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https://www.readbyqxmd.com/read/29474298/descemet-membrane-endothelial-keratoplasty-for-failed-deep-anterior-lamellar-keratoplasty-a-case-series
#1
Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Zale Mednick, Mohammad Kreimei, Clara C Chan, David S Rootman
PURPOSE: To suggest a new surgical approach for posterior opacities or persistent Descemet membrane (DM) detachment in failed deep anterior lamellar keratoplasty (DALK) and to report the outcome of Descemet membrane endothelial keratoplasty (DMEK) in a series of patients with DALK failure. METHODS: In this retrospective case series of patients who underwent DMEK for failed DALK at Toronto Western Hospital, 4 patients with failed DALK who underwent DMEK surgery were included...
February 22, 2018: Cornea
https://www.readbyqxmd.com/read/29474222/hemorrhagic-occlusive-retinal-vasculitis-after-intracameral-vancomycin-use-in-cataract-surgery-after-intravenous-exposure
#2
Tarek Alasil, James J Y Wong, Ron A Adelman, David Tom, Patrick A Coady
PURPOSE: To report a case of hemorrhagic occlusive retinal vasculitis after cataract surgery. METHODS: A 74-year-old woman presented with blurry vision and distorted vision, which started 2 days after an uncomplicated cataract surgery in the left eye. Intracameral vancomycin was injected during the case. The patient reported being treated with systemic vancomycin in the past. RESULTS: The visual acuity was 20/80 in the left eye. She had trace cells in the anterior chamber with no hypopyon and intraocular lens implant within the capsular bag in the left eye...
February 22, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29471996/the-eyes-have-it
#3
Lindsay Machan
The ocular lens is one of the most susceptible structures in the body to radiation damage. Unfortunately, much of the traditional academic and regulatory thinking on thresholds to develop radiation-induced opacities or cataracts has proven to be false. Individual vulnerability to the effects of radiation is extremely variable, largely because each individual is variably genetically equipped to repair the damage caused by radiation. Therefore many people, including some unsuspecting interventional radiologists may have no, or almost no, threshold at all for cataract development after radiation injury...
March 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29470954/the-optical-properties-of-rat-porcine-and-human-lenses-in-organ-culture-treated-with-dexamethasone
#4
Mark Bree, Douglas Borchman
Organ culturing of lenses is useful for testing the direct effect of moieties such as cations, glucose, oxygen, antioxidants or drugs on the lens. Lens opacity changes in organ cultured lenses have never been measured quantitatively. Our aims were twofold: to establish the time course of lens opacity changes in organ cultured rat, porcine and human lenses and to test the utility of our system to measure opacity changes in lenses treated with dexamethasone. Human, porcine and rat lenses were incubated with or without 5 μM dexamethasone in minimum essential medium for 13 days...
February 19, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29468215/descemet-membrane-endothelial-keratoplasty-for-corneal-decompensation-due-to-iridoschisis
#5
Miles F Greenwald, Philip I Niles, A Tim Johnson, Jesse M Vislisel, Mark A Greiner
Purpose: To report a case of bilateral iridoschisis with cataracts and corneal decompensation in a patient who underwent cataract extraction and superficial iridectomy followed by Descemet membrane endothelial keratoplasty (DMEK). Observations: A 58-year-old man with previously diagnosed iridoschisis, cataracts, and diabetes mellitus experienced progressive vision loss bilaterally due to corneal decompensation. Slit lamp examination revealed iridoschisis with iris fibrils contacting the corneal endothelium, stromal edema, and mild guttate changes bilaterally...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29468213/acute-onset-endophthalmitis-caused-by-staphylococcus-lugdunensis
#6
Robert B Garoon, Darlene Miller, Harry W Flynn
Purpose: To report a series of patients with acute-onset bacterial endophthalmitis caused by culture proven Staphylococcus lugdunensis , and to characterize clinical outcomes and microbiologic susceptibilities of this organism. Observations: The study included six eyes of 6 patients. The etiologies included cataract surgery (3), open globe injury (2), and intravitreal injection (1). Isolates of S. lugdunensis demonstrated sensitivity to vancomycin in all cases reported...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29468207/bull-s-eye-maculopathy-and-subfoveal-deposition-in-two-mucopolysaccharidosis-type-i-patients-on-long-term-enzyme-replacement-therapy
#7
Heather G Mack, R C Andrew Symons, Gerard de Jong
Purpose: To report retinal findings in two patients with mucopolysaccharidosis type I (MPS I) receiving human recombinant alpha-l-iduronidase (Laronidase) as enzyme replacement therapy. Observations: Patient 1 had visual acuity 20/20 right eye, 20/25 left eye and unremarkable anterior segment and retinal examination. Optical coherence tomography (OCT) scanning demonstrated parafoveal thinning and subfoveal hyperreflectant material. Patient 2 had visual acuity 20/20 both eyes, with dense nuclear cataract both eyes...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29464339/new-gja8-variants-and-phenotypes-highlight-its-critical-role-in-a-broad-spectrum-of-eye-anomalies
#8
Fabiola Ceroni, Domingo Aguilera-Garcia, Nicolas Chassaing, Dorine Arjanne Bax, Fiona Blanco-Kelly, Patricia Ramos, Maria Tarilonte, Cristina Villaverde, Luciana Rodrigues Jacy da Silva, Maria Juliana Ballesta-Martínez, Maria Jose Sanchez-Soler, Richard James Holt, Lisa Cooper-Charles, Jonathan Bruty, Yvonne Wallis, Dominic McMullan, Jonathan Hoffman, David Bunyan, Alison Stewart, Helen Stewart, Katherine Lachlan, Alan Fryer, Victoria McKay, Joëlle Roume, Pascal Dureau, Anand Saggar, Michael Griffiths, Patrick Calvas, Carmen Ayuso, Marta Corton, Nicola K Ragge
GJA8 encodes connexin 50 (Cx50), a transmembrane protein involved in the formation of lens gap junctions. GJA8 mutations have been linked to early onset cataracts in humans and animal models. In mice, missense mutations and homozygous Gja8 deletions lead to smaller lenses and microphthalmia in addition to cataract, suggesting that Gja8 may play a role in both lens development and ocular growth. Following screening of GJA8 in a cohort of 426 individuals with severe congenital eye anomalies, primarily anophthalmia, microphthalmia and coloboma, we identified four known [p...
February 20, 2018: Human Genetics
https://www.readbyqxmd.com/read/29464132/crowd-sourced-ontology-for-photoleukocoria-identifying-common-internet-search-terms-for-a-potentially-important-pediatric-ophthalmic-sign
#9
Sandra E Staffieri, Lisa S Kearns, Paul G Sanfilippo, Jamie E Craig, David A Mackey, Alex W Hewitt
Purpose: Leukocoria is the most common presenting sign for pediatric eye disease including retinoblastoma and cataract, with worse outcomes if diagnosis is delayed. We investigated whether individuals could identify leukocoria in photographs (photoleukocoria) and examined their subsequent Internet search behavior. Methods: Using a web-based questionnaire, in this cross-sectional study we invited adults aged over 18 years to view two photographs of a child with photoleukocoria, and then search the Internet to determine a possible diagnosis and action plan...
February 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29463862/intraoperative-head-drift-and-eye-movement-two-under-addressed-challenges-during-cataract-surgery
#10
Kerr Brogan, Basu Dawar, David Lockington, Kanna Ramaesh
PURPOSE: To objectively measure head drift during cataract surgery, and subjectively simulate eye movements and assess impact on surgical technique. MATERIALS AND METHODS: Twelve consecutively recorded routine cataract operations in the Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, were reviewed. The speculum was used as a fixed point and correlated with a superimposed virtual ruler to measure maximum head drift in each direction throughout the operations...
February 21, 2018: Eye
https://www.readbyqxmd.com/read/29462175/effect-of-cataract-surgery-on-cognitive-function-in-elderly-results-of-fujiwara-kyo-eye-study
#11
Kimie Miyata, Tadanobu Yoshikawa, Masayuki Morikawa, Masashi Mine, Nozomi Okamoto, Norio Kurumatani, Nahoko Ogata
PURPOSE: To determine whether there is a significant association between prior cataract surgery and cognitive function in an elderly Japanese cohort. SETTING: Nara Medical University, Nara, Japan. DESIGN: The Fujiwara-kyo Eye Study was a cross-sectional epidemiological study. METHODS: The subjects were ≥ 68-years who lived in the Nara Prefecture and responded to recruitment notices. All of the subjects received comprehensive ophthalmological examinations, and answered questionnaires on their socio-demographic and medical history including prior cataract surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29461682/spectacle-use-after-routine-cataract-surgery-and-vision-related-activity-limitation
#12
Daniel B Farhoudi, Anders Behndig, Kaziwe Mollazadegan, Per Montan, Mats Lundström, Maria Kugelberg
PURPOSE: To explore the relationship between acquisition of new spectacles after routine cataract surgery and vision-related activity limitation (VRAL) postoperatively. METHODS: This cohort study with intervention (survey) included 1329 patients in Sweden who had undergone a second-eye cataract surgery during March 2013. Data from the Swedish National Cataract Register were used, including evaluations of VRAL through the Catquest-9SF questionnaire before and 3 months after cataract surgery...
February 20, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29461512/delineation-of-novel-autosomal-recessive-mutation-in-gja3-and-autosomal-dominant-mutations-in-gja8-in-pakistani-congenital-cataract-families
#13
Shazia Micheal, Ilse Therésia Gabriëla Niewold, Sorath Noorani Siddiqui, Saemah Nuzhat Zafar, Muhammad Imran Khan, Arthur A B Bergen
Congenital cataract is a clinically and genetically heterogeneous disease. The present study was undertaken to find the genetic cause of congenital cataract families. DNA samples of a large consanguineous Pakistani family were genotyped with a high resolution single nucleotide polymorphism Illumina microarray. Homozygosity mapping identified a homozygous region of 4.4 Mb encompassing the gene GJA3 . Sanger sequence analysis of the GJA3 gene revealed a novel homozygous variant c.950dup p.(His318ProfsX8) segregating in an autosomal recessive (AR) manner...
February 20, 2018: Genes
https://www.readbyqxmd.com/read/29461408/brimonidine-ophthalmic-solution-0-025-for-reduction-of-ocular-redness-a-randomized-clinical-trial
#14
Eugene McLaurin, Megan E Cavet, Paul J Gomes, Joseph B Ciolino
SIGNIFICANCE: The α2-adrenergic receptor agonist brimonidine has been reported to induce conjunctival blanching in cataract, strabismus, laser refractive, and filtration procedures. Clinicians are often faced with red eyes with no apparent underlying pathology. Low-dose brimonidine reduced ocular redness in such subjects with efficacy maintained over 1 month and negligible rebound redness. PURPOSE: The aim of this study was to evaluate the safety and efficacy of brimonidine tartrate ophthalmic solution 0...
February 15, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29461140/genetic-investigation-of-ocular-developmental-genes-in-52-patients-with-anophthalmia-microphthalmia
#15
Nair Gopinathan Vidya, Sankaranarayanan Rajkumar, Abhay R Vasavada
BACKGROUND: Mutation in eye developmental genes has been reported to cause anophthalmia and microphthalmia. However, in India, especially in the Western Indian population, such reports are scarce. Hence, the present study aims to investigate mutations in 15 ocular developmental genes in patients with anophthalmia and microphthalmia in the western region of India. MATERIALS AND METHODS: Genomic DNA was isolated from the blood of 52 individuals affected with microphthalmia and anophthalmia, and 50 healthy normal controls...
February 20, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29460275/community-screening-for-visual-impairment-in-older-people
#16
REVIEW
Emily L Clarke, Jennifer R Evans, Liam Smeeth
BACKGROUND: Visual problems in older people are common and frequently under-reported. The effects of poor vision in older people are wide reaching and include falls, confusion and reduced quality of life. Much of the visual impairment in older ages can be treated (e.g. cataract surgery, correction of refractive error). Vision screening may therefore reduce the number of older people living with sight loss. OBJECTIVES: The objective of this review was to assess the effects on vision of community vision screening of older people for visual impairment...
February 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29459782/distinct-macular-thickness-changes-after-femtosecond-laser-assisted-cataract-surgery-of-age-related-cataract-and-myopia-with-cataract
#17
Yong Wang, Jun Du, Mei Yang, Yi Xu, Huaijin Guan, Jian Wu
Cataract surgery can cause macular thickness change. We used optical coherence tomography (OCT) to assess the macular thickness of different regions after femtosecond laser-assisted cataract surgery of age-related cataracts (ARC) and myopia cases with cataract (myopia group). Fifty eyes of 50 patients in ARC group and fifty eyes of 50 patients in myopia with cataract group were included. All study underwent femtosecond laser-assisted cataract surgery and macular thickness of was measured at pre-operation and 1 week, 1 month after surgery...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459041/dexamethasone-inserts-in-noninfectious-uveitis-a-single-center-experience
#18
Dominika Pohlmann, Gerrit A Vom Brocke, Sibylle Winterhalter, Theresa Steurer, Sabrina Thees, Uwe Pleyer
PURPOSE: To report the effectiveness of repeated intravitreal dexamethasone (DEX) inserts in noninfectious uveitis patients. DESIGN: Prospective, single-center, interventional clinical trial between February 2010 and March 2015. PARTICIPANTS: Patients with noninfectious uveitis with cystoid macular edema and/or vitreitis. METHODS: Patients were treated with a 700-μg intravitreal DEX insert (Ozurdex; Allergan, Inc., Irvine, CA)...
February 16, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29459040/interocular-axial-length-and-corneal-power-differences-as-predictors-of-postoperative-refractive-outcomes-after-cataract-surgery
#19
Vinay Kansal, Matthew Schlenker, Iqbal Ike K Ahmed
PURPOSE: To determine whether differences between eyes in axial length (AL) and corneal power (K) on optical biometry are predictive of refractive outcomes. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 729 patients (1458 eyes) who underwent bilateral phacoemulsification at TLC (Mississauga, Ontario, Canada) from September 2013 to August 2015. METHODS: We compared the proportion of patients having >0...
February 16, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29455164/surgical-efficiency-in-femtosecond-laser-cataract-surgery-compared-with-phacoemulsification-cataract-surgery-a-case-control-study
#20
Alexander C Day, Phillip R Smith, Hongying Lilian Tang, Francesco Aiello, Badrul Hussain, Vincenzo Maurino, John Marshall, George M Saleh
OBJECTIVES: To investigate differences in surgical time, the distance the surgical instrument travelled and number of movements required to complete manual phacoemulsification cataract surgery versus femtosecond laser cataract surgery. DESIGN: Non-randomised comparative case series. SETTING: Single surgery site, Moorfields Eye Hospital, UK. PARTICIPANTS: 40 cataract surgeries of 40 patients. INTERVENTIONS: Laser-assisted and manual phacoemulsification cataract surgery...
February 17, 2018: BMJ Open
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