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https://www.readbyqxmd.com/read/27922631/dataset-of-eye-disease-related-proteins-analyzed-using-the-unfolding-mutation-screen
#1
Caitlyn L McCafferty, Yuri V Sergeev
A number of genetic diseases are a result of missense mutations in protein structure. These mutations can lead to severe protein destabilization and misfolding. The unfolding mutation screen (UMS) is a computational method that calculates unfolding propensities for every possible missense mutation in a protein structure. The UMS validation demonstrated a good agreement with experimental and phenotypical data. 15 protein structures (a combination of homology models and crystal structures) were analyzed using UMS...
December 6, 2016: Scientific Data
https://www.readbyqxmd.com/read/27921205/consistent-pattern-in-positional-instability-of-polyfocal-full-optics-accommodative-iol
#2
Yu Cheol Kim, Kyung Tae Kang, Youngdo Yeo, Ki-San Kim, Frank S Siringo
PURPOSE: We describe cases of dislocation or subluxation of the WIOL-CF(®) polyfocal full-optics intraocular lens (IOL) and suggest a consistent pattern and possible mechanism for the IOL instability. METHODS: This is a retrospective case series of five consecutive eyes in three patients with WIOL-CF(®) IOL instability at Keimyung University Dongsan Medical Center and Kimkisan Eye Center from 2012 to 2014. The medical records and ocular exam data for these patients were analyzed...
December 5, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27920717/cataract-surgery-with-a-new-fluidics-control-phacoemulsification-system-in-nanophthalmic-eyes
#3
John S M Chang, Jack C M Ng, Vincent K C Chan, Antony K P Law
PURPOSE: To report visual outcomes and complications after cataract surgery in nanophthalmic eyes with a phacoemulsification system using the active fluidics control strategy. METHODS: This is a retrospective case series. All eyes with an axial length of less than 20 mm that underwent cataract surgery or refractive lens exchange using the Centurion Vision System (Alcon Laboratories Inc.) in Hong Kong Sanatorium and Hospital were evaluated. The visual acuity and intraoperative and postoperative complications were reported...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27920493/a-retrospective-analysis-of-intraocular-pressure-changes-after-cataract-surgery-with-the-use-of-prednisolone-acetate-1-versus-difluprednate-0-05
#4
Yael Kusne, Paul Kang, Robert E Fintelmann
PURPOSE: To compare the effect of topical prednisolone acetate 1% (PA) used after routine cataract surgery to the effect of difluprednate 0.05% (DFBA) used for the same indication on intraocular pressure (IOP). METHODS: An electronic query was created to gather information from all cataract surgeries between January 2010 and January 2015 within the electronic health record database at Barnet Dulaney Perkins, a multicenter, multiphysician private practice in Phoenix, Arizona...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27920490/a-randomized-double-masked-study-to-compare-the-ocular-safety-tolerability-and-efficacy-of-bromfenac-0-075-compared-with-vehicle-in-cataract-surgery-subjects
#5
Kamran Hosseini, Thomas Walters, Robert DaVanzo, Richard L Lindstrom
PURPOSE: The aim of this study was to evaluate the safety, tolerability, and efficacy of a low-dose version of bromfenac 0.075% in DuraSite(®) (bromfenac 0.075%) compared with DuraSite(®) vehicle (vehicle) alone for the treatment of postoperative inflammation and ocular pain after cataract surgery. METHODS: A multicenter, double-masked, vehicle-controlled, parallel-group clinical trial of 240 subjects randomized in a 2:1 ratio to bromfenac 0.075% or vehicle was conducted...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27920014/disparities-in-cataract-surgery-volumes-among-ontario-s-ophthalmologists
#6
William Hodge, Efstathia Kiatos
No abstract text is available yet for this article.
December 5, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27920012/effect-of-cataract-surgery-volume-constraints-on-recently-graduated-ophthalmologists-a-population-based-cohort-study
#7
Robert J Campbell, Sherif R El-Defrawy, Chaim M Bell, Sudeep S Gill, Philip L Hooper, Marlo Whitehead, Erica de L P Campbell, Robert Nesdole, Daniel Warder, Martin Ten Hove
BACKGROUND: Across Canada, graduates from several medical and surgical specialties have recently had difficulty securing practice opportunities, especially in specialties dependent upon limited resources. In most developed nations, cataract surgery is the most common operation performed, making practice opportunities sensitive to access to health system resources and making this procedure an exemplar of issues facing resource-intensive specialties. METHODS: We used population-based administrative data from Ontario for the period Jan...
December 5, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27919342/individual-response-to-ionizing-radiation
#8
Nicolas Foray, Michel Bourguignon, Nobuyuki Hamada
The human response to ionizing radiation (IR) varies among individuals. The first evidence of the individual response to IR was reported in the beginning of the 20th century. Considering nearly one century of observations, we here propose three aspects of individual IR response: radiosensitivity for early or late adverse tissue events after radiotherapy on normal tissues (non-cancer effects attributable to cell death); radiosusceptibility for IR-induced cancers; and radiodegeneration for non-cancer effects that are often attributable to mechanisms other than cell death (e...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27919335/cataractogenesis-following-high-let-radiation-exposure
#9
Nobuyuki Hamada, Tatsuhiko Sato
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is more effective for various biological endpoints than low-LET radiation. Human exposure to high-LET radiation occurs in cancer patients, nuclear workers, aviators, astronauts and other space travellers. From the radiation protection viewpoint, the ocular lens is among the most radiosensitive tissues in the body, and cataract (a clouding of the normally transparent lens) is classified as tissue reactions (formerly called nonstochastic or deterministic effects) with a threshold below which no effect would occur...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27919334/ionizing-radiation-induced-cataracts-recent-biological-and-mechanistic-developments-and-perspectives-for-future-research
#10
Elizabeth A Ainsbury, Stephen Barnard, Scott Bright, Claudia Dalke, Miguel Jarrin, Sarah Kunze, Rick Tanner, Joseph R Dynlacht, Roy A Quinlan, Jochen Graw, Munira Kadhim, Nobuyuki Hamada
The lens of the eye has long been considered as a radiosensitive tissue, but recent research has suggested that the radiosensitivity is even greater than previously thought. The 2012 recommendation of the International Commission on Radiological Protection (ICRP) to substantially reduce the annual occupational equivalent dose limit for the ocular lens has now been adopted in the European Union and is under consideration around the rest of the world. However, ICRP clearly states that the recommendations are chiefly based on epidemiological evidence because there are a very small number of studies that provide explicit biological, mechanistic evidence at doses <2Gy...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27919333/radiation-and-cataract-risk-impact-of-recent-epidemiologic-studies-on-icrp-judgments
#11
Roy E Shore
In its 2012 report on tissue reactions, the International Commission on Radiological Protection (ICRP) made several key assumptions regarding radiation risk to the lens of the eye, including that radiation-related minor opacities will progress to become vision-impairing cataracts, that protracted irradiation confers as much risk per unit dose as an acute exposure, and that there is a dose threshold for cataract effects at about 0.5Gy. The few studies available provide only limited support for the ICRP assumption that radiation-related minor opacities are predictive of vision-impairing cataracts; further longitudinal data are clearly needed...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27918824/schlemm-s-canal-expansion-after-uncomplicated-phacoemulsification-surgery-an-optical-coherence-tomography-study
#12
Zhennan Zhao, Xiangjia Zhu, Wenwen He, Chunhui Jiang, Yi Lu
Purpose: To evaluate the effects of phacoemulsification cataract surgery on Schlemm's canal (SC) using swept-source optical coherence tomography (OCT). Methods: Patients with a senile cataract were included. The SC area and diameter were checked by OCT at the baseline and 1 day, 1 week, 1 month, and 6 months after the cataract surgery. Multivariate linear regression analysis was performed for predictors of change in the mean SC area and diameter. Results: Twenty-five eyes (25 patients) were included in the final analysis...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918775/association-between-myopia-ultraviolet-b-radiation-exposure-serum-vitamin-d-concentrations-and-genetic-polymorphisms-in-vitamin-d-metabolic-pathways-in-a-multicountry-european-study
#13
Katie M Williams, Graham C G Bentham, Ian S Young, Ann McGinty, Gareth J McKay, Ruth Hogg, Christopher J Hammond, Usha Chakravarthy, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Astrid E Fletcher
Importance: Myopia is becoming increasingly common globally and is associated with potentially sight-threatening complications. Spending time outdoors is protective, but the mechanism underlying this association is poorly understood. Objective: To examine the association of myopia with ultraviolet B radiation (UVB; directly associated with time outdoors and sunlight exposure), serum vitamin D concentrations, and vitamin D pathway genetic variants, adjusting for years in education...
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27918589/outcomes-of-cataract-surgery-in-urban-and-rural-population-in-the-south-indian-state-of-andhra-pradesh-rapid-assessment-of-visual-impairment-ravi-project
#14
Srinivas Marmamula, Rohit C Khanna, Konegari Shekhar, Gullapalli N Rao
OBJECTIVE: To assess the visual outcomes after cataract surgery among urban and rural population aged ≥40 years in the South India state of Andhra Pradesh. METHODS: A population based cross-sectional study was conducted in which 7800 subjects were sampled from two rural and one urban location. Visual Acuity was assessed and eye examination were performed by trained personnel. A questionnaire was used to collect personal and demographic information, and history of cataract surgery...
2016: PloS One
https://www.readbyqxmd.com/read/27917889/comparative-study-between-a-spectral-domain-and-a-high-speed-single-beam-swept-source-octa-system-for-identifying-choroidal-neovascularization-in-amd
#15
R Told, L Ginner, A Hecht, S Sacu, R Leitgeb, A Pollreisz, U Schmidt-Erfurth
This comparative study between a SD- and SS-OCTA system for visualizing neovascular patterns in AMD, also assessed the influence of cataract on OCTA imaging. 25 eyes with active CNV (AMD) were documented by FA, ICGA and SD-OCT. Two OCTA devices were used: A custom built SS-OCTA (1050 nm, 400,000 A-scans/s, 5 × 5 mm, no image segmentation); AngioVue (OptoVue, CA, USA) SD-OCTA (840 nm, 70.000 A-scans/s, 3 × 3 mm, SSADA technology). Two retina experts graded CNV types and vascular patterns. Cataract influence on OCTA image quality was reported for the superficial retinal plexus (6 eyes)...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917718/the-role-of-rho-kinase-inhibitors-in-corneal-endothelial-dysfunction
#16
Naoki Okumura, Shigeru Kinoshita, Noriko Koizumi
BACKGROUND: The cornea is transparent tissue that serves as the window of the eye, allowing light to enter from the outer environment. The corneal endothelium maintains corneal transparency; thus, its dysfunction results in corneal haziness and causes severe vision loss. The only available therapeutic choice for treating corneal endothelial dysfunction has been transplantation using donor corneas; consequently, researchers have been pressed to develop new therapeutic options. METHODS: The goal of the review is to provide an overview of the research into Rho kinase (ROCK) inhibitors in the field of corneal endothelium therapy and the potential for clinical use of ROCK inhibitors...
December 5, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27917612/fear-of-falling-and-physical-function-in-older-adults-with-cataract-exploring-the-role-of-vision-as-a-moderator
#17
Anna Palagyi, Jonathon Q Ng, Kris Rogers, Lynn Meuleners, Peter McCluskey, Andrew White, Nigel Morlet, Lisa Keay
AIM: To examine fear of falling and associated factors in a cohort of older adults with cataract, and investigate the interplay of vision and physical function with respect to fear of falling. METHODS: We analyzed baseline data from a longitudinal study of adults aged ≥65 years referred for cataract surgery. Fear of falling was assessed by the Short Falls Efficacy Scale-International. Physical function was determined by the Short Physical Performance Battery...
December 4, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27917530/visual-complications-in-diabetes-mellitus-beyond-retinopathy
#18
REVIEW
A Khan, I N Petropoulos, G Ponirakis, R A Malik
Diabetic retinopathy is the most common cause of vision loss in people with diabetes mellitus; however, other causes of visual impairment/loss include other retinal and non-retinal visual problems, including glaucoma, age-related macular degeneration, non-arteritic anterior ischaemic optic neuropathy and cataracts. Additionally, when a person with diabetes complains of visual disturbance despite a visual acuity of 6/6, abnormalities in refraction, contrast sensitivity, straylight and amplitude of accommodation should be considered...
December 5, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27916715/360-degree-trabeculotomy-for-medically-refractory-glaucoma-following-cataract-surgery-and-juvenile-open-angle-glaucoma
#19
Maria E Lim, Jennifer B Dao, Sharon F Freedman
PURPOSE: While angle surgeries show good success in primary congenital glaucoma, reported success in glaucoma following cataract surgery (GFCS) and juvenile open angle glaucoma (JOAG) is variable and with relatively short follow-up. We evaluated longer-term outcomes of 360-trabeculotomy for medically-refractory GFCS and JOAG. DESIGN: Retrospective case series. METHODS: First operated eyes of consecutive patients with medically-refractory GFCS and JOAG in a single-surgeon pediatric glaucoma practice who underwent illuminated microcatheter-assisted 360-trabeculotomy from 2/2008-6/2015 were reviewed...
December 1, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27916450/dramatic-response-after-functional-hemispherectomy-in-a-patient-with-epileptic-encephalopathy-carrying-a-de-novo-col4a1-mutation
#20
Naomi Hino-Fukuyo, Atsuo Kikuchi, Masaki Iwasaki, Yuko Sato, Yuki Kubota, Tomoko Kobayashi, Tojo Nakayama, Kazuhiro Haginoya, Natsuko Arai-Ichinoi, Tetsuya Niihori, Ryo Sato, Tasuku Suzuki, Hiroki Kudo, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Shigeo Kure
We describe the first case of a successful functional hemispherectomy in a patient with epileptic encephalopathy and a de novo collagen type IV alpha 1 (COL4A1) mutation. A 4-year-old girl was COL4A1 mutation-positive and suffered from drug-resistant epilepsy, hemiplegia, and developmental delay. Magnetic resonance imaging detected no porencephaly, and she had no cataract or renal abnormality. Following a presurgical evaluation for epilepsy, she underwent a functional hemispherectomy. She has been seizure free with no intracranial hemorrhage or other perioperative complications...
December 1, 2016: Brain & Development
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