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https://www.readbyqxmd.com/read/28917433/surveillance-imaging-in-patients-with-endometrial-cancer-in-first-remission
#1
Yazan Z Alabed, Su-Chun Cheng, Christopher Mudge, Christopher Sakellis, Annick D Van den Abbeele, Susana M Campos, Heather A Jacene
OBJECTIVE: The clinical benefit of surveillance imaging in endometrial cancer remains undefined. This retrospective study was conducted to evaluate the positive predictive value (PPV) of surveillance imaging in endometrial cancer. METHODS: A total of 128 patients in first remission after treatment for endometrial cancer (uterine papillary serous, clear cell, stage III endometroid) who had surveillance imaging were retrospectively identified. The surveillance period was defined from the time of first-negative scan after treatment to the time when treatment was started for recurrent disease...
August 24, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28916969/comparison-of-platelet-lymphocyte-ratio-and-ca-19-9-in-differentiating-benign-from-malignant-head-masses-in-patients-with-chronic-pancreatitis
#2
Shanavas Kakkat, Ramesh Rajan, R S Sindhu, Bonny Natesh, S Raviram
INTRODUCTION: Pancreatic head ductal adenocarcinoma (PDAC) and inflammatory head masses (IHM) related to chronic pancreatitis are often difficult to differentiate. PDAC produces significant inflammatory response with resultant lymphopenia and thrombocytosis. The prognostic role of platelet-lymphocyte ratio (PLR) as a tumor marker has been defined. We aimed to find the role of PLR as a diagnostic marker for PDAC in differentiating benign head mass comparing with carbohydrate antigen 19-9 (CA 19-9)...
September 16, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28916254/development-of-a-natural-language-processing-engine-to-generate-bladder-cancer-pathology-data-for-health-services-research
#3
Florian R Schroeck, Olga V Patterson, Patrick R Alba, Erik A Pattison, John D Seigne, Scott L DuVall, Douglas J Robertson, Brenda Sirovich, Philip P Goodney
OBJECTIVE: To take a first step towards assembling population based cohorts of bladder cancer patients with longitudinal pathology data, we developed and validated a natural language processing (NLP) engine that abstracts pathology data from full text pathology reports. METHODS: Using 600 bladder pathology reports randomly selected from the Department of Veterans Affairs, we developed and validated an NLP engine to abstract data on histology, invasion (presence versus absence and depth), grade, presence of muscularis propria, and presence of carcinoma in situ...
September 12, 2017: Urology
https://www.readbyqxmd.com/read/28915317/the-theoretical-reliability-of-pcr-based-fish-viral-diagnostic-methods-is-critically-affected-when-they-are-applied-to-fish-populations-with-low-prevalence-and-virus-loads
#4
C P Dopazo, P Moreno, J G Olveira, J J Borrego
AIMS: The reliability of PCR techniques is an important issue in viral diagnosis, and it is even crucial when they must be applied for detection of viruses in asymptomatic carriers. The problems will arise when the aim is to study fish wild populations, where the viral loads and prevalence values are extremely low. We have evaluated several PCR procedures employed by two laboratories for monitoring fish captured in several oceanographic campaigns performed in the Gulf of Cádiz. METHODS AND RESULTS: To evaluate the reliability of different diagnostics test used, we have re-analyzed fish samples that had been previously subjected to diagnosis for a surveillance of viruses performed in 2010-2011 in wild fish populations...
September 15, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28915161/unenhanced-dual-energy-computed-tomography-visualization-of-brain-edema
#5
Mohammed F Mohammed, Olivia Marais, Adam Min, David Ferguson, Sabeena Jalakhan, Faisal Khosa, Michael OʼKeeffe, Tim OʼConnell, Heiko Schmiedeskamp, Bernhard Krauss, Axel Rohr, Savvas Nicolaou
PURPOSE: The aim of this study was to determine whether dual-energy computed tomography (DECT) imaging is superior to conventional noncontrast computed tomography (CT) imaging for the detection of acute ischemic stroke. MATERIALS AND METHODS: This was a retrospective, single-center study of 40 patients who presented to the emergency department (ED) of a major, acute care, teaching center with signs and symptoms of acute stroke. Only those patients who presented to the ED within 4 hours of symptom onset were included in this study...
September 14, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28914169/development-of-an-algorithm-for-determination-of-the-likelihood-of-virological-failure-in-hiv-positive-adults-receiving-antiretroviral-therapy-in-decentralized-care
#6
Anton Reepalu, Taye Tolera Balcha, Sten Skogmar, Per-Erik Isberg, Patrik Medstrand, Per Björkman
BACKGROUND: Early identification of virological failure (VF) limits occurrence and spread of drug-resistant viruses in patients receiving antiretroviral treatment (ART). Viral load (VL) monitoring is therefore recommended, but capacities to comply with this are insufficient in many low-income countries. Clinical algorithms might identify persons at higher likelihood of VF to allocate VL resources. OBJECTIVES: We aimed to construct a VF algorithm (the Viral Load Testing Criteria; VLTC) and compare its performance to the 2013 WHO treatment failure criteria...
2017: Global Health Action
https://www.readbyqxmd.com/read/28911071/prediction-of-pathological-response-to-neoadjuvant-treatment-in-rectal-cancer-with-a-two-protein-immunohistochemical-score-derived-from-stromal-gene-profiling
#7
S Gonçalves-Ribeiro, R Sanz-Pamplona, A Vidal, X Sanjuan, N Guillen Díaz-Maroto, A Soriano, J Guardiola, N Albert, M Martínez-Villacampa, I López, C Santos, J Serra-Musach, R Salazar, G Capellà, A Villanueva, D G Molleví
Background: Preoperative chemoradiotherapy followed by surgical mesorectal resection is the standard of care for locally advanced rectal carcinomas. Yet, predicting that patients will respond to treatment remains an unmet clinical challenge. Experimental design: Using laser-capture microdissection we isolated RNA from stroma and tumour glands from prospective pre-treatment samples (n = 15). Transcriptomic profiles were obtained hybridising PrimeView Affymetrix arrays...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28910894/-diagnostic-values-of-braf-v600e-mutation-analysis-and-bethesda-system-for-reporting-thyroid-cytopathology-in-thyroid-nodules-with-tirads-4-and-5
#8
Y Han, B W Zhao, S Y Li, J G Lyu, J D Shou, H S Xu, H Y Lou, L L Xu, L Gao, S X Xu, J Zhu
Objective: To evaluate the diagnostic efficacies of BRAF(V600E) testing and Bethesda system for reporting thyroid cytopathology (BSRTC) in thyroid nodules with thyroid imaging reporting and data system (TIRADS) category 4 and 5. Methods: A total of 187 thyroid nodules in 187 patients underwent the examinations of ultrasound-guided fine needle aspiration cytology (FNAC) and BRAF(V600E) mutation were analyzed retrospectively. Receive operating characteristic (ROC) curve was used to investigate the diagnostic values of both methods and the clinical application of BRAF(V600E) combined with BSRTC was evaluated...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28906424/accurate-identification-of-colonoscopy-quality-and-polyp-findings-using-natural-language-processing
#9
Jeffrey K Lee, Christopher D Jensen, Theodore R Levin, Ann G Zauber, Chyke A Doubeni, Wei K Zhao, Douglas A Corley
OBJECTIVES: The aim of this study was to test the ability of a commercially available natural language processing (NLP) tool to accurately extract examination quality-related and large polyp information from colonoscopy reports with varying report formats. BACKGROUND: Colonoscopy quality reporting often requires manual data abstraction. NLP is another option for extracting information; however, limited data exist on its ability to accurately extract examination quality and polyp findings from unstructured text in colonoscopy reports with different reporting formats...
September 12, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28905656/comparison-of-low-dose-and-standard-dose-abdominal-ct-scan-in-body-stuffers
#10
Hooman Bahrami-Motlagh, Zahra Mahboubi-Fooladi, Babak Salevatipour, Hossein Hassanian-Moghaddam, Seyyed Hadi Mirhashemi
PURPOSE: Detection of body stuffers is challenging in emergency departments. Because of the small size of baggies, plain radiograph is of little value in most suspects. On the other hand, abdomen CT scan is burdened by high cost and radiation dose. This study was performed to compare the image quality, radiation dose and accuracy of low-dose CT scan in comparison with standard dose. MATERIAL AND METHODS: In this prospective study, suspected body stuffers who were referred to the radiology department underwent two different protocols of abdominal non-contrast CT scan simultaneously: low-dose (with equivalent dose to conventional abdominal x-ray) and standard dose...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28905439/testing-the-performance-of-a-prototype-lateral-flow-device-using-bronchoalveolar-lavage-fluid-for-the-diagnosis-of-invasive-pulmonary-aspergillosis-in-high-risk-patients
#11
Caroline G Castillo, Carol A Kauffman, Jingyi Zhai, Hui Jiang, Stephanie M Agozino, Marisa H Miceli
The diagnosis of invasive pulmonary aspergillosis (IPA) increasingly relies on non-culture-based biomarkers in bronchoalveolar lavage (BAL) fluid. The Aspergillus lateral flow device (LFD) is a rapid immunoassay that uses a novel Aspergillus monoclonal antibody to gain specificity. The objective of the study is to compare specificity and sensitivity of the prototype LFD and the galactomannan (GM) enzyme immunoassay in BAL fluid in high-risk patients. A total of 114 BAL samples from 106 patients at high risk for IPA were studied: 8 patients had proven/probable IPA, 16 had possible IPA and 82 did not have IPA...
September 14, 2017: Mycoses
https://www.readbyqxmd.com/read/28904481/external-validation-of-risk-prediction-scores-for-invasive-candidiasis-in-a-medical-surgical-intensive-care-unit-an-observational-study
#12
Armin Ahmed, Arvind Kumar Baronia, Afzal Azim, Rungmei S K Marak, Reema Yadav, Preeti Sharma, Mohan Gurjar, Banani Poddar, Ratender Kumar Singh
BACKGROUND: The aim of this study was to conduct external validation of risk prediction scores for invasive candidiasis. METHODS: We conducted a prospective observational study in a 12-bedded adult medical/surgical Intensive Care Unit (ICU) to evaluate Candida score >3, colonization index (CI) >0.5, corrected CI >0.4 (CCI), and Ostrosky's clinical prediction rule (CPR). Patients' characteristics and risk factors for invasive candidiasis were noted. Patients were divided into two groups; invasive candidiasis and no-invasive candidiasis...
August 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28902042/performance-of-a-quick-pregnancy-test-on-whole-blood-in-early-pregnancy-units-a-prospective-cohort-study
#13
Caroline Legoupil, Isabelle Enderle, Flore-Anne Le Baccon, Claude Bendavid, Lucas Peltier, Estelle Bauville, Jean Leveque, Vincent Lavoue, Maela Le Lous
OBJECTIVE: To assess the diagnostic performance of the NG-Test human chorionic gonadotropin (hCG) WB, which is a new point-of-care (POC) hCG whole-blood test. MATERIALS AND METHODS: This prospective study included women consulted in early pregnancy units for vaginal bleeding and/or pelvic pain with unknown pregnancy status after medical consultation including a pelvic ultrasound scan. A new POC test (the NG-Test hCG WB) and the usual laboratory serum test (considered the gold standard) were performed in patients...
September 8, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28900668/validation-of-the-baragwanath-mortality-prediction-score-for-cerebral-gunshot-wounds-the-pietermaritzburg-experience
#14
V Y Kong, G V Oosthuizen, B Sartorious, J L Bruce, G L Laing, R Weale, D L Clarke
INTRODUCTION: Cerebral gunshot wounds (GSW) are highly lethal injuries. To date, only one clinical scoring system to predict mortality in a developing world setting has been described. This is the Baragwanath mortality prediction score ("ABC": admission blood pressure, brain matter spillage and consciousness level). MATERIALS AND METHODS: We performed a retrospective review of prospectively entered data for a cohort of patients with isolated cerebral GSWs over a 5-year period (January 2010-December 2014) in our institution...
September 12, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28900520/first-year-medical-students-use-of-ultrasound-or-physical-examination-to-diagnose-hepatomegaly-and-ascites-a-randomized-controlled-trial
#15
Samantha Arora, Angela C Cheung, Usman Tarique, Arnav Agarwal, Mohammed Firdouse, Jonathan Ailon
PURPOSE: To compare point-of-care ultrasound and physical examination (PEx), each performed by first-year medical students after brief teaching, for assessing ascites and hepatomegaly. Ultrasound and PEx were compared on: (1) reliability, validity and performance, (2) diagnostic confidence, ease of use, utility, and applicability. METHODS: A single-center, randomized controlled trial was performed at a tertiary centre. First-year medical students were randomized to use ultrasound or PEx to assess for ascites and hepatomegaly...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28899564/avoiding-delayed-diagnosis-of-significant-blunt-bowel-and-mesenteric-injuries-can-a-scoring-tool-make-the-difference-a-7-year-retrospective-cohort-study
#16
Tobias Zingg, Fabio Agri, Mylène Bourgeat, Bertrand Yersin, Benoît Romain, Sabine Schmidt, Nathalie Keller, Nicolas Demartines
INTRODUCTION: Significant blunt bowel and mesenteric injuries (sBBMI) are frequently missed despite the widespread use of computed tomography (CT). Early treatment improves the outcome related to these injuries. The aim of this study was to assess the prevalence of sBBMI, the incidence of delayed diagnosis and to test the performance of the Bowel Injury Prediction Score (BIPS), determined by the white blood cell (WBC) count, presence or absence of abdominal tenderness and CT grade of mesenteric injury...
September 6, 2017: Injury
https://www.readbyqxmd.com/read/28899220/diagnosis-of-mesial-temporal-sclerosis-sensitivity-specificity-and-predictive-values-of-the-quantitative-analysis-of-magnetic-resonance-imaging
#17
Ana María Granados Sánchez, Juan Felipe Orejuela Zapata
In the diagnosis of mesial temporal sclerosis (MTS), sensitivity, specificity and predictive values of qualitative assessment using conventional magnetic resonance imaging are low, mainly in mild or bilateral atrophy. Quantitative analysis may improve this performance. We evaluated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of quantitative analysis using the hippocampal volumetric index (HVI) and hippocampal asymmetry index (HAI) compared with qualitative assessment in the MTS diagnosis...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28899084/comparison-of-liquid-based-cytology-cellprepplus-and-conventional-smears-in-pancreaticobiliary-disease
#18
Myeong Ho Yeon, Hee Seok Jeong, Hee Seung Lee, Jong Soon Jang, Seungho Lee, Soon Man Yoon, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Joung-Ho Han, Hye-Suk Han, Ho Chang Lee
Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUSFNA) and brushing cytology are used worldwide to diagnose pancreatic and biliary malignant tumors. Liquid-based cytology (LBC) has been developed and it is currently used to overcome the limitations of conventional smears (CS). In this study, the authors aimed to compare the diagnostic value of the CellPrepPlus (CP; Biodyne) LBC method with CS in samples obtained using EUS-FNA and brushing cytology. Methods: This study prospectively enrolled 75 patients with pancreatic or biliary lesions from June 2012 to October 2013...
September 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28898532/immunological-efficacy-of-herbal-medicines-in-prostate-cancer-patients-treated-by-personalized-peptide-vaccine
#19
Noriko Koga, Fukuko Moriya, Kayoko Waki, Akira Yamada, Kyogo Itoh, Masanori Noguchi
This randomized phase II study investigated the immunological efficacy of herbal medicines (HMs) using Hochu-ekki-to and Keishi-bukuryo-gan in combination with personalized peptide vaccination (PPV) for castration-resistant prostate cancer (CRPC). Seventy patients with CRPC were assigned to two arms; PPV plus HMs or PPV alone. Two to four peptides were chosen from 31 peptides derived from cancer antigens for the eight-time subcutaneous injection of PPV according to the patient's human leukocyte antigen type and levels of antigen-specific immunoglobulin G (IgG) titer before PPV treatment...
September 12, 2017: Cancer Science
https://www.readbyqxmd.com/read/28894912/optimisation-of-the-mr-protocol-in-pregnant-women-with-suspected-acute-appendicitis
#20
Ilah Shin, Yong Eun Chung, Chansik An, Hye Sun Lee, Honsoul Kim, Joon Seok Lim, Myeong-Jin Kim
PURPOSE: To investigate the optimal magnetic resonance (MR) imaging protocol in pregnant women suspected of having acute appendicitis. MATERIALS AND METHODS: One hundred and forty-six pregnant women with suspected appendicitis were included. MR images were reviewed by two radiologists in three separate sessions. In session 1, only axial single-shot turbo spin echo (SSH-TSE) T2-weighted images (WI) were included with other routine sequences. In sessions 2 and 3, coronal and sagittal T2WI were sequentially added...
September 11, 2017: European Radiology
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