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https://www.readbyqxmd.com/read/29156470/-functional-and-anatomic-outcomes-of-primary-and-secondary-internal-limiting-membrane-transplantation-in-large-and-persistent-macular-holes
#1
Jelka A Hess, Stephan Michels, Matthias D Becker
Background The gold standard therapy for full-thickness macular holes (FTMH) is vitrectomy (PPV) with peeling of the internal limiting membrane (ILM), gas tamponade of the vitreous cavity and postoperative face-down positioning. Nevertheless, eyes with large macular holes (> 400 µm) and surgical failures remain difficult to manage. Recently, ILM transplantation (ILM-TX) techniques were developed with acceptable results, advocating different mechanisms of hole closure: in such a setting, the ILM could serve as a scaffold for neuronal tissue in the pedicle ILM flap technique or the ILM could induce a contraction of the FTMH rims through shrinking of a folded ILM plug...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29155289/the-diagnostic-sensitivity-of-the-memorial-delirium-assessment-scale-mdas-spanish-version
#2
Elena Barahona, Rita Pinhao, Victoria Galindo, Antonio Noguera
Although Memorial Delirium Assessment Scale (MDAS) is a successful tool for delirium evaluation and monitoring, it is nevertheless important to determine whether cut-off scores vary according to the studied population. The main objective of this study is to evaluate the diagnostic sensitivity of the recently validated Spanish version of the MDAS. The secondary objective is to analyze possible diagnostic differences when used in a hospice or general hospital setting. METHODOLOGY: A prospective study was conducted with advanced cancer patients in two settings (hospice & general hospital)...
November 15, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29153664/microcirculatory-blood-flow-derangements-during-severe-preeclampsia-and-hellp-syndrome
#3
Gustavo Adolfo Ospina-Tascón, Albaro José Nieto Calvache, Edgardo Quiñones, Humberto José Madriñan, Juan David Valencia, William Fernando Bermúdez, Javier Carvajal, María Fernanda Escobar, Daniel de Backer
OBJECTIVE: To evaluate the microcirculatory blood flow in severe preeclampsia and compare it with healthy pregnant and non-pregnant women controls, using a portable intravital-microscopy technique. METHODS: Using a side-stream dark field (SDF) device, we prospectively evaluated the sublingual microcirculatory blood flow before placental delivery in 40 women with severe preeclampsia (PE-group) complicated (n=8) or not (n=32) with HELLP syndrome, 40 healthy pregnant women (HP-group) matched by gestational and chronological age, and 20 healthy non-pregnant women (NP-group)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153041/association-of-procalcitonin-values-and-bacterial-infections-in-pediatric-patients-receiving-extracorporeal-membrane-oxygenation
#4
Vi Ean Tan, Wayne S Moore, Arun Chopra, Jeffrey J Cies
OBJECTIVE: There is increasing data in pediatrics demonstrating procalcitonin (PCT) is more sensitive and specific than other biomarkers in the setting of bacterial infections. However, the use of PCT in neonatal and pediatric extracorporeal membrane oxygenation (ECMO) is not well described. Therefore, the purpose of this study was to describe the clinical utility of PCT in determining the absence or presence of bacterial infections in neonatal and pediatric patients on ECMO. METHODS: This was a retrospective electronic medical record (EMR) review of data between January 1, 2010 to June 30, 2016 at a single, free-standing, children 's hospital...
November 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29152000/muscle-weakness-in-the-empty-and-full-can-tests-cannot-differentiate-rotator-cuff-tear-from-cervical-spondylotic-amyotrophy-pain-provocation-is-a-useful-finding
#5
REVIEW
Eiichiro Iwata, Hideki Shigematsu, Kazuya Inoue, Takuya Egawa, Yoshihiro Sakamoto, Yasuhito Tanaka
Purpose: Rotator cuff tears and cervical spondylotic amyotrophy (CSA) are often confused as the main symptom in those with difficulty in shoulder elevation. Empty and full can tests are frequently used for the clinical diagnosis of rotator cuff tears. The aim of the present study was to investigate whether the empty and full can test results can help differentiate rotator cuff tears from CSA. Methods: Twenty-seven consecutive patients with rotator cuff tears and 25 with CSA were enrolled...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29150184/-glutamate-dehydrogenase-its-diagnostic-value-in-clostridioides-difficile-diarrhea
#6
Daniela Vaustat, Raquel Rollet
Clostridioides difficile is the main etiological agent of diarrhea associated with health care, it produces toxins and glutamate dehydrogenase (GDH), an enzyme that is highly conserved in this species. Rapid diagnosis and effective treatment produce prompt improvement of the patient and subsequent control of the microorganism spread. There are several techniques whose results are interpreted in the context of algorithms. However, the optimal diagnostic method is yet unknown. The performance of GDH as a screening test for the diagnosis of C...
November 14, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29149433/predictive-values-of-pulse-pressure-variation-and-stroke-volume-variation-for-fluid-responsiveness-in-patients-with-pneumoperitoneum
#7
Marko Zlicar, Vesna Novak-Jankovic, Rok Blagus, Maurizio Cecconi
Animal studies suggest that dynamic predictors remain useful in patients with pneumoperitoneum, but human data is conflicting. Our aim was to determine predictive values of pulse pressure variation (PPV) and stroke volume variation (SVV) in patients with pneumoperitoneum using LiDCORapid™ haemodynamic monitor. Standardised fluid challenges of colloid were administered to patients undergoing laparoscopic procedures, one fluid challenge per patient. Intra-abdominal pressure was automatically held at 12 mmHg...
November 17, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29148213/dynamic-expiratory-ct-an-effective-non-invasive-diagnostic-exam-for-fragile-children-with-suspected-tracheo-bronchomalacia
#8
Nicola Ullmann, Aurelio Secinaro, Laura Menchini, Serena Caggiano, Elisabetta Verrillo, Teresa Pia Santangelo, Renato Cutrera, Paolo Tomà
BACKGROUND: Tracheobronchomalacia, defined as variable collapse of the airways, has been recognized as an important cause of respiratory morbidity but still widely underdiagnosed. Bronchoscopy is still considered as the gold standard, but numerous limitations are known, especially for fragile sick children. Moreover, information on parenchymal lung disease cannot be described. There is a real need for a reliable, non-invasive test to help detection of airway and parenchymal malformations in children, specifically when bronchoscopy cannot be performed...
November 17, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29146307/long-term-visual-outcomes-and-safety-profile-of-27-gauge-pars-plana-vitrectomy-for-posterior-segment-disease
#9
M Ali Khan, Alexander Kuley, Christopher D Riemann, Maria H Berrocal, Rohit R Lakhanpal, Jason Hsu, Arunan Sivalingam, Allen C Ho, Carl D Regillo
PURPOSE: To report longer-term outcomes of 27-gauge pars plana vitrectomy (PPV) in eyes with posterior segment disease. DESIGN: Multicenter, retrospective, interventional case series. PARTICIPANTS: A total of 390 eyes of 360 patients undergoing 27-gauge PPV for a vitreoretinal surgery indication. INTERVENTION: Three-port, transconjunctival, 27-gauge PPV. MAIN OUTCOME MEASURES: Change in visual acuity (VA) and occurrence of intraoperative and postoperative complications with a minimum follow-up of 365 days...
November 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29145346/role-of-delayed-time-point-imaging-during-abdominal-and-pelvic-cancer-screening-using-fdg-pet-ct-in-the-general-population
#10
Shotaro Naganawa, Takeharu Yoshikawa, Koichiro Yasaka, Eriko Maeda, Naoto Hayashi, Osamu Abe
Although delayed-time-point imaging is expected to improve the results of [F]-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT), how examinees will benefit from dual-time-point imaging versus initial-time-point imaging alone, remains unclear. This study investigated the role of delayed-time-point imaging in improving the results of abdominal and pelvic cancer screening using FDG-PET/CT.This retrospective review included 3131 screening results (average subject age: 55.5 years, range: 40-88 years)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144794/endoscopic-ultrasound-guided-fine-needle-aspiration-eus-fna-in-the-diagnosis-of-adrenal-metastasis-in-a-high-risk-population
#11
Catherine D Zhang, Dana Erickson, Michael J Levy, Ferga C Gleeson, Diva R Salomao, Danae A Delivanis, Irina Bancos
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis of adrenal metastasis in a high-risk population Objective: While the left adrenal gland is readily accessible via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), data regarding the utility of EUS-FNA in the diagnosis of adrenal lesions remain limited. We aimed to 1) describe the clinical context, adverse event rate, and diagnostic performance of EUS-FNA and 2) compare the safety profile and diagnostic accuracy of EUS-FNA with percutaneous adrenal biopsy...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143611/one-or-two-serological-assay-testing-strategy-for-diagnosis-of-hbv-and-hcv-infection-the-use-of-predictive-modelling
#12
John V Parry, Philippa Easterbrook, Anita R Sands
BACKGROUND: Initial serological testing for chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is conducted using either rapid diagnostic tests (RDT) or laboratory-based enzyme immunoassays (EIA)s for detection of hepatitis B surface antigen (HBsAg) or antibodies to HCV (anti-HCV), typically on serum or plasma specimens and, for certain RDTs, capillary whole blood. WHO recommends the use of standardized testing strategies - defined as a sequence of one or more assays to maximize testing accuracy while simplifying the testing process and ideally minimizing cost...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143393/an-algorithm-to-detect-unexpected-increases-in-frequency-of-reports-of-adverse-events-in-eudravigilance
#13
Luis C Pinheiro, Gianmario Candore, Cosimo Zaccaria, Jim Slattery, Peter Arlett
PURPOSE: The European Medicines Agency developed an algorithm to detect unexpected increases in frequency of reports, to enhance the ability to detect adverse events that manifest as increases in frequency, in particular quality defects, medication errors, and cases of abuse or misuse. METHODS: An algorithm based on a negative binomial time-series regression model run on 6 sequential observations prior to the monitored period was developed to forecast monthly counts of reports...
November 16, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29141754/effectiveness-of-the-hydrogen-sulfide-test-as-a-water-quality-indicator-for-diarrhea-risk-in-rural-bangladesh
#14
Mahfuza Islam, Ayse Ercumen, Abu Mohd Naser, Leanne Unicomb, Mahbubur Rahman, Benjamin F Arnold, John M Colford, Stephen P Luby
Microbiological water quality is usually assessed by the identification of Escherichia coli (E. coli), a fecal indicator. The hydrogen sulfide (H2S) test is an inexpensive, easy-to-use, and portable alternative field-based water quality test. Our study evaluated the H2S test's effectiveness as a water quality indicator for diarrhea risk. Field workers collected stored drinking water samples for H2S analysis and detection of E. coli by membrane filtration and measured caregiver-reported diarrhea among children < 5 years in the same households 1 month later...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141709/rapid-diagnostic-testing-of-hospitalized-malawian-children-reveals-opportunities-for-improved-hiv-diagnosis-and-treatment
#15
Theresa F Madaline, Sarah E Hochman, Karl B Seydel, Alice Liomba, Alex Saidi, Grace Matebule, Wenzhu B Mowrey, Bernadette O'Hare, Danny A Milner, Kami Kim
Recent World Health Organization (WHO) guidelines recommend antiretroviral therapy (ART) for all HIV-infected people; previously CD4+ T lymphocyte quantification (CD4 count) or clinical staging determined eligibility for children ≥ 5 years old in low- and middle-income countries. We examined positive predictive value (PPV) of a rapid diagnostic test (RDT) algorithm and ART eligibility for hospitalized children with newly diagnosed HIV infection. We enrolled 363 hospitalized Malawian children age 2 months to 16 years with two serial positive HIV RDT from 2013 to 2015...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140606/mr-textural-analysis-on-t2-flair-images-for-the-prediction-of-true-oligodendroglioma-by-the-2016-who-genetic-classification
#16
Wenting Rui, Yan Ren, Yin Wang, Xinyi Gao, Xiao Xu, Zhenwei Yao
BACKGROUND: The genetic status of 1p/19q is important for differentiating oligodendroglioma, isocitrate-dehydrogenase (IDH)-mutant, and 1p/19q-codeleted from diffuse astrocytoma, IDH-mutant according to the 2016 World Health Organization (WHO) criteria. PURPOSE: To assess the value of magnetic resonance textural analysis (MRTA) on T2 fluid-attenuated inversion recovery (FLAIR) images for making a genetically integrated diagnosis of true oligodendroglioma by WHO guidelines...
November 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29139544/automatic-detection-of-dna-double-strand-sreaks-after-irradiation-using-an-%C3%AE-h2ax-assay
#17
Tim Hohmann, Jacqueline Kessler, Urszula Grabiec, Matthias Bache, Dyrk Vordermark, Faramarz Dehghani
Radiation therapy belongs to the most common approaches for cancer therapy leading amongst others to DNA damage like double strand breaks (DSB). DSB can be used as a marker for the effect of radiation on cells. For visualization and assessing the extent of DNA damage the γH2AX foci assay is frequently used. The analysis of the γH2AX foci assay remains complicated as the number of γH2AX foci has to be counted. The quantification is mostly done manually, being time consuming and leading to person-dependent variations...
November 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29139066/improving-quality-of-banked-milk-utility-of-dornic-acid-test
#18
Swapnil Bhisikar, Jayashree Mondkar, Swati Manerkar, Sorabh Goel, Desma D'Dsouza, Sujata Baveja
OBJECTIVE: To identify, if Dornic acid test done on human milk bank sample is as effective as doing routine culture, both pre and post pasteurization. METHODS: The authors analyzed 477 samples, both pre and post pasteurization. Dornic acid measurement was performed by using N/9 NaOH and titrated to get dornicity of the sample. Senstivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) at different Dornic acid levels were calculated...
November 15, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29136209/use-of-18f-fluorodeoxyglucose-positron-emission-tomography-in-the-diagnosis-of-polymyalgia-rheumatica-a-prospective-study-of-99-patients
#19
Liesbet Henckaerts, Olivier Gheysens, Steven Vanderschueren, Karolien Goffin, Daniel Blockmans
Objective: Previous studies have shown that the majority of patients with PMR have increased 18F-fluorodeoxyglucose (FDG) uptake around the shoulders, hips and processes of the cervical and lumbar spine on PET. The specificity of these findings for PMR is, however, not known. Methods: We prospectively included 99 consecutive patients with a possible clinical diagnosis of PMR. All patients underwent 18F-FDG-PET scanning before treatment with glucocorticoids was started...
October 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29135995/efficacy-of-a-new-rapid-diagnostic-test-kit-to-diagnose-sri-lankan-cutaneous-leishmaniasis-caused-by-leishmania-donovani
#20
Gayani De Silva, Vijani Somaratne, Sujai Senaratne, Manuja Vipuladasa, Rajitha Wickremasinghe, Renu Wickremasinghe, Shalindra Ranasinghe
BACKGROUND: Cutaneous leishmaniasis (CL) in Sri Lanka is caused by Leishmania donovani. This study assessed the diagnostic value of a new rapid diagnostic immunochromatographic strip (CL-Detect™ IC-RDT), that captures the peroxidoxin antigen of Leishmania amastigotes. METHODOLOGY/PRINCIPAL FINDINGS: We sampled 74 clinically suspected CL lesions, of which 59 (79.7%) were positive by PCR, 43 (58.1%) by Giemsa stained slit skin smear (SSS) and 21 (28.4%) by the new IC-RDT...
2017: PloS One
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