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https://www.readbyqxmd.com/read/27801415/-comparative-evaluation-of-the-intensity-of-reparative-processes-in-the-lower-extremity-soft-tissues-of-diabetic-patients-receiving-local-negative-pressure-wound-treatment-and-standard-wound-care
#1
G R Galstyan, A Yu Tokmakova, E L Zaitseva, L P Doronina, I A Voronkova, R V Molchkov
AIM: To study the intensity of soft tissue repair in patients with diabetic foot syndrome (DFS) during local negative pressure wound treatment versus standard wound care. SUBJECTS AND METHODS: The investigators estimated the clinical (wound sizes, local tissue oxygenation), histological (light microscopy), and immunohistochemical (CD31, CD68, MMP-9, and TIMP-1) markers for reparative processes in patients with DFS during vacuum therapy versus standard wound care...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27759589/influences-of-macrohemodynamic-conditions-on-systemic-microhemodynamic-changes-in-burns
#2
Jochen-Frederick Hernekamp, Florian Neubrech, Tomke Cordts, Volker J Schmidt, Ulrich Kneser, Thomas Kremer
PURPOSE: The clinical course after major burns is characterized by microcirculatory changes and consecutive capillary leakage. However, current clinical monitoring does not properly assess microcirculation, whereas macrohemodynamic changes are continuously evaluated. Here, we assess if macrohemodynamic and microhemodynamic parameters after burn trauma are correlated in a rat model. METHODS: Burn plasma harvested from donor rats 4 hours after thermal injury (30% total body surface area, 100 °C water, 12 seconds) was administered intravenously to healthy animals during 2 hours of intravital microscopy (burn group [BG])...
October 17, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/26818116/sunitinib-treatment-reduces-tumor-growth-and-limits-changes-in-microvascular-properties-after-minor-surgical-intervention-in-an-in-vivo-model-of-secondary-breast-cancer-growth-in-bone
#3
Malte Schroeder, Lennart Viezens, Jasmin Wellbrock, Walter Fiedler, Wolfgang Rüther, Petra Algenstaedt, Nils Hansen-Algenstaedt, Christian Schaefer
BACKGROUND AND OBJECTIVES: Surgical interventions can alter the balance between pro- and anti-angiogenic growth factors and thereby modulate tumor growth. Since the microcirculatory properties of tumors underlie organ-specific differences, the microhemodynamic characteristics of bone metastasis have not yet been fully described. Angiogenesis inhibitors are increasingly being used to treat advanced stages of cancer. We hypothesized that the anti-angiogenic drug sunitinib abrogates alterations in microvascular properties following a minor surgical intervention in an in vivo model of secondary breast cancer growth in the bone...
April 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26488374/a-novel-and-sensitive-approach-for-the-evaluation-of-liver-ischemia-reperfusion-injury-after-liver-transplantation
#4
Martina Brandlhuber, Marco Armbruster, Blaž Zupanc, Paola Coan, Emmanuel Brun, Wieland Sommer, Markus Rentsch
OBJECTIVES: The purpose of our study was to evaluate the potential of x-ray propagation-based phase-contrast imaging (PCI) computed tomography (CT) for the detection and characterization of early changes after ischemia-reperfusion (IR) in a standardized rat liver transplantation (LTx) model. MATERIALS AND METHODS: Syngeneic orthotopic liver transplantation was performed in male Lewis rats. Ischemia-reperfusion injury (IRI)-induced changes of liver parenchyma were investigated in a time-dependent manner (2, 16, 24, and 32 hours)...
March 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26360650/influence-of-cdp-choline-administration-on-early-burn-edema-in-rats
#5
Jochen Frederick Hernekamp, Sissi Xi Hu, Volker Jürgen Schmidt, Julian Vogelpohl, Ulrich Kneser, Thomas Kremer
PURPOSE: The cholinergic anti-inflammatory pathway may play an important role in early burn edema. Therefore, we evaluated the influence of cdp-choline on early systemic burn edema and leukocyte activation in shock in rat mesenteries after burn plasma transfer. METHODS: Burn plasma harvested from donor rats 4 hours after thermal injury (30% total body surface area, 100°C water, 12 seconds) was administered intravenously to healthy animals during 2 hours of intravital microscopy...
October 2015: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/26120994/-characteristics-of-microcirculation-in-patients-with-acute-ischemic-stroke-and-chronic-cerebral-ischemia
#6
A V Anisimova, A I Krupatkin, V V Sidorov, M V Zakharkina, E V Iutskova, S S Galkin
OBJECTIVE: To study microcirculation in patients with acute ischemic stroke (IS) using the method of laser Doppler fluorimetry (LDF). MATERIAL AND METHODS: We examined 19 patients with acute carotid IS, including 12 patients who received thrombolytic therapy. The reference group included 22 patients with chronic cerebral ischemia without a history of IS. Computed and magnetic resonance tomography of the brain, ultrasound diagnosis of head and neck vessels, the study of the changes in neurological status, emotional sphere, cognitive functions and laboratory methods were used...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26038010/5-ht2a-receptor-antagonism-reduces-burn-induced-macromolecular-efflux-in-rats
#7
J F Hernekamp, H Klein, K Schmidt, U Kneser, T Kremer
BACKGROUND: Major thermal injuries lead to a systemic inflammatory response with systemic capillary leakage and multiple organ dysfunction. This systemic inflammatory response is induced by a variety of immunmodulative molecules including TNFα and serotonin. Unspecific serotonin antagonism leads to reduced macromolecular efflux in rat mesenteries after burn plasma transfer. The aim of the present study was to evaluate the effect of specific 5-HT2a antagonism on early burn edema. METHODS: Donor rats (DR) underwent thermal injury (100 °C water, 30% BSA, 12 s) for positive controls...
October 2015: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26016325/-effects-of-chronic-hypokinetic-stress-on-microhemodynamics-of-tissue
#8
E N Chuyan, M Yu Ravaeva
By laser Doppler flowmetry investigated tissue microhemodynamics rats kept hypokinesia under 10 days. Investigation of the structure of rhythms blood flow oscillations in microvasculature revealed that chronic hypokinetic stress leads to a significant reduction of the oscillator and nonoscillation microhemodynamics indicators, reflected in the development of vasoconstriction, reducing the metabolic function of the endothelium and the allocation to them of nitric oxide, a violation of inflow and outflow of blood, the dominance of shunt blood flow, decreasing the number of functioning capillaries...
March 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
https://www.readbyqxmd.com/read/25795500/sepsis-associated-acute-kidney-injury-macrohemodynamic-and-microhemodynamic-alterations-in-the-renal-circulation
#9
REVIEW
John R Prowle, Rinaldo Bellomo
Traditionally, renal ischemia has been regarded as central to the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). Accordingly, hemodynamic management of SA-AKI has emphasized restoration of renal perfusion, whereas, experimentally, ischemia reperfusion models have been emphasized. However, in human beings, SA-AKI usually is accompanied by hyperdynamic circulation. Moreover, clinical and experimental evidence now suggests the importance of inflammatory mechanisms in the development of AKI and microcirculatory dysfunction more than systemic alteration in renal perfusion...
January 2015: Seminars in Nephrology
https://www.readbyqxmd.com/read/25588402/-impact-of-various-second-stage-implant-surgery-methods-on-adjacent-gingival-tissues-microcirculation
#10
COMPARATIVE STUDY
A A Kulakov, E K Krechina, A S Kasparov, E V Verzilov, S S Seregin
The paper presents the rezults of laser doppler flowmetry (LDF) studies of microcirculation in gingival tissues around dental implants disclosed by different methods. Microhemodynamics in gingival tissues when using a scalpel recovered after 14 days, carbon dioxide laser -- 7 days and erbium laser -- 3 days, which may be important in the choice of the operation tactics.
2014: Stomatologii︠a︡
https://www.readbyqxmd.com/read/25508964/-microcirculatory-reactivity-features-in-almost-healthy-people-during-acute-moderate-hypoxia-and-hyperoxia-modeling
#11
(no author information available yet)
The dynamics of the microvascular circulation and tissue oxygenation in the hypoxic test and subsequent hyperoxia are considered. In 30 healthy young men indicators of microcirculation and tissue oxygenation (laser Doppler flowmetry, and the optical tissue oximetry) during the hypoxic test - HT (10 min breathing by gas mixture with 10% O2 followed by hyperoxia (30% O2) were registered. It is found that the HT does not entail changes in the relative level of tissue oxygen saturation (SO2), but leads to a relative degree of tissue oxygen extraction significant reduction (δSaO2-SO2) with a rapid recovery in the hyperoxic phase...
July 2013: Fiziologiia Cheloveka
https://www.readbyqxmd.com/read/25486833/-microcirculatory-reactivity-features-in-almost-healthy-people-during-acute-moderate-hypoxia-and-hyperoxia-modeling
#12
O S Glazachev, E N Dudnik
The dynamics of the microvascular circulation and tissue oxygenation in the hypoxic test and subsequent hyperoxia are considered. In 30 healthy young men indicators of microcirculation and tissue oxygenation (laser Doppler flowmetry, and the optical tissue oximetry) during the hypoxic test - HT (10 min breathing by gas mixture with 10% O2 followed by hyperoxia (30% O2) were registered. It is found that the HT does not entail changes in the relative level of tissue oxygen saturation (SO2), but leads to a relative degree of tissue oxygen extraction significant reduction (δSaO2-SO2) with a rapid recovery in the hyperoxic phase...
July 2013: Fiziologiia Cheloveka
https://www.readbyqxmd.com/read/24920392/localized-increase-of-tissue-oxygen-tension-by-magnetic-targeted-drug-delivery
#13
Celine Liong, Daniel Ortiz, Eilleen Ao-ieong, Mahantesh S Navati, Joel M Friedman, Pedro Cabrales
Hypoxia is the major hindrance to successful radiation therapy of tumors. Attempts to increase the oxygen (O2) tension (PO2) of tissue by delivering more O2 have been clinically disappointing, largely due to the way O2 is transported and released by the hemoglobin (Hb) within the red blood cells (RBCs). Systemic manipulation of O2 transport increases vascular resistance due to metabolic autoregulation of blood flow to prevent over oxygenation. This study investigates a new technology to increase O2 delivery to a target tissue by decreasing the Hb-O2 affinity of the blood circulating within the targeted tissue...
July 4, 2014: Nanotechnology
https://www.readbyqxmd.com/read/24885482/two-dimensional-strain-hardening-membrane-model-for-large-deformation-behavior-of-multiple-red-blood-cells-in-high-shear-conditions
#14
Swe Soe Ye, Yan Cheng Ng, Justin Tan, Hwa Liang Leo, Sangho Kim
BACKGROUND: Computational modeling of Red Blood Cell (RBC) flow contributes to the fundamental understanding of microhemodynamics and microcirculation. In order to construct theoretical RBC models, experimental studies on single RBC mechanics have presented a material description for RBC membranes based on their membrane shear, bending and area moduli. These properties have been directly employed in 3D continuum models of RBCs but practical flow analysis with 3D models have been limited by their computationally expensive nature...
2014: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/24569506/phosphodiesterase-4-inhibition-dose-dependently-stabilizes-microvascular-barrier-functions-and-microcirculation-in-a-rodent-model-of-polymicrobial-sepsis
#15
Sven Flemming, Nicolas Schlegel, Christian Wunder, Michael Meir, Wolfgang Baar, Jakob Wollborn, Norbert Roewer, Christoph-Thomas Germer, Martin Alexander Schick
BACKGROUND: Breakdown of microvascular endothelial barrier functions contributes to disturbed microcirculation, organ failure, and death in sepsis. Increased endothelial cAMP levels by systemic application of phosphodiesterase 4 inhibitors (PD-4-I) have previously been demonstrated to protect microvascular barrier properties in a model of systemic inflammation (systemic inflammatory response syndrome) suggesting a novel therapeutic option to overcome this problem. However, in a clinically relevant model of polymicrobial sepsis long-term effects, immunomodulatory effects and effectivity of PD-4-I to stabilize microvascular barrier functions and microcirculation remained unexplored...
June 2014: Shock
https://www.readbyqxmd.com/read/24480871/microhemodynamic-parameters-quantification-from-intravital-microscopy-videos
#16
Daniel Ortiz, Juan Carlos Briceño, Pedro Cabrales
Blood flow and blood-endothelium interactions correspond with the genesis of cardiovascular diseases. Therefore, quantitative analysis of blood flow dynamics at the microcirculation level is of special interest. Regulatory mechanisms mediated by blow flow have been studied in detail using in vitro approaches. However, these mechanisms have not been fully validated in vivo due to technical limitations that arise when quantifying microhemodynamics with the required level of detail. Intravital microscopy combined with high-speed video recordings has been used for the analysis of blood flow in small blood vessels of chronic and acute experimental tissue preparations...
March 2014: Physiological Measurement
https://www.readbyqxmd.com/read/24455900/-physiological-features-of-skin-ageing-in-human
#17
REVIEW
I V Tikhonova, A V Tankanag, N K Chemeris
The issue deals with the actual problem of gerontology, notably physiological features of human skin ageing. In the present review the authors have considered the kinds of ageing, central factors, affected on the ageing process (ultraviolet radiation and oxidation stress), as well as the research guidelines of the ageing changes in the skin structure and fuctions: study of mechanical properties, microcirculation, pH and skin thickness. The special attention has been payed to the methods of assessment of skin blood flow, and to results of investigations of age features of peripheral microhemodynamics...
July 2013: Uspekhi Fiziologicheskikh Nauk
https://www.readbyqxmd.com/read/24246440/effects-of-perfluorocarbon-emulsions-on-microvascular-blood-flow-and-oxygen-transport-in-a-model-of-severe-arterial-gas-embolism
#18
Luciana N Torres, Bruce D Spiess, Ivo P Torres Filho
BACKGROUND: Arterial gas embolism (AGE) is a clinical problem that occurs directly in cardiopulmonary bypass machines in open-heart surgeries, or indirectly (through cardiac or pulmonary right to left shunts) in dive accidents, resulting in serious morbidity and even death. Perfluorocarbon (PFC) emulsions have been used for the treatment of AGE in an animal model. We hypothesized that PFC emulsions enhance microvascular blood flow, speed bubble resolution, and oxygenation in AGE compared with saline in a model of cremaster muscle from anesthetized rats...
March 2014: Journal of Surgical Research
https://www.readbyqxmd.com/read/24021606/effects-of-various-physical-treatment-methods-on-arteriolar-vasomotion-and-microhemodynamic-functional-characteristics-in-case-of-deficient-regulation-of-organ-blood-flow-results-of-a-placebo-controlled-double-blind-study
#19
COMPARATIVE STUDY
Rainer Christian Klopp, Wolfgang Niemer, Wolfgang Schmidt
As part of a placebo-controlled study, high-resolution measurement methods were used to examine, on the basis of representative functional characteristics of microcirculation, whether and to what extent six different, commercially available, physical treatment devices were suitable for influencing, through complementary therapy, deficient blood-flow regulation. Of the six commercially available devices tested, two proved to be ineffective and three not effective enough to be therapeutically relevant. Only in one device was it possible to show a complementary-therapeutic effect: the device uses a specific, biorhythmically defined stimulus for vasomotion...
2013: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/23963134/contribution-of-protein-z-and-protein-z-dependent-protease-inhibitor-in-generalized-shwartzman-reaction
#20
Antje Butschkau, Philipp Nagel, Eberhard Grambow, Dietmar Zechner, George J Broze, Brigitte Vollmar
OBJECTIVE: Sepsis, a leading cause of mortality in critically ill patients, is closely linked to the excessive activation of coagulation and inflammation. Protein Z, a cofactor for the protein Z-dependent protease inhibitor, enhances the inhibition of coagulation factor Xa, and protein Z-dependent protease inhibitor inhibits factor XIa in a protein Z-independent fashion. The functions of protein Z and protein Z-dependent protease inhibitor in the inflammatory and coagulant responses to septic illness have not been evaluated...
December 2013: Critical Care Medicine
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