitatively understand previous motives for weight loss attempts as well as strategies used to facilitate behavior changes. METHODS: Patients who were either scheduled to have knee replacement or had one recently completed within the last 3 months were recruited to participate...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28751487/ability-to-join-the-workforce-and-work-productivity-among-drug-users-under-methadone-maintenance-treatment-in-a-mountainous-area-of-northern-vietnam-a-cross-sectional-study
#3
Vuong Minh Nong, Victoria L Boggiano, Lan Huong Thi Nguyen, Cuong Tat Nguyen, Long Hoang Nguyen, Tran Xuan Bach, Hung Van Nguyen, Canh Dinh Hoang, Carl A Latkin, Minh Thuc Thi Vu
OBJECTIVES: A major measure of treatment success for drug users undergoing rehabilitation is the ability to enter the workforce and generate income. This study examines the absenteeism and productivity among people who inject drugs (PWID) enrolled in methadone maintenance treatment (MMT) in Northern Vietnam. SETTING: We conducted a cross-sectional study in two clinics in Tuyen Quang province. PARTICIPANTS: A total of 241 patients enrolled in MMT...
July 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28715728/mobile-phone-use-during-driving-effects-on-speed-and-effectiveness-of-driver-compensatory-behaviour
#4
Pushpa Choudhary, Nagendra R Velaga
This study analysed and modelled the effects of conversation and texting (each with two difficulty levels) on driving performance of Indian drivers in terms of their mean speed and accident avoiding abilities; and further explored the relationship between speed reduction strategy of the drivers and their corresponding accident frequency. 100 drivers of three different age groups (young, mid-age and old-age) participated in the simulator study. Two sudden events of Indian context: unexpected crossing of pedestrians and joining of parked vehicles from road side, were simulated for estimating the accident probabilities...
July 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28454866/how-do-older-adult-drivers-self-regulate-characteristics-of-self-regulation-classes-defined-by-latent-class-analysis
#5
Gwen Bergen, Bethany A West, Feijun Luo, Donna C Bird, Katherine Freund, Richard H Fortinsky, Loren Staplin
PROBLEM: Motor-vehicle crashes were the second leading cause of injury death for adults aged 65-84years in 2014. Some older drivers choose to self-regulate their driving to maintain mobility while reducing driving risk, yet the process remains poorly understood. METHODS: Data from 729 older adults (aged ≥60years) who joined an older adult ride service program between April 1, 2010 and November 8, 2013 were analyzed to define and describe classes of driving self-regulation...
June 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28390758/alternative-distraction-osteogenesis-technique-after-implant-placement-for-alveolar-ridge-augmentation-of-the-maxilla
#6
Renato Luiz Maia Nogueira, Rafael Lima Verde Osterne, Ricardo Teixeira Abreu, Phelype Maia Araújo
An alternative technique to reconstruct atrophic alveolar vertical bone after implant placement is presented. The technique consists of distraction osteogenesis or direct surgical repositioning of an implant-and-bone block segment after segmental osteotomies that can be used in esthetic or unesthetic cases. Initially, casts indicating the implant position are obtained and the future ideal prosthetic position is determined to guide the model surgery. After the model surgery, a new provisional prosthesis is fabricated, and an occlusal splint, which is used as a surgical guide and a device for distraction osteogenesis, is custom fabricated...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28353678/assessment-of-lipophilicity-indices-derived-from-retention-behavior-of-antioxidant-compounds-in-rp-hplc
#7
Ioana Anamaria Sima, Agata Kot-Wasik, Andrzej Wasik, Jacek Namieśnik, Costel Sârbu
Reverse phase high pressure liquid chromatography was employed in order to evaluate the lipophilicity of antioxidant compounds from different classes, such as phenolic acids, flavanones, flavanols, flavones, anthocyanins, stilbenes, xantonoids, and proanthocyanidins. The retention time of each compound was measured using five different HPLC columns: RP18 (LiChroCART, Purosphere RP-18e), C8 (Zorbax, Eclipse XDBC8), C16-Amide (Discovery RP-Amide C16), CN100 (Saulentechnik, Lichrosphere), and pentafluorophenyl (Phenomenex, Kinetex PFP), and the mobile phase consisted of methanol and water (0...
March 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28336179/control-of-dna-end-resection-by-yeast-hmo1p-affects-efficiency-of-dna-end-joining
#8
Arvind Panday, LiJuan Xiao, Ashish Gupta, Anne Grove
The primary pathways for DNA double strand break (DSB) repair are homologous recombination (HR) and non-homologous end-joining (NHEJ). The choice between HR and NHEJ is influenced by the extent of DNA end resection, as extensive resection is required for HR but repressive to NHEJ. Conversely, association of the DNA end-binding protein Ku, which is integral to classical NHEJ, inhibits resection. In absence of key NHEJ components, a third repair pathway is exposed; this alternative-end joining (A-EJ) is a highly error-prone process that uses micro-homologies at the breakpoints and is initiated by DNA end resection...
May 2017: DNA Repair
https://www.readbyqxmd.com/read/28331090/hili-inhibits-hiv-replication-in-activated-t-cells
#9
B Matija Peterlin, Pingyang Liu, Xiaoyun Wang, Daniele Cary, Wei Shao, Marie Leoz, Tian Hong, Tao Pan, Koh Fujinaga
P-element-induced wimpy-like (Piwil) proteins restrict the replication of mobile genetic elements in the germ line. They are also expressed in many transformed cell lines. In this study, we discovered that the human Piwil 2 (Hili) protein can also inhibit HIV replication, especially in activated CD4(+) T cells that are the preferred target cells for this virus in the infected host. Although resting cells did not express Hili, its expression was rapidly induced following T cell activation. In these cells and transformed cell lines, depletion of Hili increased levels of viral proteins and new viral particles...
June 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28299163/youth-awareness-on-sexually-transmitted-infections-hiv-and-aids-in-secondary-schools-in-the-dschang-municipality-cameroon-the-mobile-caravan-project
#10
Martin Sanou Sobze, Armand Tsapi Tiotsia, Ghyslaine Bruna Djeunang Dongho, Guy Aurelien Foaleng Tankui, Joseph Fokam, Kien-Atsu Tsi, Jimmy Roger Fotso, Yannick Ngueko Azeufack, Patrick Pete Nkamedjie, Adogaye Ben Bechir Sali, Rodrigue Biguioh Mabvouna, Lucia Ercoli, Vittorio Colizzi, Gianluca Russo
Awareness is a preventive action to instill in individuals certain concepts to improve their health. It is an essential element in the prevention of sexually transmitted infection (STI)/HIV and early pregnancies among adolescents. In 2012, the prevalence of HIVin Cameroon was estimated at 4.3%. The young population appear to be the most affected (3.2%); very close to that of the Dschang Health District (Cameroon; 3.1%) in the 15-19 years age group. Theaimof this study was to evaluate the contribution of the Mobile Caravan project on the preventive aspect of STI/HIV/AIDS among youths of Dschang in 10 secondary schools within three years...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28269616/cluster-based-architecture-and-network-maintenance-protocol-for-medical-priority-aware-cognitive-radio-based-hospital
#11
Ishtiak Al Mamoon, A K M Muzahidul Islam, Sabariah Baharun, Ashir Ahmed, Shozo Komaki
Due to the rapid growth of wireless medical devices in near future, wireless healthcare services may face some inescapable issue such as medical spectrum scarcity, electromagnetic interference (EMI), bandwidth constraint, security and finally medical data communication model. To mitigate these issues, cognitive radio (CR) or opportunistic radio network enabled wireless technology is suitable for the upcoming wireless healthcare system. The up-to-date research on CR based healthcare has exposed some developments on EMI and spectrum problems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28249429/subdiffusion-absorption-process-in-a-system-consisting-of-two-different-media
#12
Tadeusz Kosztołowicz
Subdiffusion with reaction A+B→B is considered in a system which consists of two homogeneous media joined together; the A particles are mobile, whereas B are static. Subdiffusion and reaction parameters, which are assumed to be independent of time and space variables, can be different in both media. Particles A move freely across the border between the media. In each part of the system, the process is described by the subdiffusion-reaction equations with fractional time derivative. By means of the method presented in this paper, we derive both the fundamental solutions (the Green's functions) P(x, t) to the subdiffusion-reaction equations and the boundary conditions at the border between the media...
February 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28227874/cluster-based-architecture-and-network-maintenance-protocol-for-medical-priority-aware-cognitive-radio-based-hospital
#13
Ishtiak Al Mamoon, A K M Muzahidul Islam, Sabariah Baharun, Ashir Ahmed, Shozo Komaki, Ishtiak Al Mamoon, A K M Muzahidul Islam, Sabariah Baharun, Ashir Ahmed, Shozo Komaki, Ishtiak Al Mamoon, Shozo Komaki, Ashir Ahmed, A K M Muzahidul Islam, Sabariah Baharun
Due to the rapid growth of wireless medical devices in near future, wireless healthcare services may face some inescapable issue such as medical spectrum scarcity, electromagnetic interference (EMI), bandwidth constraint, security and finally medical data communication model. To mitigate these issues, cognitive radio (CR) or opportunistic radio network enabled wireless technology is suitable for the upcoming wireless healthcare system. The up-to-date research on CR based healthcare has exposed some developments on EMI and spectrum problems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28208769/localisation-microscopy-of-breast-epithelial-erbb-2-receptors-and-gap-junctions-trafficking-after-%C3%AE-irradiation-neuregulin-1%C3%AE-and-trastuzumab-application
#14
Götz Pilarczyk, Ines Nesnidal, Manuel Gunkel, Margund Bach, Felix Bestvater, Michael Hausmann
In cancer, vulnerable breast epithelium malignance tendency correlates with number and activation of ErbB receptor tyrosine kinases. In the presented work, we observe ErbB receptors activated by irradiation-induced DNA injury or neuregulin- 1 β application, or alternatively, attenuated by a therapeutic antibody using high resolution fluorescence localization microscopy. The gap junction turnover coinciding with ErbB receptor activation and co-transport is simultaneously recorded. DNA injury caused by 4 Gray of 6 MeV photon γ -irradiation or alternatively neuregulin- 1 β application mobilized ErbB receptors in a nucleograde fashion-a process attenuated by trastuzumab antibody application...
February 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28197216/introducing-the-comprehensive-unit-based-safety-program-for-mechanically-ventilated-patients-in-saudi-arabian-intensive-care-units
#15
Raymond M Khan, Maha Aljuaid, Hanan Aqeel, Mohammed M Aboudeif, Shaimaa Elatwey, Rajeh Shehab, Yasser Mandourah, Khalid Maghrabi, Hassan Hawa, Imran Khalid, Ismael Qushmaq, Asad Latif, Bickey Chang, Sean M Berenholtz, Sultan Tayar, Khloud Al-Harbi, Amin Yousef, Anas A Amr, Yaseen M Arabi
Over the past decade, there have been major improvements to the care of mechanically ventilated patients (MVPs). Earlier initiatives used the concept of ventilator care bundles (sets of interventions), with a primary focus on reducing ventilator-associated pneumonia. However, recent evidence has led to a more comprehensive approach: The ABCDE bundle (Awakening and Breathing trial Coordination, Delirium management and Early mobilization). The approach of the Comprehensive Unit-based Safety Program (CUSP) was developed by patient safety researchers at the Johns Hopkins Hospital and is supported by the Agency for Healthcare Research and Quality to improve local safety cultures and to learn from defects by utilizing a validated structured framework...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28179216/navigating-ethics-in-the-digital-age-introducing-connected-and-open-research-ethics-core-a-tool-for-researchers-and-institutional-review-boards
#16
John Torous, Camille Nebeker
Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate...
February 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28111875/black-phosphorus-rediscovered-from-bulk-material-to-monolayers
#17
REVIEW
Rui Gusmão, Zdenek Sofer, Martin Pumera
Phosphorus is a nonmetal with several allotropes, from the highly reactive white phosphorus to the thermodynamically stable black phosphorus (BP) with a puckered orthorhombic layered structure. The bulk form of BP was first synthesized in 1914, but received little attention until it was rediscovered in 2014 as a member of the new wave of 2D layered nanomaterials. BP can be exfoliated to a single sheet that acts as a semiconductor with a tunable direct band gap, a high carrier mobility at room temperature, and an in-plane anisotropy...
January 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28096446/rpn-yhga-like-proteins-of-escherichia-coli-k-12-and-their-contribution-to-reca-independent-horizontal-transfer
#18
Anthony W Kingston, Christine Ponkratz, Elisabeth A Raleigh
Bacteria use a variety of DNA-mobilizing enzymes to facilitate environmental niche adaptation via horizontal gene transfer. This has led to real-world problems, like the spread of antibiotic resistance, yet many mobilization proteins remain undefined. In the study described here, we investigated the uncharacterized family of YhgA-like transposase_31 (Pfam PF04754) proteins. Our primary focus was the genetic and biochemical properties of the five Escherichia coli K-12 members of this family, which we designate RpnA to RpnE, where Rpn represents recombination-promoting nuclease...
April 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/27973626/electrokinetic-flows-in-liquid-crystal-thin-films-with-fixed-anchoring
#19
Christopher Conklin, Jorge Viñals
We study ionic and mass transport in a liquid crystalline fluid film in its nematic phase under an applied electrostatic field. Both analytic and numerical solutions are given for some prototypical configurations of interest in electrokinetics: thin films with spatially nonuniform nematic director that are either periodic or comprise a set of isolated disclinations. We present a quantitative description of the mechanisms inducing spatial charge separation in the nematic, and of the structure and magnitude of the resulting flows...
December 14, 2016: Soft Matter
https://www.readbyqxmd.com/read/27919379/understanding-latent-structures-of-clinical-information-logistics-a-bottom-up-approach-for-model-building-and-validating-the-workflow-composite-score
#20
Moritz Esdar, Ursula Hübner, Jan-David Liebe, Jens Hüsers, Johannes Thye
BACKGROUND AND PURPOSE: Clinical information logistics is a construct that aims to describe and explain various phenomena of information provision to drive clinical processes. It can be measured by the workflow composite score, an aggregated indicator of the degree of IT support in clinical processes. This study primarily aimed to investigate the yet unknown empirical patterns constituting this construct. The second goal was to derive a data-driven weighting scheme for the constituents of the workflow composite score and to contrast this scheme with a literature based, top-down procedure...
January 2017: International Journal of Medical Informatics
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