Ana Simon-Chica, Alexander Klesen, Ramona Emig, Andy Chan, Joachim Greiner, Dominic Grün, Achim Lother, Ingo Hilgendorf, Eva A Rog-Zielinska, Ursula Ravens, Peter Kohl, Franziska Schneider-Warme, Rémi Peyronnet
Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical environment has been identified as a key modulator of various cell functions, and MΦ mechanosensitivity is likely to be critical - in particular in a rhythmically contracting organ such as the heart. Cultured MΦ, differentiated in vitro from bone marrow (MΦBM ), form a popular research model. This study explores the activity of mechanosensitive ion channels (MSC) in murine MΦBM and compares it to MSC activity in MΦ enzymatically isolated from cardiac tissue (tissue-resident MΦ; MΦTR )...
April 20, 2024: Journal of Physiology