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https://www.readbyqxmd.com/read/28548488/a-fluorescent-split-aptamer-for-visualizing-rna-rna-assembly-in-vivo
#1
Khalid K Alam, Kwaku D Tawiah, Matthew F Lichte, David Porciani, Donald H Burke
RNA-RNA assembly governs key biological processes and is a powerful tool for engineering synthetic genetic circuits. Characterizing RNA assembly in living cells often involves monitoring fluorescent reporter proteins, which are at best indirect measures of underlying RNA-RNA hybridization events and are subject to additional temporal and load constraints associated with translation and activation of reporter proteins. In contrast, RNA aptamers that sequester small molecule dyes and activate their fluorescence are increasingly utilized in genetically encoded strategies to report on RNA-level events...
May 26, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28547895/review-of-flexible-temperature-sensing-networks-for-wearable-physiological-monitoring
#2
REVIEW
Qiao Li, Li-Na Zhang, Xiao-Ming Tao, Xin Ding
Physiological temperature varies temporally and spatially. Accurate and real-time detection of localized temperature changes in biological tissues regardless of large deformation is crucial to understand thermal principle of homeostasis, to assess sophisticated health conditions, and further to offer possibilities of building a smart healthcare and medical system. Additionally, continuous temperature mapping in flexible and stretchable formats opens up many other potential areas, such as artificially electronic skins and reflection of emotional changes...
May 26, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28547651/photoplethysmography-for-blood-volumes-and-oxygenation-changes-during-intermittent-vascular-occlusions
#3
T Y Abay, P A Kyriacou
Photoplethysmography (PPG) is an optical technique that measures blood volume variations. The main application of dual-wavelength PPG is pulse oximetry, in which the arterial oxygen saturation (SpO[Formula: see text]) is calculated noninvasively. However, the PPG waveform contains other significant physiological information that can be used in conjunction to SpO[Formula: see text] for the assessment of oxygenation and blood volumes changes. This paper investigates the use of near infrared spectroscopy (NIRS) processing techniques for extracting relative concentration changes of oxygenated ([Formula: see text]HbO[Formula: see text]), reduced ([Formula: see text]HHb) and total haemoglobin ([Formula: see text]tHb) from dual-wavelength PPG signals during intermittent pressure-increasing vascular occlusions...
May 25, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28546952/time-dependency-of-morphological-remodeling-of-endothelial-cells-in-response-to-substrate-stiffness
#4
Zahra Goli-Malekabadi, Mohammad Tafazzoli-Shadpour, Ali Tamayol, Ehsan Seyedjafari
Introduction: Substrate stiffness regulates cellular behavior as cells experience different stiffness values of tissues in the body. For example, endothelial cells (ECs) covering the inner layer of blood vessels are exposed to different stiffness values due to various pathologic and physiologic conditions. Despite numerous studies, cells by time span sense mechanical properties of the substrate, but the response is not well understood. We hypothesized that time is a major determinant influencing the behavior of cells seeded on substrates of varying stiffness...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28545837/emerging-technologies-for-prediction-of-drug-candidate-efficacy-in-the-preclinical-pipeline
#5
Denis Menshykau
The pharmaceutical industry is tackling increasingly complex multifactorial diseases, resulting in increases in research & development (R&D) costs and reductions in the success rates for drug candidates during Phase 2 and 3 clinical trials, with a lack of efficacy being the primary reason for drug candidate failure. This implies that the predictive power of current preclinical assays for drug candidate efficacy is suboptimal and, therefore, that alternatives should be developed. Here, I review emerging in vitro, imaging, and in silico technologies and discuss their potential contribution to drug efficacy assessment...
May 22, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28545577/proanthocyanidin-accumulation-and-transcriptional-responses-in-the-seed-coat-of-cranberry-beans-phaseolus-vulgaris-l-with-different-susceptibility-to-postharvest-darkening
#6
José A Freixas Coutin, Seth Munholland, Anjali Silva, Sanjeena Subedi, Lewis Lukens, William L Crosby, K Peter Pauls, Gale G Bozzo
BACKGROUND: Edible dry beans (Phaseolus vulgaris L.) that darken during postharvest storage are graded lower and are less marketable than their non-darkened counterparts. Seed coat darkening in susceptible genotypes is dependent upon the availability of proanthocyanidins, and their subsequent oxidation to reactive quinones. Mature cranberry beans lacking this postharvest darkening trait tend to be proanthocyanidin-deficient, although the underlying molecular and biochemical determinants for this metabolic phenomenon are unknown...
May 25, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28544893/agreement-of-invasive-and-non-invasive-blood-pressure-measurements-in-anaesthetised-pigs-using-the-surgivet-v9203
#7
Philomena P Tuohy, Anthea L Raisis, Eleanor A Drynan
The automated oscillometric method is a common method for measuring blood pressure non-invasively and is broadly and confidently used in the veterinary setting. Twenty-one pigs undergoing anesthesia for exploratory laparotomy were enrolled in a study to evaluate the performance of the Surgivet V9203 non-invasive blood pressure (NIBP) monitor. The aim was to compare measurements of arterial blood pressure obtained simultaneously using the Surgivet V9203 oscillometric system and an intra-arterial catheter-transducer system, both at the level of the metatarsus...
May 19, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28542864/circadian-clustering-of-spontaneous-epileptic-seizures-emerges-after-pilocarpine-induced-status-epilepticus
#8
Julika Pitsch, Albert J Becker, Susanne Schoch, Johannes Alexander Müller, Marco de Curtis, Vadym Gnatkovsky
OBJECTIVE: Seizures in mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis are thought to develop with various latency intervals after an initial transient brain insult. To study seizure dynamics after an initial transient precipitating insult in a systematic fashion, we utilized continuous video-electroencephalography (EEG) monitoring after the induction of status epilepticus (SE) in a mouse MTLE model. METHODS: Continuous 24/7 video/telemetric hippocampal EEG recordings in the systemic pilocarpine MTLE mouse model...
May 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28541225/stability-of-enzymatic-biosensors-for-wearable-applications
#9
Apurva Sonawane, Pandiaraj Manickam, Shekhar Bhansali
Technological evolution in wearable sensors is accounting for major growth and transformation in multitude of industries ranging from healthcare to computing & informatics to communication and biomedical sciences. The major driver for this transformation is the new-found ability to continuously monitor and analyze the patients' physiology in patients' natural setting. Numerous wearable sensors are already on the market and are summarized. Most of the current technologies have focused on electro-physiological, electro-mechanical or acoustic measurements...
May 19, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28539087/artificial-intelligence-methodologies-and-their-application-to-diabetes
#10
Mercedes Rigla, Gema García-Sáez, Belén Pons, Maria Elena Hernando
In the past decade diabetes management has been transformed by the addition of continuous glucose monitoring and insulin pump data. More recently, a wide variety of functions and physiologic variables, such as heart rate, hours of sleep, number of steps walked and movement, have been available through wristbands or watches. New data, hydration, geolocation, and barometric pressure, among others, will be incorporated in the future. All these parameters, when analyzed, can be helpful for patients and doctors' decision support...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28539064/recent-advances-in-applying-mass-spectrometry-and-systems-biology-to-determine-brain-dynamics
#11
Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Neurological disorders encompass various pathologies which disrupt normal brain physiology and function. Poor understanding of their underlying molecular mechanisms and their societal burden argues for the necessity of novel prevention strategies, early diagnostic techniques and alternative treatment options to reduce the scale of their expected increase. Areas Covered: This review scrutinizes mass spectrometry based approaches used to investigate brain dynamics in various conditions, including neurodegenerative and neuropsychiatric disorders...
May 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28538685/the-effect-of-leaf-stacking-on-leaf-reflectance-and-vegetation-indices-measured-by-contact-probe-during-the-season
#12
Eva Neuwirthová, Zuzana Lhotáková, Jana Albrechtová
The aims of the study were: (i) to compare leaf reflectance in visible (VIS) (400-700 nm), near-infrared (NIR) (740-1140 nm) and short-wave infrared (SWIR) (2000-2400 nm) spectral ranges measured monthly by a contact probe on a single leaf and a stack of five leaves (measurement setup (MS)) of two broadleaved tree species during the vegetative season; and (ii) to test if and how selected vegetation indices differ under these two MS. In VIS, the pigment-related spectral region, the effect of MS on reflectance was negligible...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28538300/the-influence-of-pitch-size-on-running-performance-and-physiological-responses-during-hurling-specific-small-sided-games
#13
Shane Malone, Kieran D Collins
Malone, S and Collins, K. The Influence of pitch size on running performance and physiological responses during hurling-specific small-sided games. J Strength Cond Res 31(6): 1518-1524, 2017-The current study examined how the impact of pitch dimensions influences physiological and running performance during 4-minute small-sided games (SSGs). Twenty-four (n = 24) hurling players were monitored with global positioning system and heart rate monitors during the in-season training period. Total distance (in meters), high-speed running distance (in meters) (≥17 km·h), very high-speed running distance (≥22 km·h) (in meters), total accelerations (n), acceleration distance (in meters), and peak and mean velocity (in kilometers per hour) were calculated...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538140/comparison-of-policies-for-recognising-and-responding-to-clinical-deterioration-across-five-victorian-health-services
#14
Julie Considine, Anastasia F Hutchison, Helen Rawson, Alison M Hutchinson, Tracey Bucknall, Trisha Dunning, Mari Botti, Maxine M Duke, Maryann Street
Objectives The aim of the present study was to describe and compare organisational guidance documents related to recognising and responding to clinical deterioration across five health services in Victoria, Australia.Methods Guidance documents were obtained from five health services, comprising 13 acute care hospitals, eight subacute care hospitals and approximately 5500 beds. Analysis was guided by a specific policy analysis framework and a priori themes.Results In all, 22 guidance documents and five graphic observation and response charts were reviewed...
May 25, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28537378/self-healing-highly-sensitive-electronic-sensors-enabled-by-metal-ligand-coordination-and-hierarchical-structure-design
#15
Yangyang Han, Xiaodong Wu, Xinxing Zhang, Canhui Lu
Electronic sensors capable of capturing mechanical deformation are highly desirable for next generation of artificial intelligence products. However, it remains a challenge to prepare self-healing, highly sensitive and cost-efficient sensors for both tiny and large human motion monitoring. Here, a new kind of self-healing, sensitive, and versatile strain sensors has been developed by combining metal-ligand chemistry with hierarchical structure design. Specifically, a self-healing and nanostructured conductive layer is deposited onto a self-healing elastomer substrate cross-linked by metal-ligand coordinate bonds, forming a hierarchically structured sensor...
May 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28536207/impaired-cerebral-autoregulation-measurement-and-application-to-stroke
#16
REVIEW
Li Xiong, Xiuyun Liu, Ty Shang, Peter Smielewski, Joseph Donnelly, Zhen-Ni Guo, Yi Yang, Thomas Leung, Marek Czosnyka, Rong Zhang, Jia Liu, Ka Sing Wong
Cerebral autoregulation (CA) is a protective mechanism that maintains cerebral blood flow at a relatively constant level despite fluctuations of cerebral perfusion pressure or arterial blood pressure. It is a universal physiological mechanism that may involve myogenic, neural control as well as metabolic regulations of cerebral vasculature in response to changes in pressure or cerebral blood flow. Traditionally, CA has been represented by a sigmoid curve with a wide plateau between about 50 mm Hg and 170 mm Hg of steady-state changes in mean arterial pressure, defined as static CA...
June 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28535956/highly-unsaturated-fatty-acids-hufa-mediate-and-monitor-food-s-impact-on-health
#17
REVIEW
Bill Lands
A hyperbolic, saturable, competitive dynamic of ligand binding to metabolic enzymes and lipid mediator receptors gives non-linear dose-response interactions that need careful management when planning or interpreting nutrient-based interventions. Relatively indiscriminate metabolism during accumulation of HUFA from n-3 and n-6 nutrients allows the amounts of n-3 and n-6 nutrients to determine the HUFA balance accumulated in tissue phospholipids. However, when HUFA-based eicosanoid actions are more intense with n-6 than n-3 mediators, they cause healthy physiology to shift toward pathophysiology...
May 20, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28535598/antarctic-seals-molecular-biomarkers-as-indicators-for-pollutant-exposure-health-effects-and-diet
#18
K Lehnert, L Weirup, K C Harding, T Härkönen, O Karlsson, J Teilmann
Weddell (Leptonychotes weddellii), Ross (Ommatophoca rossii) and crabeater seals (Lobodon carcinophaga) are phocid seals with a circumpolar distribution around Antarctica. As long-lived and large top predators, they bioaccumulate contaminants and are considered as sentinels of ecosystem health. Antarctic seals are increasingly exposed to climate change, pollution, shipping and fisheries. To reveal and understand possible anthropogenic impacts on their immune and health status, this study investigates sensitive biomarkers of the xenobiotic metabolism and immune system in relation to mercury (Hg) burden...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28535363/elite-status-maintained-a-12-year-physiological-and-performance-follow-up-of-two-olympic-champion-rowers
#19
Pavle Mikulic, Nikola Bralic
This case study reports the results of a 12-year (2005-2016) follow-up study of two Olympic champion rowers. The rowers were prospective athletes at the junior level when the study began, and we monitored their relevant physiological and performance data annually. Our findings indicated that their V̇O2max gradually increased up to about 22 years of age and leveled off at a value of approximately 7 l·min(-1) with minimal fluctuations thereafter. However, the variables that directly influence the V̇O2max changed...
May 23, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28534832/the-boom-in-3d-printed-sensor-technology
#20
REVIEW
Yuanyuan Xu, Xiaoyue Wu, Xiao Guo, Bin Kong, Min Zhang, Xiang Qian, Shengli Mi, Wei Sun
Future sensing applications will include high-performance features, such as toxin detection, real-time monitoring of physiological events, advanced diagnostics, and connected feedback. However, such multi-functional sensors require advancements in sensitivity, specificity, and throughput with the simultaneous delivery of multiple detection in a short time. Recent advances in 3D printing and electronics have brought us closer to sensors with multiplex advantages, and additive manufacturing approaches offer a new scope for sensor fabrication...
May 19, 2017: Sensors
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