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Clinical electrocardiography

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https://www.readbyqxmd.com/read/28649950/quantification-of-aortic-valve-calcification-on-contrast-enhanced-ct-of-patients-prior-to-transcatheter-aortic-valve-implantation
#1
Matthias Eberhar, Monika Mastalerz, Thomas Frauenfelder, Felix C Tanner, Francesco Maisano, Fabian Nietlispach, Burkhardt Seifert, Hatem Alkadhi, Thi Dan Linh Nguyen-Kim
AIMS: To develop a formula enabling the quantification of aortic valve calcification (AVC) on contrast-enhanced CT of patients undergoing transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: 217 consecutive patients with severe aortic valve stenosis undergoing non-enhanced (NECT) and contrast-enhanced electrocardiography-gated CT angiography (CECT) prior to TAVI were subdivided into a training (n=145) and validation cohort (n=72). AVC was semi-automatically segmented on CECT (AVCCE)...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28649790/safety-of-a-benazepril-and-pimobendan-combination-tablet-in-adult-healthy-dogs
#2
E A Kuntz, G Strehlau, J M Giraudel, J N King
The objective of the study was to investigate the safety of a combination tablet of benazepril and pimobendan, Fortekor PLUS(®) , in a randomized, blinded, parallel-group design study in healthy adult beagle dogs. The test article, Fortekor PLUS(®) tablets, was administered orally twice daily for 6 months at one, two, and four times the highest recommended dosage of 0.5 mg/kg benazepril hydrochloride/0.25 mg/kg pimobendan (four males and four females per group). An additional control group was sham-dosed...
June 26, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28643129/magnetohydrodynamic-voltage-recorder-for-comparing-peripheral-blood-flow
#3
Kevin J Wu, T Stan Gregory, Michael C Lastinger, Jonathan R Murrow, Zion Tsz Ho Tse
Blood flow is a clinical metric for monitoring of cardiovascular diseases but current measurements methods are costly or uncomfortable for patients. It was shown that the interaction of the magnetic field (B 0) during MRI and blood flow in the body, through the magnetohydrodynamic (MHD) effect, produce voltages (V MHD) observable through intra-MRI electrocardiography (ECG), which are correlated with regional blood flow. This study shows the reproducibility of V MHD outside the MRI and its application in a portable flow monitoring device...
June 22, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28629243/effect-of-therapeutic-hypothermia-on-myocardial-dysfunction-in-term-neonates-with-perinatal-asphyxia-%C3%A2-a-randomized-controlled-trial
#4
Rakesh Kotha, B Vishnu Bhat, B Adhisivam, P Ajith
OBJECTIVE: To evaluate the effect of therapeutic hypothermia on myocardial dysfunction in term neonates with perinatal asphyxia. MATERIAL AND METHODS: This Randomized Controlled Trial conducted in a tertiary care teaching hospital, south India included 120 newborns with perinatal asphyxia who were randomized to 2 groups (therapeutic hypothermia and normothermia). Cardiac enzyme profile changes between groups were assessed at 0, 24, 72 hrs CPK-MB and troponin I levels were estimated by immune inhibition and quantitative immunochromatography methods respectively...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28628222/the-value-of-electrocardiography-in-prognosticating-clinical-deterioration-and-mortality-in-acute-pulmonary-embolism-a-systematic-review-and-meta-analysis
#5
REVIEW
Amro Qaddoura, Geneviève C Digby, Conrad Kabali, Piotr Kukla, Zhong-Qun Zhan, Adrian M Baranchuk
The role of electrocardiography (ECG) in prognosticating pulmonary embolism (PE) is increasingly recognized. ECG is quickly interpretable, noninvasive, inexpensive, and available in remote areas. We hypothesized that ECG can provide useful information about PE prognostication. We searched MEDLINE, EMBASE, Google Scholar, Web of Science, abstracts, conference proceedings, and reference lists through February 2017. Eligible studies used ECG to prognosticate for the main outcomes of death and clinical deterioration or escalation of therapy...
June 19, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28614483/-public-health-impact-of-a-remote-diagnosis-system-implemented-in-regional-and-district-hospitals-in-paraguay
#6
Pedro Galván, Miguel Velázquez, Gualberto Benítez, José Ortellado, Ronald Rivas, Antonio Barrios, Enrique Hilario
Objective: Determine the viability of a remote diagnosis system implemented to provide health care to remote and scattered populations in Paraguay. Methods: The study was conducted in all regional and general hospitals in Paraguay, and in the main district hospitals in the country's 18 health regions. Clinical data, tomographic images, sonography, and electrocardiograms (ECGs) of patients who needed a diagnosis by a specialized physician were entered into the system...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28612913/the-usefulness-of-soluble-st2-and-galectin-3-as-novel-biomarkers-for-better-risk-stratification-in-hypertrophic-cardiomyopathy
#7
Monika Gawor, Mateusz Śpiewak, Jadwiga Janas, Katarzyna Kożuch, Aleksandra Wróbel, Łukasz Mazurkiewicz, Rafał Baranowski, Magdalena Marczak, Jacek Grzybowski
BACKGROUND: Estimation of sudden cardiac death (SCD) risk is an integral part of clinical management of patients with hypertrophic cardiomyopathy (HCM). Identification of novel biomarkers of this disease can provide additional criteria for SCD risk stratification. Soluble suppression of tumorigenicity (sST2) and galectin-3 (Gal-3) are useful biomarkers for prognosis of heart failure (HF). Both of them appear to mediate cardiac fibrosis - an important pathogenetic process in HCM. Data about sST2 and Gal-3 usefulness in patients with HCM are limited...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28611540/evaluation-of-qtc-interval-prolongation-in-breast-cancer-patients-after-treatment-with-epirubicin-cyclophosphamide-and-docetaxel-and-the-influence-of-interobserver-variation
#8
Julian Puppe, Deborah van Ooyen, Jeanne Neise, Fabinshy Thangarajah, Christian Eichler, Stefan Krämer, Roman Pfister, Peter Mallmann, Marina Wirtz, Guido Michels
BACKGROUND: Chemotherapy with anthracyclines is associated with life-threatening electrocardiographic alterations including corrected QT (QTc) interval prolongation. PATIENTS AND METHODS: In this study we assessed the effect of epirubicin, cyclophosphamide, and docetaxel (EC-Doc) on the QTc interval in 10 patients with early breast cancer. Cardiac toxicity was assessed with symptoms, transthoracic echocardiography, electrocardiography (ECG), and serum cardiac markers at baseline and after 4 cycles of EC and 4 cycles of docetaxel...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28588112/the-hoorn-diabetes-care-system-dcs-cohort-a-prospective-cohort-of-persons-with-type-2-diabetes-treated-in-primary-care-in-the-netherlands
#9
Amber Awa van der Heijden, Simone P Rauh, Jacqueline M Dekker, Joline W Beulens, Petra Elders, Leen M 't Hart, Femke Rutters, Nienke van Leeuwen, Giel Nijpels
PURPOSE: People with type 2 diabetes (T2D) have a doubled morbidity and mortality risk compared with persons with normal glucose tolerance. Despite treatment, clinical targets for cardiovascular risk factors are not achieved. The Hoorn Diabetes Care System cohort (DCS) is a prospective cohort representing a comprehensive dataset on the natural course of T2D, with repeated clinical measures and outcomes. In this paper, we describe the design of the DCS cohort. PARTICIPANTS: The DCS consists of persons with T2D in primary care from the West-Friesland region of the Netherlands...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28567129/noninvasive-fetal-electrocardiography-part-ii-segmented-beat-modulation-method-for-signal-denoising
#10
Angela Agostinelli, Agnese Sbrollini, Luca Burattini, Sandro Fioretti, Francesco Di Nardo, Laura Burattini
BACKGROUND: Fetal well-being evaluation may be accomplished by monitoring cardiac activity through fetal electrocardiography. Direct fetal electrocardiography (acquired through scalp electrodes) is the gold standard but its invasiveness limits its clinical applicability. Instead, clinical use of indirect fetal electrocardiography (acquired through abdominal electrodes) is limited by its poor signal quality. OBJECTIVE: Aim of this study was to evaluate the suitability of the Segmented-Beat Modulation Method to denoise indirect fetal electrocardiograms in order to achieve a signal-quality at least comparable to the direct ones...
2017: Open Biomedical Engineering Journal
https://www.readbyqxmd.com/read/28559852/is-abdominal-fetal-electrocardiography-an-alternative-to-doppler-ultrasound-for-fhr-variability-evaluation
#11
Janusz Jezewski, Janusz Wrobel, Adam Matonia, Krzysztof Horoba, Radek Martinek, Tomasz Kupka, Michal Jezewski
Great expectations are connected with application of indirect fetal electrocardiography (FECG), especially for home telemonitoring of pregnancy. Evaluation of fetal heart rate (FHR) variability, when determined from FECG, uses the same criteria as for FHR signal acquired classically-through ultrasound Doppler method (US). Therefore, the equivalence of those two methods has to be confirmed, both in terms of recognizing classical FHR patterns: baseline, accelerations/decelerations (A/D), long-term variability (LTV), as well as evaluating the FHR variability with beat-to-beat accuracy-short-term variability (STV)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28553625/the-comparison-effects-of-two-methods-of-adaptive-support-ventilation-minute-ventilation-110-and-adaptive-support-ventilation-minute-ventilation-120-on-mechanical-ventilation-and-hemodynamic-changes-and-length-of-being-in-recovery-in-intensive-care-units
#12
Babak Ali Kiaei, Parviz Kashefi, Seyed Taghi Hashemi, Daryoush Moradi, Ahmad Mobasheri
BACKGROUND: The conventional method for ventilation is supported by accommodative or adaptive support ventilation (ASV) that the latter method is done with two methods: ASV minute ventilation (mv): 110% and ASV mv: 120%. Regarding these methods this study compared the differences in duration of mechanical ventilation and hemodynamic changes during recovery and length of stay in Intensive Care Units (ICU). MATERIALS AND METHODS: In a clinical trial study, forty patients candidate for ventilation were selected and randomly divided into two groups of A and B...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28550021/effects-of-continuous-positive-airway-pressure-on-neurocognitive-architecture-and-function-in-patients-with-obstructive-sleep-apnoea-study-protocol-for-a-multicentre-randomised-controlled-trial
#13
Huajun Xu, Hui Wang, Jian Guan, Hongliang Yi, Yingjun Qian, Jianyin Zou, Yunyan Xia, Yiqun Fu, Xinyi Li, Xiao Jiao, Hengye Huang, Pin Dong, Ziwei Yu, Jun Yang, Mingliang Xiang, Jiping Li, Yanqing Chen, Peihua Wang, Yizhou Sun, Yuehua Li, Xiaojian Zheng, Wei Jia, Shankai Yin
OBJECTIVES: Many clinical studies have indicated that obstructive sleep apnoea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some neurocognitive protective effects against the adverse effects of OSA. However, the effects of CPAP treatment on neurocognitive architecture and function remain unclear. Therefore, this multicentre trial was designed to investigate whether and when neurocognitive architecture and function in patients with OSA can be improved by CPAP treatment and to explore the role of gut microbiota in improving neurocognitive function during treatment...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28549119/systematic-review-of-cost-effectiveness-of-myocardial-perfusion-scintigraphy-in-patients-with-ischaemic-heart-disease-a-report-from-the-cardiovascular-committee-of-the-european-association-of-nuclear-medicine-endorsed-by-the-european-association-of-cardiovascular
#14
Elin Trägårdh, Siok Swan Tan, Jan Bucerius, Alessia Gimelli, Oliver Gaemperli, Oliver Lindner, Denis Agostini, Christopher Übleis, Roberto Sciagrà, Riemer H Slart, S Richard Underwood, Fabien Hyafil, Marcus Hacker, Hein J Verberne
Coronary artery disease (CAD) is a major cause of death and disability. Several diagnostic tests, such as myocardial perfusion scintigraphy (MPS), are accurate for the detection of CAD, as well as having prognostic value for the prediction of cardiovascular events. Nevertheless, the diagnostic and prognostic value of these tests should be cost-effective and should lead to improved clinical outcome. We have reviewed the literature on the cost-effectiveness of MPS in different circumstances: (i) the diagnosis and management of CAD; (ii) comparison with exercise electrocardiography (ECG) and other imaging tests; (iii) as gatekeeper to invasive coronary angiography (ICA), (iv) the impact of appropriate use criteria; (v) acute chest pain, and (vi) screening of asymptomatic patients with type-2 diabetes...
May 26, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28545342/echocardiographic-and-clinical-findings-in-patients-with-fabry-disease-during-long-term-enzyme-replacement-therapy-a-nationwide-danish-cohort-study
#15
Christoffer Valdorff Madsen, Henning Bundgaard, Åse Krogh Rasmussen, Søren Schwartz Sørensen, Jørgen Holm Petersen, Lars Køber, Ulla Feldt-Rasmussen, Helle Petri
OBJECTIVES: In patients with Fabry disease (FD), left ventricular hypertrophy and arrhythmias are frequently observed and cardiac involvement is the leading cause of death. Long-term efficacy of enzyme replacement therapy (ERT) on cardiac involvement is unclear. We assessed and compared long-term progression of cardiac involvement according to ERT and non-ERT. METHODS: We retrospectively assessed and compared long-term progression of cardiac involvement in adult patients with FD in the nationwide Danish cohort...
May 25, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28529306/normalization-of-diffuse-st-depression-with-avr-elevation-after-rehydration-in-a-patient-with-severe-aortic-stenosis
#16
Sachin R Patel, Vikas J Patel, Brittany Clark, George Rust
BACKGROUND Isolated ST elevation in lead aVR in combination with global ST depression with normalization after rehydration is a unique electrocardiographic pattern that is associated with a broad range of diagnoses. Its association with left main coronary artery disease and other acute coronary syndromes suggest the need for early and aggressive cardiac evaluation. CASE REPORT A 53-year-old man presented with altered mental status and loss of consciousness. He was unresponsive, hypotensive, tachycardiac, and diaphoretic...
May 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28511161/-the-diagnostics-and-clinical-pattern-of-nonalcoholic-fatty-liver-disease-in-patients-with-pre-diabetes-and-type-2-diabetes-and-obesity
#17
Ксенія І Чубірко
INTRODUCTION: The data of epidemiological researches confirm the tendency in increasing of non alcoholic fatty liver disease (NAFLD) in patients with insulin resistance which occurs because of obesity, diabetes type 2 and metabolic syndrome. AIM: Optimization of diagnostic and treatment efficacy in patients with non alcoholic steatosis and steatohepatitis on the background of obesity. MATERIALS AND METHODS: General clinical examination of patients, laboratory and instrumental methods ( fatty liver index, non invasive assessment of liver, morphology, electrocardiography, treadmillergometry, ultrasound examination of abdominal organs, liver elastography,CT,MRI, methods of statistical analysis...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28502795/multi-scale-tailor-made-heart-simulation-can-predict-the-effect-of-cardiac-resynchronization-therapy
#18
Jun-Ichi Okada, Takumi Washio, Machiko Nakagawa, Masahiro Watanabe, Yoshimasa Kadooka, Taro Kariya, Hiroshi Yamashita, Yoko Yamada, Shin-Ichi Momomura, Ryozo Nagai, Toshiaki Hisada, Seiryo Sugiura
BACKGROUND: The currently proposed criteria for identifying patients who would benefit from cardiac resynchronization therapy (CRT) still need to be optimized. A multi-scale heart simulation capable of reproducing the electrophysiology and mechanics of a beating heart may help resolve this problem. The objective of this retrospective study was to test the capability of patient-specific simulation models to reproduce the response to CRT by applying the latest multi-scale heart simulation technology...
May 11, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28499665/persistent-t-wave-inversion-predicts-myocardial-damage-after-st-elevation-myocardial-infarction
#19
Martin Reindl, Sebastian Johannes Reinstadler, Hans-Josef Feistritzer, Lea Niess, Constantin Koch, Agnes Mayr, Gert Klug, Bernhard Metzler
BACKGROUND: Persistent T-wave inversion (PTI) after ST-elevation myocardial infarction (STEMI) is associated with worse clinical outcome; however, the underlying mechanism between PTI and poor prognosis is incompletely understood. We sought to investigate the relationship between PTI and myocardial damage assessed by cardiac magnetic resonance (CMR) following STEMI. METHODS: In this prospective observational study, we included 142 consecutive revascularized STEMI patients...
May 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28499391/safety-of-three-different-product-doses-in-autologous-chondrocyte-implantation-results-of-a-prospective-randomised-controlled-trial
#20
Christoph Becher, Volker Laute, Stefan Fickert, Wolfgang Zinser, Philipp Niemeyer, Thilo John, Peter Diehl, Thomas Kolombe, Rainer Siebold, Jakob Fay
BACKGROUND: This study was conducted to assess the efficacy and safety of the three dose levels of the three-dimensional autologous chondrocyte implantation product chondrosphere® in the treatment of cartilage defects (4-10 cm(2)) of knee joints. We hereby report the safety results for a 36-month post-treatment observation period. METHODS: This was a prospective phase II trial with a clinical intervention comprising biopsy for culturing spheroids and their subsequent administration (level of evidence: I)...
May 12, 2017: Journal of Orthopaedic Surgery and Research
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