keyword
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#1
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536642/clinical-prediction-model-for-primary-aldosteronism-subtyping-and-special-focus-on-adrenal-volumetric-assessment
#2
JOURNAL ARTICLE
Tugba Barlas, Erhan Turgut Ilgit, Mehmet Koray Akkan, Emetullah Cindil, Isil Imge Gultekin, Hulya Nur Sodan, Mehmet Muhittin Yalcin, Ethem Turgay Cerit, Sinan Sozen, Mujde Akturk, Fusun Toruner, Ayhan Karakoc, Alev Eroglu Altinova
PURPOSE: Our aim was to develop a prediction model based on a simple score with clinical, laboratory, and imaging findings for the subtype diagnosis of primary aldosteronism (PA). The contribution of adrenal volumetric assessment to PA subtyping was also investigated. METHODS: Thirty-five patients with adequate cannulation in adrenal venous sampling (AVS) were included. Laboratory data, the saline infusion test (SIT), and the AVS results of patients with PA were retrospectively evaluated...
March 27, 2024: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38536636/a-direct-comparison-of-three-screening-methods-for-autism-spectrum-disorder-in-a-high-likelihood-sibling-population
#3
JOURNAL ARTICLE
Chui Mae Wong, Nurhafizah Mohd Zambri, Hui Hua Fan, Lily H S Lau, L Mary Daniel, Hwan Cui Koh
Targeted screening of children at increased likelihood of autism is recommended. However, autism screening tools are usually validated for use mainly in low-likelihood populations. This study compared the accuracy of the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), the ASDetect app, and the Social Attention and Communication Surveillance, Revised (SACS-R). Siblings of autistic children underwent autism screening at 12, 18 and 30 months old. At each visit, caregivers completed the M-CHAT-R/F and ASDetect while trained nurses tested the siblings using the SACS-R...
March 27, 2024: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#4
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536577/can-artificial-intelligence-detect-type-2-diabetes-in-women-by-evaluating-the-pectoral-muscle-on-tomosynthesis-diagnostic-study
#5
JOURNAL ARTICLE
Meltem M Yashar, Ilayda Begum Izci, Fatma Zeynep Gungoren, Abdulkadir A Eren, Ali A Mert, Irmak I Durur-Subasi
OBJECTIVES: This retrospective single-center analysis aimed to evaluate whether artificial intelligence can detect type 2 diabetes mellitus by evaluating the pectoral muscle on digital breast tomosynthesis (DBT). MATERIAL METHOD: An analysis of 11,594 DBT images of 287 consecutive female patients (mean age 60, range 40-77 years) was conducted using convolutional neural networks (EfficientNetB5). The inclusion criterion was left-sided screening images with unsuspicious interpretation who also had a current glycosylated hemoglobin A1c (HBA1c) % value...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536057/ankyloglossia-in-newborns-incidence-and-breastfeeding-follow-up-at-1-and-6-months
#6
JOURNAL ARTICLE
Carlo V Bellieni, Ivana LA Gioia, Irene Calcagna, Alessandra Cartocci, Lorenzo DE Stefano, Ernesto Iadanza
BACKGROUND: Ankyloglossia is an anatomical variation of the lingual frenulum that negatively interferes with the functionality of the tongue. This condition can affect breastfeeding negatively. The aim of this study is to assess the prevalence of ankyloglossia among healthy babies born in Siena Hospital and the correlation between ankyloglossia and breastfeeding difficulties. METHODS: We performed an observational prospective study conducted on healthy and breastfed newborns born in Siena Hospital in the period between January and June 2022...
March 26, 2024: Minerva pediatrics
https://read.qxmd.com/read/38535936/identification-and-mechanistic-analysis-of-toxic-degradation-products-in-the-advanced-oxidation-pathways-of-fluoroquinolone-antibiotics
#7
JOURNAL ARTICLE
Shuhai Sun, Zhonghe Wang, Qikun Pu, Xinao Li, Yuhan Cui, Hao Yang, Yu Li
The degradation of fluoroquinolones (FQs) via advanced oxidation processes (AOPs) is a promising avenue, yet the complete mineralization of certain FQ molecules remains elusive, raising concerns about the formation of toxic by-products. This study delineates five primary AOP degradation pathways for 16 commercially available FQ molecules, inferred from existing literature. Density functional theory (DFT) was employed to calculate the bond dissociation energies within these pathways to elucidate the correlation between bond strength and molecular architecture...
March 6, 2024: Toxics
https://read.qxmd.com/read/38535924/plasma-concentrations-of-high-mobility-group-box-1-proteins-and-soluble-receptors-for-advanced-glycation-end-products-are-relevant-biomarkers-of-cognitive-impairment-in-alcohol-use-disorder-a-pilot-study
#8
JOURNAL ARTICLE
Fernando Rodríguez de Fonseca, Francisco Medina-Paz, Mira Sapozhnikov, Isaac Hurtado-Guerrero, Leticia Rubio, Stella Martín-de-Las-Heras, Nerea Requena-Ocaña, María Flores-López, María Del Mar Fernández-Arjona, Patricia Rivera, Antonia Serrano, Pedro Serrano, Sara C Zapico, Juan Suárez
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and inflammation in the brain, activated by increased reactive oxygen/nitrogen species (ROS/RNS), advanced glycation end-products (AGEs) and high-mobility group box 1 protein (HMGB1). In a pilot study, we examine the potential clinical value of circulating biomarkers of oxidative stress including ROS/RNS, HMGB1, the soluble receptor for AGE (sRAGE), the brain biomarker of aging apolipoprotein D (ApoD), and the antioxidant regulator nuclear factor erythroid 2-related factor 2 (NRF2) as predictive indices for cognitive impairment (CI) in abstinent patients with AUD ( n = 25) compared to patients with established Alzheimer's disease (AD, n = 26) and control subjects ( n = 25)...
February 29, 2024: Toxics
https://read.qxmd.com/read/38535732/isak-based-anthropometric-standards-for-elite-male-and-female-soccer-players
#9
JOURNAL ARTICLE
Cristian Petri, Francesco Campa, Francis Holway, Luca Pengue, Luis Suarez Arrones
This study aimed to provide reference values for anthropometric characteristics of elite male and female soccer players, considering a group of individuals from the general population as controls. The anthropometric profiles of 357 elite soccer players [184 males (age 24.3 ± 4.3 y) and 173 females (age 25.2 ± 5.1 y)] participating in the first Italian league (Serie A) and 363 subjects from the general population [188 males (age 24.2 ± 4.8 y) and 175 females (age 25.0 ± 5.1 y)] were measured according to the guidelines of the International Society for the Advancement of Kinanthropometry (ISAK)...
February 23, 2024: Sports
https://read.qxmd.com/read/38535309/advancing-personalized-medicine-by-analytical-means-selection-of-three-metabolites-that-allows-discrimination-between-glaucoma-diabetes-and-controls
#10
JOURNAL ARTICLE
David Bernal-Casas, Joan Serrano-Marín, Juan Sánchez-Navés, Josep M Oller, Rafael Franco
This paper aimed at devising an intelligence-based method to select compounds that can distinguish between open-angle glaucoma patients, type 2 diabetes patients, and healthy controls. Taking the concentration of 188 compounds measured in the aqueous humour (AH) of patients and controls, linear discriminant analysis (LDA) was used to identify the right combination of compounds that could lead to accurate diagnosis. All possibilities, using the leave-one-out approach, were considered through ad hoc programming and in silico massive data production and statistical analysis...
February 29, 2024: Metabolites
https://read.qxmd.com/read/38535129/portuguese-neonatal-screening-program-a-cohort-study-of-18-years-using-ms-ms
#11
JOURNAL ARTICLE
Maria Miguel Gonçalves, Ana Marcão, Carmen Sousa, Célia Nogueira, Helena Fonseca, Hugo Rocha, Laura Vilarinho
The Portuguese Neonatal Screening Program (PNSP) conducts nationwide screening for rare diseases, covering nearly 100% of neonates and screening for 28 disorders, including 24 inborn errors of metabolism (IEMs). The study's purpose is to assess the epidemiology of the screened metabolic diseases and to evaluate the impact of second-tier testing (2TT) within the PNSP. From 2004 to 2022, 1,764,830 neonates underwent screening using tandem mass spectrometry (MS/MS) to analyze amino acids and acylcarnitines in dried blood spot samples...
March 20, 2024: International Journal of Neonatal Screening
https://read.qxmd.com/read/38535062/the-role-of-sars-cov-2-nucleocapsidic-antigen-and-krebs-von-den-lungen-6-serum-levels-in-predicting-covid-19-pneumonia-outcome
#12
JOURNAL ARTICLE
Stefano Sanduzzi Zamparelli, Vincenzo Fucci, Gaetano Rea, Francesco Perna, Marialuisa Bocchino, Alessandro Sanduzzi Zamparelli
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a significant threat worldwide, with severe cases leading to hospitalization and death. This study aims to evaluate the potential use of serum nucleocapsid antigen (NAg) and Krebs von den Lungen-6 glycoprotein (KL-6) as biomarkers of severe COVID-19 and to investigate their correlation with clinical, radiological, and biochemical parameters. METHODS: This retrospective study included 128 patients with confirmed SARS-CoV-2 infection admitted to a Neapolitan hospital in Italy between October 2020 and July 2021...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38535018/a-rapid-on-line-evaluation-role-protocol-in-the-diagnostic-performance-improvement-in-endoscopic-ultrasound-guided-tissue-acquisition-for-solid-pancreatic-lesions
#13
JOURNAL ARTICLE
Yunlong Cai, Xiaolong Rao, Jixin Zhang, Guanyi Liu, Yiling Zheng, Taohua Yue, Weidong Nian, Long Rong
We assessed the rapid on-line evaluation (ROLE) protocol as a modification to the conventional rapid on-site evaluation (ROSE) in the diagnostic performance improvement in endoscopic ultrasound-guided tissue acquisition (EUS-TA) for solid pancreatic lesions. This single-center, retrospective study involved consecutive patients with solid pancreatic lesions undergoing EUS-TA at Peking University First Hospital between October 2017 and March 2021. Among 137 patients enrolled, 75 were in the ROLE group and 62 were in the non-ROSE group...
March 12, 2024: Diagnostics
https://read.qxmd.com/read/38534997/comparison-of-transoral-and-transcervical-ultrasonography-with-mri-for-the-diagnostic-work-up-of-oropharynx-tumors-a-protocol-for-a-multicenter-clinical-trial-spotus
#14
JOURNAL ARTICLE
Martin Garset-Zamani, Gitte Bjørn Hvilsom, Thomas Kjærgaard, Christina Caroline Plaschke, Christoffer Holst Hahn, Mikkel Kaltoft, Padraig O'Leary, Natalie Lassen Frid, Rikke Norling, Danijela Dejanovic, Johanna Maria Hall, Tina Klitmøller Agander, Signe Bergliot Nielsen, Annette Kjær Ersbøll, Irene Wessel, Christian von Buchwald, Tobias Todsen
This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534991/evaluation-of-two-assay-serological-testing-strategies-for-anti-hcv-screening-in-italian-populations-a-dual-screening-approach
#15
JOURNAL ARTICLE
Elena Zocca, Silva Seraceni, Teresa Cafaro, Tamara Emanuela Cervone, Laura Cardarelli, Massimiliano Valisi, Isabella Polidori, Massimo Pieri, Flaminia Tomassetti, Francesco Broccolo
(1) Background: Hepatitis C virus (HCV) screening mostly uses a one-assay anti-HCV testing approach, which has a higher probability of false-positive results in populations with low HCV prevalence. (2) Methods: In this investigation, 17,926 participants were screened for HCV, and the reactives were tested using a two-assay anti-HCV approach: Elecsys ElectroChemiLuminescence (ECL) and a ChemiLuminescence ImmunoAssay (CLIA), respectively. A recombinant immunoblot assay (RIBA) was performed to confirm anti-HCV positivity...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38534929/does-pre-emptive-availability-of-predict-2-1-results-change-ordering-practices-for-oncotype-dx-a-multi-center-prospective-cohort-study
#16
JOURNAL ARTICLE
Arif Ali Awan, Deanna Saunders, Gregory Pond, Caroline Hamm, Nadia Califaretti, Mihaela Mates, Vikaash Kumar, Mohammed F K Ibrahim, Ana-Alicia Beltran-Bless, Lisa Vandermeer, John Hilton, Mark Clemons
For early-stage hormone receptor (HR)-positive and HER2-negative breast cancer, tools to estimate treatment benefit include free and publicly available algorithms (e.g., PREDICT 2.1) and expensive molecular assays (e.g., Oncotype DX). There remains a need to identify patients who de-rive the most benefit from molecular assays and where this test may be of poor value. In this multicenter prospective cohort study, we evaluated whether use of PREDICT 2.1 would impact physician decision making. For the first 6 months of the study, data on physician use of both PREDICT 2...
February 27, 2024: Current Oncology
https://read.qxmd.com/read/38534771/prognostic-value-of-p63-expression-in-muscle-invasive-bladder-cancer-and-association-with-molecular-subtypes-preliminary-report
#17
JOURNAL ARTICLE
Francesca Sanguedolce, Ugo Giovanni Falagario, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Stefano Ascani, Simona Tortorella, Gian Maria Busetto, Angelo Cormio, Giuseppe Carrieri, Luigi Cormio
There is an ongoing need for biomarkers that could reliably predict the outcome of BC and that could guide the management of this disease. In this setting, we aimed to explore the prognostic value of the transcription factor P63 in patients with muscle-invasive bladder cancer (MIBC) having undergone radical cystectomy. The correlation between P63 expression and clinicopathological features (tumor stage, nodes involvement, patterns of muscularis propria invasion, papillary architecture, anaplasia, concomitant carcinoma in situ, lymphovascular invasion, perineural invasion, necrosis) and molecular subtyping (basal and luminal type tumors) was tested in 65 radical cystectomy specimens and matched with cancer-specific survival (CSS) and overall survival (OS)...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534634/fungal-endophthalmitis-clinical-characteristics-pathogens-and-factors-affecting-visual-outcome
#18
JOURNAL ARTICLE
Xiaoxia Li, Zhi Chen, Xiuwen Zhang, Zimei Zhou, Maureen Boost, Taomin Huang, Xingtao Zhou
AIMS: The aims of this study are to investigate the etiology, microbiological spectrum, and risk factors associated with visual outcomes of fungal endophthalmitis (FE) in a tertiary eye specialty hospital in Shanghai, China. METHODS: This was a retrospective, single-center case series. The clinical characteristics, etiology, microbiological spectrum, and management, as well as the visual outcomes, were analyzed. Logistic regression was used to analyze the factors related to visual outcomes...
February 20, 2024: Antibiotics
https://read.qxmd.com/read/38534571/influence-of-skin-marker-positioning-and-their-combinations-on-hip-joint-center-estimation-using-the-functional-method
#19
JOURNAL ARTICLE
Lucas Martinez, Matthieu Lalevée, Thomas Poirier, Helena Brunel, Jean Matsoukis, Stéphane Van Driessche, Fabien Billuart
Accurate estimation of hip joint center (HJC) position is crucial during gait analysis. HJC is obtained with predictive or functional methods. But in the functional method, there is no consensus on where to place the skin markers and which combination to use. The objective of this study was to analyze how different combinations of skin markers affect the estimation of HJC position relative to predictive methods. Forty-one healthy volunteers were included in this study; thirteen markers were placed on the pelvis and hip of each subject's lower limbs...
March 21, 2024: Bioengineering
https://read.qxmd.com/read/38534141/the-association-of-intraocular-efavirenz-concentrations-and-hiv-1-viral-load-among-persons-with-hiv
#20
JOURNAL ARTICLE
Yiwen Qian, Pei Zhang, Luoziyi Wang, Jinshan Suo, Lin Yin, Yuceng Wang, Lijun Zhang, Zhiliang Wang
OBJECTIVE: Efavirenz (EFV) is commonly used in combination antiretroviral therapy (cART). However, in our previous study, many persons living with human immunodeficiency virus (HIV) exhibited ocular complications despite undergoing effective cART. Here, we aimed to determine the intraocular EFV concentrations in the vitreous and analyze the factors affecting viral load in the vitreous in patients with HIV-associated retinopathies. DESIGN: Observational, retrospective study...
March 25, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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