keyword
https://read.qxmd.com/read/38475849/advancing-the-national-immunization-program-in-an-era-of-achieving-universal-vaccine-coverage-in-china-and-beyond
#1
EDITORIAL
Shu Chen, Lance E Rodewald, Anna Heng Du, Shenglan Tang
BACKGROUND: Immunization is a cornerstone of public health. Despite great success, China's National Immunization Program (NIP) faces challenges, such as the integration of several World Health Organization-recommended vaccines and other systemic issues. The Innovation Laboratory for Vaccine Delivery Research (VaxLab), supported by the Bill & Melinda Gates Foundation and established in 2021 at Duke Kunshan University, focuses on enhancing China's NIP through research and policy advocacy...
March 13, 2024: Infectious Diseases of Poverty
https://read.qxmd.com/read/38471664/prevention-and-treatment-of-hpv-related-cancer-through-a-mrna-vaccine-expressing-apc-targeting-antigen
#2
JOURNAL ARTICLE
Xiaoxuan Li, Huiyan Wang, Wujiang Lai, Jinrong Liao, Wenyu Mo, Keke Huang, Liqing He, Xiaomei Liang, Zhibin Yu, Jiang Xu, Xianwu Hua, Fujun Hou, Jun Ding, William Wei-Guo Jia, Kuan Zhang, Yifeng Wang
Persistent human papillomavirus (HPV) infection is associated with multiple malignancies. Developing therapeutic vaccines to eliminate HPV-infected and malignant cells holds significant value. In this study, we introduced a lipid nanoparticle encapsulated mRNA vaccine expressing tHA-mE7-mE6. Mutations were introduced into E6 and E7 of HPV to eliminate their tumourigenicity. A truncated influenza haemagglutinin protein (tHA), which binds to the CD209 receptor on the surface of dendritic cells (DCs), was fused with mE7-mE6 in order to allow efficient uptake of antigen by antigen presenting cells...
March 12, 2024: Immunology
https://read.qxmd.com/read/38462683/advancements-in-mrna-vaccines-a-promising-approach-for-combating-human-papillomavirus-related-cancers
#3
EDITORIAL
Laraib Iqbal, Minal Jehan, Sumran Azam
The human papillomavirus (HPV) is a typical sexually transmitted disease that affects different epithelial cells and can cause a number of health problems. HPV is mainly spread through sexual contact and is extremely contagious, even in the absence of obvious symptoms. It is linked to a number of malignancies, such as oropharyngeal, cervical, anal, vulvar, vaginal, and cutaneous as well as anogenital and cutaneous warts. Different vaccines targeting various HPV virus strains have been produced to prevent HPV infections...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38459177/awareness-knowledge-and-attitudes-of-human-papillomavirus-infection-screening-and-vaccination-a-survey-study-in-greece
#4
JOURNAL ARTICLE
Vasilios Pergialiotis, Dimitrios Papageorgiou, Athanasios Douligeris, Anastasia Mortaki, Dimitrios Efthymios Vlachos, Nikolaos Thomakos, Alexandros Rodolakis, Dimitrios Haidopoulos
PURPOSE: To evaluate the awareness and existing knowledge of a portion of the Greek population about prevention, screening, and HPV vaccination. METHODS: A questionnaire designed in Google forms has been distributed through social media between June 2021 and December 2021 in men and women aged > 16 years old. Statistical analysis was performed using the SPSS 20.0 program. Inferential analysis was performed to evaluate differences in responses among men and women...
March 8, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38453661/a-systematic-review-of-the-treatment-of-active-anogenital-warts-with-human-papillomavirus-vaccines
#5
REVIEW
Samuel E Villemure, Kyle John Wilby
BACKGROUND: Anogenital warts (AGWs) caused by the human papillomavirus (HPV) are a common manifestation of HPV infection. Treatment strategies generally include topical therapies to promote wart regression or removal through surgical or other means. These strategies are effective but are associated with high rates of recurrence. HPV vaccines are known to be effective for prevention of AGWs yet preliminary data suggest they may offer therapeutic benefit for regression of active AGWs. OBJECTIVES: This study aimed to determine the efficacy of HPV vaccines for treatment of active AGWs...
2024: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/38431444/safety-and-immunogenicity-of-innovax-bivalent-human-papillomavirus-vaccine-in-girls-9-14%C3%A2-years-of-age-interim-analysis-from-a-phase-3-clinical-trial
#6
JOURNAL ARTICLE
Khalequ Zaman, Anne E Schuind, Samuel Adjei, Kalpana Antony, John J Aponte, Patrick By Buabeng, Firdausi Qadri, Troy J Kemp, Lokman Hossain, Ligia A Pinto, Kristen Sukraw, Niranjan Bhat, Tsiri Agbenyega
BACKGROUND: World Health Organization human papillomavirus (HPV) vaccination recommendations include a single- or two-dose schedule in individuals 9-20 years old and advice for generating data on single-dose efficacy or immunobridging. The ongoing Phase 3 trial of Innovax's bivalent (types 16 and 18) HPV vaccine (Cecolin®) assesses in low- and middle-income countries alternative dosing schedules and generates data following one dose in girls 9-14 years old. Interim data for the 6-month dosing groups are presented...
March 1, 2024: Vaccine
https://read.qxmd.com/read/38429618/efficacy-of-behavioral-economic-nudges-to-assist-teen-mothers-the-healthy-adolescent-transitions-randomized-controlled-trial
#7
JOURNAL ARTICLE
Jack Stevens, Joseph Rausch, Ngozi Osuagwu, Robyn Lutz
Communities may often lack the resources to deliver intensive programs to assist teen mothers, and many eligible adolescents may decline participation in lengthy interventions. Therefore, alternative approaches involving less resource and time may be needed. Behavioral economics (BE) can inform the development of such novel interventions. BE often feature low-intensity approaches designed to "nudge" people to help them reach their long-term goals. Nudges can include giving reminders, making the desired behavior more convenient, and optimizing the verbal presentation of recommended options...
March 2, 2024: Prevention Science: the Official Journal of the Society for Prevention Research
https://read.qxmd.com/read/38402149/analysis-of-influencing-factors-of-hpv-vaccination-willingness-of-female-sex-workers-in-urban-entertainment-venues-based-on-the-imb-model-in-guangxi-china
#8
JOURNAL ARTICLE
Zhi-Yan He, Jun-Hong Wei, Jian-Ming Jiang, Rui Hu, Guang-Zi Qi
OBJECTIVE: Understanding HPV vaccination willingness and its influencing factors among female sex workers (FSWs) in entertainment venues in an urban area of Guangxi, China. METHODS: From 15 August to 15 October 2022, FSWs in entertainment venues with commercial sex trade in an urban area of Guangxi were selected as the study subjects for the questionnaire survey using the method of intentional sampling. The questionnaire based on the information-motivation-behavior (IMB) skills model was used to collect the basic characteristics, HPV and HPV vaccine-related information and cognition, motivation to vaccinate, behavioral skills and willingness to vaccinate from the research targets...
February 24, 2024: BMC Women's Health
https://read.qxmd.com/read/38400791/improving-hpv-related-oropharyngeal-cancer-knowledge-and-hpv-vaccination-rates-via-virtual-workshops
#9
JOURNAL ARTICLE
Lauran K Evans, Shaghauyegh S Azar, Haidee Chen, Miryam Saad, Sneha Subhash, Brooke M Su-Velez, Maie A St John
OBJECTIVE: To validate the efficacy of a virtual, interdisciplinary workshop in improving HPV knowledge, and vaccination practices among primary care and dental trainees. METHODS: A virtual platform was utilized to hold HPV educational workshops with primary care and dental trainees. Online surveys were distributed before and after the 1-h interactive workshop, led by otolaryngology residents. Surveys included the workshop's impact on (a) improving knowledge of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) and (b) affecting change in HPV vaccination practices...
February 24, 2024: Laryngoscope
https://read.qxmd.com/read/38400111/vaccine-hesitancy-among-european-parents-psychological-and-social-factors-influencing-the-decision-to-vaccinate-against-hpv-a-systematic-review-and-meta-analysis
#10
REVIEW
Teodora Achimaș-Cadariu, Andrei Pașca, Nicoleta-Monica Jiboc, Aida Puia, Dan Lucian Dumitrașcu
BACKGROUND: Due to low adherence to HPV vaccination programs, the European region struggles with vaccination rates lower than 30% among the targeted population. The present report investigated various socio-demographic and psychological factors influencing European parents' hesitancy towards vaccinating their children. METHODS: As of September 2023, four databases were searched. After applying inclusion criteria, all articles comparing psychological and socio-demographic factors in parents who vaccinate or do not vaccinate their children were included...
January 26, 2024: Vaccines
https://read.qxmd.com/read/38374849/human-papillomavirus-infection-hpv-prevalence-in-the-black-sea-region-of-turkey-primary-hpv-screening-for-cervical-cancer
#11
JOURNAL ARTICLE
Mustafa Cengiz Dura, Hilal Aktürk, Özgür Aslan, Şükrü Yıldız, Mehmet Kefeli, Handan Çelik
OBJECTIVE: Planning vaccination and treatment options requires knowledge about the regional incidence of human papillomavirus infection (HPV) and its genotypes. The aim of our study was to determine the regional prevalence of HPV with genotypic subclassification and to evaluate the efficacy of HPV testing in cervical screening.  Material and Method: This retrospective cohort study analyzed records of 10,152 women aged 30-65 from the On Dokuz Mayıs University Medical Faculty's Gynecology Clinic, excluding those with a history of cervical disease, hysterectomy, or current pregnancy...
January 2024: Curēus
https://read.qxmd.com/read/38368784/a-consolidated-framework-for-implementation-research-based-process-to-develop-theoretically-informed-human-papillomavirus-vaccination-educational-materials-for-young-adults
#12
JOURNAL ARTICLE
Joyce Cui, Mariana Arevalo, Melody Chavez, Melinda L Maconi, Carley Geiss, Susan T Vadaparampil, Veronica Barrios-Monroy, Alissa Pena, Shannon M Christy
OBJECTIVE: To develop theory-informed human papillomavirus (HPV) vaccine education materials that appeal to 18-26-year-olds. METHODS: First, draft materials informed by Theory of Planned Behavior (TPB) and Health Belief Model (HBM) were developed. Next, an initial set of Consolidated Framework for Implementation Research (CFIR)-guided interviews were conducted with 18-26-year-old participants to receive feedback about content, format, appeal, implementation facilitators and barriers, and potential delivery modalities...
February 12, 2024: Patient Education and Counseling
https://read.qxmd.com/read/38367273/efficacy-and-immunogenicity-of-as04-hpv-16-18-vaccine-in-females-with-existing-cervical-hr-hpv-infection-at-first-vaccination-a-pooled-analysis-of-four-large-clinical-trials-worldwide
#13
JOURNAL ARTICLE
Tian-Meng Wen, Xiao-Qian Xu, Xue-Lian Zhao, Cheng-Hao Pan, Yu-Shu Feng, Ting-Ting You, Meng Gao, Shang-Ying Hu, Fang-Hui Zhao
Females with existing high-risk HPV (HR-HPV) infections remain at risk of subsequent multiple or recurrent infections, on which benefit from HPV vaccines was under-reported. We pooled individual-level data from four large-scale, RCTs of AS04-HPV-16/18 vaccine to evaluate efficacy and immunogenicity in females DNA-positive to any HR-HPV types at first vaccination. Females receiving the AS04-HPV-16/18 vaccine in the original RCTs constituted the vaccine group in the present study, while those unvaccinated served as the control group...
February 17, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38365419/comparing-one-dose-of-hpv-vaccine-in-girls-aged-9-14-years-in-tanzania-doris-with-one-dose-in-young-women-aged-15-20-years-in-kenya-ken-she-an-immunobridging-analysis-of-randomised-controlled-trials
#14
JOURNAL ARTICLE
Kathy Baisley, Troy J Kemp, Nelly R Mugo, Hilary Whitworth, Maricianah A Onono, Betty Njoroge, Jackton Indangasi, Elizabeth A Bukusi, Priya R Prabhu, Paul Mutani, Denise A Galloway, David Mwanzalime, Saidi Kapiga, Charles J Lacey, Richard J Hayes, John Changalucha, Ligia A Pinto, Ruanne V Barnabas, Deborah Watson-Jones
BACKGROUND: The first randomised controlled trial of single-dose human papillomavirus (HPV) vaccine efficacy, the Kenya single-dose HPV-vaccine efficacy (KEN SHE) trial, showed greater than 97% efficacy against persistent HPV16 and HPV18 infection at 36 months among women in Kenya. We compared antibody responses after one dose of HPV vaccine in the Dose Reduction Immunobridging and Safety Study (DoRIS), the first randomised trial of the single- dose regimen in girls aged 9-14 years, the target age range for vaccination, with those after one dose of the same vaccine in KEN SHE...
March 2024: Lancet Global Health
https://read.qxmd.com/read/38356279/the-community-nurse-s-role-on-the-promotion-of-papillomavirus-vaccination-among-young-students-a-study-protocol
#15
JOURNAL ARTICLE
Valentina Simonetti, Marco Tomietto, Dania Comparcini, Francesco Pastore, Pasquale Stefanizzi, Silvio Tafuri, Giancarlo Cicolini
Vaccination is the principal strategy for primary prevention of infection by Human Papilloma Virus (HPV), which causes different pathological conditions, up to cancer, in both males and females. However, to date, knowledge among adolescents and their parents about the HPV vaccine is still low. The aim of this quasi-experimental, multicenter study is to assess the effectiveness of a digital educational intervention, conducted by a multidisciplinary health-care team including a Community Nurse, to increase adolescents' HPV vaccination uptake, their knowledge, self-efficacy, feelings and involvement in HPV vaccine decision-making, and parents' vaccination hesitancy...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38352726/parental-gender-influences-their-intention-to-hpv-vaccinate-their-children-and-the-association-between-hpv-and-covid-19-vaccination-intentions
#16
JOURNAL ARTICLE
Emiko Oka, Yutaka Ueda, Asami Yagi, Yuri Ito, Yoshihiko Hosokawa, Takahiro Tabuchi, Tadashi Kimura
PURPOSE: The coronavirus disease of 2019 (COVID-19) pandemic has increased public awareness of infectious diseases and interest in vaccines, including the human papilloma virus (HPV) vaccine. We investigated differences between parental gender and intentions to vaccinate their child for HPV and COVID-19. METHODS: We analyzed data from Japan's COVID-19 and Society Internet Survey (JACSIS), a web-based cross-sectional survey of 2,444 respondents in 2021. RESULTS: Females were more knowledgeable and more afraid of HPV and COVID-19 than males...
March 2024: Vaccine: X
https://read.qxmd.com/read/38339423/safety-efficacy-and-immunogenicity-of-therapeutic-vaccines-for-patients-with-high-grade-cervical-intraepithelial-neoplasia-cin-2-3-associated-with-human-papillomavirus-a-systematic-review
#17
REVIEW
Caroline Amélia Gonçalves, Gabriela Pereira-da-Silva, Renata Cristina Campos Pereira Silveira, Paulo César Morales Mayer, Adriana Zilly, Luís Carlos Lopes-Júnior
Despite the knowledge that HPV is responsible for high-grade CIN and cervical cancer, little is known about the use of therapeutic vaccines as a treatment. We aimed to synthesize and critically evaluate the evidence from clinical trials on the safety, efficacy, and immunogenicity of therapeutic vaccines in the treatment of patients with high-grade CIN associated with HPV. A systematic review of clinical trials adhering to the PRISMA 2020 statement in MEDLINE/PubMed, Embase, CENTRAL Cochrane, Web of Science, Scopus, and LILACS was undertaken, with no data or language restrictions...
February 5, 2024: Cancers
https://read.qxmd.com/read/38327242/associations-between-risk-perception-and-hpv-knowledge-and-vaccine-uptake-highlighting-the-lgbtq-population
#18
JOURNAL ARTICLE
Oluwatobiloba Ayo-Ajibola, Ryan J Davis, Matthew E Lin, Jonathan D West, Niels C Kokot, Tamara Chambers
INTRODUCTION: Gay and bisexual males and other LGBTQ+ communities are more frequently exposed to factors associated with an increased risk of human papillomavirus (HPV) acquisition. Vaccination is critical to protect against HPV+ head and neck cancer (HNC). We characterized the association of perceived level of risk of contraction with HPV knowledge, and vaccine decision-making. STUDY DESIGN: Cross-sectional cohort. SETTING: LGBTQ and general survey Reddit forums (control)...
February 8, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38321763/predictors-of-human-papillomavirus-vaccine-intention-and-uptake-among-us-hispanic-parents-a-cross-sectional-study
#19
JOURNAL ARTICLE
Madeline Fernandez-Pineda, Carlos R Melendez, Melanie Fernandez, Rosina Cianelli, Jessica Roman, Natalia Villegas, Yui Matsuda, Nilda Peragallo Montano
Introduction: This study explored the influence of the Theory of Planned Behavior constructs on human papillomavirus (HPV) vaccine (HPVV) intentions and uptake among Hispanic parents in South Florida for their children aged 9-21. Method: A descriptive exploratory analysis was conducted using 39 surveys completed by Hispanic parents. These surveys encompassed demographic data and questions about HPVV uptake, intention, attitudes, subjective norms, knowledge, self-efficacy, and awareness. Results: Most participants were uninsured (77%), unemployed (59%), and had low Americanism acculturation (74%)...
February 6, 2024: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://read.qxmd.com/read/38314927/effectiveness-of-prophylactic-hpv-vaccines-against-cervical-abnormalities-and-hpv-infection-in-japan-the-j-hers-2021-multicenter-study
#20
JOURNAL ARTICLE
Yoshihiko Saeki, Mayumi Saito, Takuya Irie, Fujiko Itoh, Akiko Enatsu, Hiroko Komura, Miho Fujii, Ryota Fujii, Natsuko Hidaka, Toshiyuki Maehama, Nobuhiko Shirasu, Tomoo Waseda, Takeo Shibata, Emi Takada, Kazuki Mibe, Jinichi Sakamoto, Sousuke Yamada, Masahiro Takakura, Toshiyuki Sasagawa
This study investigated the efficacy of the prophylactic human papillomavirus (HPV) vaccine, which was initiated between 2009 and 2013 in Japan. The study involved 1529 eligible women aged 16-39 years who visited 11 outpatient clinics in Japan for various reasons. These patients underwent HPV genotype analysis and a Pap test of cervical cell samples. A total of 299 women (19.6%) had received the prophylactic HPV vaccine (bivalent:quadrivalent vaccine ratio = 2:1). Of the 5062 participants in the Japanese Human Papillomavirus Disease Education and Research Survey (J-HERS 2011), which was conducted in the pre-vaccination era, 3236 eligible participants were included as controls...
February 2024: Journal of Medical Virology
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