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Lenneke Schrier, Rob Zuiker, Frans W H M Merkus, Erica S Klaassen, Zheng Guan, Bert Tuk, Joop M A van Gerven, Ronald van der Geest, Geert Jan Groeneveld
AIM: To evaluate the pharmacokinetics, pharmacodynamics, nasal tolerance and effects on sedation of a highly concentrated aqueous intranasal midazolam formulation (Nazolam) and to compare these to intravenous midazolam. METHODS: In this four-way crossover, double-blind, double-dummy, randomized, placebo-controlled study, 16 subjects received 2.5 mg Nazolam, 5.0 mg Nazolam, 2.5 mg intravenous midazolam or placebo on different occasions. Pharmacokinetics of midazolam and α-hydroxy-midazolam were characterized and related to outcome variables for sedation (Saccadic Peak Velocity, the Bond and Lader Visual Analogue Scale for sedation, the Simple Reaction Time Task and the Observer's Assessment of Alertness/Sedation)...
October 25, 2016: British Journal of Clinical Pharmacology
Júlio Cezar M A Mancini, Márcio Ricardo Taveira Garcia, Ilka Regina Souza de Oliveira, Ronaldo Rodrigues de Freitas, João Gualberto C Luz
PURPOSE: This study assessed the arterial blood supply to the mandible of edentulous patients treated for mandibular fractures using colour Doppler ultrasound. METHODS: The blood supply of edentulous patients surgically treated for mandibular fractures (group A) and edentulous fracture-free individuals (group B) was assessed. Only the fractured sides were evaluated in the first group (N = 17), whereas each side was evaluated in the second group (N = 20)...
October 1, 2016: Oral and Maxillofacial Surgery
Vojko Flis, Stojan Potrc, Nina Kobilica, Arpad Ivanecz
BACKGROUND: Recent reports have shown that patients with vascular tumour invasion who undergo concurrent vascular resection can achieve long-term survival rates equivalent to those without vascular involvement requiring pancreaticoduodenectomy alone. There is no consensus about which patients benefit from the portal-superior mesenteric vein resection and there is no consensus about the best surgical technique of vessel reconstruction (resection with or without graft reconstruction). As published series are small the aim of this study was to evaluate our experience in pancreatectomies with en bloc vascular resection and reconstruction of vessels...
September 1, 2016: Radiology and Oncology
Shu-Yan Wu, Li-Dan Wang, Jin-Ling Li, Guang-Mei Xu, Mei-Ling He, Yuan-Yuan Li, Rui Huang
Salmonella enterica serovar typhimurium (S. typhimurium) is globally distributed and causes massive morbidity and mortality in humans and animals. S. typhimurium carries Salmonella plasmid virulence (spv) locus, which is highly conserved and closely related to bacterial pathogenicity, while its exact role in host immune responses during infection remains to be elucidated. To counteract the invaders, the host has evolved numerous strategies, among which the innate immunity and autophagy act as the first defense...
September 22, 2016: Fish & Shellfish Immunology
Antoine J Marchand, Philippe Seguin, Yannick Malledant, Marion Taleb, Hélène Raoult, Jean Yves Gauvrit
BACKGROUND: Computed tomography angiography (CTA) is largely performed in European countries as an ancillary test for diagnosing brain death. However, CTA suffers from a lack of sensitivity, especially in patients who have previously undergone decompressive craniectomy. The aim of this study was to assess the performance of a revised four-point venous CTA score, including non-opacification of the infratentorial venous circulation, for diagnosing brain death. METHODS: A preliminary study of 43 control patients with normal CTAs confirmed that the infratentorial superior petrosal vein (SPV) was consistently visible...
December 2016: Annals of Intensive Care
W Lim, D Lambrick, A R Mauger, B Woolley, J Faulkner
The self-paced maximal oxygen uptake (VO2max) test (SPV), which is based on the Borg 6-20 Ratings of Perceived Exertion (RPE) scale, allows participants to self-regulate their exercise intensity during a closed-loop incremental maximal exercise test. As previous research has assessed the utility of the SPV test within laboratory conditions, the purpose to this study was to assess the effect of trial familiarisation on the validity and reproducibility of a field-based, SPV test. In a cross-sectional study, fifteen men completed one laboratory-based graded exercise test (GXT) and three field-based SPV tests...
September 2016: Biology of Sport
Michael Dahl, Chris Hayes, Bodil Steen Rasmussen, Anders Larsson, Niels H Secher
BACKGROUND: Whether during spontaneous breathing arterial pressure variations (APV) can detect a volume deficit is not established. We hypothesized that amplification of intra-thoracic pressure oscillations by breathing through resistors would enhance APV to allow identification of a reduced cardiac output (CO). This study tested that hypothesis in healthy volunteers exposed to central hypovolemia by head-up tilt. METHODS: Thirteen healthy volunteers were exposed to central hypovolemia by 45° head-up tilt while breathing through a facemask with 7...
2016: BMC Anesthesiology
Adegoke H Bakare, Oluwatooyin F Osundahunsi, Joseph O Olusanya
The rheological (Pasting, farinograph, and alveograph) properties of wheat flour (WF) replaced with breadfruit four (05-40%) was analyzed. Baking and sensory qualities of the resulting bread were evaluated. Differences in baking properties of loaves produced under laboratory and industrial conditions were analyzed with t-test, whereas ANOVA was used for other analyses. Peak and final viscosities in the composite blends (CB) ranged from 109.20 to 114.06 RVU and 111.86 to 134.40 RVU, respectively. Dough stability decreased from 9...
July 2016: Food Science & Nutrition
Fabrizio Bertelloni, Marianne Chemaly, Domenico Cerri, Françoise Le Gall, Valentina Virginia Ebani
The fecal samples from 213 captive reptiles were examined, and 29 (13.61%) Salmonella enterica isolates were detected: 14/62 (22.58%) from chelonians, 14/135 (10.37%) from saurians, and 1/16 (6.25%) from ophidians. The isolates were distributed among 14 different serotypes: Miami, Ebrie, Hermannsweder, Tiergarten, Tornov, Pomona, Poona, Goteborg, Abaetetube, Nyanza, Kumasi, Typhimurium, 50:b:z6, 9,12:z29:1,5, and a non-motile serotype with antigenic formula 1,4,[5],12:-:-. Salmonella typhimurium and 50:b:z6 isolates showed the spv plasmid virulence genes, responsible of the capability to induce extra-intestinal infections...
June 2016: Acta Microbiologica et Immunologica Hungarica
Benjamin Grévin, Pierre-Olivier Schwartz, Laure Biniek, Martin Brinkmann, Nicolas Leclerc, Elena Zaborova, Stéphane Méry
Self-assembled donor-acceptor dyads are used as model nanostructured heterojunctions for local investigations by noncontact atomic force microscopy (nc-AFM) and Kelvin probe force microscopy (KPFM). With the aim to probe the photo-induced charge carrier generation, thin films deposited on transparent indium tin oxide substrates are investigated in dark conditions and upon illumination. The topographic and contact potential difference (CPD) images taken under dark conditions are analysed in view of the results of complementary transmission electron microscopy (TEM) experiments...
2016: Beilstein Journal of Nanotechnology
Celia Rogero, David F Pickup, Jaime Colchero, Eneko Azaceta, Ramón Tena-Zaera, Elisa Palacios-Lidón
Kelvin probe force microscopy in darkness and under illumination is reported to provide nanoscale-resolved surface photovoltage maps of hybrid materials. In particular, nanoscale charge injection and charge recombination mechanisms occurring in ZnO polycrystalline surfaces functionalized with Protoporphyrin IX (H2PPIX) are analyzed. Local surface potential and surface photovoltage maps not only reveal that upon molecular adsorption the bare ZnO work function increases, but also they allow study of its local dependence...
July 6, 2016: ACS Applied Materials & Interfaces
Xianjin Yang, Edouard Debonneuil, Alex Zhavoronkov, Bud Mishra
Advances in financial engineering are radically reshaping the biomedical marketplace. For instance, new methods of pooling diversified drug development programs by placing them in a special purpose vehicle (SPV) have been proposed to create a securitized cancer megafund allowing for debt and equity participation. In this study, we perform theoretical and numerical simulations that highlight the role of empirical validation of the projects comprising a cancer megafund. We quantify the degree to which the deliberately designed structure of derivatives and investments is key to its liquidity...
June 3, 2016: Oncotarget
Yurii T Tsukanov, Anton Y Tsukanov, Evgenii G Levdanskiy
The aim of this study was to examine secondary varicose small pelvic veins (VSPV) and their treatment with micronized purified flavonoid fraction (MPFF). We examined 70 patients with a history of acute iliac thrombosis of > 1 year. Patients with urination difficulties associated with other symptoms (n = 24) received MPFF 1,000 mg once daily for 1 month. Clinical manifestations were assessed by collecting complaints and analyzing results of physician examinations. VSPV was identified in 48 (68.6%) patients, the majority (58%) had grade 2 (7...
June 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Peter F Ehrlich, Thomas E Hamilton, Kenneth Gow, Douglas Barnhart, Fernando Ferrer, Jessica Kandel, Richard Glick, Roshni Dasgupta, Arlene Naranjo, Ying He, Elizabeth J Perlman, John A Kalapurakal, Geetika Khanna, Jeffrey S Dome, James Geller, Elizabeth Mullen
BACKGROUND: The purpose of this study was to evaluate the frequency and characteristics of surgical protocol violations (SPVs) among children undergoing surgery for renal tumors who were enrolled on the Children's Oncology Group (COG) renal tumor biology and classification study AREN03B2. METHODS: AREN03B2 was opened in February 2006, and as on March 31, 2013, there were 3,664 eligible patients. The surgical review forms for 3,536 patients with unilateral disease were centrally reviewed for SPVs...
November 2016: Pediatric Blood & Cancer
Bridget M Seitz, Teresa Krieger-Burke, Gregory D Fink, Stephanie W Watts
The purpose of this study was to investigate serial ultrasound imaging in rats as a fully non-invasive method to (1) quantify the diameters of splanchnic veins in real time as an indirect surrogate for the capacitance function of those veins, and (2) assess the effects of drugs on venous dimensions. A 21 MHz probe was used on anesthetized male Sprague-Dawley rats to collect images containing the portal vein (PV), superior mesenteric vein (SMV), abdominal inferior vena cava (IVC), and splenic vein (SpV; used as a landmark in timed studies) and the abdominal aorta (AA)...
2016: Frontiers in Pharmacology
Lei Cheng
Dandy first described the course of the superior petrosal vein (SPV) and its importance during surgery in 1929. Although it has been reported that this vein can be sacrificed without complication, unfavourable outcomes may occur after dividing the SPV. We review these consequences, which may include peduncular hallucinosis and hearing loss, or even hemorrhage, and discuss factors that may contribute to complications. Preservation of the SPV should be attempted whenever possible to increase the safety of surgery...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Weihua Pei, He Zhang, Yijun Wang, Xuhong Guo, Xiao Xing, Yong Huang, Yuxing Xie, Xiaowei Yang, Hongda Chen
OBJECTIVE: A skin-potential variation (SPV) insensitive dry electrode is developed to remove the interference of SPV. METHODS: Based on conventional microneedles array (MNA) - based electrode, a layer of Parylene membrane is coated at the root of microneedles to insulate the electrode from the corneum layer. Only tips of the needles are exposed to make it can contact with the stratum germinativum layer directly. RESULTS: As a result, skin potential will not be coupled into the recording electrode...
May 4, 2016: IEEE Transactions on Bio-medical Engineering
Nicholas J Hanson, Cory M Scheadler, Taylor L Lee, Noah C Neuenfeldt, Timothy J Michael, Michael G Miller
PURPOSE: The Bruce protocol is traditionally used to assess maximal cardiorespiratory fitness (VO2max), but may have limitations, such as an unknown duration and large work rate increases. The use of self-paced VO2max tests (SPVs) may be beneficial if they are able to elicit similar maximal values in a set period of time. In addition, differences in modality between SPVs have not been explored. The purpose of this study was to compare SPVs, utilizing two different modes, with the Bruce (treadmill) protocol...
July 2016: European Journal of Applied Physiology
Jeannine Bergmann, Carmen Krewer, Charlotte Selge, Friedemann Müller, Klaus Jahn
BACKGROUND: The subjective postural vertical (SPV), i.e., the perceived upright orientation of the body in relation to gravity, is disturbed in patients with pusher behavior. So far, the SPV has been measured only when these patients were sitting, and the results were contradictory as regards the side of the SPV deviation. OBJECTIVE: The objective was to investigate the SPV in patients with different degrees of severity of pusher behavior while standing. METHODS: Eight stroke patients with pusher behavior, ten age-matched stroke patients without pusher behavior, and ten age-matched healthy control subjects were included...
June 2016: Topics in Stroke Rehabilitation
Stefan Yu Bögli, Maresa Afthinos, Giovanni Bertolini, Dominik Straumann, Melody Ying-Yu Huang
PURPOSE: Impairment of visual acuity (VA) can be seen early on in various diseases and has a major impact on patients' daily activities. Zebrafish is an important model for studying visual disorders. We developed a new method in zebrafish larva to easily and precisely measure the VA, which should allow for better estimation of affected vision such as after genetic manipulation or pharmacologic intervention. METHODS: We used an optokinetic reflex (OKR) paradigm with a staircase technique to estimate VA of zebrafish larva...
April 2016: Investigative Ophthalmology & Visual Science
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