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https://www.readbyqxmd.com/read/29935106/frataxin-mediated-pink1-parkin-dependent-mitophagy-in-hepatic-steatosis-the-protective-effects-of-quercetin
#1
Peiyi Liu, Hongkun Lin, Yanyan Xu, Feng Zhou, Jing Wang, Jingjing Liu, Xinhong Zhu, Xiaoping Guo, Yuhan Tang, Ping Yao
SCOPE: Naturally occurring quercetin has been found to induce mitophagy and prevent non-alcoholic fatty liver disease (NAFLD). However, it still remains elusive whether frataxin upregulation by quercetin contributes to the beneficial effect through mitophagy or not. METHODS AND RESULTS: Adult male C57BL/J mice were fed a high fat diet (HFD, 60% of energy from fat) with quercetin (100 mg/kg.bw) or not for 10 weeks. Quercetin alleviated HFD-induced histopathological changes, disorders of lipid metabolism, mitochondrial damage...
June 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29935035/lncrna-gm5091-alleviates-alcoholic-hepatic-fibrosis-by-sponging-mir-27b-23b-24-in-mice
#2
Bo Zhou, Wenwen Yuan, Xinping Li
The regulatory roles of lncRNAs in the development of alcoholic hepatic fibrosis (AHF) have not been revealed. Here, we found lncRNA Gm5091 was being downregulated in mouse hepatic stellate cells (HSCs) during AHF. Then, Gm5091 was respectively overexpressed and knocked down in alcohol-treated primary HSCs. Our results showed that Gm5091 negatively regulated cell migration, ROS content, IL-1β secretion, and expression of Collagen I and markers of HSC activation including α-SMA and Desmin. Furthermore, bioinformatics analysis showed that Gm5091 sequence contained binding sites of miR-27b, miR-23b and miR-24, and we proved that miR-27b/23b/24 all bound to Gm5091 by using RNA pull-down assay...
June 23, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29934721/chances-of-renal-recovery-or-liver-transplantation-after-hospitalization-for-alcoholic-liver-disease-requiring-dialysis
#3
Adrienne Lenhart, Salwa Hussain, Reena Salgia
BACKGROUND: Acute kidney injury in the setting of alcoholic liver disease portends a poor prognosis without liver transplant. AIMS: Using a tertiary care population, we aimed to evaluate the outcomes of renal replacement therapy in patients with alcoholic liver disease and acute kidney injury with < 6 months sobriety. METHODS: A retrospective review of hospitalized patients with alcoholic hepatitis/acute on chronic alcoholic cirrhosis and hepatorenal syndrome or acute tubular necrosis was performed...
June 22, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29932157/shanxi-aged-vinegar-protects-against-alcohol-induced-liver-injury-via-activating-nrf2-mediated-antioxidant-and-inhibiting-tlr4-induced-inflammatory-response
#4
Ting Xia, Jin Zhang, Jiahui Yao, Bo Zhang, Wenhui Duan, Chaoya Zhao, Peng Du, Jia Song, Yu Zheng, Min Wang
Shanxi aged vinegar (SAV) is a typical fermented and antioxidant food, which has various health-promoting effects. This work aimed to explore the effects of SAV on alcohol-induced liver injury. A mice model of alcoholic liver injury was established to illuminate its potential mechanisms. All mice pretreated with SAV and then received an ethanol solution (50% w / v , 4.8 g/kg b.w.). The results showed that SAV ameliorated alcohol-induced histological changes and elevation of liver enzymes. SAV attenuated alcohol-induced oxidative stress by declining levels of hepatic oxidants, and restoring depletion of antioxidant enzyme activities in mice livers...
June 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29931819/circulating-levels-of-3-hydroxymyristate-a-direct-quantification-of-endotoxemia-in-non-infected-cirrhotic-patients
#5
Delphine Weil, Jean-Paul Pais de Barros, Guillaume Mourey, Caroline Laheurte, Benoit Cypriani, Nicolas Badet, Eric Delabrousse, Emilie Grandclément, Vincent Di Martino, Philippe Saas, Laurent Lagrost, Thierry Thévenot
BACKGROUND&AIMS: The quantification of lipopolysaccharide (LPS) in biological fluids is challenging. We aimed to measure plasma LPS concentration using a new method of direct quantification of 3-hydroxymyristate (3-HM), a lipid component of LPS, and to evaluate correlations between 3-HM and markers of liver function, endothelial activation, portal hypertension and enterocyte damage. METHODS: Plasma from 90 non-infected cirrhotic patients (30 Child-Pugh [CP]-A, 30 CP-B, 30 CP-C) was prospectively collected...
June 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29931479/corticosteroids-nutrition-pentoxifylline-or-fecal-microbiota-transplantation-for-severe-alcoholic-hepatitis
#6
Cyriac Abby Philips, Nikhil Phadke, Karthik Ganesan, Shatakshi Ranade, Philip Augustine
INTRODUCTION: Alcohol-induced intestinal dysbiosis is central to the development of the severe alcoholic liver disease. We present the first study to compare outcomes in patients of severe alcoholic hepatitis (SAH) on nutritional therapy, corticosteroids, pentoxifylline, and healthy donor fecal transplantation (FMT) and discuss distinct microbial community and microbiome metabolic functional changes after FMT. METHODS: Out of 1271 liver disease patients, 809 (63...
June 21, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29930810/efficacy-of-orlistat-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#7
Hu Wang, Li Wang, Yujia Cheng, Zhiqing Xia, Yifeng Liao, Jiang Cao
In the present meta-analysis, the efficacy and safety of orlistat in the treatment of non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) were evaluated. PubMed, Embase, the Cochrane Library, Web of Science, and Wan Fang data were searched for controlled trials of orlistat in patients with NAFLD or NASH, published before August 2017. Three randomized controlled trials and four single-arm trials were included. The involved participants with NAFLD or NASH (330 patients) were analyzed for clinical outcomes including alteration in hepatic histological variables and biomarkers of liver function...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29928260/liver-enlargement-predicts-obstructive-sleep-apnea-hypopnea-syndrome-in-morbidly-obese-women
#8
Giovanna Scartabelli, Giorgia Querci, Letizia Marconi, Giovanni Ceccarini, Paolo Piaggi, Paola Fierabracci, Guido Salvetti, Giovanni Cizza, Salvatore Mazzeo, Jacopo Vitti, Slava Berger, Antonio Palla, Ferruccio Santini
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are both the result of the accumulation of ectopic fat mass. Identifying predictors of risk of OSAHS may be useful to select the subjects requiring instrumental sleep evaluation. In this cross-sectional study, we have investigated the potential role of hepatic left lobe volume (HLLV) in predicting the presence of OSAHS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29928018/polymorphisms-in-the-receptor-for-advanced-glycation-end-products-rage-gene-and-circulating-rage-levels-as-a-susceptibility-factor-for-non-alcoholic-steatohepatitis-nash
#9
Rohini Mehta, Gladys Shaw, Peter Masschelin, Sean Felix, Munkzhul Otgonsuren, Ancha Baranova, Zachary Goodman, Zobair Younossi
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and major cause of chronic liver disease in developed countries. Its prevalence is increasing in parallel with the prevalence of obesity and other components of the metabolic syndrome. As the liver is central to the clearance and catabolism of circulating advanced glycosylation end-products (AGEs), AGEs and their cognate receptors-RAGE (receptor for AGEs) system might be involved in NAFLD in obese patients. To examine this, we investigated four common polymorphisms of RAGE gene: 1704G/T (rs184003), G82S (rs2070600), -374T/A (rs1800624) and -429T/C (rs1800625) in 340 obese patients with metabolic syndrome...
2018: PloS One
https://www.readbyqxmd.com/read/29925420/hepatic-steatosis-risk-is-partly-driven-by-increased-de-novo-lipogenesis-following-carbohydrate-consumption
#10
Francis W B Sanders, Animesh Acharjee, Celia Walker, Luke Marney, Lee D Roberts, Fumiaki Imamura, Benjamin Jenkins, Jack Case, Sumantra Ray, Samuel Virtue, Antonio Vidal-Puig, Diana Kuh, Rebecca Hardy, Michael Allison, Nita Forouhi, Andrew J Murray, Nick Wareham, Michele Vacca, Albert Koulman, Julian L Griffin
BACKGROUND: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Here, we investigate whether a sub-set of triacylglycerols (TAGs) were associated with hepatic steatosis and whether they arise from de novo lipogenesis (DNL) from the consumption of carbohydrates. RESULTS: We conduct direct infusion mass spectrometry of lipids in plasma to study the association between specific TAGs and hepatic steatosis assessed by ultrasound and fatty liver index in volunteers from the UK-based Fenland Study and evaluate clustering of TAGs in the National Survey of Health and Development UK cohort...
June 20, 2018: Genome Biology
https://www.readbyqxmd.com/read/29924722/interaction-of-volatile-organic-compounds-and-underlying-liver-disease-a-new-paradigm-for-risk
#11
Anna L Lang, Juliane I Beier
Occupational and environmental exposures to industrial chemicals are known to cause hepatotoxicity and liver injury, in humans and in animal models. Historically, research has focused on severe acute liver injury (e.g., fulminant liver failure) or endstage diseases (e.g., cirrhosis and HCC). However, it has become recently recognized that toxicants can cause more subtle changes to the liver. For example, toxicant-associated steatohepatitis (TASH), characterized by hepatic steatosis, and inflammation, was recently recognized in an occupational cohort exposed to vinyl chloride...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924298/metabolic-signature-of-healthy-lifestyle-and-its-relation-with-risk-of-hepatocellular-carcinoma-in-a-large-european-cohort
#12
Nada Assi, Marc J Gunter, Duncan C Thomas, Michael Leitzmann, Magdalena Stepien, Véronique Chajès, Thierry Philip, Paolo Vineis, Christina Bamia, Marie-Christine Boutron-Ruault, Torkjel M Sandanger, Amaia Molinuevo, Hendriek Boshuizen, Anneli Sundkvist, Tilman Kühn, Ruth Travis, Kim Overvad, Elio Riboli, Augustin Scalbert, Mazda Jenab, Vivian Viallon, Pietro Ferrari
Background: Studies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors. Objective: In this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma (HCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Design: Within a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares (PLS) analysis related 7 modified healthy lifestyle index (HLI) variables (diet, BMI, physical activity, lifetime alcohol, smoking, diabetes, and hepatitis) to 132 targeted serum-measured metabolites and a liver function score...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29924135/exenatide-ameliorates-hepatic-steatosis-and-attenuates-fat-mass-and-fto-gene-expression-through-pi3k-signaling-pathway-in-nonalcoholic-fatty-liver-disease
#13
Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29923681/microbiome-and-bile-acid-profiles-in-duodenal-aspirates-from-cirrhotics-the-microbiome-microbial-markers-and-liver-disease-study
#14
Jonathan P Jacobs, Tien S Dong, Vatche Agopian, Venu Lagishetty, Vinay Sundaram, Mazen Noureddin, Walid Ayoub, Francisco Durazo, Jihane Benhammou, Pedram Enayati, David Elashoff, Marc T Goodman, Joseph Pisegna, Shehnaz Hussain
AIM: Cirrhosis is a leading cause of death in the world, yet there are no well-established risk stratifying tools for lethal complications including hepatocellular carcinoma (HCC). Patients with liver cirrhosis undergo routine endoscopic surveillance, providing ready access to duodenal aspirate samples which may be a source for identifying novel biomarkers. The aim of this study was to characterize the microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis to demonstrate feasibility of developing biomarkers for HCC risk stratification...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29921322/the-influence-of-polymorphic-gstm1-gene-on-the-increased-susceptibility-of-non-viral-hepatic-cirrhosis-evidence-from-observational-studies
#15
REVIEW
Ye Gu, Jing Zhao, Li Ao, Jianning Ma, Kena Bao, Min Liu, Weiping Huang
It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms in non-viral HC susceptibility. The results showed that GSTM1 null was associated with the increased risk of non-viral HC (OR = 1.337, 95% CI 1.112-1.804, p = 0.005). Subgroup analysis of cirrhosis type revealed that GSTM1 null was a prominent risk factor for alcoholic HC (OR = 1...
June 19, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29915740/a-study-on-the-altered-glycemic-and-lipid-parameters-and-prevalence-of-insulin-resistance-in-nonalcoholic-fatty-liver-disease
#16
Sangeetha Suresh, Bijayraj Rajanbabu, Vimal Mavila Veetil, Abeed Hussain, Jaseena Nadu Veetil
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet clear. Insulin resistance (IR) is found to be a common risk factor for the development of diabetes, obesity and fatty liver. Aims and Objectives: The aim and objective of this study is to determine the prevalence of undetected diabetes, dyslipidemia, and IR in subjects with NAFLD...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915639/a-case-of-concomitant-obstructive-sleep-apnea-and-non-alcoholic-steatohepatitis-treated-with-cpap-therapy
#17
Bharat Bajantri, Dmitry Lvovsky
Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915227/microrna-214-promotes-hepatic-stellate-cell-activation-and-liver-fibrosis-by-suppressing-sufu-expression
#18
Liping Ma, Xiaoxue Yang, Rong Wei, Tinghong Ye, Jian-Kang Zhou, Maoyao Wen, Ruoting Men, Ping Li, Biao Dong, Lunxu Liu, Xianghui Fu, Heng Xu, Rami I Aqeilan, Yu-Quan Wei, Li Yang, Yong Peng
MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, the role of miRNAs in liver fibrosis is poorly understood. Because the activation of hepatic stellate cells (HSCs) is a pivotal event in the initiation and progression of hepatic fibrosis, we investigate the differential expression of miRNAs in activated and quiescent rat HSCs by microarray analysis and find that miR-214 (miR-214-3p) is significantly upregulated during HSC activation. Moreover, the robust induction of miR-214 is correlated with liver fibrogenesis in carbon tetrachloride (CCl4 )-treated rats and mice, high-fat diet-induced non-alcoholic steatohepatitis in mice, and cirrhosis in humans...
June 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29914094/-ganoderma-lucidum-ameliorates-non-alcoholic-steatosis-by-upregulating-energy-metabolizing-enzymes-in-the-liver
#19
Soonwoong Jung, Hyeonwi Son, Chung Eun Hwang, Kye Man Cho, Sang Won Park, Hyun Joon Kim
Non-alcoholic steatosis is a common health problem worldwide due to altered food habits and life styles, and it is intimately linked with various metabolic disorders. In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. C57BL/6 mice fed with normal diet (ND) or high fat diet (HFD) were administered GL extract or vehicle for 16 weeks. HFD feeding increased serum alanine aminotransferase level and hepatic lipid droplet, but these increases were significantly attenuated by GL...
June 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29913436/nefa-sensitive-orai1-expression-in-regulation-of-de-novo-lipogenesis
#20
Bingbing Zhang, Wei Yang, Ying Zou, Ming Li, Han Guo, Hongyou Zhang, Cheng Xia, Chuang Xu
BACKGROUND/AIMS: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with metabolic syndrome and type-2 diabetes. NFκB is known to upregulate Orai1, the Ca2+ channel responsible for store-operated Ca2+ entry. The present study explored the role of NEFA-sensitive NFκB-dependent Orai1 expression in the regulation of lipid synthesis...
June 15, 2018: Cellular Physiology and Biochemistry
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