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https://www.readbyqxmd.com/read/28923582/glaucoma-following-corneal-replacement
#1
REVIEW
Monika Baltaziak, Hall F Chew, Dominik W Podbielski, Iqbal Ike K Ahmed
Glaucoma is a well-known complication following corneal transplantation surgery. Traditional corneal transplantation surgery, specifically penetrating keratoplasty (PK), has been slowly replaced by the advent of new corneal transplantation procedures: primarily lamellar keratoplasties. There has also been an emergence of keratoprosthesis implants for eyes that are high risk of failure with PK. Consequently, there are different rates of glaucoma, pathogenesis, and potential treatment in the form of medical, laser or surgical therapy...
September 16, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28919702/micro-invasive-glaucoma-surgery-migs-a-review-of-surgical-procedures-using-stents
#2
Lutz E Pillunat, Carl Erb, Anselm Gm Jünemann, Friedemann Kimmich
Over the last decade several novel surgical treatment options and devices for glaucoma have been developed. All these developments aim to cause as little trauma as possible to the eye, to safely, effectively, and sustainably reduce intraocular pressure (IOP), to produce reproducible results, and to be easy to adopt. The term "micro-invasive glaucoma surgery (MIGS)" was used for summarizing all these procedures. Currently MIGS is gaining more and more interest and popularity. The possible reduction of the number of glaucoma medications, the ab interno approach without damaging the conjunctival tissue, and the probably safer procedures compared to incisional surgical methods may explain the increased interest in MIGS...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28906020/diagnostic-impact-of-anterior-segment-angiography-of-limbal-stem-cell-insufficiency-in-pax6-related-aniridia
#3
Barbara Käsmann-Kellner, Lorenz Latta, Fabian Fries, Arne Viestenz, Berthold Seitz
BACKGROUND: PAX6 is a master gene of ocular development and postnatal ocular equilibrium. Congenital aniridia is the hallmark of PAX6 gene haploinsufficiency (Chr. 11 p. 13), but PAX6-associated aniridia is a profound, progressive pan-ocular developmental disorder often leading to blindness. Limbal stem cell insufficiency and corneal findings in PAX6 syndrome: There is congenital visual impairment with advancing loss of vision mainly due to secondary glaucoma and to corneal blindness caused by limbal stem cell insufficiency (LSCI)...
September 14, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28887719/protective-effects-of-carbenoxolone-an-11%C3%AE-hsd1-inhibitor-against-chemical-induced-dry-eye-syndrome
#4
Yoon-Ju Na, Kyoung-Jin Choi, Sung Bum Park, Hye-Rim Sung, Won Hoon Jung, Hee Youn Kim, Sang Dal Rhee, Ki Young Kim
Dry eye syndrome (DES) is a disorder of the eye due to tear deficiency or excessive evaporation that causes damage to the eye and is associated with discomfort and dryness. 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) is an enzyme that converts inactive cortisone to active cortisol. Recently, 11β-HSD1 has been expressed in human and rodent eyes and has been recognized as a target of glaucoma. In this study, the therapeutic effects and underlying mechanisms of topical carbenoxolone, an 11β-HSD1 inhibitor, were investigated in benzalkonium chloride (BAC)-treated human conjunctival epithelial cells and a rat DES model...
September 8, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28878627/optic-nerve-degeneration-after-retinal-ischemia-reperfusion-in-a-rodent-model
#5
Marina Renner, Gesa Stute, Mohammad Alzureiqi, Jacqueline Reinhard, Susanne Wiemann, Heiko Schmid, Andreas Faissner, H Burkhard Dick, Stephanie C Joachim
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion. Several studies demonstrated that ischemia/reperfusion (I/R) leads to morphological and functional changes of different retinal cell types. However, little is known about the ischemic effects on the optic nerve. The goal of this study was to evaluate these effects. Ischemia was induced by raising the intraocular pressure (IOP) in one eye of rats to 140 mmHg for 1 h followed by natural reperfusion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28858959/can-adapted-motivational-interviewing-improve-uptake-of-surgical-or-laser-treatment-for-glaucoma-in-nigeria-randomized-controlled-trial
#6
Mohammed M Abdull, Jim McCambridge, Jennifer Evans, Fatima Muazu, Clare Gilbert
PURPOSE: To assess whether adapted motivational interviewing (MI) has any impact on the proportion of participants who subsequently underwent surgery or laser treatment for glaucoma. MATERIALS AND METHODS: A single site randomized controlled trial in Bauchi, Nigeria. Participants were new patients with a confirmed diagnosis of primary open-angle glaucoma in 1 or both eyes, where surgery or laser was recommended. Intervention was a session of MI adapted for glaucoma and the local context, using an interview guide based on local qualitative research...
August 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28857945/can-adapted-motivational-interviewing-improve-uptake-of-surgical-or-laser-treatment-for-glaucoma-in-nigeria-randomized-controlled-trial
#7
Mohammed M Abdull, Jim McCambridge, Jennifer Evans, Fatima Muazu, Clare Gilbert
PURPOSE: To assess whether adapted motivational interviewing (MI) has any impact on the proportion of participants who subsequently underwent surgery or laser treatment for glaucoma. MATERIALS AND METHODS: A single site randomized controlled trial in Bauchi, Nigeria. Participants were new patients with a confirmed diagnosis of primary open-angle glaucoma in 1 or both eyes, where surgery or laser was recommended. Intervention was a session of MI adapted for glaucoma and the local context, using an interview guide based on local qualitative research...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28830369/dislocation-of-a-previously-successful-xen-glaucoma-implant-into-the-anterior-chamber-a-case-report
#8
Nikolaos Dervenis, Athanasia Maria Mikropoulou, Panagiotis Dervenis, Amanda Lewis
BACKGROUND: XEN glaucoma implant (XEN gel stent, Aquesys, Inc) is a new minimally invasive device approved for the treatment of glaucoma. CASE PRESENTATION: A 45 year old female was being followed and treated for primary open angle glaucoma in our tertiary referral center. Due to failure of medical treatment in controlling the glaucoma, surgery was offered to the patient. The XEN 45 μ-fistula implant was successfully placed in both eyes and adequate intraocular pressure control was achieved for 4 months...
August 22, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28809847/genome-wide-expression-datasets-of-anti-vegf-and-dexamethasone-treatment-of-angiogenesis-in-the-rat-cornea
#9
Anthony Mukwaya, Pierfrancesco Mirabelli, Anton Lennikov, Maria Xeroudaki, Mira Schaupper, Beatrice Peebo, Neil Lagali
Therapeutics against pathologic new blood vessel growth, particularly those targeting vascular endothelial growth factor (VEGF) are of enormous clinical interest. In the eye, where anti-VEGF agents are in widespread clinical use for treating retinal and corneal blindness, only partial or transient efficacy and resistance to anti-VEGF agents are among the major drawbacks. Conversely, corticosteroids have long been used in ophthalmology for their potency in suppressing inflammation and angiogenesis, but their broad biological activity can give rise to side effects such as glaucoma and cataract...
August 15, 2017: Scientific Data
https://www.readbyqxmd.com/read/28804247/ophthalmology-in-north-america-early-stories-1491-1801
#10
REVIEW
Christopher T Leffler, Stephen G Schwartz, Ricardo D Wainsztein, Adam Pflugrath, Eric Peterson
New World plants, such as tobacco, tomato, and chili, were held to have beneficial effects on the eyes. Indigenous healers rubbed or scraped the eyes or eyelids to treat inflammation, corneal opacities, and even eye irritation from smoke. European settlers used harsh treatments, such as bleeding and blistering, when the eyes were inflamed or had loss of vision with a normal appearance (gutta serena). In New Spain, surgery for corneal opacity was performed in 1601 and cataract couching in 1611. North American physicians knew of contralateral loss of vision after trauma or surgery (sympathetic ophthalmia), which they called "sympathy...
2017: Ophthalmology and Eye Diseases
https://www.readbyqxmd.com/read/28774519/undetected-angle-closure-in-patients-with-a-diagnosis-of-open-angle-glaucoma
#11
Devesh K Varma, Sarah M Simpson, Amandeep S Rai, Iqbal Ike K Ahmed
OBJECTIVE: The aim of this study was to identify the proportion of patients referred to a tertiary glaucoma centre with a diagnosis of open-angle glaucoma (OAG) who were found to have angle closure glaucoma. DESIGN: Retrospective chart review. METHODS: Consecutive new patients referred for glaucoma management to a tertiary centre between July 2010 and December 2011 were reviewed. Patients whose referrals for glaucoma assessment specified angle status as "open" were included...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28767090/a-magnetic-balanced-inductive-link-for-the-simultaneous-uplink-data-and-power-telemetry
#12
Chen Gong, Dake Liu, Zhidong Miao, Min Li
When using the conventional two-coil inductive link for the simultaneous wireless power and data transmissions in implantable biomedical sensor devices, the strong power carrier could overwhelm the uplink data signal and even saturate the external uplink receiver. To address this problem, we propose a new magnetic-balanced inductive link for our implantable glaucoma treatment device. In this inductive link, an extra coil is specially added for the uplink receiving. The strong power carrier interference is minimized to approach zero by balanced canceling of the magnetic field of the external power coil...
August 2, 2017: Sensors
https://www.readbyqxmd.com/read/28737758/real-world-experience-with-0-2%C3%A2-%C3%AE-g-day-fluocinolone-acetonide-intravitreal-implant-iluvien-in-the-united-kingdom
#13
C Bailey, U Chakravarthy, A Lotery, G Menon, J Talks
AimsTo compare safety outcomes and visual function data acquired in the real-world setting with FAME study results in eyes treated with 0.2 μg/day fluocinolone acetonide (FAc).MethodsFourteen UK clinical sites contributed to pseudoanonymised data collected using the same electronic medical record system. Data pertaining to eyes treated with FAc implant for diabetic macular oedema (DMO) was extracted. Intraocular pressure (IOP)-related adverse events were defined as use of IOP-lowering medication, any rise in IOP>30 mm Hg, or glaucoma surgery...
July 24, 2017: Eye
https://www.readbyqxmd.com/read/28730968/modulation-of-the-immune-system-for-the-treatment-of-glaucoma
#14
Katharina Bell, Nadine von Thun Und Hohenstein-Blaul, Julia Teister, Franz H Grus
At present intraocular pressure (IOP) lowering therapies are the only approach to treat glaucoma. Neuroprotective strategies to protect the retinal ganglion cells (RGC) from apoptosis are lacking to date. Results from clinical studies revealed altered immunoreactivities against retinal and optic nerve antigens in sera and aqueous humor of glaucoma patients and point toward an autoimmune involvement in glaucomatous neurodegeneration and RGC death. IgG accumulations along with plasma cells were found localised in human glaucomatous retinae in a pro-inflammatory environment possibly maintained by microglia...
July 19, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28730285/an-update-on-implants-for-minimally-invasive-glaucoma-surgery-migs
#15
REVIEW
Ejaz Ansari
For several years, the gold standard for surgical treatment of glaucoma has been trabeculectomy. Although very successful at reducing intraocular pressure (IOP), there are several potential complications of trabeculectomy, including sight-threatening ones. This has stimulated much research aimed at the development of new and effective procedures to lower IOP with an enhanced safety profile. Minimally invasive glaucoma surgery (MIGS) procedures prioritise patient safety but also demonstrate efficacy in reducing IOP...
July 20, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28721823/genetic-risk-factors-for-glaucoma-and-exfoliation-syndrome-identified-by-genome-wide-association-studies
#16
Yoichi Sakurada, Fumihiko Mabuchi
Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells and optic nerve axons. According to its anatomical features, glaucoma is mainly subdivided into primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Exfoliation syndrome (XFS) and glaucoma (XFG) are characterized by the accumulation of extracellular materials in ocular tissues, particularly the lens surface and pupillary border. In addition to the two major forms of glaucoma, XFG is the most common cause of secondary open-angle glaucoma...
July 18, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28720436/direct-measurement-of-pressure-independent-aqueous-humour-flow-using-iperfusion
#17
Michael Madekurozwa, Ester Reina-Torres, Darryl R Overby, Joseph M Sherwood
Reduction of intraocular pressure is the sole therapeutic target for glaucoma. Intraocular pressure is determined by the dynamics of aqueous humour secretion and outflow, which comprise several pressure-dependent and pressure-independent mechanisms. Accurately quantifying the components of aqueous humour dynamics is essential in understanding the pathology of glaucoma and the development of new treatments. To better characterise aqueous humour dynamics, we propose a method to directly measure pressure-independent aqueous humour flow...
September 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28700902/a-novel-algorithm-to-detect-glaucoma-risk-using-texton-and-local-configuration-pattern-features-extracted-from-fundus-images
#18
U Rajendra Acharya, Shreya Bhat, Joel E W Koh, Sulatha V Bhandary, Hojjat Adeli
Glaucoma is an optic neuropathy defined by characteristic damage to the optic nerve and accompanying visual field deficits. Early diagnosis and treatment are critical to prevent irreversible vision loss and ultimate blindness. Current techniques for computer-aided analysis of the optic nerve and retinal nerve fiber layer (RNFL) are expensive and require keen interpretation by trained specialists. Hence, an automated system is highly desirable for a cost-effective and accurate screening for the diagnosis of glaucoma...
September 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28671927/micropulse-cyclophotocoagulation-initial-results-in-refractory-glaucoma
#19
Matthew E Emanuel, Davinder S Grover, Ronald L Fellman, David G Godfrey, Oluwatosin Smith, Michelle R Butler, Helen L Kornmann, William J Feuer, Swati Goyal
PURPOSE: The purpose of this study is to evaluate the use of micropulse transscleral cyclophotocoagulation (MP-TSCPC), a new and increasingly popular treatment, in patients with uncontrolled glaucoma. METHODS: A retrospective chart review was performed for all patients who underwent a MP-TSCPC at the Glaucoma Associates of Texas. RESULTS: A total of 84 eyes were treated with MP-TSCPC in this study with a mean follow-up time of 4.3 months. The mean age of treated patients was 74 years and 48 (57%) were female...
August 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28658977/n-hydroxymethylglycinate-with-edta-is-an-efficient-eye-drop-preservative-with-very-low-toxicity-an-in-vitro-comparative-study
#20
Martina Cristaldi, Melania Olivieri, Gabriella Lupo, Carmelina D Anfuso, Salvatore Pezzino, Dario Rusciano
PURPOSE: Preservatives are used in multi-dose ophthalmic topical medications in order to prevent contamination by bacteria and fungi. However, prolonged use of preserved eye drops, as it may happen in dry eye or glaucoma, may damage cells of the ocular surface. Therefore, an important goal is to find preservatives with low toxicity which are mild to host cells, still able to prevent drug contamination so to maintain their sterility and efficacy. Hence, aim of this study has been to compare the relative toxicity on a rabbit corneal cell line of a new preservative, made by the association of N-hydroxy-methyl-glycinate (NIG) with disodium-ethylene diamine tetra-acetate (EDTA), with other known and widely used eye-drops preservatives...
June 28, 2017: Cutaneous and Ocular Toxicology
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