Maureen A ter Laak, Carolien Roos, Daan J Touw, Paul R M van Hattum, Anneke Kwee, Frederik K Lotgering, Ben Willem J Mol, Mariƫlle G van Pampus, Martina M Porath, Marc E A Spaanderman, Joris A M van der Post, Dimitri N M Papatsonis, Nils E van 't Veer
OBJECTIVE: The pharmacokinetics of nifedipine as a tocolytic agent has not been studied in great detail in pregnant women and has instead focused on immediate release tablets and gastrointestinal therapeutic system (GITS) tablets. The aim of this study was to determine nifedipine slow-release half-life and distribution volume in pregnant women and to compare these with pharmacokinetic parameters of nifedipine in non-pregnant subjects described in the literature. MATERIALS: This is a study parallel to a trial studying women with threatened preterm labor between 26 + 0 and 32 + 2 weeks after initial tocolysis and a completed course of corticosteroids, who were randomly allocated to maintenance nifedipine (slow-release tablets 20 mg 4 times daily) or placebo...
January 2015: International Journal of Clinical Pharmacology and Therapeutics