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Variability in practice

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https://www.readbyqxmd.com/read/29677464/improving-the-quality-of-preclinical-research-echocardiography-observations-training-and-guidelines-for-measurement
#1
Daniel G Donner, Helen Kiriazis, Xiao-Jun Du, Thomas H Marwick, Julie R McMullen
Informal training in preclinical research may be a contributor to the poor reproducibility of preclinical cardiology research and low rates of translation into clinical research and practice. Mouse echocardiography is a widely used technique to assess cardiac structure and function in drug intervention studies using disease models. The inter-observer variability (IOV) of clinical echocardiographic measurements has been shown to improve with formalized training, but preclinical echocardiography lacks similarly critical standardization of training...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29677066/agreement-analysis-what-he-said-she-said-versus-you-said
#2
Thomas R Vetter, Patrick Schober
Correlation and agreement are 2 concepts that are widely applied in the medical literature and clinical practice to assess for the presence and strength of an association. However, because correlation and agreement are conceptually distinct, they require the use of different statistics. Agreement is a concept that is closely related to but fundamentally different from and often confused with correlation. The idea of agreement refers to the notion of reproducibility of clinical evaluations or biomedical measurements...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29677058/a-survey-of-current-anesthesia-trends-for-electrophysiology-procedures
#3
Eric W Nelson, Erick M Woltz, Bethany J Wolf, Michael R Gold
BACKGROUND: There has been a dramatic shift in recent years in anesthesia coverage for electrophysiology (EP) procedures. An anesthesiologist and electrophysiologist at our institution jointly developed a survey, which was distributed to the Society of Cardiovascular Anesthesiologists and the Heart Rhythm Society. Its goal was to document current practice patterns and examine perceived variability in coverage. METHODS: On approval of the leadership from the Society of Cardiovascular Anesthesiologists and the Heart Rhythm Society, an online survey was administered to the membership...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29676892/multiple-pathways-to-bacterial-load-reduction-by-stormwater-best-management-practices-tradeoffs-in-performance-volume-and-treated-area
#4
Jordyn Wolfand, Colin D Bell, Alexandria B Boehm, Terri Hogue, Richard G Luthy
Stormwater best management practices (BMPs) are implemented to reduce microbial pollution in runoff, but their removal efficiencies differ. Enhanced BMPs, such as those with media amendments, can increase removal of fecal indicator bacteria (FIB) in runoff from 0.25-log10 to above 3-log10 ; however, their implications for watershed-scale management are poorly understood. In this work, a computational model was developed to simulate watershed-scale bacteria loading and BMP performance, using the Ballona Creek Watershed (Los Angeles County, CA) as a case study...
April 20, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29676208/tactics-of-material-participation-how-patients-shape-their-engagement-through-e-health
#5
Karen Dam Nielsen, Henriette Langstrup
The increasingly popular goal of 'patient participation' comes with a conceptual vagueness, at times rendering it an all-too flexible political trope or platitude and, in practice, resulting in unclear invitations to patients. We seek to open up the alluring yet troubling figure of patient participation, by inquiring into how patients enact participation in different ways. Based on close ethnographic engagement in a user test of the e-health system P-Record, we show how a group of heart patients shaped their participation along three lines of tactics of material participation: 'activism', 'partnership' and 'compliance'...
April 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29675980/longitudinal-assessment-of-hippocampus-structure-in-children-with-type-1-diabetes
#6
Lara C Foland-Ross, Allan L Reiss, Paul K Mazaika, Nelly Mauras, Stuart A Weinzimer, Tandy Aye, Michael J Tansey, Neil H White
The extant literature finds that children with type 1 diabetes (T1D) experience mild cognitive alterations compared to healthy age-matched controls. The neural basis of these cognitive differences is unclear but may relate in part to the effects of dysglycemia on the developing brain. We investigated longitudinal changes in hippocampus volume in young children with early-onset T1D. Structural magnetic resonance imaging data were acquired from 142 children with T1D and 65 age-matched control subjects (4-10 years of age at study entry) at two time points, 18 months apart...
April 19, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29675923/latent-therapeutic-demand-model-for-the-immunoglobulin-replacement-therapy-of-primary-immune-deficiency-disorders-in-the-usa
#7
J S Stonebraker, J Hajjar, J S Orange
BACKGROUND AND OBJECTIVES: Our research aim is to model latent therapeutic demand (LTD) for the immunoglobulin replacement therapy (IgGRT) of primary immune deficiency disorders (PIDDs) in the USA. Given the high level of variability of IgGRT use and major differences among American and European practices in the management of patients with PIDDs, we develop a USA-specific LTD model for common variable immune deficiency (CVID), hyper IGM syndrome, severe combined immune deficiency, Wiskott-Aldrich syndrome and X-linked agammaglobulinemia (XLA)...
April 20, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29675882/diffusion-tensor-imaging-using-multiple-coils-for-mouse-brain-connectomics
#8
John C Nouls, Alexandra Badea, Robert B J Anderson, Gary P Cofer, G Allan Johnson
The correlation between brain connectivity and psychiatric or neurological diseases has intensified efforts to develop brain connectivity mapping techniques on mouse models of human disease. The neural architecture of mouse brain specimens can be shown non-destructively and three-dimensionally by diffusion tensor imaging, which enables tractography, the establishment of a connectivity matrix and connectomics. However, experiments on cohorts of animals can be prohibitively long. To improve throughput in a 7-T preclinical scanner, we present a novel two-coil system in which each coil is shielded, placed off-isocenter along the axis of the magnet and connected to a receiver circuit of the scanner...
April 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29675875/effects-of-a-supportive-care-bundle-on-sleep-variables-of-preterm-infants-during-hospitalization
#9
Hsiang-Yun Lan, Luke Yang, Kao-Hsian Hsieh, Ti Yin, Yue-Cune Chang, Jen-Jiuan Liaw
Sleep is important for preterm infants' brain development, but they are frequently exposed to painful procedures in the neonatal intensive care unit (NICU) that disturb their sleep cycle and affect their growth. The purpose of this study was to examine the prolonged effects of a supportive care bundle (modulation of the infants' states, non-nutritive sucking, facilitated tucking, and oral sucrose feeding) on preterm infants' sleep variables (sleep efficiency, total sleep time, sleep latency, and frequency of wake bouts) during hospitalization...
April 20, 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29675669/can-we-draw-general-conclusions-from-interval-training-studies
#10
Ricardo Borges Viana, Claudio Andre Barbosa de Lira, João Pedro Araújo Naves, Victor Silveira Coswig, Fabrício Boscolo Del Vecchio, Rodrigo Ramirez-Campillo, Carlos Alexandre Vieira, Paulo Gentil
Interval training (IT) has been used for many decades with the purpose of increasing performance and promoting health benefits while demanding a relatively small amount of time. IT can be defined as intermittent periods of intense exercise separated by periods of recovery and has been divided into high-intensity interval training (HIIT), sprint interval training (SIT), and repeated sprint training (RST). IT use has resulted in the publication of many studies and many of them with conflicting results and positions...
April 19, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29675654/development-of-a-professional-certification-in-cancer-patient-education
#11
Janet Papadakos, Anna D'souza, Adeline Masse, Susan Boyko, Susan Clarke, Meredith Giuliani, Keira MacKinnon, Sarah McBain, Meg McCallum, Jan MacVinnie, Tina Papadakos
Patient educators come into the field from diverse professional backgrounds and often lack training in how to teach and develop patient education resources since no formal patient education professional certification program exists. A professional certification program for patient educators would further define the professional scope of practice and reduce variability in performance. The purpose of this study was to (1) determine the level of interest among Canadian cancer patient educators in a patient education professional certification program and (2) determine the competencies to be included in the professional certification program...
April 19, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29675653/medical-student-exposure-to-cancer-patients-whilst-on-clinical-placement-a-retrospective-analyses-of-clinical-log-books
#12
Darren L Starmer
In Australia, one in two men and one in three women will be diagnosed with cancer by the age of 85. Several studies have demonstrated a decline in the number of medical graduates having examined cancer patients during their training. The aim of this study was to evaluate the exposure of medical students to cancer patients during clinical placements. Eighty-eight logbooks (response rate = 24.75%) containing 9430 patients were analysed. A total of 829 patients (8.79%) had a diagnosis of cancer. Most cancer patients were seen on surgical placements, whilst general practice placements returned the lowest numbers...
April 19, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29675359/three-dimensional-speckle-tracking-echocardiography-detects-different-patterns-of-right-atrial-dysfunction-in-selected-disorders-a-short-summary-from-the-magyar-path-study
#13
Attila Nemes, Péter Domsik, Anita Kalapos, Árpád Kormányos, Nóra Ambrus, Tamás Forster
The right atrium (RA) is the most under-evaluated heart chamber in the clinical practice. Three-dimensional (3D) speckle-tracking echocardiography (STE) merges the benefits of 3D echocardiography and STE: volumetric and strain assessment of the RA can be performed at the same time from the same digitally acquired 3D echocardiographic dataset with a special equipment using a virtual 3D model of the RA. A diagnostic focused study is under way at the Second Department of Medicine and Cardiology Center, University of Szeged, Hungary to assess 3D-STE-derived RA variables in different patient populations, which serves as a substudy of Motion Analysis of the heart and Great vessels bY three-dimensionAl speckle-tRacking echocardiography in Pathological cases (MAGYAR-Path) Study...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29675282/self-medication-practice-in-limmu-genet-jimma-zone-southwest-ethiopia-does-community-based-health-insurance-scheme-have-an-influence
#14
Bayu Begashaw Bekele, Shibiru Tesema Berkesa, Enyew Tefera, Abera Kumalo
Background: Self-medication, which is a form of self-care, is an important initial response to illness, and many illnesses can be successfully treated at this stage. It is practiced by a considerable proportion of the population and is affected by sociodemographic and economic factors. This study was conducted to assess the practice of self-medication and associated factors in Limmu Genet's town households, Jimma Zone, Southwest Ethiopia. Methods and Materials: A community based cross-sectional study was done...
2018: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29675269/translation-of-remote-control-regenerative-technologies-for-bone-repair
#15
Hareklea Markides, Jane S McLaren, Neil D Telling, Noura Alom, E'atelaf A Al-Mutheffer, Richard O C Oreffo, Andrew Zannettino, Brigitte E Scammell, Lisa J White, Alicia J El Haj
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of in vitro bone tissue engineering strategies and provides an effective means of controlling cell behaviour towards therapeutic outcomes. However, the delivery of mechanical stimuli to exogenous MSC populations, post implantation, poses a significant translational hurdle...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29675096/nomograms-to-predict-individual-prognosis-of-patients-with-primary-small-cell-carcinoma-of-the-bladder
#16
Fan Dong, Yifan Shen, Fengbin Gao, Xiao Shi, Tianyuan Xu, Xianjin Wang, Xiaohua Zhang, Shan Zhong, Minguang Zhang, Shanwen Chen, Zhoujun Shen
Objectives: To develop reliable nomograms to estimate individualized overall survival (OS) and cancer specific survival (CSS) for patients with primary small cell carcinoma of the bladder (SCCB) and compare the predictive value with the AJCC stages. Patients and Methods: 582 eligible SCCB patients identified in the Surveillance, Epidemiology, and End Results (SEER) dataset were randomly divided into training (n=482) and validation (n=100) cohorts. Akaike information criterion was used to select the clinically important variables in multivariate Cox models when establishing nomograms...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29674329/regional-variability-in-fecal-microbiota-transplantation-practices-a-survey-of-the-southern-ontario-fecal-microbiota-transplantation-movement
#17
Susy S Hota, Salman Surangiwala, Aimee S Paterson, Bryan Coburn, Susan M Poutanen
BACKGROUND: There is growing evidence that fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection, but little guidance exists for implementation of FMT programs. The objective of this study is to describe the program characteristics and protocols of 9 planned or operating FMT programs in the Southern Ontario Fecal Microbiota Transplantation (SOFT) Movement, to help guide future FMT program implementation. METHODS: A 59-item survey was administered electronically to clinical leads of the SOFT Movement on June 2, 2016...
April 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29674259/spatial-variability-in-orchards-after-land-transformation-consequences-for-precision-agriculture-practices
#18
Asier Uribeetxebarria, Elisa Daniele, Alexandre Escolà, Jaume Arnó, José A Martínez-Casasnovas
The change from traditional to a more mechanized and technical agriculture has involved, in many cases, land transformations. This has supposed alteration of landforms and soils, with significant consequences. The effects of induced soil variability and the subsequent implications in site-specific crop management have not been sufficiently studied. The present work investigated the application of a resistivity soil sensor (Veris 3100), to map the apparent electrical conductivity (ECa), and detailed multispectral airborne images to analyse soil and crop spatial variability to assist in site-specific orchard management...
April 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29674135/mean-hba-1c-hba-1c-variability-and-mortality-in-people-with-diabetes-aged-70-years-and-older-a-retrospective-cohort-study
#19
Angus Forbes, Trevor Murrells, Henrietta Mulnier, Alan J Sinclair
BACKGROUND: Glycaemic targets for older people have been revised in recent years because of concern that more stringent targets are associated with increased mortality. We aimed to investigate the association between glycaemic control (mean HbA1c ) and variability (variability of HbA1c over time) and mortality in older people with diabetes. METHODS: We did a 5-year retrospective cohort study using The Health Improvement Network database, which includes data from 587 UK primary care practices...
April 16, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29673688/reliability-and-validity-of-microscribe-3dxl-system-in-comparison-with-radiographic-cephalometric-system-angular-measurements
#20
Maher M Barmou, Saba F Hussain, Mohamed I Abu Hassan
AIM: The aim of the study was to assess the reliability and validity of cephalometric variables from MicroScribe-3DXL. MATERIALS AND METHODS: Seven cephalometric variables (facial angle, ANB, maxillary depth, U1/FH, FMA, IMPA, FMIA) were measured by a dentist in 60 Malay subjects (30 males and 30 females) with class I occlusion and balanced face. Two standard images were taken for each subject with conventional cephalometric radiography and MicroScribe-3DXL. All the images were traced and analysed...
April 17, 2018: International Orthodontics
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