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Myocardial Injury

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https://www.readbyqxmd.com/read/29457680/chronic-lead-exposure-enhances-the-sympathoexcitatory-response-associated-with-p2x4-receptor-in-rat-stellate-ganglia
#1
Gaochun Zhu, Zhenying Chen, Bo Dai, Chaoran Zheng, Huaide Jiang, Yurong Xu, Xuan Sheng, Jingjing Guo, Yu Dan, Shangdong Liang, Guilin Li
Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chronic lead exposure and the possible mechanisms are still unknown. The aim of this study was to explore the change of the sympathoexcitatory response induced by chronic lead exposure via the P2X4 receptor in the stellate ganglion (SG)...
February 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29457560/prophylactic-intra-aortic-balloon-counterpulsation-before-surgical-myocardial-revascularization-in-patients-with-acute-myocardial-infarction
#2
Philippe Grieshaber, Tobias Schneider, Lukas Oster, Coskun Orhan, Peter Roth, Bernd Niemann, Andreas Böning
INTRODUCTION: Prophylactic intra-aortic balloon counterpulsation (pIABC) is recommended for high-risk patients undergoing coronary artery bypass grafting (CABG) surgery. Criteria for high-risk patients benefiting from pIABC are unclear. This study aimed to specifically describe the effect of pIABC on outcomes of patients with acute myocardial infarction (AMI) undergoing CABG. METHODS: In 178 of 484 AMI patients (non-ST-segment elevation myocardial infarction [NSTEMI] or ST-segment elevation myocardial infarction [STEMI] ≤5 days before surgery) without cardiogenic shock who underwent CABG between 2008 and 2013, pIABC was initiated preoperatively...
February 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29456986/extract-from-teucrium-polium-l-protects-rat-heart-against-oxidative-stress-induced-by-ischemic-reperfusion-injury
#3
Maryam Mahmoudabady, Milad Haghshenas, Saeed Niazmand
Background: The deleterious effect of oxidative stress on myocardial ischemia-reperfusion (I/R) has already been shown in previous studies. Since Teucrium polium has anti-oxidative and cardio-protective properties, the aim of this study was to investigate the effects of this plant on I/R injuries in the isolated rat heart. Materials and Methods: The myocardial I/R injury of rat was created by Langendorff retrograde perfusion technology. The heart was preperfused with Krebs-Henseleit (K-H) solution containing T...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456238/remote-ischemic-postconditioning-ripc-of-the-upper-arm-results-in-protection-from-cardiac-ischemia-reperfusion-injury-following-primary-percutaneous-coronary-intervention-pci-for-acute-st-segment-elevation-myocardial-infarction-stemi
#4
Bangming Cao, Haipeng Wang, Chi Zhang, Ming Xia, Xiangjun Yang
BACKGROUND The aim of this study was to evaluate the role of remote ischemic postconditioning (RIPC) of the upper arm on protection from cardiac ischemia-reperfusion injury following primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). MATERIAL AND METHODS Eighty patients with STEMI were randomized into two groups: primary PCI (N=44) and primary PCI+RIPC (N=36). RIPC consisted of four cycles of 5 minutes of occlusion and five minutes of reperfusion by cuff inflation and deflation of the upper arm, commencing within one minute of the first PCI balloon dilatation...
February 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29456049/six-month-outcomes-after-high-risk-coronary-artery-bypass-graft-surgery-and-preoperative-intra-aortic-balloon-counterpulsation-use-an-inception-cohort-study
#5
Edward Litton, Frances Bass, Anthony Delaney, Graham Hillis, Silvana Marasco, Shay McGuinness, Paul S Myles, Christopher M Reid, Julian A Smith
OBJECTIVE: To inform the design of a pivotal randomized controlled trial of prophylactic intra-aortic balloon counterpulsation (IABC) in patients undergoing coronary artery bypass graft (CABG) at high risk of postoperative low cardiac output syndrome (LCOS). DESIGN: Inception cohort study. SETTING: A total of 13 established cardiac centers in Australia, Canada, New Zealand, and the United Kingdom. PARTICIPANTS: Adult patients were eligible for inclusion if they were listed for CABG surgery and had 2 or more LCOS risk factors (low ejection fraction, severe left main coronary artery disease, redo sternotomy, unstable angina)...
January 5, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29455951/sex-hormone-contributes-to-sexually-dimorphic-susceptibility-in-cvb3-induced-viral-myocarditis-via-modulating-ifn-%C3%AE-nk-cell-production
#6
Nannan Zhou, Yan Yue, Sidong Xiong
BACKGROUND: Viral myocarditis is a widespread cardiac disease associated with inflammation and myocardial injury and is predominantly caused by coxsackievirus B3 (CVB3) infection in humans as well as in mice. CVB3-induced myocarditis shows sexually dimorphic sensitivity and is more prevalent in male mice. Our previous studies showed that natural killer (NK) cells played an indispensable role in CVB3-induced myocarditis, and female mice exhibited less pathological cardiac interferon gamma (IFN-γ)+ NK cell infiltration than did male mice...
January 6, 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29455574/immune-responsive-resolvin-d1-programs-myocardial-infarction-induced-cardiorenal-syndrome-in-heart-failure
#7
Ganesh V Halade, Vasundhara Kain, Charles N Serhan
Resolvins are innate, immune responsive, bioactive mediators generated after myocardial infarction (MI) to resolve inflammation. The MI-induced bidirectional interaction between progressive left ventricle (LV) remodeling and kidney dysfunction is known to advance cardiorenal syndrome (CRS). Whether resolvins limit MI-induced cardiorenal inflammation is unclear. Thus, to define the role of exogenous resolvin D (RvD)-1 in post-MI CRS, we subjected 8-12-wk-old male C57BL/6 mice to coronary artery ligation. RvD1 was injected 3 h after MI...
February 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29454761/diagnostic-accuracy-of-cardiovascular-magnetic-resonance-in-acute-myocarditis-a-systematic-review-and-meta-analysis
#8
Christos P Kotanidis, Maria-Anna Bazmpani, Anna-Bettina Haidich, Charalambos Karvounis, Charalambos Antoniades, Theodoros D Karamitsos
OBJECTIVES: The purpose of this systematic review was to explore the diagnostic accuracy of various cardiovascular magnetic resonance (CMR) index tests for the diagnosis of acute myocarditis in adult patients. BACKGROUND: Acute myocarditis remains one of the most challenging diagnoses in cardiology. CMR has emerged as the diagnostic tool of choice to detect acute myocardial injury and necrosis in patients with suspected myocarditis. METHODS: We considered all diagnostic cohort and case-control studies...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29453330/interphysician-agreement-on-subclassification-of-myocardial-infarction
#9
Anton Gard, Bertil Lindahl, Gorav Batra, Nermin Hadziosmanovic, Marcus Hjort, Karolina Elisabeth Szummer, Tomasz Baron
OBJECTIVE: The universal definition of myocardial infarction (MI) differentiates MI due to oxygen supply/demand mismatch (type 2) from MI due to plaque rupture (type 1) as well as from myocardial injuries of non-ischaemic or multifactorial nature. The purpose of this study was to investigate how often physicians agree in this classification and what factors lead to agreement or disagreement. METHODS: A total of 1328 patients diagnosed with MI at eight different Swedish hospitals 2011 were included...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29453108/telomeres-and-telomerase-in-heart-regeneration
#10
REVIEW
Esther Aix, Alex Gallinat, Ignacio Flores
Although recent advances have overturned the old view of the human heart as an inert postmitotic organ, it is clear that the adult heart´s capacity to regenerate after an ischemic episode is very limited. Unlike humans, zebrafish and other lower vertebrates vigorously regenerate damaged myocardium after cardiac injury. Understanding how the zebrafish is able to conserve life-long cardiac regeneration capacity while mammals lose it soon after birth is crucial for the development of new treatments for myocardial infarction...
February 3, 2018: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29452461/angiogenesis-precedes-cardiomyocyte-migration-in-regenerating-mammalian-hearts
#11
Arnar B Ingason, Andrew B Goldstone, Michael J Paulsen, Akshara D Thakore, Vi N Truong, Bryan B Edwards, Anahita Eskandari, Tanner Bollig, Amanda N Steele, Y Joseph Woo
OBJECTIVE: Although the mammalian heart's ability to fully regenerate is debated, its potential to extensively repair itself is gaining support. We hypothesized that heart regeneration relies on rapid angiogenesis to support myocardial regrowth and sought to characterize the timeline for angiogenesis and cell proliferation in regeneration. METHODS: One-day-old CD-1 mice (P1, N = 60) underwent apical resection or sham surgery. Hearts were explanted at serial time points from 0 to 30 days postresection and analyzed with immunohistochemistry to visualize vessel ingrowth and cardiomyocyte migration into the resected region...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29452370/blood-cardioplegia-for-cardiac-surgery-in-acute-myocardial-infarction-rat-experiments-with-two-widely-used-solutions
#12
Andreas Boening, Lena Assling-Simon, Martina Heep, Kerstin Boengler, Bernd Niemann, Julia Schipke, Christian Mühlfeld, Philippe Grieshaber
OBJECTIVES: Blood cardioplegia (BCP) can be used in different ways to protect the heart from ischaemia-reperfusion injury during cardiac surgery. Because there could be differences between warm and cold intermittent cardioplegia with or without warm reperfusion, we investigated the influence of 2 blood cardioplegia solutions on cardiac function, metabolism and infarct size in stable and infarcted rat hearts. METHODS: The hearts of 32 male Wistar rats were excised and inserted into a blood-perfused isolated heart apparatus...
February 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29448942/cold-exposure-induced-oxidative-stress-and-apoptosis-in-the-myocardium-by-inhibiting-the-nrf2-keap1-signaling-pathway
#13
Peifang Cong, Yunen Liu, Nannan Liu, Yubiao Zhang, Changci Tong, Lin Shi, Xuelei Liu, Xiuyun Shi, Ying Liu, Zhou Tong, Mingxiao Hou
BACKGROUND: Exposure to cold weather is associated with infaust cardiovascular responses, including myocardial infarction and arrhythmias. However, the exact mechanisms of these adverse changes in the myocardium under cold stress are unknown. This study was designed to investigate the mechanisms of cardiac injury induced by cold stress in mice. METHODS: The mice were randomly divided into three groups, normal control (no handling), 1-week cold stress and 2-week cold stress...
February 15, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29448828/role-of-terminal-warm-blood-cardioplegia-in-complex-congenital-heart-surgery
#14
Pribadi Wiranda Busro, Harvey Romolo, Sudigdo Sastroasmoro, Jusuf Rachmat, Mohammad Sadikin, Anwar Santoso, Cindy Elfira Boom, Suhendro Suwarto, Ahmad Aulia Jusuf
Introduction Myocardial protection is vital to ensure successful open heart surgery. Cardioplegic solution is one method to achieve good myocardial protection. Inevitably, ischemia-reperfusion injury occurs with aortic crossclamping. Histidine-tryptophan-ketoglutarate solution is a frequently used cardioplegia for complex congenital heart surgery. We postulated that addition of terminal warm blood cardioplegia before removal of the aortic crossclamp might improve myocardial protection. Method A randomized controlled trial was conducted on 109 cyanotic patients aged, 1 to 5 years who underwent complex biventricular repair...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29447430/aucubin-protects-against-pressure-overload-induced-cardiac-remodelling-via-%C3%AE-3-ar-nnos-cascades
#15
Qing-Qing Wu, Yang- Xiao, Ming-Xia Duan, Yuan Yuan, Xiao-Han Jiang, Zheng Yang, Hai-Han Liao, Wei Deng, Qi-Zhu Tang
BACKGROUND AND PURPOSE: Aucubin, the predominant component of Eucommia ulmoides Oliv., plays an indispensable role in regulating oxidative stress. Considering that oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart failure. EXPERIMENTAL APPROACH: In the first set of experiments, H9c2 cardiomyocytes and neonatal rat cardiomyocytes pre-treated with aucubin (1, 3 10, 25, 50 μM) were challenged with phenylephrine...
February 15, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29447379/acute-exercise-is-not-cardioprotective-and-may-induce-apoptotic-signalling-in-heart-surgery-a-randomized-controlled-trial
#16
Benedikte T Smenes, Fredrik H Bækkerud, Katrine H Slagsvold, Erlend Hassel, Martin Wohlwend, Maria Pinho, Morten Høydal, Ulrik Wisløff, Øivind Rognmo, Alexander Wahba
OBJECTIVES: During open-heart surgery, the myocardium experiences ischaemia-reperfusion injury. A single bout of moderate, 30-min exercise induces preconditioning and protects the heart from ischaemia-reperfusion injury in rats, but this has never been investigated in humans. We aimed to investigate whether 1 bout of moderate exercise 24 h prior to surgery protects against mitochondrial and cardiac damage. METHODS: Patients scheduled for elective coronary artery bypass were eligible for this pilot study...
February 13, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29442529/signaling-mediators-modulated-by-cardioprotective-interventions-in-healthy-and-diabetic-myocardium-with-ischaemia-reperfusion-injury
#17
Feyzizadeh Saeid, Javadi Aniseh, Badalzadeh Reza, Vafaee S Manouchehr
Ischaemic heart diseases are one of the major causes of death in the world. In most patients, ischaemic heart disease is coincident with other risk factors such as diabetes. Patients with diabetes are more prone to cardiac ischaemic dysfunctions including ischaemia-reperfusion injury. Ischaemic preconditioning, postconditioning and remote conditionings are reliable interventions to protect the myocardium against ischaemia-reperfusion injuries through activating various signaling pathways and intracellular mediators...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29441020/eriodictyol-attenuates-myocardial-ischemia-reperfusion-injury-through-the-activation-of-jak2
#18
Defang Li, Ning Lu, Jichun Han, Xiaoyu Chen, Wenjin Hao, Wenjuan Xu, Xiaona Liu, Lei Ye, Qiusheng Zheng
Myocardial ischemia-reperfusion (I/R) injury remains the leading risk factor of disability and mortality worldwide. In this study, the myocardial protective effect of eriodictyol (EDT) and the underlying mechanism in an ex vivo model of global myocardial I/R was investigated. After treatment with different concentrations of EDT, the decreased hemodynamic parameters induced by myocardial I/R injury were significantly attenuated by EDT. The elevated levels of IL-6, CRP, IL-8, and TNF-α were effectively reduced by EDT treatment...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29439657/effects-of-procyanidin-on-cardiomyocyte-apoptosis-after-myocardial-ischemia-reperfusion-in-rats
#19
Dan Liu
BACKGROUND: This study is aimed at investigating the effects of procyanidin on cardiomyocyte apoptosis of myocardial ischemia/reperfusion (I/R) injury in rats. METHODS: Sprague-Dawley rats were randomly assigned into four groups: control group (normal saline), ischemic group (normal saline), procyanidin low-dose group (procyanidin 50 mg/kg/day) and procyanidin high-dose group (procyanidin 100 mg/kg/day) by intragastric administration for 2 weeks. After last administration, myocardial I/R model was induced by ligating left anterior descending artery for 30 min followed by 120 min of perfusion...
February 13, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29438868/investigation-of-the-reverse-effect-of-danhong-injection-on-doxorubicin-induced-cardiotoxicity-in-h9c2-cells-insight-by-lc-ms-based-non-targeted-metabolomic-analysis
#20
Xiaojiao Yi, Junfeng Zhu, Jinghui Zhang, Yun Gao, Zhongjian Chen, Shihai Lu, Zongwei Cai, Yanjun Hong, Yongjiang Wu
Although Danhong injection (DHI) has been clearly shown to attenuate ischemic myocardial injury and improve heart function, there is no research regarding its role in doxorubicin (DOX)-induced cardiomyopathy. In this study, we aimed to investigate the reverse effect of DHI on DOX-induced cardiotoxicity in H9c2 cells. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay demonstrated that DHI had no cytotoxicity towards the relevant cell line unless the concentration was as high as 50 μL/mL...
February 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
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