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https://www.readbyqxmd.com/read/29050009/real-world-results-of-intravitreal-ranibizumab-bevacizumab-or-triamcinolone-for-diabetic-macular-edema
#1
İrem Koç, Sibel Kadayıfçılar, Bora Eldem
OBJECTIVE: To compare the visual and anatomical outcomes of intravitreal ranibizumab (group 1), bevacizumab (group 2), and triamcinolone (group 3) for center-involving diabetic macular edema. METHODS: We retrospectively enrolled 275 eyes of 208 consecutive patients. Visual acuity (VA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters and central macular thickness (CMT) values on optical coherence tomography were extracted. Reported side effects were noted...
October 20, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29049920/factors-associated-with-vision-related-quality-of-life-among-the-adult-population-living-in-nagorno-karabagh
#2
T Harutyunyan, A Giloyan, V Petrosyan
OBJECTIVES: Visual impairment and blindness are major public health problems causing significant suffering, disability, loss of productivity, and diminishing quality of life for millions of people. This study explored the factors associated with the overall vision-related quality of life (VRQoL) and its different domains in the adult population of Nagorno Karabakh and assessed the independent contribution of specific eye diseases to VRQoL. STUDY DESIGN: A cross-sectional study...
October 16, 2017: Public Health
https://www.readbyqxmd.com/read/29049739/cataract-avoidance-with-proton-therapy-in-ocular-melanomas
#3
Juliette Thariat, Sophie Jacob, Jean-Pierre Caujolle, Celia Maschi, Stéphanie Baillif, Gaelle Angellier, Thibaud Mathis, Laurence Rosier, Adela Carnicer, Joel Hérault, Julia Salleron
Purpose: The lens is a radiosensitive organ. Any dose of cephalic irradiation can give rise to radiation-induced cataracts. Contrary to other forms of radiotherapy, proton therapy (PT) can spare all or part of the lens due to accurate dose deposition. We investigated whether a lens-sparing approach was relevant to avoid cataracts in uveal melanoma patients. Methods: Patients were referred for PT from onco-ophthalmologists of private and academic institutions. Patients without preexisting cataracts or implants were entered in a prospective database...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049230/goniosynechialysis-combined-with-cataract-extraction-for-iridoschisis-a-case-report
#4
Zhipeng You, Yan Qin, Guodong Li, Ke Shi
RATIONALE: Iridoschisis is a rare eye disease. In this case report, we described the examination and diagnosis of a case of iridoschisis accompanied by secondary glaucoma. We also observed the effects of treating the patient with a combination of goniosynechialysis and cataract removal. PATIENT CONCERN: A 67-year-old female patient presented with decreased vision in both eyes. An eye examination indicated that visual acuities (VAs) were 20/100 and light perception in the right and left eyes, respectively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049074/physiology-and-role-of-intraocular-pressure-in-contemporary-anesthesia
#5
Dermot J Kelly, Sinéad M Farrell
More than 26 million Americans suffer with cataracts, and with 3.6 million cataract extractions performed annually in the United States, it is the most common surgical procedure. The integrity of the delicate structures of the eye that mediate vision is dependent on the intraocular pressure (IOP). Yet, IOP acts to compress the vessels within the globe-akin to a Starling resistor-and is a key component that determines the ocular perfusion pressure, defined as the difference between arterial pressure and IOP...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29048725/biallelicframeshift-mutation-in-rin2-in-a-patient-with-intellectual-disability-and-cataract-without-rin2-syndrome
#6
Claudia J M van Amen-Hellebrekers, Sandra Jansen, Alexander P A Stegmann, Servi J C Stevens, Rolph Pfundt, Bert B A de Vries
No abstract text is available yet for this article.
October 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29048240/natural-course-of-posterior-subcapsular-cataract-over-a-short-time-period
#7
Thomas Neumayer, Nino Hirnschall, Michael Georgopoulos, Oliver Findl
Purpose/aim of the study: To observe and analyze the weekly changes in morphology and size of vacuoles, so called Wedl cells, in eyes with posterior subcapsular cataract (PSC). MATERIALS AND METHODS: Thirty-six eyes of 36 patients with pronounced PSC were included in this prospective study. High-resolution retroillumination images were taken, and the changes in size and shape of Wedl cells were analyzed at baseline and at 2 and 4 weeks later using dedicated imaging software. RESULTS: In total, 1087 Wedl cells were observed...
October 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29045958/-clinical-characteristics-of-glucocorticoid-induced-eye-adverse-reactions-in-children-with-primary-nephrotic-syndrome
#8
Y Zhao, B G Su, H J Xiao, H W Zhang, X Y Liu, F Wang, J Ding
OBJECTIVE: To investigate the clinical features and side effects, with regard to glucocorticoid-induced ocular hypertension, glaucoma or cataract in children with primary nephrotic syndrome. METHODS: Clinical data were collected and analyzed from 71 cases of primary nephrotic syndrome with glucocorticoid-induced ocular hypertension, glaucoma or cataract from Jun. 2014 to Jun. 2016. These children were hospitalized in Peking University First Hospital. RESULTS: Totally 1 580 children with primary nephrotic syndrome were collected, glucocorticoid-induced complications in eyes were found in 71 cases, and the incidence was 4...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29044088/management-of-idiopathic-intracranial-hypertension-in-an-infant-with-bilateral-congenital-cataract-and-associated-comitant-sensory-esotropia
#9
Jyoti Himanshu Matalia, Sheetal Shirke, Hemant Anaspure, Pooja Ghalla, Minal Kekatpure
In this report, we describe the management of a child with bilateral cataract, nystagmus, and comitant sensory esotropia. Routine ultrasonography done before cataract surgery revealed bilateral disc edema confirmed as idiopathic intracranial hypertension by a pediatric neurologist. The primary intervention for cataract surgery was followed by nonresolving papilledema, despite maximum medical therapy. To salvage the optic nerve function in a nonverbal child, bilateral optic nerve sheath decompression was planned with simultaneous medial rectus recessions for the persistent esotropia with the satisfactory postoperative outcome...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044079/ultrasonographic-evaluation-of-transition-from-normal-to-ectatic-area-a-comparison-between-myopic-staphylomata-and-coloboma
#10
Anubha Rathi, Brijesh Takkar, Pradeep Venkatesh, Nripen Gaur, Atul Kumar
Choroidal coloboma and posterior staphyloma are two clinically distinct entities, with choroidal excavation being a unifying feature. They are associated with early onset cataract which can make ophthalmoscopy difficult. This report studies the transition between the normal and ectatic area in these cases with ultrasound. We evaluate "posterior hump" as a sign of differentiation between these two conditions.
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044063/cognitive-functions-and-normal-tension-glaucoma
#11
Akvile Daveckaite, Evelina Grusauskiene, Kestutis Petrikonis, Antanas Vaitkus, Lina Siaudvytyte, Ingrida Januleviciene
PURPOSE: Only a few studies have analyzed the potential link between glaucoma and cognitive function impairment. They have found controversial results. This study aims to perform quick cognitive function assessment with clock drawing test (CDT) using two different scoring systems and compare between normal tension glaucoma (NTG) and cataract patients. METHODS: Totally, 30 NTG and 30 patients with cataracts were included in a prospective, pilot study. The predrawn circle was given, and patients were asked to draw the clock showing a time of 11:10...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044058/femtosecond-laser-assisted-cataract-surgery-versus-2-2-mm-clear-corneal-phacoemulsification
#12
H Ranjini, Praveen R Murthy, Gowri J Murthy, Vinay R Murthy
PURPOSE: Phacoemulsification is the surgical procedure of choice for cataract, providing excellent visual and safety outcomes. Femtosecond laser-assisted cataract surgery (FLACS) is an addition to the surgical armamentarium. The study aims to compare the outcomes of FLACS using LenSx™ (Alcon Inc., USA) to standard 2.2 mm clear corneal phacoemulsification. Prospective case-control, comparative, interventional study was conducted in a tertiary care center. METHODS: In each group, 55 eyes of 55 patients underwent cataract surgery using either FLACS or conventional phacoemulsification (control group)...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29042749/a-review-of-results-after-implantation-of-a-secondary-intraocular-lens-to-correct-residual-refractive-error-after-cataract-surgery
#13
Kjell Gunnar Gundersen, Rick Potvin
PURPOSE: The purpose of this study was to provide clinical outcomes data related to secondary intraocular lens (IOL) implantation for the correction of residual refractive error after cataract surgery. PATIENTS AND METHODS: A chart review was conducted to identify all eyes implanted with the monofocal spherical or toric AddOn(®) secondary IOL. Data were collated from charts where uncomplicated initial cataract surgery was completed. Measures of interest included the original IOL implanted, the postoperative refractive error (before secondary IOL implantation) and the associated corrected and uncorrected visual acuities (VAs)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29042737/nance-horan-syndrome-a-rare-case-report
#14
Shambhu Sharma, Pankaj Datta, Janak Raj Sabharwal, Sonia Datta
Dentofacial anomalies may guide us to the diagnosis of many congenital and hereditary syndromes. A 9-year-old boy was diagnosed with Nance-Horan syndrome. This syndrome is an extremely rare X-linked genetic disorder which is entirely expressed in males with semi-dominant transmission which results from mutations occurring in male gametes. It is characterized by facial dysmorphism such as long face, prominent nose and mandibular prognathism, ocular abnormalities such as congenital cataract, microcornea, microphthalmia and strabismus, and dental anomalies including mulberry molars and screwdriver-shaped incisors...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042367/safety-and-efficacy-of-long-term-treatment-of-chronic-persistent-itp-with-eltrombopag-final-results-of-the-extend-study
#15
Raymond S M Wong, Mansoor N Saleh, Abderrahim Khelif, Abdulgabar Salama, Maria Socorro O Portella, Paul Burgess, James B Bussel
In phase 2/3 trials, eltrombopag treatment for ≤6 months in patients with chronic/persistent immune thrombocytopenia (ITP) increased platelet counts and reduced bleeding. The open-label EXTEND study evaluated long-term safety and efficacy of eltrombopag in adults with ITP who had completed a previous eltrombopag study. For the 302 patients enrolled, median duration of eltrombopag treatment was 2.37 years (2 days to 8.76 years). Median platelet counts increased to ≥50×10(9)/L by week 2 and were sustained throughout the treatment period...
October 17, 2017: Blood
https://www.readbyqxmd.com/read/29041796/prevalence-of-eye-pathology-in-a-group-of-diabetic-patients-at-national-district-hospital-outpatient-department-in-bloemfontein-south-africa
#16
Joleen P Cairncross, Wilhelm J Steinberg, Mathys J Labuschagne
BACKGROUND: Diabetic retinopathy is the third most common cause of blindness after cataracts and glaucoma in South Africa. Primary healthcare interventions providing eye care services play an important role in preventing complications. AIM: To determine the prevalence of eye pathology in a group of diabetic patients at National District Hospital by screening for diabetes-associated ocular pathology. SETTING: Outpatients Department run by Department of Family Medicine at National District Hospital in Bloemfontein from June to July 2014...
September 27, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29040121/outcomes-and-rationale-of-excision-and-mucous-membrane-grafting-in-palpebral-vernal-keratoconjunctivitis
#17
Geetha Iyer, Shweta Agarwal, Bhaskar Srinivasan
PURPOSE: To report outcomes of mucous membrane grafting (MMG) for refractory giant papillae in vernal keratoconjunctivitis. METHODS: Eleven eyes of 6 patients having giant papillae and recurrent shield ulcers refractory to topical medications, cryotherapy, and supratarsal steroid injections and shave excision of papillae underwent surgical resection of the giant papillae with MMG. Average occurrence of shield ulcers was twice per eye per year before the procedure with 50% of eyes having steroid-induced cataract and glaucoma...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29039721/a-recurrent-splice-site-mutation-in-epha2-causing-congenital-posterior-nuclear-cataract
#18
Vanita Berry, Nikolas Pontikos, Monica Albarca-Aguilera, Vincent Plagnol, Andreas Massouras, DeQuincy Prescott, Anthony T Moore, Gavin Arno, Michael E Cheetham, Michel Michaelides
Intoduction: Inherited cataract, opacification of the lens, is the most common worldwide cause of blindness in children. We aimed to identify the genetic cause of autosomal dominant (AD) posterior nuclear cataract in a four generation British family. METHODS: Whole genome sequence (WGS) was performed on two affected and one unaffected individual of the family and further validated by direct sequencing. Haplotype analysis was performed via genotying. RESULTS: A splice-site mutation c...
October 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29039457/high-throughput-sequencing-reveals-novel-lincrna-in-age-related-cataract
#19
Na Zhang, Chunmei Zhang, Xu Wang, Yanhua Qi
Age-related cataract (ARC) is a major cause of blindness. Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are non-protein-coding transcripts >200 nucleotides in length. LncRNAs are involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Furthermore, the dysregulation of lncRNAs causes a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders and various cancers...
October 11, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038958/glaucoma-following-childhood-cataract-surgery-the-south-india-experience
#20
Ifeoma Ezegwui, Meenakshi Ravindran, Neelam Pawar, Fathima Allapitchai, Ramakrishnan Rengappa, R Ramalakshmi Raman
PURPOSE: To determine the characteristics and risk factors for the development of glaucoma after cataract surgery in children seen at a major referral tertiary eye centre in South India. METHODS: This is a retrospective review of the medical records of consecutive patients seen at the glaucoma/paediatric eye clinic of the centre, with a diagnosis of glaucoma secondary to aphakia/pseudophakia over a 5-year period. RESULTS: There were 21 eyes of 14 children that developed glaucoma and 23 eyes of 12 children were selected as control...
October 16, 2017: International Ophthalmology
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