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https://www.readbyqxmd.com/read/29222626/the-effect-of-phacoemulsification-on-intraocular-pressure-in-eyes-with-hyperfiltration-following-trabeculectomy-a-prospective-study
#1
Ivano Riva, Andreas Katsanos, Francesco Oddone, Luciano Quaranta
INTRODUCTION: The aim of this study was to evaluate the effect of visually non-significant cataract extraction in patients with hypotony maculopathy and reduced visual acuity due to over-filtering blebs after trabeculectomy. METHODS: Patients with intraocular pressure (IOP) < 6 mmHg and documented hypotony maculopathy due to over-filtering blebs after trabeculectomy were prospectively recruited. Eligible patients underwent visually non-significant cataract phacoemulsification, no earlier than 12 weeks from the diagnosis of hypotony maculopathy...
December 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29222283/hereditary-thrombocytopenias-a-growing-list-of-disorders
#2
REVIEW
Patrizia Noris, Alessandro Pecci
The introduction of high throughput sequencing (HTS) techniques greatly improved the knowledge of inherited thrombocytopenias (ITs) over the last few years. A total of 33 different forms caused by molecular defects affecting at least 32 genes have been identified; along with the discovery of new disease-causing genes, pathogenetic mechanisms of thrombocytopenia have been better elucidated. Although the clinical picture of ITs is heterogeneous, bleeding has been long considered the major clinical problem for patients with IT...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222017/increasing-susceptibility-to-oxidative-stress-by-cataract-causing-crystallin-mutations
#3
Wei-Jie Zhao, Yong-Bin Yan
Cataract, a crystallin protein aggregation disease, is the leading cause of human blindness worldwide. Congenital cataract may be induced by many factors and genetic disorders accounts for about half of the cases. Inherited mutations can promote cataract formation by affecting crystallin structure, solubility, stability, protein interactions and aggregatory propensity. In this research, we investigated the potential role of oxidative damage in congenital cataracts caused by six mutations in γC- and γD-crystallins, the predominant structural proteins in the lens...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29219957/anterior-chamber-lens-implantation-in-vitrectomised-eyes
#4
G S Negretti, M Lai, P Petrou, R Walker, D Charteris
PurposeTo investigate long-term visual acuity (VA) outcomes and complication rates in vitrectomised eyes undergoing anterior chamber intraocular lens (ACIOL) insertion.Patients and methodsA single-centre, retrospective case series including all patients who had undergone ACIOL placement at the time of vitrectomy surgery or having had previous vitrectomy, between January 2007 and January 2013. Patients were identified using an electronic database and paper casefile notes were analysed for all patients. Patients were excluded if they had <3 months follow-up...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29219952/early-onset-posterior-subscapular-cataract-in-a-series-of-myotonic-dystrophy-type-2-patients
#5
C Papadopoulos, K Kekou, S Xirou, S Kitsiou-Tzeli, E Kararizou, G K Papadimas
PurposeEarly onset posterior subscapular cataract (<50 years of age) is a characteristic feature of myotonic dystrophy type 2 (DM2). Nevertheless, despite being operated at a young age, many patients remain undiagnosed for years. The purpose of this study was to assess the prevalence of early onset posterior subscapular cataract as a presenting symptom of the disease in a cohort of patients with DM2.Patients and methodsWe retrospectively reviewed medical records of DM2 patients followed in our institution for the presence of early onset posterior subscapular cataract, of any secondary causes of cataract, of the age of onset of muscle weakness and of final disease diagnosis...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29217945/a-3-year-review-of-the-outcome-of-pars-plana-vitrectomy-for-dropped-lens-fragments-after-cataract-surgery-in-a-tertiary-eye-hospital-in-dhaka-bangladesh
#6
Lateefat Olokoba, Tajul Islam, Nazmun Nahar, Abdulraheem Mahmoud, Abdulfatai Olokoba
Background: Dropped lens fragments into the vitreous are uncommon, but potentially sight threatening complications of cataract surgery. The recommended approach for removal of dropped lens matter is pars plana vitrectomy with or without ultrasonic emulsification with the fragmatome. This study aimed to determine the visual outcome following pars plana vitrectomy for dropped lens fragments complicating cataract surgery at 6 weeks, 3 months and 6 months. Methods: This study is a retrospective review of patients who had PPV as treatment for dropped lens fragments complicating cataract surgery at Ispahani Islamia Eye hospital and Institute...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217756/light-focusing-human-micro-lenses-derived-from-zebrafish-like-lens-cell-masses-model-lens-development-and-drug-induced-cataract-in-vitro
#7
Patricia Murphy, Md Humayun Kabir, Tarini Srivastava, Michele E Mason, Chitra Umala Dewi, Seakcheng Lim, Andrian Yang, Djordje Djordjevic, Murray C Killingsworth, Joshua W K Ho, David G Harman, Michael D O'Connor
Cataracts cause vision loss and blindness by impairing the ability of the ocular lens to focus light onto the retina. Various cataract risk factors have been identified including drug treatments, age, smoking, and diabetes. However, the molecular events responsible for these different forms of cataract are ill-defined, and the advent of modern cataract surgery in the 1960s virtually eliminated access to human lenses for research. Here we demonstrate large-scale production of light-focusing human micro-lenses from spheroidal masses of human lens epithelial cells purified from differentiating pluripotent stem cells...
December 7, 2017: Development
https://www.readbyqxmd.com/read/29217351/endophthalmitis-then-and-now
#8
Nidhi Relhan, Richard K Forster, Harry W Flynn
PURPOSE: To report historically evolving strategies (then and now) in prevention and management of endophthalmitis. DESIGN: A perspective on relevant topics in the prophylaxis and management of endophthalmitis. METHODOLOGY: This is an author selected review of studies leading to changes in strategies for endophthalmitis management over the last 100 years. RESULTS: The current perspective discusses the trends and strategies over the past century...
December 4, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29217020/cataract-surgery-outcomes-and-complications-in-retinal-dystrophy-patients
#9
Emma C Davies, Roberto Pineda
OBJECTIVE: To investigate intraoperative complications, postoperative findings, and visual acuity outcomes in patients with retinal dystrophy after cataract surgery. DESIGN: Retrospective chart review at an academic tertiary referral centre. PARTICIPANTS: Thirty eyes from 18 patients with retinitis pigmentosa and other retinal dystrophies (Usher syndrome, Refsum disease, and Leber congenital amaurosis) who underwent cataract surgery were identified by searching the electronic medical record system from January 2010 to September 2015 for all patients treated by a single physician with billing codes for retinal dystrophy and cataract surgery...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29216854/acute-clouding-of-trifocal-lens-during-implantation-a-case-report
#10
Qian Liu, Suhua Zhang, Xiaogang Wang, Weifang Cao, Yading Jia
BACKGROUND: Intraoperative IOLs clouding of several kinds of hydrophilic acrylic intraocular lenses (IOLs) have been reported due to temperature changes. This phenomenon reported previously occurred in cold countries and during the winter months. However, no clinical case was reported about trifocal IOL opacification during operation. We report a case in which acute opacification of the optical region occurred simultaneously when AT LISA tri 839mp(Carl Zeiss) was implanted into the eye...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29215393/therapeutic-effects-of-lamellar-keratoplasty-on-terrien-marginal-degeneration
#11
Lin Li, Hualei Zhai, Lixin Xie, Jun Cheng, Weiwei Liu
PURPOSE: To evaluate the therapeutic effects of lamellar keratoplasty (LK) on Terrien marginal degeneration (TMD). METHODS: Retrospective interventional case series. Medical records of 63 patients (71 eyes) who received LK for TMD at Qingdao Eye Hospital, Shandong Eye Institute from December 1995 to March 2014 were reviewed. A total of 56 eyes were treated with partial LK and 15 eyes with total LK. Complications, visual acuity recovery, and graft status were evaluated...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29214740/a-prospective-multicentre-randomized-placebo-controlled-superiority-trial-in-patients-with-suspected-bacterial-endophthalmitis-after-cataract-surgery-on-the-adjuvant-use-of-intravitreal-dexamethasone-to-intravitreal-antibiotics
#12
Sonia Manning, Luana C Ugahary, Eric W Lindstedt, René J Wubbels, Jaap T van Dissel, Jan T G Jansen, Ivan Gan, Arnoud T van Goor, Carlien A Bennebroek, Dymph J van der Werf, Annette Ossewaarde-van Norel, Chris C Mayland Nielsen, Mauk Tilanus, Pieter R van den Biesen, Peter A Schellekens, Ellen La Heij, Koorosh Faridpooya, Koen van Overdam, Marc Veckeneer, Jan C van Meurs
PURPOSE: We aimed to determine whether intravitreal dexamethasone as an adjuvant to intravitreal antibiotics is beneficial in the treatment of suspected bacterial endophthalmitis after cataract surgery. METHODS: Randomized, placebo-controlled superiority trial in three tertiary referral centres in the Netherlands. Patients with suspected bacterial endophthalmitis within 6 weeks after cataract surgery were eligible. A diagnostic vitreous biopsy was taken for culture, and patients received intravitreal injections of 400 μg dexamethasone (without preservatives) or placebo, in addition to 0...
December 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29212481/early-anti-vegf-treatment-for-hemorrhagic-occlusive-retinal-vasculitis-as-a-complication-of-cataract-surgery
#13
Konstantinos Andreanos, Petros Petrou, George Kymionis, Dimitrios Papaconstantinou, Ilias Georgalas
BACKGROUND: We report a case of hemorrhagic occlusive retinal vasculitis (HORV) after prophylactic intracameral vancomycin use during an uneventful cataract surgery treated with early anti-VEGF treatment. CASE PRESENTATION: A 51-year-old female underwent uneventful cataract surgery with prophylactic intracameral vancomycin during the procedure. On the seventh post-operative-day, she presented with sudden painful, visual loss. Fundus examination revealed peripheral hemorrhagic retinal vasculitis...
December 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29211038/prevalence-of-self-reported-diagnosed-cataract-and-associated-risk-factors-among-elderly-south-africans
#14
Nancy Phaswana-Mafuya, Karl Peltzer, Amelia Crampin, Edmund Ahame, Zinhle Sokhela
This paper estimates the prevalence of self-reported cataract and associated risk factors among individuals aged ≥50 years in South Africa. Data from a nationally-representative cross-sectional Study on Global AGEing and Adult Health (SAGE) (N = 3646) conducted in South Africa from 2007-2008 was analyzed. The primary outcome was self-reported cataract, and exposures included socio-demographics, self-reported co-morbidities, and behavioral factors. Linearized multivariate logistic regression models were used...
December 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29210839/cataract-surgery-in-ocular-surface-diseases-clinical-challenges-and-outcomes
#15
Virender S Sangwan, Swati Gupta, Shilpa Das
PURPOSE OF REVIEW: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. RECENT FINDINGS: Ocular surface diseases are commonly associated with corneal scarring and vascularization, conjunctival inflammation, symblepharon and forniceal shortening...
January 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29210129/effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity
#16
REVIEW
Yi-Rong Li, Shiming Li, Chi-Chien Lin
Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence...
December 6, 2017: BioFactors
https://www.readbyqxmd.com/read/29208840/awareness-and-eye-health-seeking-practices-for-cataract-among-urban-slum-population-of-delhi-the-north-india-eye-disease-awareness-study
#17
Vasundhra Misra, Praveen Vashist, Senjam Suraj Singh, Sumit Malhotra, Vivek Gupta, S N Dwivedi, Sanjeev K Gupta
PURPOSE: The objective of the study was to assess the awareness and health-seeking practices related to cataract in urban slums of Delhi. METHODS: This study design was a population-based cross-sectional study. Participants aged 18-60 years were recruited from randomly selected five slums of South Delhi. They were interviewed using a semi-structured interview schedule on awareness and eye health-seeking practices related to cataract. The practices were recorded if the respondents themselves or any other member of the family was diagnosed with cataract in previous 2 years...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208839/safety-efficacy-and-cost-effectiveness-of-consecutive-bilateral-cataract-surgery-on-two-successive-days-in-tribes-at-base-hospital-through-community-outreach-program-a-prospective-study-of-aravali-mountain-north-west-india
#18
Amit Mohan, Navjot Kaur, Vishal C Bhatanagar
PURPOSE: The aim of the study was to evaluate the safety and efficacy of consecutive bilateral cataract surgery (CBCS) on two successive days in a single hospital visit. METHODS: Prospective study was conducted on 565 patients of various tribes of hilly area of West Rajasthan who had come to our hospital through community outreach programmed (CORP) between January 2015 and March 2016. Patients with significant bilateral cataract without any other ocular morbidity were advised bilateral manual small incision cataract surgery on two consecutive days...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208837/antibiotic-prophylaxis-practice-patterns-for-cataract-surgery-in-india-results-from-an-online-survey
#19
Aditya S Kelkar, David F Chang, Jai A Kelkar, Hetal M Mehta, Tatyarao Lahane, Ragini Parekh
PURPOSE: The aim of this study is to assess the current antibiotic prophylaxis practice patterns for cataract surgery in India. METHODS: This was a questionnaire-based E-survey carried out at a tertiary eye care center in India. An E-mail invitation to complete an online 20 point questionnaire survey was sent to all members of the All India Ophthalmological Society with valid E-mail addresses using a digital E-mail service. Duplicate entries were prevented. RESULTS: Out of 1228 total respondents (8...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208835/effects-of-fuchs-uveitis-syndrome-on-the-ultrastructure-of-the-anterior-lens-epithelium-a-transmission-electron-microscopic-study
#20
Kemal Tekin, Yasemin Ozdamar Erol, Mustafa Fevzi Sargon, Merve Inanc, Pinar Cakar Ozdal, Nilufer Berker
PURPOSE: The purpose of the study was to investigate the electron microscopic findings of the lens epithelial cells (LECs) in patients with Fuchs uveitis syndrome (FUS) who suffered from cataracts and to compare those with age-matched controls. METHODS: This study was a prospective, comparative case series. The anterior lens capsules (ALC: basement membrane and associated LECs) were taken from 12 eyes of 12 cases of FUS and ten eyes of ten control patients. The ALCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM)...
December 2017: Indian Journal of Ophthalmology
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