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https://www.readbyqxmd.com/read/28806320/the-value-of-quality-assured-magnetic-resonance-imaging-of-the-breast-for-the-early-detection-of-breast-cancer-in-asymptomatic-women
#1
Uwe Fischer, Susanne Luftner-Nagel, Friedemann Baum, Katharina Marten-Engelke, Susanne Wienbeck
PURPOSE: The aim of this study was to evaluate the exclusive performance of quality-assured high-resolution breast magnetic resonance imaging (MRI) for early detection of breast cancer in a population of asymptomatic women. MATERIALS AND METHODS: A total of 1189 MRI examinations performed in 789 asymptomatic women (mean age, 51.1 years) were evaluated. All examinations were performed using open bilateral surface coil, dedicated compression device, and high spatial resolution (matrix, 512 × 512)...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28802956/magnetic-resonance-imaging-compared-with-rectal-endoscopic-sonography-for-the-prediction-of-infiltration-depth-in-colorectal-endometriosis
#2
Arane Kim, Pedro Fernandez, Brigitte Martin, Laurent Palazzo, Lara Ribeiro-Parenti, Francine Walker, Margot Bucau, Dominique Luton, Carmen Chis, Martin Koskas
STUDY OBJECTIVE: To compare the accuracies of magnetic resonance imaging (MRI) and rectal endoscopic sonography (RES) in the prediction of the infiltration depth of colorectal endometriosis. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: University teaching hospital. PATIENTS: Forty patients with symptomatic deep infiltrating endometriosis (DIE) of the rectum who underwent colorectal resection were included...
August 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28801976/implications-of-fetoplacental-mosaicism-on-cell-free-dna-testing-for-sex-chromosome-aneuploidies
#3
Francesca Romana Grati, Komal Bajaj, Valentina Zanatta, Francesca Malvestiti, Barbara Malvestiti, Livia Marcato, Beatrice Grimi, Federico Maggi, Giuseppe Simoni, Susan J Gross, Jose Ferreira
OBJECTIVE: The unique biological behavior of sex chromosomes has implications for cell-free DNA (cfDNA) testing. Our purpose is to predict the i) false positive/negative rates (FPR/FNR) of cfDNA testing consequent to feto-placental mosaicism for any sex chromosome anomaly (SCA) ii) positive (PPV) and negative predictive values (NPV) of a high- and low-risk cfDNA result for any SCA. METHOD: Retrospective analysis of 67030 chorionic villus sampling (CVS) karyotypes, including feto-placental mosaicism cases...
August 11, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28801558/visceral-adiposity-index-lipid-accumulation-product-and-intracranial-atherosclerotic-stenosis-in-middle-aged-and-elderly-chinese
#4
Rui Li, Qi Li, Min Cui, Zegang Ying, Lin Li, Tingting Zhong, Yingchao Huo, Peng Xie
We investigated the association of the newly established lipid accumulation product (LAP) and visceral adiposity index (VAI) with intracranial atherosclerotic stenosis (ICAS) in middle-aged and elderly Chinese. From June 2012 to January 2013, consecutive patients ≥40 years of age who underwent cerebral vascular imaging for various medical reasons were enrolled in this study. Multivariate logistic regression models were used to evaluate the correlation of VAI and LAP with the risk of ICAS. In total, 845 patients were included in the study...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801439/validation-of-asthma-recording-in-the-clinical-practice-research-datalink-cprd
#5
Francis Nissen, Daniel R Morales, Hana Mullerova, Liam Smeeth, Ian J Douglas, Jennifer K Quint
OBJECTIVES: The optimal method of identifying people with asthma from electronic health records in primary care is not known. The aim of this study is to determine the positive predictive value (PPV) of different algorithms using clinical codes and prescription data to identify people with asthma in the United Kingdom Clinical Practice Research Datalink (CPRD). METHODS: 684 participants registered with a general practitioner (GP) practice contributing to CPRD between 1 December 2013 and 30 November 2015 were selected according to one of eight predefined potential asthma identification algorithms...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801118/-value-of-gastric-fluid-to-start-antibiotics-in-premature-babies-suspected-of-having-early-neonatal-bacterial-infection
#6
R N'Guessan, J-M Jellimann, J-M Hascoët, R Vieux, H Tahar
The objective of this study was to evaluate the value of direct examination and culture of gastric fluid in the treatment of early neonatal bacterial infections (INBP) in pre-term infants. MATERIALS AND METHODS: Observational study conducted over 6 months in a Type III center. All hospitalized premature babies who had routine gastric fluid sampling at birth during the period of the study were included. They were classified into two groups: premature infants with probable or suspected infection and treated as such (Group 1) and premature infants with no infection or only having colonization (Group 2)...
August 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28800858/diagnostic-value-of-synovial-white-blood-cell-count-and-serum-c-reactive-protein-for-acute-periprosthetic-joint-infection-after-knee-arthroplasty
#7
Sang-Gyun Kim, Jae-Gyoon Kim, Ki-Mo Jang, Seung-Bum Han, Hong-Chul Lim, Ji-Hoon Bae
BACKGROUND: The diagnosis of periprosthetic joint infection (PJI) remains difficult, particularly in acute postoperative stage. The purpose of this study was to investigate the optimal cutoff value of synovial white blood cell (WBC) count, percentage of polymorphonuclear cells, erythrocyte sedimentation rate, and C-reactive protein (CRP) for diagnosing early postoperative infection after knee joint arthroplasty. METHODS: We retrospectively reviewed primary total knee arthroplasties and unicompartmental knee arthroplasties, with a knee aspiration within 3 weeks of surgery, from January 2006 to November 2016...
July 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28800647/effects-of-vitrectomy-and-lensectomy-on-older-rhesus-macaques-oxygen-distribution-antioxidant-status-and-aqueous-humor-dynamics
#8
Carla J Siegfried, Ying-Bo Shui, Baohe Tian, T Michael Nork, Gregg A Heatley, Paul L Kaufman
Purpose: The purpose of this study is to evaluate effects of vitrectomy (PPV) and lens extraction with intraocular lens implantation (PE/IOL) on molecular oxygen (pO2) distribution, aqueous humor antioxidant-oxidant balance, aqueous humor dynamics, and histopathologic changes in the trabecular meshwork (TM) in the older macaque monkey. Methods: Six rhesus monkeys underwent PPV followed by PE/IOL. pO2, outflow facility, and intraocular pressure (IOP) were measured...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28799874/limitations-of-multidetector-computed-tomography-angiography-for-the-diagnosis-of-blunt-cerebrovascular-injury
#9
Ramesh Grandhi, Gregory M Weiner, Nitin Agarwal, David M Panczykowski, William J Ares, Jesse S Rodriguez, Jonathan A Gelfond, John G Myers, Louis H Alarcon, David O Okonkwo, Brian T Jankowitz
OBJECTIVE Blunt cerebrovascular injuries (BCVIs) following trauma carry risk for morbidity and mortality. Since patients with BCVI are often asymptomatic at presentation and neurological sequelae often occur within 72 hours, timely diagnosis is essential. Multidetector CT angiography (CTA) has been shown to be a noninvasive, cost-effective, reliable means of screening; however, the false-positive rate of CTA in diagnosing patients with BCVI represents a key drawback. Therefore, the authors assessed the role of DSA in the screening of BCVI when utilizing CTA as the initial screening modality...
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28799555/silicone-oil-versus-gas-tamponade-for-giant-retinal-tear-associated-fovea-sparing-retinal-detachment-a-comparison-of-outcome
#10
P J Banerjee, A Chandra, P Petrou, D G Charteris
PurposeSilicone oil is the most common choice of tamponade agent used when managing a giant retinal tear (GRT). Concern exists regarding its potential detrimental effect on vision. We herein report on visual and surgical outcomes of all patients treated at Moorfields Eye Hospital for a GRT over a five year period. We further analysed a subgroup of fovea-sparing retinal detachments (RD) treated by pars plana vitrectomy (PPV) with either silicone oil or gas tamponade.MethodsRetrospective comparative, non-randomised, cross-sectional review of patients with a new diagnosis of GRT from 1 September 2005 to 31 August 2010ResultsOne hundred twenty four eyes of 118 patients were identified with mean age of 45...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28798033/a-prospective-study-comparing-99m-tc-hdp-planar-bone-scintigraphy-and-whole-body-spect-ct-with-18-f-fluoride-pet-ct-and-18-f-fluoride-pet-mri-for-diagnosing-bone-metastases
#11
Johan Löfgren, Jann Mortensen, Sine Hvid Rasmussen, Claus Madsen, Annika Loft, Adam Espe Hansen, Peter Oturai, Karl Erik Jensen, Mette Louise Mørk, Michala Reichkendler, Liselotte Højgaard, Barbara M Fischer
We prospectively evaluate and compare the diagnostic performance of (99m)Tc-HDP planar bone scintigraphy (pBS), (99m)Tc-HDP SPECT/CT, (18)F-NaF PET/CT and (18)F-NaF PET/MRI for the detection of bone metastases. Methods: 117 patients with histologically proven malignancy referred for clinical pBS were prospectively enrolled. pBS and whole-body SPECT/CT were performed followed by (18)F-NaF PET/CT within 9 days. (18)F-NaF PET/MRI was also performed in 46 patients. A "truth panel" including clinical follow-up served as standard of reference...
August 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28797261/evaluation-of-carestart%C3%A2-malaria-hrp2-pldh-pf-pan-combo-test-in-a-malaria-low-transmission-region-of-senegal
#12
Mamadou Alpha Diallo, Khadim Diongue, Mouhamadou Ndiaye, Amy Gaye, Awa Deme, Aida S Badiane, Daouda Ndiaye
BACKGROUND: This study was initiated from the observation that prevalence of malaria obtained with rapid diagnostic test (RDT) (CareStart™Malaria HRP2/pLDH Combo Test) was higher than in microscopy in a malaria low transmission area of Senegal. PCR was then performed to evaluate the performance of the RDT compared to microscopy in clinical settings. METHODS: The study included 215 patients suspected of malaria in two peri-urban area of Dakar. Finger-pick blood samples were tested using RDT (CareStart™Malaria HRP2/pLDH Combo Test)...
August 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28797213/surveillance-imaging-in-mantle-cell-lymphoma-in-first-remission-lacks-clinical-utility
#13
Daniel M Guidot, Jeffrey M Switchenko, Loretta J Nastoupil, Jean L Koff, Kristie A Blum, Joseph Maly, Christopher R Flowers, Jonathon B Cohen
Mantle cell lymphoma (MCL) is a heterogeneous disease with high relapse rates. Limited data guide the use of surveillance imaging following treatment. We constructed a retrospective cohort from two academic institutions of patients with MCL who completed first-line therapy and underwent follow-up for relapse, analyzing the effect of surveillance imaging on survival. Of 217 patients, 102 had documented relapse, with 38 (37%) diagnosed by surveillance imaging and 64 (63%) by other methods. Relapse diagnosis by surveillance imaging had no significant advantage in overall survival from diagnosis date (hazard ratio [HR] = 0...
August 10, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28797178/mri-fusion-targeted-transrectal-prostate-biopsy-and-the-role-of-prostate-specific-antigen-density-and-prostate-health-index-for-the-detection-of-clinically-significant-prostate-cancer-in-southeast-asian-men
#14
Teck Wei Tan, Keng Siang Png, Chau Hung Lee, Arianto Yuwono, Yuyi Yeow, Kian-Tai Chong, Yee Mun Lee, Cher Heng Tan, Yung Khan Tan
OBJECTIVES: To test the hypothesis that targeted biopsy has a higher detection rate for clinically significant prostate (csPCa) than systematic biopsy. We defined csPCa as any Gleason sum ≥ 7 cancer. In patients with Prostate Imaging - Reporting and Data System (PI-RADS) 3 lesions, to determine if factors such as PSA density (PSAD) and prostate health index (PHI) can predict csPCa and help select patients for biopsy. MATERIALS AND METHODS: We report the first series of targeted biopsies in Southeast Asian men, with comparison against systematic biopsy...
August 11, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28795890/point-of-care-fluorescence-imaging-predicts-the-presence-of-pathogenic-bacteria-in-wounds-a-clinical-study
#15
M Y Rennie, L Lindvere-Teene, K Tapang, R Linden
OBJECTIVE: Bacteria in chronic wounds are invisible to the naked eye and can lead to delayed wound healing. Point-of-care bacterial fluorescence imaging illuminates a wound with 405nm light, triggering bacteria to produce red fluorescence and enabling real-time bacterial localisation. Prospective, single-blind clinical trials (clinicaltrials.gov #NCT02682069, #NCT03091361) were conducted to determine the positive predictive value (PPV) of this red fluorescence for detecting bacteria in chronic wounds...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28795870/positive-predictive-value-between-medical-chart-body-mass-index-category-and-obesity-versus-codes-in-a-claims-data-warehouse
#16
Eleanor O Caplan, Pravin S Kamble, Raymond A Harvey, B Gabriel Smolarz, Andrew Renda, Jonathan R Bouchard, Joanna C Huang
OBJECTIVE: To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS: This was a retrospective validation study utilizing administrative claims and medical chart data from 1/1/2009 to 8/31/2015. Randomly selected samples of patients enrolled in a Medicare Advantage Prescription Drug (MAPD) or commercial health plan and with a V85 claim were identified...
August 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28795715/spin-dynamics-of-light-induced-charge-separation-in-composites-of-semiconducting-polymers-and-pc60bm-revealed-using-q-band-pulse-epr
#17
E A Lukina, E Suturina, E Reijerse, W Lubitz, L V Kulik
Light-induced processes in composites of semiconducting polymers and fullerene derivatives have been widely studied due to their usage as active layers of organic solar cells. However the process of charge separation under light illumination - the key process of an organic solar cell is not well understood yet. Here we report a Q-band pulse electron paramagnetic resonance study of composites of the fullerene derivative PC60BM ([6,6]-phenyl-C61-butyric acid methyl ester) with different p-type semiconducting polymers regioregular and regiorandom P3HT (poly(3-hexylthiophene-2,5-diyl), MEH-PPV (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]), PCDTBT (poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)]), PTB7 (poly({4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl}{3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl}))), resulting in a detailed description of the in-phase laser flash-induced electron spin echo (ESE) signal...
August 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28795453/validation-of-the-modified-4-tiered-categorization-system-through-comparison-with-the-5-tiered-categorization-system-of-the-2015-american-thyroid-association-guidelines-for-classifying-small-thyroid-nodules-on-ultrasound
#18
Ji Hye Lee, Kyunghwa Han, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
BACKGROUND: The purpose of this study was to validate the modified 4-tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines. METHODS: From January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines...
August 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28793848/18f-fdg-pet-ct-may-exclude-malignancy-in-sonographically-suspicious-and-scintigraphically-hypofunctional-thyroid-nodules-and-reduce-unnecessary-thyroid-surgeries
#19
Marcus Ruhlmann, Jürgen Ruhlmann, Rainer Görges, Ken Herrmann, Gerald Antoch, Hans-Wilhelm Keller, Verena Ruhlmann
BACKGROUND: The aim of this study was to evaluate whether [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful in the further characterization of sonographically suspicious and scintigraphically hypofunctional thyroid nodules. METHODS: 65 patients with a sonographically suspicious thyroid nodules that were hypofunctional on 99m-Tc-pertechnetate scintigraphy (diameter > 1 cm) were retrospectively analyzed. All patients underwent evaluation with FDG-PET/CT...
August 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28793295/identifying-relapses-in-multiple-sclerosis-patients-through-administrative-data-a-validation-study-in-the-lazio-region-italy
#20
Paola Colais, Nera Agabiti, Marina Davoli, Fabio Buttari, Diego Centonze, Chiara De Fino, Marta Di Folco, Graziella Filippini, Ada Francia, Simonetta Galgani, Claudio Gasperini, Manuela Giuliani, Massimiliano Mirabella, Viviana Nociti, Carlo Pozzilli, AnnaMaria Bargagli
BACKGROUND: Relapse is frequently considered an outcome measure of disease activity in relapsing-remitting multiple sclerosis (MS). The objectives of this study were to identify relapse episodes in patients with MS in the Lazio region using health administrative databases and to evaluate the validity of the algorithm using patients enrolled at MS treatment centers. METHODS: MS cases were identified in the period between January 1, 2006 and December 31, 2009 using data from regional Health Information Systems (HIS)...
August 9, 2017: Neuroepidemiology
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