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https://www.readbyqxmd.com/read/29764557/-development-and-application-of-disposable-constant-volume-and-negative-pressure-drainage-device
#1
Dongzhi Liu
The common negative pressure drainage bottle used in the vacuum sealing drainage (VSD) cannot quantitative and automatically cut off. Excessive drainage damages the negative pressure source, causes drainage interruption, so once drainage was continuously performed, medical staff need to closely observe drainage bottle calibration. It was also important to known whether there was a large amount of fresh blood sucked out during continuous drainage because it could lose too much blood. To solve these two problems, we designed a kind of negative pressure drainage device, which volume was constant, with the function of automatic cutting off continuous drainage...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29744563/diagnostic-workup-etiologies-and-management-of-acute-right-ventricle-failure-a-state-of-the-art-paper
#2
REVIEW
Antoine Vieillard-Baron, R Naeije, F Haddad, H J Bogaard, T M Bull, N Fletcher, T Lahm, S Magder, S Orde, G Schmidt, M R Pinsky
INTRODUCTION: This is a state-of-the-art article of the diagnostic process, etiologies and management of acute right ventricular (RV) failure in critically ill patients. It is based on a large review of previously published articles in the field, as well as the expertise of the authors. RESULTS: The authors propose the ten key points and directions for future research in the field. RV failure (RVF) is frequent in the ICU, magnified by the frequent need for positive pressure ventilation...
May 9, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29727526/incidence-of-hypochloremic-metabolic-alkalosis-in-dogs-and-cats-with-and-without-nasogastric-tubes-over-a-period-of-up-to-36-hours-in-the-intensive-care-unit
#3
Annie Chih, Elke Rudloff, Cheryl Waldner, Andrew K J Linklater
OBJECTIVE: To evaluate the incidence of hypochloremic metabolic alkalosis (HCMA) in dogs and cats in the ICU that had intermittent nasogastric tube (NGT) aspiration for up to 36 hours. DESIGN: Prospective cohort study (December 2013 to October 2014). SETTING: Privately owned emergency and referral teaching hospital. ANIMALS: Forty-nine client-owned dogs and 16 client-owned cats. INTERVENTIONS: Patients wherein NGT placement was recommended and client consent was obtained were included in the interventional group...
May 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29698339/disparities-in-adherence-to-pediatric-diabetic-ketoacidosis-management-guidelines-across-a-spectrum-of-emergency-departments-in-the-state-of-indiana-an-observational-in-situ-simulation-based-study
#4
Kamal Abulebda, Samer Abu-Sultaneh, Erin E White, Michele L Kirby, Brian C Phillips, Courtney T Frye, Lee D Murphy, Riad Lutfi
BACKGROUND: Diabetic ketoacidosis (DKA) is a common presentation to an emergency department (ED), with the majority presenting to community EDs. Adherence to clinical guidelines in these EDs can reduce morbidity and mortality. Few methods to describe practice gaps for DKA management have been reported. OBJECTIVES: We hypothesized that high-fidelity in situ simulation can be used to measure and compare the quality of the care provided to pediatric patients with DKA presenting to community EDs in the state of Indiana...
April 24, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29692608/increased-matrix-metalloproteinase-9-to-tissue-inhibitor-of-metalloproteinase-1-ratio-in-smokers-with-airway-hyperresponsiveness-and-accelerated-lung-function-decline
#5
Chun-Yu Lo, Hung-Yu Huang, Jung-Ru He, Tzu-Ting Huang, Chih-Chen Heh, Te-Fang Sheng, Kian Fan Chung, Han-Pin Kuo, Chun-Hua Wang
Background: Airway hyperresponsiveness (AHR) is associated with airway inflammation and a rapid decline in lung function and is a predictor of future risk of COPD among smokers. Alveolar macrophages (AMs) from patients with COPD release a greater amount of matrix metalloproteinase (MMP)-9. We hypothesized that the imbalance between MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) is related to AHR in smokers. Patients and methods: Healthy smokers with AHR (AHR + S) or smokers without AHR (AHR - S; divided according to a methacholine challenge test) and nonsmokers without AHR (AHR - NS) were enrolled...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29673129/the-electrochemical-performance-of-silicon-nanoparticles-in-concentrated-electrolyte
#6
Zenghua Chang, Jiantao Wang, Zhaohui Wu, Min Gao, Shuaijin Wu, Shigang Lu
Silicon is a promising material for anodes in energy storage devices. However, excessive growth of solid electrolyte interphase (SEI) caused by the severe volume change during the (de)lithiation processes lead to a dramatic capacity fading. Here we report a super-concentrated electrolyte composed of Lithium bis(fluorosulfonyl)imide (LiFSI) and propylene carbonate (PC) with a molar ratio of 1 to 2 to improve the cycling performance of silicon nano particles (SiNPs). The SiNP electrode shows a remarkably improved cycling performance with an initial delithiation capacity of ca...
April 19, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29665203/tolvaptan-alleviates-excessive-fluid-retention-of-nephrotic-diabetic-renal-failure-unresponsive-to-furosemide
#7
Tesshu Takada, Tsuguto Masaki, Ayako Hoshiyama, Takuya Toki, Yuji Kamata, Masayoshi Shichiri
Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention. We aimed to investigate the efficacy of tolvaptan, an oral arginine vasopressin type 2 receptor antagonist, in a case series of 14 severe diabetic renal failure patients who were severely refractory to maximal doses of furosemide and had excessive fluid retention despite preserved cardiac function and residual renal function...
April 17, 2018: Nephrology
https://www.readbyqxmd.com/read/29627971/how-to-tackle-congestion-in-acute-heart-failure
#8
Pieter Martens, Wilfried Mullens
Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual congestion at discharge following an acute heart failure episodes is one of the strongest predictors of poor outcome, the goal of therapy should be to resolve congestion completely. Important to comprehend is that increased cardiovascular filling pressures are not solely the resultant of intravascular volume excess but can also be induced by a decreased venous capacitance...
April 11, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29618001/body-fluid-processing-workspace-quality-improvement-initiative-in-a-high-volume-reference-laboratory
#9
Michelle R Campbell, Karrie K Milam, Kelly R Fisher
Objectives: In a clinical laboratory, the design of the workspace directs the workflow and significantly affects the productivity of clinical laboratory scientists (CLS). With the chronic shortage of CLS, a well-designed workspace is essential to take full advantage of available staff, especially in high-volume laboratories. Methods: Through the use of quality improvement tools, a manual body fluid testing workspace was redesigned to address weaknesses in the layout that led to excessive physical steps taken by staff...
March 29, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29579733/optimization-of-a-two-dimensional-liquid-chromatography-supercritical-fluid-chromatography-mass-spectrometry-2d-lc-sfs-ms-system-to-assess-in-vivo-inter-conversion-of-chiral-drug-molecules
#10
Meenakshi Goel, Eli Larson, C J Venkatramani, Mohammad A Al-Sayah
Enantioselective analysis is an essential requirement during the pharmaceutical development of chiral drug molecules. In pre-clinical and clinical studies, the Food and Drug Administration (FDA) mandates the assessment of "in vivo" inter-conversion of chiral drugs to determine their physiological effects. In-vivo analysis of the active pharmaceutical ingredient (API) and its potential metabolites could be quite challenging due to their low abundance (ng/mL levels) and matrix interferences. Therefore, highly selective and sensitive analytical techniques are required to separate the API and its metabolites from the matrix components and one another...
March 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29574681/effect-of-goal-directed-haemodynamic-therapy-in-free-flap-reconstruction-for-head-and-neck-cancer
#11
H J Kim, E J Kim, H J Lee, J Y Min, T W Kim, E C Choi, W S Kim, B-N Koo
BACKGROUND: In free flap reconstruction for head and neck cancer, achieving a haemodynamic target using excessive fluid infusion is associated with decreased flap survival rates and extended hospital stays. We hypothesized that goal-directed haemodynamic therapy would improve flap survival rates and shorten hospitalization periods. METHODS: Patients scheduled for free flap reconstruction were randomly assigned to a goal-directed haemodynamic therapy group (n = 31) or a conventional haemodynamic therapy control group (n = 31)...
March 25, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29560750/association-of-non-invasive-hemodynamics-with-arterial-stiffness-in-rheumatoid-arthritis
#12
Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Nikolaos Koletsos, Spyros Aslanidis, Stella Douma
OBJECTIVES: Arterial stiffness has emerged as a surrogate marker of cardiovascular disease. We investigated the role of myocardial performance and hemodynamic parameters in arterial stiffness in patients with rheumatoid arthritis (RA), which is accompanied by excess cardiovascular risk. DESIGN: Arterial stiffness was evaluated with pulse wave velocity (PWV) in RA patients and controls. Cardiac and hemodynamic characterization was based on impedance cardiography...
March 21, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29538608/validation-of-the-nursing-interventions-and-activities-for-patients-on-hemodialytic-therapy
#13
Amália de Fátima Lucena, Cecília Zys Magro, Maria Conceição da Costa Proença, Ananda Ughini Bertoldo Pires, Vítor Monteiro Moraes, Graziella Badin Aliti
OBJECTIVE: To validate interventions and nursing activities proposed by the Nursing Interventions Classification for patients with acute renal failure or acute chronic renal disease in hemodialysis therapy with the Excess Fluid Volume and Risk for Imbalanced Fluid Volume nursing diagnoses. METHODS: Validation of content with 19 expert nurses from a university hospital. The data collection was made from September to November 2011 through instruments that contained the interventions and nursing activities in study...
March 12, 2018: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/29523958/assessment-and-management-of-fluid-overload-in-children-on-dialysis
#14
Wesley Hayes, Fabio Paglialonga
Dysregulation of intravascular fluid leads to chronic volume overload in children with end-stage kidney disease (ESKD). Sequelae include left ventricular hypertrophy and remodeling and impaired cardiac function. As a result, cardiovascular complications are the commonest cause of mortality in the pediatric dialysis population. The clinical need to optimize intravascular volume in children with ESKD is clear; however, its assessment and management is the most challenging aspect of the pediatric dialysis prescription...
March 9, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29519668/ultrasonographic-evaluation-of-gastric-contents-in-term-pregnant-women-fasted-for-six-hours
#15
S Hakak, C L McCaul, L Crowley
BACKGROUND: Current fasting guidelines suggest six hours are adequate to minimise the aspiration risk after a light meal consumed by pregnant women undergoing elective caesarean section. We assessed gastric contents in non-labouring pregnant women, using ultrasonographic analysis. METHODS: In a prospective study, pregnant women ≥36 weeks' gestation, without conditions likely to influence gastric emptying, underwent ultrasonographic analysis of their gastric antrum, after six hours of fasting following a standardised light meal...
May 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29482906/applied-physiology-of-fluid-resuscitation-in-critical-illness
#16
REVIEW
Sabrina Arshed, Michael R Pinsky
Fluids during resuscitation from shock increase mean systemic pressure and venous return. The pressure gradient for venous return must increase. Mean systemic pressure is the amount of vascular space in unstressed and stressed volume, mostly unstressed. Shock states can decrease mean systemic pressure by increasing unstressed volume, decreasing total blood volume, or decreasing the pressure gradient for venous return. Crystalloids across bodily spaces restore normal volume, whereas colloids remain in the intravascular space...
April 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29478061/fluid-overload-and-inflammation-axis
#17
Marijke J E Dekker, Frank M van der Sande, Florence van den Berghe, Karel M L Leunissen, Jeroen P Kooman
Extracellular fluid overload (FO), which is assessed using bioimpedance technologies, is an important predictor of outcome in dialysis patients and in patients with early stages of chronic kidney disease. While traditional cardiovascular abnormalities are assumed to mediate this risk, recently also, the importance of noncardiovascular factors, such as systemic inflammation and malnutrition has been shown. While both FO and inflammation are independent risk factors for mortality, recent studies have shown that their combined presence can lead to a cumulative risk profile...
2018: Blood Purification
https://www.readbyqxmd.com/read/29474273/damage-control-resuscitation-in-pediatric-trauma
#18
Meghan Gilley, Suzanne Beno
PURPOSE OF REVIEW: Damage control resuscitation is an overall management strategy used in trauma patients to rapidly restore physiologic stability, while mitigating hypothermia, coagulopathy and acidosis. We review the evidence and current practice of damage control resuscitation in pediatric trauma patients with a specific focus on fluid management. RECENT FINDINGS: There have been a number of studies over the last several years examining crystalloid fluid resuscitation, balanced blood product transfusion practice and hemostatic agents in pediatric trauma...
June 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29467481/the-mechanistic-causes-of-peripheral-intravenous-catheter-failure-based-on-a-parametric-computational-study
#19
Russell Piper, Peter J Carr, Lachlan J Kelsey, Andrew C Bulmer, Samantha Keogh, Barry J Doyle
Peripheral intravenous catheters (PIVCs) are the most commonly used invasive medical device, yet up to 50% fail. Many pathways to failure are mechanistic and related to fluid mechanics, thus can be investigated using computational fluid dynamics (CFD). Here we used CFD to investigate typical PIVC parameters (infusion rate, catheter size, insertion angle and tip position) and report the hemodynamic environment (wall shear stress (WSS), blood damage, particle residence time and venous stasis volumes) within the vein and catheter, and show the effect of each PIVC parameter on each hemodynamic measure...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29464511/computational-investigation-of-a-self-powered-fontan-circulation
#20
Marcus W Ni, Ray O Prather, Giovanna Rodriguez, Rachel Quinn, Eduardo Divo, Mark Fogel, Alain J Kassab, William M DeCampli
Children born with anatomic or functional "single ventricle" must progress through two or more major operations to sustain life. This management sequence culminates in the total cavopulmonary connection, or "Fontan" operation. A consequence of the "Fontan circulation", however, is elevated central venous pressure and inadequate ventricular preload, which contribute to continued morbidity. We propose a solution to these problems by increasing pulmonary blood flow using an "injection jet" (IJS) in which the source of blood flow and energy is the ventricle itself...
February 20, 2018: Cardiovascular Engineering and Technology
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