Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Run Zhou Ye, Kirill Lipatov, Daniel Diedrich, Anirban Bhattacharyya, Bradley J Erickson, Brian W Pickering, Vitaly Herasevich
OBJECTIVE: This study aims to design, validate and assess the accuracy a deep learning model capable of differentiation Chest X-Rays between pneumonia, acute respiratory distress syndrome (ARDS) and normal lungs. MATERIALS AND METHODS: A diagnostic performance study was conducted using Chest X-Ray images from adult patients admitted to a medical intensive care unit between January 2003 and November 2014. X-ray images from 15,899 patients were assigned one of three prespecified categories: "ARDS", "Pneumonia", or "Normal"...
March 28, 2024: Journal of Critical Care
#22
JOURNAL ARTICLE
Tracy E Madsen, Lili Ding, Jane C Khoury, Mary Haverbusch, Daniel Woo, Simona Ferioli, Felipe De Los Rios La Rosa, Sharyl R Martini, Opeolu Adeoye, Pooja Khatri, Matthew L Flaherty, Jason Mackey, Eva A Mistry, Stacie Demel, Elisheva Coleman, Adam Jasne, Sabreena Slavin, Kyle B Walsh, Michael Star, Joseph P Broderick, Brett Kissela, Dawn O Kleindorfer
BACKGROUND AND OBJECTIVES: Understanding the current status of and temporal trends of stroke epidemiology by age, race, and stroke subtype is critical to evaluate past prevention efforts and to plan future interventions to eliminate existing inequities. We investigated trends in stroke incidence and case fatality over a 22-year time period. METHODS: In this population-based stroke surveillance study, all cases of stroke in acute care hospitals within a 5-county population of southern Ohio/northern Kentucky in adults aged ≥20 years were ascertained during a full year every 5 years from 1993 to 2015...
February 13, 2024: Neurology
#23
JOURNAL ARTICLE
Carolina Kymie Vasques Nonaka, Adlas Michel de Jesus Ribeiro, Gisele Vieira Rocha, Helena Souza da Hora, Antônio Augusto Fonseca Junior, Fernanda de Macêdo Lima, Iasmin Nogueira Bastos, Samara Alves Sa Teles, Thamires Gomes Lopes Weber, Vanessa Ferreira Costa, Zaquer Suzana Costa-Ferro, Clarissa Araújo Gurgel Rocha, Silvia Inês Sardi, Gúbio Soares, Ana Verena Almeida Mendes, Bruno Solano de Freitas Souza
The global challenge posed by the prolonged COVID-19 pandemic underscores the critical need for ongoing genomic surveillance to identify emerging variants and formulate effective public health strategies. This retrospective observational study, conducted in a reference hospital in Northeast Brazil and comprising 2116 cases, employed PCR genotyping together with epidemiological data to elucidate the impact of the Gamma variant during its emergence, revealing distinct patterns in hospitalization rates, severity of illness, and outcomes...
March 20, 2024: Viruses
#24
REVIEW
Viviana Cortiana, Rabab Hunaid Abbas, Soumiya Nadar, Diksha Mahendru, Jade Gambill, Gayathri Pramil Menon, Chandler H Park, Yan Leyfman
The constantly escalating population of cancer survivors worldwide has prompted a focused exploration of their unique needs and experiences within the context of healthcare medicine. This review initiates its analysis inspired by Dr. Lidia Schapira's insightful keynote conference on the Survivorship 1.0 and Survivorship 2.0 Programs, shedding light on their implementation challenges and setting the stage for a comprehensive analysis of cancer survivorship initiatives. Within the transformed landscape of cancer care, patient-centric strategies embedded in cancer survivorship programs comprising vital elements such as connection, support, and education are presented...
March 20, 2024: Cancers
#25
JOURNAL ARTICLE
Helen P Bartlett, Clinton C Dawson, Cody M Glickman, David W Osborn, Christopher R Evans, Benjamin J Garcia, Lauren C Frost, Jason E Cummings, Nicholas Whittel, Richard A Slayden, Jason W Holder
To address intracellular mycobacterial infections, we developed a cocktail of four enzymes that catalytically attack three layers of the mycobacterial envelope. This cocktail is delivered to macrophages, through a targeted liposome presented here as ENTX_001. Endolytix Cocktail 1 (EC1) leverages mycobacteriophage lysin enzymes LysA and LysB, while also including α-amylase and isoamylase for degradation of the mycobacterial envelope from outside of the cell. The LysA family of proteins from mycobacteriophages has been shown to cleave the peptidoglycan layer, whereas LysB is an esterase that hydrolyzes the linkage between arabinogalactan and mycolic acids of the mycomembrane...
March 27, 2024: Microbiology Spectrum
#26
Saleh S Al Qahtani, Dunya Alfaraj, Mohammed O Alzayer, Zainab Juma, Mohamed Abdulla, Husain Faraj, Abdulla Juma, Mohamed M Moussa
The delayed onset of posttraumatic subdural hemorrhage (SDH) represents non-specific clinical features, complicating the diagnostic process, especially in individuals predisposed due to pre-existing risk factors and comorbidities. This case report delineates the medical trajectory of a 61-year-old female patient who sustained a traumatic fall, initially displaying neither clinical nor radiological signs indicative of hemorrhage. However, three weeks post-injury, she developed altered mental status, cephalgia, and emesis...
February 2024: Curēus
#27
JOURNAL ARTICLE
Naveed Ahmed, Mohammad Tahir Yousafzai, Farah Naz Qamar
BACKGROUND: The Enterics for Global Health (EFGH) Shigella surveillance study is a longitudinal multicountry study that aims to estimate incidence rates and document consequences of Shigella diarrhea within 7 countries in Africa, Asia, and Latin America. In addition to a high incidence of childhood diarrhea, Pakistan is facing a problem of antimicrobial resistance in urban and peri-urban areas of Karachi. METHODS: In Pakistan, EFGH will be conducted in Karachi, which is one of the metropolitan cities bordering the Arabian Sea and has a diverse population of 1...
March 2024: Open Forum Infectious Diseases
#28
JOURNAL ARTICLE
Mats L Moskopp, Dag Moskopp, Lennart W Sannwald
INTRODUCTION: Initial management of traumatic brain injury (TBI) without immediate need for surgical therapy varies across centers. The additional value of routine repeat cranial computerized tomography (CT) to neurological monitoring is controversial. This retrospective study investigates the impact of routine follow-up CT after 6 h (CT6h) in initially conservatively managed TBI on surgical decision making. Furthermore, the impact of coagulopathy on lesion size and progression was examined...
March 26, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
#29
JOURNAL ARTICLE
Lisa C Lindley, Christina N Policastro, Brianne Dosch, Joshua G Ortiz Baco, Charles Q Cao
As the awareness on violent deaths from guns, drugs, and suicides emerges as a public health crisis in the United States, attempts to prevent injury and mortality through nursing research are critical. The National Violent Death Reporting System provides public health surveillance of US violent deaths; however, understanding the National Violent Death Reporting System's research utility is limited. The purpose of our rapid review of the 2019-2023 literature was to understand to what extent artificial intelligence methods are being used with the National Violent Death Reporting System...
March 26, 2024: Computers, Informatics, Nursing: CIN
#30
JOURNAL ARTICLE
Su Yeon Lee, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim
OBJECTIVES: In 2018, the Centers for Disease Control and Prevention introduced the Adult Sepsis Event (ASE) definition, using electronic health records (EHRs) data for surveillance and sepsis quality improvement. However, data regarding ASE outside the United States remain limited. We therefore aimed to validate the diagnostic accuracy of the ASE and to assess the prevalence and mortality of sepsis using ASE. DESIGN: Retrospective cohort study. SETTING: A single center in South Korea, with 2732 beds including 221 ICU beds...
March 26, 2024: Critical Care Medicine
#31
REVIEW
Taeeun Kim, Sang-Ho Choi
Respiratory syncytial virus (RSV) constitutes a significant cause of respiratory illness and mortality among older adults, a demographic that is expanding with considerable impact on healthcare systems worldwide. The actual burden of RSV in this population may still be underestimated, owing to factors such as low awareness and suboptimal diagnostic sensitivity in adults, the lack of robust RSV surveillance systems, and the infrequent use of diagnostic testing. Recent advancements in respiratory virus detection have spurred further exploration into appropriate preventive and therapeutic strategies...
March 12, 2024: Infection & Chemotherapy
#32
JOURNAL ARTICLE
Peter Lemmer, Lydia Christina Rohr, Marie Henning, Kerem Bulut, Paul Manka, Ali Canbay, Jan-Peter Sowa
INTRODUCTION: Early detection of patients with advanced chronic liver disease is critical for prevention of complications and inclusion in surveillance programs for hepatocellular carcinoma. In daily clinical care, it remains challenging to differentiate early cirrhosis from lower fibrosis grades without performing a liver biopsy. Aim of the present study was to assess performance of different non-invasive detection tools to differentiate cirrhosis from lower fibrosis grades. METHODS: Data of 116 patients (51 male, 65 female) with chronic liver disease of various origin undergoing liver biopsy was analysed...
March 25, 2024: Digestive Diseases
#33
JOURNAL ARTICLE
Chandan Bhambhani, Qing Kang, Daniel H Hovelson, Erin Sandford, Mary Olesnavich, Sarah M Dermody, Jenny Wolfgang, Kirsten L Tuck, Collin Brummel, Apurva D Bhangale, Kuang He, Marc G Gutierrez, Ryan H Lindstrom, Chia-Jen Liu, Melissa Tuck, Malathi Kandarpa, Michelle Mierzwa, Keith Casper, Mark E Prince, John C Krauss, Moshe Talpaz, N Lynn Henry, Maria D Giraldez, Nithya Ramnath, Scott A Tomlins, Paul L Swiecicki, J Chad Brenner, Muneesh Tewari
BACKGROUNDTransrenal cell-free tumor DNA (TR-ctDNA), which transits from the bloodstream into urine, has the potential to enable noninvasive cancer detection for a wide variety of nonurologic cancer types.MethodsUsing whole-genome sequencing, we discovered that urine TR-ctDNA fragments across multiple cancer types are predominantly ultrashort (<50 bp) and, therefore, likely to be missed by conventional ctDNA assays. We developed an ultrashort droplet digital PCR assay to detect TR-ctDNA originating from HPV-associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC) and confirmed that assaying ultrashort DNA is critical for sensitive cancer detection from urine samples...
February 8, 2024: JCI Insight
#34
JOURNAL ARTICLE
Pauline Yeung Ng, April Ip, Andrew Kei-Yan Ng, Simon Wai-Ching Sin, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Desmond Yat-Hin Yap
BACKGROUND: The SARS-CoV-2 virus can bind to angiotensin-converting enzyme 2 receptors on host renal cells and may cause acute kidney injury (AKI). The comparative risks of AKI in patients severely ill with COVID-19 and influenza A have not been examined. METHODS: This is a retrospective cohort study including patients with positive PCR results for SARS-CoV-2 or influenza A virus admitted to the intensive care units (ICUs) of 15 public hospitals in Hong Kong between 1st January 2013 and 30th April 2023...
April 2024: EClinicalMedicine
#35
JOURNAL ARTICLE
Yolanda Peña-López, María Slocker-Barrio, Juan-Carlos de-Carlos-Vicente, Marta Serrano-Megías, Iolanda Jordán-García, Jordi Rello
OBJECTIVES: An objective categorization of respiratory infections based on outcomes is an unmet clinical need. Ventilator-associated pneumonia and tracheobronchitis remain used in clinical practice, whereas ventilator-associated events (VAE) are limited to surveillance purposes. RESEARCH METHODOLOGY/DESIGN: This was a secondary analysis from a multicentre observational prospective cohort study. VAE were defined as a sustained increase in minimum Oxygen inspired fraction (FiO2) and/or Positive end-expiratory pressures (PEEP) of ≥ 0...
March 19, 2024: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
#36
JOURNAL ARTICLE
Niccolò Buetti, Alexis Tabah, Nour Setti, Stéphane Ruckly, François Barbier, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Matteo Bassetti, Andrew Conway Morris, Kostoula Arvaniti, José-Artur Paiva, Ricard Ferrer, Haibo Qiu, Giorgia Montrucchio, Andrea Cortegiani, Bircan Kayaaslan, Liesbet De Bus, Jan J De Waele, Jean-François Timsit
PURPOSE: The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process and outcome indicators in patients with hospital-acquired bloodstream infections (HABSI). METHODS: We used data on HABSI from the prospective EUROBACT-2 study to evaluate the associations between centre/country factors on a process or an outcome indicator: adequacy of antimicrobial therapy within the first 24 h or 28-day mortality, respectively...
March 18, 2024: Intensive Care Medicine
#37
JOURNAL ARTICLE
André Fernandes, Joao Nuno Patricio, Rita Jorge, Raquel Nazareth, Carlos S Pereira
Introduction Ventilator-associated pneumonia (VAP) is the most common infectious complication related to admission to an Intensive Treatment Unit (ITU). Ventilator-associated lower respiratory tract infection (VA-LRTI) is a broader diagnosis than VAP. By disregarding radiological criteria, it will include both VAP and ventilator-associated tracheobronchitis. This study, conducted in the setting of a Portuguese ITU, aims to study the incidence, microbiology and clinical outcome of VA-LRTI and its association with COVID-19...
February 2024: Curēus
#38
REVIEW
Benedict Stanberry, Nikki Webber-Jones
BACKGROUND: This study supports a value-based approach to prostate cancer (PCa) treatment by systematically reviewing economic evaluations that compare the cost and cost-effectiveness of low-dose-rate brachytherapy (LDR-BT) with that of other treatment options for localised and locally advanced PCa. METHODS: Studies published between 2008 and 2023 were searched for in MEDLINE, EMBASE and Tufts Medical Center's Cost-Effectiveness Analysis (CEA) Registry (Prospero protocol CRD42023-442027)...
March 13, 2024: Prostate Cancer and Prostatic Diseases
#39
JOURNAL ARTICLE
Nickelas Huffman, Ignacio Pasqualini, Shujaa T Khan, Alison K Klika, Matthew E Deren, Yuxuan Jin, Kyle N Kunze, Nicolas S Piuzzi
» The application of artificial intelligence (AI) in the field of orthopaedic surgery holds potential for revolutionizing health care delivery across 3 crucial domains: (I) personalized prediction of clinical outcomes and adverse events, which may optimize patient selection, surgical planning, and enhance patient safety and outcomes; (II) diagnostic automated and semiautomated imaging analyses, which may reduce time burden and facilitate precise and timely diagnoses; and (III) forecasting of resource utilization, which may reduce health care costs and increase value for patients and institutions...
March 1, 2024: JBJS Reviews
#40
JOURNAL ARTICLE
Courtney M Rowan, Brenna LaBere, Cameron C Young, Laura D Zambrano, Margaret M Newhams, Suden Kucukak, Elizabeth R McNamara, Elizabeth H Mack, Julie C Fitzgerald, Katherine Irby, Aline B Maddux, Jennifer E Schuster, Michele Kong, Heda Dapul, Stephanie P Schwartz, Melania M Bembea, Laura L Loftis, Amanda R Kolmar, Christopher J Babbitt, Ryan A Nofziger, Mark W Hall, Shira J Gertz, Natalie Z Cvijanovich, Matt S Zinter, Natasha B Halasa, Tamara T Bradford, Gwenn E McLaughlin, Aalok R Singh, Charlotte V Hobbs, Kari Wellnitz, Mary A Staat, Bria M Coates, Hillary R Crandall, Mia Maamari, Kevin M Havlin, Adam J Schwarz, Christopher L Carroll, Emily R Levy, Kristin L Moffitt, Angela P Campbell, Adrienne G Randolph, Janet Chou
BACKGROUND: We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care. METHODS: 55 hospitals in 30 U.S. states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients <21 years admitted March 12, 2020-December 30, 2021 to the pediatric intensive care unit (PICU) or high acuity unit for acute COVID-19 were included...
March 11, 2024: Clinical Infectious Diseases
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
