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JOURNAL ARTICLE
Sara Ruiz-Rubio, Irene Ortiz-Leal, Mateo V Torres, Aitor Somoano, Pablo Sanchez-Quinteiro
The fossorial water vole, Arvicola scherman, is an herbivorous rodent that causes significant agricultural damages. The application of cairomones and alarm pheromones emerges as a promising sustainable method to improve its integrated management. These chemical signals would induce stress responses that could interfere with the species regular reproductive cycles and induce aversive reactions, steering them away from farmlands and meadows. However, there is a paucity of information regarding the water vole vomeronasal system, both in its morphological foundations and its functionality, making it imperative to understand the same for the application of chemical communication in pest control...
December 19, 2023: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
#22
JOURNAL ARTICLE
Oksana Cohen, Anat Kahan, Idan Steinberg, Sebastian Malinowski, Dan Rokni, Marc Spehr, Yoram Ben-Shaul
Social communication is crucial for survival of many species. In most vertebrates, a dedicated chemosensory system, the vomeronasal system (VNS), evolved to process ethologically relevant chemosensory cues. The first central processing stage of the VNS is the accessory olfactory bulb (AOB), which sends information to downstream brain regions via AOB mitral cells (AMCs). Recent studies provided important insights about the functional properties of AMCs, but little is known about the principles that govern their coordinated activity...
October 27, 2023: Journal of Neuroscience
#23
JOURNAL ARTICLE
Shoko Nakamuta, Hideki Noda, Hideaki Kato, Takuya Yokoyama, Yoshio Yamamoto, Nobuaki Nakamuta
Many tetrapod vertebrates have two distinct olfactory organs, the olfactory epithelium (OE) and vomeronasal organ (VNO). In turtles, the olfactory organ consists of two types of sensory epithelia, the upper chamber epithelium (UCE; corresponding to the OE) and the lower chamber epithelium (LCE; corresponding to the VNO). In many turtle species, the UCE contains ciliated olfactory receptor cells (ORCs) and the LCE contains microvillous ORCs. To date, several transcription factors involved in the development of the OE and VNO have been identified in mammals...
November 2023: Journal of Morphology
#24
JOURNAL ARTICLE
Nandkishore Prakash, Heidi Y Matos, Sonia Sebaoui, Luke Tsai, Tuyen Tran, Adejimi Aromolaran, Isabella Atrachji, Nya Campbell, Meredith Goodrich, David Hernandez-Pineda, Maria Jesus Herrero, Tsutomu Hirata, Julieta Lischinsky, Wendolin Martinez, Shisui Torii, Satoshi Yamashita, Hassan Hosseini, Katie Sokolowski, Shigeyuki Esumi, Yuka Imamura Kawasawa, Kazue Hashimoto-Torii, Kevin S Jones, Joshua G Corbin
In terrestrial vertebrates, the olfactory system is divided into main (MOS) and accessory (AOS) components that process both volatile and nonvolatile cues to generate appropriate behavioral responses. While much is known regarding the molecular diversity of neurons that comprise the MOS, less is known about the AOS. Here, focusing on the vomeronasal organ (VNO), the accessory olfactory bulb (AOB), and the medial amygdala (MeA), we reveal that populations of neurons in the AOS can be molecularly subdivided based on their ongoing or prior expression of the transcription factors Foxp2 or Dbx1, which delineate separate populations of GABAergic output neurons in the MeA...
October 17, 2023: Journal of Comparative Neurology
#25
Quynh Anh Thi Nguyen, Andrea Rocha, Yuna Yamashita, Ricky Chhor, Christian Stadler, Crystal Pontrello, Sachiko Haga-Yamanaka
Animals have the innate ability to select optimal defensive behavioral outputs with an appropriate intensity in response to predator threat in specific contexts. Such innate behavioral decisions are thought to be computed in the medial hypothalamic nuclei that contain neural populations directly controlling defensive behavioral outputs. The vomeronasal organ (VNO) is one of the major sensory input channels through which predator cues are detected with ascending inputs to the medial hypothalamic nuclei, especially to the ventromedial hypothalamus (VMH)...
September 29, 2023: bioRxiv
#26
JOURNAL ARTICLE
Florent Sauve, Sreekala Nampoothiri, Sophie A Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dewisme, Edouard G Mills, Gaetan Ternier, Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereño-Orbea, Maria Mercado-Gómez, Asis Palazon, Virginie Mattot, Florence Pasquier, Sophie Catteau-Jonard, Maria Martinez-Chantar, Erik Hrabovszky, Mercé Jourdain, Dominique Deplanque, Annamaria Morelli, Giulia Guarnieri, Laurent Storme, Cyril Robil, François Trottein, Ruben Nogueiras, Markus Schwaninger, Pascal Pigny, Julien Poissy, Konstantina Chachlaki, Claude-Alain Maurage, Paolo Giacobini, Waljit Dhillo, S Rasika, Vincent Prevot
BACKGROUND: We have recently demonstrated a causal link between loss of gonadotropin-releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive deficits during pathological aging, including Down syndrome and Alzheimer's disease. Olfactory and cognitive alterations, which persist in some COVID-19 patients, and long-term hypotestosteronaemia in SARS-CoV-2-infected men are also reminiscent of the consequences of deficient GnRH, suggesting that GnRH system neuroinvasion could underlie certain post-COVID symptoms and thus lead to accelerated or exacerbated cognitive decline...
September 13, 2023: EBioMedicine
#27
JOURNAL ARTICLE
Kévin Poissenot, Anne-Charlotte Trouillet, Elliott Trives, Chantal Moussu, Didier Chesneau, Maxime Meunier, Virginie Lattard, Areski Chorfa, Fabrice Saez, Joël Drevet, Chrystelle Le Danvic, Patricia Nagnan-Le Meillour, Pablo Chamero, Matthieu Keller
In mammals, especially rodents, social behaviours, such as parenting, territoriality or mate attraction, are largely based on olfactory communication through chemosignals. These behaviours are mediated by species-specific chemosignals, including small organic molecules and proteins that are secreted in the urine or in various fluids from exocrine glands. Chemosignal detection is mainly ensured by olfactory neurons in two specific sensory organs, the vomeronasal organ (VNO) and the main olfactory epithelium (MOE)...
September 10, 2023: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
#28
JOURNAL ARTICLE
Navin K Ojha, Frank Zufall, Trese Leinders-Zufall
The transient receptor potential canonical (TRPC) ion channels play important biological roles, but their activation mechanisms are incompletely understood. Here, we describe recent methodological advances using small molecular probes designed for photopharmacology of TRPC channels by focusing on results obtained from the mouse olfactory system. These studies developed and used photoswitchable diacylglycerol (DAG) analogs for ultrarapid activation of native TRPC2 channels in vomeronasal sensory neurons and type B cells of the main olfactory epithelium...
2023: Methods in Molecular Biology
#29
JOURNAL ARTICLE
Alyssa J J Paganoni, Rossella Cannarella, Roberto Oleari, Federica Amoruso, Renata Antal, Marco Ruzza, Chiara Olivieri, Rosita A Condorelli, Sandro La Vignera, Fationa Tolaj, Anna Cariboni, Aldo E Calogero, Paolo Magni
Gonadotropin-releasing hormone (GnRH) neurons are key neuroendocrine cells in the brain as they control reproduction by regulating hypothalamic-pituitary-gonadal axis function. In this context, anti-Müllerian hormone (AMH), growth hormone (GH), and insulin-like growth factor 1 (IGF1) were shown to improve GnRH neuron migration and function in vitro. Whether AMH, GH, and IGF1 signaling pathways participate in the development and function of GnRH neurons in vivo is, however, currently still unknown. To assess the role of AMH, GH, and IGF1 systems in the development of GnRH neuron, we evaluated the expression of AMH receptors (AMHR2), GH (GHR), and IGF1 (IGF1R) on sections of ex vivo mice at different development stages...
August 22, 2023: International Journal of Molecular Sciences
#30
JOURNAL ARTICLE
Shoko Nakamuta, Atsuhiro Sakuma, Masato Nikaido, Hideaki Kato, Masao Miyazaki, Yoshio Yamamoto, Nobuaki Nakamuta
The vomeronasal organ is an olfactory organ found in amphibians and higher vertebrates. Type 1 vomeronasal receptors, one of the major olfactory receptors in vertebrates, are expressed in the vomeronasal organ in mammals. In amphibians and fish, they are expressed in the olfactory epithelium. The lungfish, which is the species of fish most closely related to amphibians, has a primitive vomeronasal organ: the recess epithelium. Expression of type 1 vomeronasal receptors has been reported in both the olfactory epithelium and the recess epithelium in three species of African lungfish and one species of South American lungfish...
August 2, 2023: Acta Histochemica
#31
JOURNAL ARTICLE
Laurel R Yohe, Nicholas T Krell
The extensive diversity observed in bat nasal chemosensory systems has been well-documented at the histological level. Understanding how this diversity evolved and developing hypotheses as to why particular patterns exist require a phylogenetic perspective, which was first outlined in the work of anatomist Kunwar Bhatnagar. With the onset of genetics and genomics, it might be assumed that the puzzling patterns observed in the morphological data have been clarified. However, there is still a widespread mismatch of genetic and morphological correlations among bat chemosensory systems...
July 31, 2023: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
#32
JOURNAL ARTICLE
Daniel R Pfau, Sarah Baribeau, Felix Brown, Niki Khetarpal, S Marc Breedlove, Cynthia L Jordan
The transient receptor potential cation channel 2 (TRPC2) conveys pheromonal information from the vomeronasal organ (VNO) to the brain. Both male and female mice lacking this gene show altered sex-typical behavior as adults. We asked whether TRPC2, highly expressed in the VNO, normally participates in the development of VNO-recipient brain regions controlling mounting and aggression, two behaviors affected by TRPC2 loss. We now report significant effects of TRPC2 loss in both the posterodorsal aspect of the medial amygdala (MePD) and ventromedial nucleus of the hypothalamus (VMH) of male and female mice...
July 27, 2023: Journal of Comparative Neurology
#33
JOURNAL ARTICLE
Mateo V Torres, Irene Ortiz-Leal, Andrea Ferreiro, José Luis Rois, Pablo Sanchez-Quinteiro
Dama gazelle is a threatened and rarely studied species found primarily in northern Africa. Human pressure has depleted the dama gazelle population from tens of thousands to a few hundred individuals. Since 1970, a founder population consisting of the last 17 surviving individuals in Western Sahara has been maintained in captivity, reproducing naturally. In preparation for the future implementation of assisted reproductive technology, certain aspects of dama gazelle reproductive biology have been established...
July 26, 2023: Microscopy Research and Technique
#34
JOURNAL ARTICLE
Wenqian Xie, Meiqi Chen, Yuyao Shen, Yuning Liu, Haolin Zhang, Qiang Weng
In numerous animals, one essential chemosensory organ that detects chemical signals is the vomeronasal organ (VNO), which is involved in species-specific behaviors, including social and sexual behaviors. The purpose of this study is to investigate the mechanism underlying the processing of chemosensory cues in semi-aquatic mammals using muskrats as the animal model. Muskrat ( Ondatra zibethicus ) has a sensitive VNO system that activates seasonal breeding behaviors through receiving specific substances, including pheromones and hormones...
June 27, 2023: International Journal of Molecular Sciences
#35
JOURNAL ARTICLE
Jan Weiss, Hélène Vacher, Anne-Charlotte Trouillet, Trese Leinders-Zufall, Frank Zufall, Pablo Chamero
BACKGROUND: Rodents utilize chemical cues to recognize and avoid other conspecifics infected with pathogens. Infection with pathogens and acute inflammation alter the repertoire and signature of olfactory stimuli emitted by a sick individual. These cues are recognized by healthy conspecifics via the vomeronasal or accessory olfactory system, triggering an innate form of avoidance behavior. However, the molecular identity of the sensory neurons and the higher neural circuits involved in the detection of sick conspecifics remain poorly understood...
July 10, 2023: BMC Biology
#36
JOURNAL ARTICLE
Violaine Mechin, Patrick Pageat, Marion Boutry, Eva Teruel, Céline Portalier, Pietro Asproni
Chemical communication in mammals is ensured by exchanging chemical signals through the vomeronasal organ (VNO) and its ability to detect pheromones. The alteration of this organ has been proven to impact animal life, participating in the onset of aggressive behaviors in social groups. To date, few studies have highlighted the possible causes leading to these alterations, and the farming environment has not been investigated, even though irritant substances such as ammonia are known to induce serious damage in the respiratory tract...
June 7, 2023: Animals: An Open Access Journal From MDPI
#37
JOURNAL ARTICLE
Shoko Nakamuta, Masanori Mori, Miho Ito, Masanori Kurita, Masao Miyazaki, Yoshio Yamamoto, Nobuaki Nakamuta
The olfactory organ of turtles consists of an upper chamber epithelium (UCE) with associated glands, and a lower chamber epithelium (LCE) devoid of glands. The UCE and LCE are referred to as the air-nose and the water-nose, respectively, because the UCE is thought to detect airborne odorants, while the LCE detects waterborne odorants. However, it is not clear how the two are used in the olfactory organ. Odorant receptors (ORs) are the major olfactory receptors in turtles; they are classified as class I and II ORs, distinguished by their primary structure...
June 2, 2023: Cell and Tissue Research
#38
JOURNAL ARTICLE
Adrián Portalés, Pablo Chamero, Sandra Jurado
Normal aging and many age-related disorders such as Alzheimer's disease cause deficits in olfaction; however, it is currently unknown how natural and pathological aging impacts the detection of social odors which might contribute to the impoverishment of social behavior at old age further worsening overall health. Analysis of the vomeronasal organ, the main gateway to pheromone-encoded information, indicated that natural and pathological aging distinctively affects the neurogenic ability of the vomeronasal sensory epithelium...
May 2, 2023: Molecular Neurobiology
#39
JOURNAL ARTICLE
Frédéric Causeret, Maxime Fayon, Matthieu X Moreau, Enrico Ne, Roberto Oleari, Carlos Parras, Anna Cariboni, Alessandra Pierani
In vertebrates, the embryonic olfactory epithelium contains progenitors that will give rise to distinct classes of neurons, including olfactory sensory neurons (OSNs; involved in odor detection), vomeronasal sensory neurons (VSNs; responsible for pheromone sensing), and gonadotropin-releasing hormone (GnRH) neurons that control the hypothalamic-pituitary-gonadal axis. Currently, these three neuronal lineages are usually believed to emerge from uniform pools of progenitors. Here, we found that the homeodomain transcription factor Dbx1 is expressed by neurogenic progenitors in the developing and adult mouse olfactory epithelium...
May 1, 2023: Journal of Comparative Neurology
#40
JOURNAL ARTICLE
Mao Kobayashi-Sakashita, Yasushi Kiyokawa, Yukari Takeuchi
In rats, a mixture of hexanal and 4-methylpentanal is a main component of the alarm pheromone. When detected by the main olfactory system (MOS) and the vomeronasal system, respectively, they activate the anterior part of the bed nucleus of the stria terminalis (BNSTa). Therefore, the information from the two olfactory systems is expected to be integrated before being transmitted to the BNSTa. To specify the integration site, we examined Fos expression in 16 brain regions in response to water (n = 10), hexanal (n = 9), 4-methylpentanal (n = 9), the mixture (n = 9), or the alarm pheromone (n = 9) in male rats...
April 28, 2023: Neuroscience
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