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Variability in practice

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https://www.readbyqxmd.com/read/28211579/impact-of-treatment-variability-on-survival-in-immuno-competent-and-immuno-compromised-patients-with-primary-central-nervous-lymphoma
#1
Reem Karmali, Chadi Nabhan, Adam M Petrich, Jeffrey Raizer, David Peace, Rimas Lukas, Leo I Gordon, Sanjib Basu, Vineela Chukkapalli, Parameswaran Venugopal
Patients with primary central nervous system lymphoma (PCNSL) treated in the 'real-world' setting do not represent those treated on clinical trials and might not be treated similarly. We studied characteristics and variability in care for 113 newly diagnosed PCNSL patients treated at 5 institutions in the Chicago area between 2000 and 2012. In 111 patients, single modality therapy with a high dose methotrexate (HD-MTX) regimen +/- rituximab, was most commonly employed (n = 65), and 34 underwent radiotherapy (+/- systemic therapy)...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28210404/infraorbital-nerve-decompression-for-infraorbital-neuralgia-causalgia-following-blowout-orbital-fractures-a-case-series
#2
Bijan Beigi, Mazda Beigi, Nuwan Niyadurupola, Manuel Saldana, Nabil El-Hindy, Deepak Gupta
The purpose of this study was to present the management of a series of patients referred with infraorbital nerve paraesthesia that developed after insignificant orbital floor fracture without diplopia or exophthalmos, and that did not require initial surgical repair. This is a retrospective interventional case series. The main outcome and measures were assessment of preoperative symptoms including neuralgia and sensory symptoms; review of periorbital computed tomography (CT) scans; and assessment of postoperative effects of surgery for infraorbital nerve decompression...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28210344/differences-in-movement-speed-before-and-after-a-split-step-between-professional-and-junior-tennis-players
#3
Aleš Filipčič, Bojan Leskošek, Goran Munivrana, Gabriela Ochiana, Tjaša Filipčič
This study investigated tennis players' speed before, during and after the split-step, deceleration before and acceleration after the split-step in four different stroke groups in three age categories. Seven male professional, eleven male and ten female junior tennis players were recorded with video cameras at official tournaments. Using the SAGIT system, we gathered data on 8,545 split-steps. Tennis players performed a split-step in 82.9% of cases. A tennis player's speed, deceleration and acceleration were measured 0...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28210299/respiratory-clinical-guidelines-inform-ward-based-nurses-clinical-skills-and-knowledge-required-for-evidence-based-care
#4
REVIEW
Alisha M Johnson, Sheree M S Smith
Respiratory clinical guidelines provide clinicians with evidence-based guidance for practice. Clinical guidelines also provide an opportunity to identify the knowledge and technical and non-technical skills required by respiratory ward-based registered nurses. The aim of this review was to use a systematic process to establish the core technical and non-technical skills and knowledge identified in evidence-based clinical guidelines that enable the care of hospitalised adult respiratory patients. 17 guidelines were identified in our systematic review...
September 2016: Breathe
https://www.readbyqxmd.com/read/28209549/factors-affecting-consultation-length-in-a-japanese-diabetes-practice
#5
Yusuke Kabeya, Junko Uchida, Masao Toyoda, Takeshi Katsuki, Yoichi Oikawa, Kiyoe Kato, Toshihide Kawai, Akira Shimada, Yoshihito Atsumi, Megumu Higaki
AIMS: Sufficient consultation time is important for establishing good doctor-patient relationship. We examined the factors that affect consultation length in Japanese diabetes practice. METHODS: This was a cross-sectional study performed at a diabetes clinic in central Tokyo, Japan. Regular diabetes consultations of 1197 patients with 22 physicians were analyzed. Consultation time and clinical characteristics were obtained from the electronic records. A negative binomial model, which included patient and physician characteristics, was constructed to examine the association of the variables with consultation length...
January 29, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28209417/influence-of-hospital-level-practice-patterns-on-variation-in-the-application-of-minimally-invasive-surgery-in-united-states-pediatric-patients
#6
Arianne T Train, Carroll M Harmon, David H Rothstein
BACKGROUND: Although disparities in access to minimally invasive surgery are thought to exist in pediatric surgical patients in the United States, hospital-level practice patterns have not been evaluated as a possible contributing factor. METHODS: Retrospective cohort study using the Kids' Inpatient Database, 2012. Odds ratios of undergoing a minimally invasive compared to open operation were calculated for six typical pediatric surgical operations after adjustment for multiple patient demographic and hospital-level variables...
February 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28209377/how-do-parents-label-their-physical-disciplinary-practices-a-focus-on-the-definition-of-corporal-punishment
#7
Sabrina Fréchette, Elisa Romano
The lack of consensus about the definition of corporal punishment (CP) contributes to the varying research findings and fuels the debate surrounding its use. Related to the problem of definitional variability is also the possibility that some parents may not be aware that their physical disciplinary strategies (PDS) are forms of CP. As a first step to move beyond the debate and to tailor educational efforts to change cultural norms and parents' behaviors, the objective of the current study was to clarify what parents self-label as CP...
February 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28209152/municipal-resources-and-patient-outcomes-through-the-first-year-after-a-hip-fracture
#8
Sabine Ruths, Valborg Baste, Marit Stordal Bakken, Lars Birger Engesæter, Stein Atle Lie, Siren Haugland
BACKGROUND: Hip fractures represent major critical events for older people, and put huge demands on economic and personnel resources. Most hip fracture patients are in need of postoperative rehabilitation services. Through the Coordination Reform, the municipalities in Norway were given increased responsibility for community-based treatment and rehabilitation after surgery. The purpose of this study was to examine associations between municipal resources and patient outcomes through the first year after a hip fracture, focusing on survival and health-related quality of life...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28208876/prescribing-pattern-of-antifungal-medications-at-a-tertiary-care-hospital-in-oman
#9
Khalid A Al Balushi, Mohammed A Alzaabi, Fatma Alghafri
INTRODUCTION: Inappropriate use of antifungal agents is implicated in the global burden of antifungal resistance, adverse outcomes like persistent infections, unnecessary exposure and increased cost. Data collection from time to time is to be done in order to have a check on the resistance/sensitivity pattern of the commonly prescribed antifungal drugs. AIM: To describe the pattern of antifungal drug prescription and administration to patients attending a university hospital in Oman...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208872/analgesics-self-medication-and-its-association-with-sleep-quality-among-medical-undergraduates
#10
Amit Kumar, Vandana, Ahmad Nadeem Aslami
INTRODUCTION: Self medication especially with analgesics is a common practice among undergraduate medical students. Variation in analgesic self medication prevalence and pattern is often seen due to geographical and target population differences. The mutual influence of pain and sleep quality might persuade students self medication behaviour. AIM: To assess analgesic self medication and its association with sleep quality among the medical undergraduates. MATERIALS AND METHODS: A cross-sectional questionnaire based study was conducted from December 2015 to February 2016 among 320 medical undergraduates...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208798/maternal%C3%A2-folic%C3%A2-acid%C3%A2-supplementation%C3%A2-during%C3%A2-pregnancy%C3%A2-and%C3%A2-childhood%C3%A2-allergic%C3%A2-disease%C3%A2-outcomes-%C3%A2-a%C3%A2-question%C3%A2-of%C3%A2-timing
#11
REVIEW
Catrina L McStay, Susan L Prescott, Carol Bower, Debra J Palmer
Since the early 1990s, maternal folic acid supplementation has been recommended prior  to and during the first trimester of pregnancy, to reduce the risk of infant neural tube defects. In  addition, many countries have also implemented the folic acid fortification of staple foods, in order  to promote sufficient intakes amongst women of a childbearing age, based on concerns surrounding  variable dietary and supplementation practices. As many women continue to take folic acid  supplements beyond the recommended first trimester, there has been an overall increase in folate  intakes, particularly in countries with mandatory fortification...
February 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28208739/a-guide-to-the-variability-of-flavonoids-in-brassica-oleracea
#12
REVIEW
Vera Mageney, Susanne Neugart, Dirk C Albach
Flavonoids represent a typical secondary metabolite class present in cruciferous vegetables. Their potential as natural antioxidants has raised considerable scientific interest. Impacts on the human body after food consumption as well as their effect as pharmaceutical supplements are therefore under investigation. Their numerous physiological functions make them a promising tool for breeding purposes. General methods for flavonoid analysis are well established, though new compounds are still being identified...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208707/gaitkeeper-a-system-for-measuring-canine-gait
#13
Cassim Ladha, Jack O'Sullivan, Zoe Belshaw, Lucy Asher
It is understood gait has the potential to be used as a window into neurodegenerative disorders, identify markers of subclinical pathology, inform diagnostic algorithms of disease progression and measure the efficacy of interventions. Dogs' gaits are frequently assessed in a veterinary setting to detect signs of lameness. Despite this, a reliable, affordable and objective method to assess lameness in dogs is lacking. Most described canine lameness assessments are subjective, unvalidated and at high risk of bias...
February 8, 2017: Sensors
https://www.readbyqxmd.com/read/28207981/a-multiparametric-magnetic-resonance-imaging-based-risk-model-to-determine-the-risk-of-significant-prostate-cancer-prior-to-biopsy
#14
Pim J van Leeuwen, Andrew Hayen, James E Thompson, Daniel Moses, Ron Shnier, Maret Böhm, Magdaline Abuodha, Anne-Maree Haynes, Francis Ting, Jelle Barentsz, Monique Roobol, Justin Vass, Krishan Rasiah, Warick Delprado, Phillip D Stricker
OBJECTIVES: To develop and externally validate a predictive model for detection of significant prostate cancer (PC). SUBJECTS AND METHODS: Development of the model was based on prospective cohort including 393 men who underwent mpMRI prior to biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent a mpMRI followed by biopsy for abnormal PSA/DRE. A model was developed with age, PSA, DRE, prostate volume, previous biopsy and PIRADS score as predictors for significant PC (Gleason 7 with >5% grade 4, ≥ 20% cores positive or ≥ 7mm of PC in any core)...
February 16, 2017: BJU International
https://www.readbyqxmd.com/read/28207960/improving-nutritional-practices-in-premature-infants-can-increase-their-growth-velocity-and-the-breastfeeding-rates
#15
Salvador Piris Borregas, María López Maestro, María José Torres Valdivieso, José Carlos Martínez Ávila, Gerardo Bustos Lozano, Carmen Rosa Pallás Alonso
AIM: This study analysed the changes in growth velocity (GV) of preterm infants weighing less than 1,500g based on different nutritional practices over a 24-year period. METHODS: A retrospective study with prospectively collected data was performed in a level three Spanish neonatal intensive care unit. Data on birth weight, gestational age (GA) and GV were collected from 1990 to 2013 and breastfeeding data was gathered from 2000. A generalised linear model corrected by GA and small for gestational age was applied...
February 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28207855/novel-approaches-for-the-taxonomic-and-metabolic-characterization-of-lactobacilli-integration-of-16s-rrna-gene-sequencing-with-maldi-tof-ms-and-1h-nmr
#16
Claudio Foschi, Luca Laghi, Carola Parolin, Barbara Giordani, Monica Compri, Roberto Cevenini, Antonella Marangoni, Beatrice Vitali
Lactobacilli represent a wide range of bacterial species with several implications for the human host. They play a crucial role in maintaining the ecological equilibrium of different biological niches and are essential for fermented food production and probiotic formulation. Despite the consensus about the 'health-promoting' significance of Lactobacillus genus, its genotypic and phenotypic characterization still poses several difficulties. The aim of this study was to assess the integration of different approaches, genotypic (16S rRNA gene sequencing), proteomic (MALDI-TOF MS) and metabolomic (1H-NMR), for the taxonomic and metabolic characterization of Lactobacillus species...
2017: PloS One
https://www.readbyqxmd.com/read/28207666/are-they-complying-physicians-knowledge-attitudes-and-readiness-to-change-regarding-low-back-pain-treatment-guideline-adherence
#17
Sheera Epstein-Sher, Dena H Jaffe, Amnon Lahad
STUDY DESIGN: Cross-sectional survey of 145 primary care practitioners (PCPs). OBJECTIVE: To examine low back pain (LBP) guideline knowledge, readiness to implement (RTI) these guidelines, and LBP attitudes and beliefs among Israeli PCPs and determine whether physician age, guideline familiarity, and medical specialty affect these variables. SUMMARY OF BACKGROUND DATA: LBP is a common condition managed primarily by PCPs. Little is known, however, about physician's LBP knowledge, attitudes, and beliefs and how these factors (knowledge, A&B) influence their practice behavior...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28207296/gambit-a-parameterless-model-based-evolutionary-algorithm-for-mixed-integer-problems
#18
Krzysztof L Sadowski, Dirk Thierens, Peter A N Bosman
Learning and exploiting problem structure is one of the key challenges in optimization. This is especially important for black-box optimization (BBO) where prior structural knowledge of a problem is not available. Existing model-based Evolutionary Algorithms (EAs) are very efficient at learning structure in both the discrete, and in the continuous domain. In this paper, discrete and continuous model-building mechanisms are integrated for the Mixed-Integer (MI) domain, comprising discrete and continuous variables...
February 16, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/28207283/modeling-information-content-via-dirichlet-multinomial-regression-analysis
#19
Alberto Ferrari
Shannon entropy is being increasingly used in biomedical research as an index of complexity and information content in sequences of symbols, e.g. languages, amino acid sequences, DNA methylation patterns and animal vocalizations. Yet, distributional properties of information entropy as a random variable have seldom been the object of study, leading to researchers mainly using linear models or simulation-based analytical approach to assess differences in information content, when entropy is measured repeatedly in different experimental conditions...
February 16, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28207174/species-distribution-models-may-misdirect-assisted-migration-insights-from-the-introduction-of-douglas-fir-to-europe
#20
Juliette Boiffin, Vincent Badeau, Nathalie Bréda
Species distribution models (SDMs), which statistically relate species occurrence to climatic variables, are widely used to identify areas suitable for species growth under future climates and to plan for assisted migration. When SDMs are projected across times or spaces, it is assumed that species climatic requirements remain constant. However, empirical evidence supporting this assumption is rare, and SDM predictions could be biased. Historical human-aided movements of tree species can shed light on the reliability of SDM predictions in planning for assisted migration...
October 4, 2016: Ecological Applications: a Publication of the Ecological Society of America
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